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https://www.readbyqxmd.com/read/30116175/rosuvastatin-reduces-neuroinflammation-in-the-hemorrhagic-transformation-after-rt-pa-treatment-in-a-mouse-model-of-experimental-stroke
#1
Dan Lu, Yanfang Liu, Hongcheng Mai, Jiankun Zang, Lingling Shen, Yusheng Zhang, Anding Xu
Hemorrhagic transformation (HT) is a serious complication that stimulates inflammation during reperfusion therapy after acute ischemic stroke. Rosuvastatin, a 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, might improve the outcome of HT by inhibiting neuroinflammation. This study aimed to explore the protective effects of rosuvastatin against HT after recombinant tissue plasminogen activator (rt-PA) treatment in mice with experimental stroke via the attenuation of inflammation. A total of one hundred sixty-nine male BALB/c mice were used in the experiment...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30092232/hemopexin-reduces-blood-brain-barrier-injury-and-protects-synaptic-plasticity-in-cerebral-ischemic-rats-by-promoting-epcs-through-the-ho-1-pathway
#2
Yongyan Yang, Beibei Dong, Jun Lu, Guolin Wang, Yonghao Yu
Ischemic stroke causes endothelial dysfunction and blood-brain barrier dysfunction, thus damages synaptic plasticity such as learning and memory. In this study we aim to investigate the effect of hemopexin (HPX) in protecting synaptic plasticity and blood brain barrier integrity from toxic heme, and determine whether this effect is via the activation of endothelial progenitor cells (EPCs) through the heme oxygenase-1(HO-1) pathway. Our data indicates HPX showed a significant effect in inducing the expression of HO-1, promoting the migration and differentiation of EPCs, facilitating new blood vessel formation thus protecting blood-brain barrier integrity...
August 6, 2018: Brain Research
https://www.readbyqxmd.com/read/30089862/attenuation-of-stroke-damage-by-angiotensin-ii-type-2-receptor-stimulation-via-peroxisome-proliferator-activated-receptor-gamma-activation
#3
Bao-Shuai Shan, Masaki Mogi, Jun Iwanami, Hui-Yu Bai, Harumi Kan-No, Akinori Higaki, Li-Juan Min, Masatsugu Horiuchi
The brain renin-angiotensin system plays a crucial role in ischemic stroke. It is known that stimulation of the angiotensin II type 2 (AT2 ) receptor protects against ischemic brain injury. We recently demonstrated that AT2 receptor stimulation by compound 21 (C21), a direct AT2 receptor agonist, inhibited vascular intimal proliferation with activation of peroxisome proliferator-activated receptor-gamma (PPAR-γ). However, whether direct AT2 receptor stimulation protects against ischemic brain injury via PPAR-γ activation is still unknown...
August 8, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30074164/combination-therapy-with-lxw7-and-ceria-nanoparticles-protects-against-acute-cerebral-ischemia-reperfusion-injury-in-rats
#4
Ting Zhang, Chang-Yan Li, Jing-Jing Jia, Jie-Shan Chi, Da Zhou, Jian-Zhou Li, Xiao-Ma Liu, Jun Zhang, Li Yi
Ischemia/reperfusion is known to greatly increase oxidative stress in the penumbra, which results in brain damage. Integrin αvβ3 is selectively up-regulated with ischemic injury to the brain and remains elevated throughout reperfusion. We determined whether or not a new compound biotinylated-LXW7-ceria nanoparticle (CeNP) (bLXW7-CeNP) plays a role in brain protection in the rat model of middle cerebral artery occlusion/reperfusion and shows better effects than CeNPs alone in improving the outcomes of focal oxidative stress and apoptosis more effectively...
February 2018: Current medical science
https://www.readbyqxmd.com/read/30066928/simvastatin-improves-cerebrovascular-injury-caused-by-ischemia%C3%A2-reperfusion-through-nf%C3%A2-%C3%AE%C2%BAb%C3%A2-mediated-apoptosis-via-myd88-trif-signaling
#5
Zhiying Chen, Yuanyuan Xiang, Bing Bao, Xiangbin Wu, Zhongbin Xia, Jianyou You, Hongbing Nie
Cerebrovascular injury is the most prevalent human cerebrovascular disease and frequently results in ischemic stroke. Simvastatin may be a potential therapeutic agent for the treatment of patients with cerebrovascular injury. The present study aimed to investigate the efficacy of and the potential mechanisms regulated by simvastatin in a rat model of ischemia‑reperfusion (I/R)‑induced cerebrovascular injury. Cerebrovascular injury model rats were established and were subsequently treated with simvastatin or a vehicle control following I/R injury...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30054859/spatial-dynamics-of-vascular-and-biochemical-injury-in-rat-hippocampus-following-striatal-injury-and-a%C3%AE-toxicity
#6
Zareen Amtul, Carmen Frías, Jasmine Randhawa, David J Hill, Edith J Arany
The hippocampus, a brain region vital for memory and learning, is sensitive to the damage caused by ischemic/hypoxic stroke and is one of the main regions affected by Alzheimer's disease. The pathological changes that might occur in the hippocampus and its connections, because of cerebral injury in a distant brain region, such as the striatum, have not been examined. Therefore, in the present study, we evaluated the combined effects of endothelin-1-induced ischemia (ET1) in the striatum and β-amyloid (Aβ) toxicity on hippocampal pathogenesis, dictated by the anatomical and functional intra- and inter-regional hippocampal connections to the striatum...
July 28, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30051168/mmp10-promotes-efficient-thrombolysis-after-ischemic-stroke-in-mice-with-induced-diabetes
#7
Manuel Navarro-Oviedo, Carmen Roncal, Agustina Salicio, Miriam Belzunce, Obdulia Rabal, Estefanía Toledo, Beatriz Zandio, Jose A Rodríguez, Jose A Páramo, Roberto Muñoz, Josune Orbe
Diabetes is an important risk factor for ischemic stroke (IS). Tissue-type plasminogen activator (tPA) has been associated with less successful revascularization and poor functional outcome in diabetes. We assessed whether a new thrombolytic strategy based on MMP10 was more effective than tPA in a murine IS model of streptozotocin (STZ)-induced diabetes. Wild-type mice were administered a single dose of streptozotocin (STZ) (180 mg/kg) to develop STZ-induced diabetes mellitus. Two weeks later, IS was induced by thrombin injection into the middle cerebral artery and the effect of recombinant MMP10 (6...
July 27, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/30025123/systemic-7-8-dihydroxyflavone-treatment-protects-immature-retinas-against-hypoxic-ischemic-injury-via-m%C3%A3-ller-glia-regeneration-and-mapk-erk-activation
#8
Hsiu-Mei Huang, Chao-Ching Huang, Meng-Han Tsai, Yi-Chieh Poon, Ying-Chao Chang
Purpose: Perinatal hypoxic-ischemic (HI) injury causes significant damages in the immature retina. The brain-derived neurotrophic factor is well known for its neuroprotective role but has limited clinical applications. A selective agonist of tyrosine kinase receptor B, 7,8-dihydroxyflavone (DHF), is a powerful therapeutic tool, when administered systemically. However, it remains unclear whether DHF treatment can protect the immature retinas against HI injury. Methods: Postnatal (P) day 7 rat pups were intraperitoneally injected with DHF or vehicle 2 hours before and 18 hours after being subjected to HI injury...
June 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30018671/mst1-suppression-reduces-early-brain-injury-by-inhibiting-the-nf-%C3%AE%C2%BA-b-mmp-9-pathway-after-subarachnoid-hemorrhage-in-mice
#9
Jie Qu, Hengli Zhao, Qiang Li, Pengyu Pan, Kang Ma, Xin Liu, Hua Feng, Yujie Chen
Background: Mammalian sterile 20-like kinase 1 (MST1), the key component of the Hippo-YAP pathway, exhibits an important role in the pathophysiological process of various neurological disorders, including ischemic stroke and spinal cord injury. However, during subarachnoid hemorrhage, the involvement of MST1 in the pathophysiology of early brain injury remains unknown. Methods: We employed intravascular filament perforation to establish the subarachnoid hemorrhage (SAH) mouse model...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/30015849/evaluation-of-intestinal-injury-inflammatory-response-and-oxidative-stress-following-intracerebral-hemorrhage-in-mice
#10
Yijun Cheng, Jieyu Zan, Yaying Song, Guoyuan Yang, Hanbing Shang, Weiguo Zhao
Intestinal injury is a common complication following intracerebral hemorrhage (ICH), which leads to malnutrition, impaired immunity and unsatisfactory prognosis. Previous studies have revealed the pathogenesis of intestinal injury following traumatic brain injury using ischemic stroke models. However, the effects of ICH on intestinal injury remain unknown. The present study aimed to investigate the pathological alterations and molecular mechanism, as well as the time course of intestinal injury following ICH in mice...
October 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30007159/sema3e-plexind1-inhibition-is-a-therapeutic-strategy-for-improving-cerebral-perfusion-and-restoring-functional-loss-after-stroke-in-aged-rats
#11
Yi-Fan Zhou, Peng-Cheng Li, Jie-Hong Wu, James Andrew Haslam, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Xu-Xia Wang, Hao Lei, Xiao-Li Lan, Qing Robert Miao, Zhen-Yu Yue, Ya-Nan Li, Bo Hu
Brain tissue survival and functional recovery after ischemic stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in the ischemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has been demonstrated to be a critical regulator in embryonic and postnatal vascular formation via binding to its receptor PlexinD1. However, whether Sema3E/PlexinD1 signaling is involved in poststroke neovascularization remains unknown. To determine the contribution of Sema3E/PlexinD1 signaling to poststroke recovery, aged rats (18 months) were subjected to a transient middle cerebral artery occlusion...
June 11, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29966831/mir-155-deletion-reduces-ischemia-induced-paralysis-in-an-aortic-aneurysm-repair-mouse-model-utility-of-immunohistochemistry-and-histopathology-in-understanding-etiology-of-spinal-cord-paralysis
#12
Hamdy Awad, Anna Bratasz, Gerard Nuovo, Richard Burry, Xiaomei Meng, Hesham Kelani, Melissa Brown, Mohamed E Ramadan, Jim Williams, Lamia Bouhliqah, Phillip G Popovich, Zhen Guan, Cynthia Mcallister, Sarah E Corcoran, Brian Kaspar, D Michele Basso, José J Otero, Claudia Kirsch, Ian C Davis, Carlo Maria Croce, Jean-Jacques Michaille, Esmerina Tili
Spinal cord paralysis is relatively common after surgical repair of thoraco-abdominal aortic aneurysm (TAAA) and its etiology is unknown. The present study was designed to examine the histopathology of the disease and investigate whether miR-155 ablation would reduce spinal cord ischemic damage and delayed hindlimb paralysis induced by aortic cross-clamping (ACC) in our mouse model. The loss of locomotor function in ACC-paralyzed mice correlated with the presence of extensive gray matter damage and central cord edema, with minimal white matter histopathology...
June 18, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29956801/tanshinone-iia-improves-hypoxic-ischemic-encephalopathy-through-tlr%C3%A2-4%C3%A2-mediated-nf%C3%A2-%C3%AE%C2%BAb-signal-pathway
#13
Chengzhi Fang, Lili Xie, Chunmei Liu, Chunhua Fu, Wei Ye, Hong Liu, Binghong Zhang
Hypoxic ischemic encephalopathy (HIE) is the most common brain injury following hypoxia and/or ischemia caused by various factors during the perinatal period, resulting in detrimental neurological deficits in the nervous system. Tanshinone IIA (Tan‑IIA) is a potential agent for the treatment of cardiovascular and cerebrovascular diseases. In this study, the efficacy of Tan‑IIA was investigated in a newborn mouse model of HIE. The dynamic mechanism of Tan‑IIA was also investigated in the central nervous system of neonate mice...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29949404/blood-brain-barrier-dysfunction-in-ischemic-stroke-targeting-tight-junctions-and-transporters-for-vascular-protection
#14
Wazir Abdullahi, Dinesh Tripathi, Patrick T Ronaldson
The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of endogenous and exogenous xenobiotics and associated metabolites. This is accomplished by molecular characteristics of brain microvessel endothelial cells such as tight junction protein complexes and functional expression of influx and efflux transporters. One of the pathophysiological features of ischemic stroke is disruption of the BBB, which significantly contributes to development of brain injury and subsequent neurological impairment...
June 27, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29945912/inhibition-of-microrna-155-supports-endothelial-tight-junction-integrity-following-oxygen-glucose-deprivation
#15
Juan Carlos Pena-Philippides, Amy Sabrina Gardiner, Ernesto Caballero-Garrido, Rong Pan, Yiliang Zhu, Tamara Roitbak
BACKGROUND: Brain microvascular endothelial cells form a highly selective blood brain barrier regulated by the endothelial tight junctions. Cerebral ischemia selectively targets tight junction protein complexes, which leads to significant damage to cerebral microvasculature. Short noncoding molecules called microRNAs are implicated in the regulation of various pathological states, including endothelial barrier dysfunction. In the present study, we investigated the influence of microRNA-155 (miR-155) on the barrier characteristics of human primary brain microvascular endothelial cells (HBMECs)...
June 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29935175/targeting-vascular-inflammation-in-ischemic-stroke-recent-developments-on-novel-immunomodulatory-approaches
#16
Shashank Shekhar, Mark W Cunningham, Mallikarjuna R Pabbidi, Shaoxun Wang, George W Booz, Fan Fan
Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury, and recovery or wound healing. A central target of inflammation is disruption of the blood brain barrier or neurovascular unit. Here we discuss recent developments in identifying potential molecular targets and immunomodulatory approaches to preserve or protect barrier function and limit infarct damage and functional impairment...
August 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29932327/simultaneous-blood-brain-barrier-crossing-and-protection-for-stroke-treatment-based-on-edaravone-loaded-ceria-nanoparticles
#17
Qunqun Bao, Ping Hu, Yingying Xu, Tiansheng Cheng, Chenyang Wei, Limin Pan, Jianlin Shi
Cerebral vasculature and neuronal networks will be largely destroyed due to the oxidative damage by overproduced reactive oxygen species (ROS) during a stroke, accompanied by the symptoms of ischemic injury and blood-brain barrier (BBB) disruption. Ceria nanoparticles, acting as an effective and recyclable ROS scavenger, have been shown to be highly effective in neuroprotection. However, the brain access of nanoparticles can only be achieved by targeting the damaged area of BBB, leading to the disrupted BBB being unprotected and to turbulence of the microenvironment in the brain...
July 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#18
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29895321/neural-stem-cell-therapy-for-subacute-and-chronic-ischemic-stroke
#19
REVIEW
Austin C Boese, Quan-Son Eric Le, Dylan Pham, Milton H Hamblin, Jean-Pyo Lee
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Clinically, extensive injury from ischemic stroke results from ischemia-reperfusion (IR), which is accompanied by inflammation, blood-brain barrier (BBB) damage, neural cell death, and extensive tissue loss. Tissue plasminogen activator (tPA) is still the only US Food and Drug Administration-approved clot-lysing agent...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29882126/irisin-peptide-protects-brain-against-ischemic-injury-through-reducing-apoptosis-and-enhancing-bdnf-in-a-rodent-model-of-stroke
#20
Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakili
Evidence has shown therapeutic potential of irisin in cerebral stroke. The present study aimed to assess the effects of recombinant irisin on the infarct size, neurological outcomes, blood-brain barrier (BBB) permeability, apoptosis and brain-derived neurotrophic factor (BDNF) expression in a mouse model of stroke. Transient focal cerebral ischemia was established by middle cerebral artery occlusion (MCAO) for 45 min and followed reperfusion for 23 h in mice. Recombinant irisin was administrated at doses of 0...
June 7, 2018: Neurochemical Research
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