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R De, L Y Liu, Y Qian, L P Jia, H J Dong, R N Zhu, Y H Liu, Y Q Lyu, L Q Zhao
Objective: To investigate the relationship between human bocavirus 2 (HBoV2) infection and acute diarrhea in children younger than 5 years of age in a case-control study. Methods: This was a prospective case-control study. During May 2016 to December 2016, fecal specimens were collected from children ≤5 years of age with acute diarrhea who visited the Affiliated Children's Hospital of Capital Institute of Pediatrics (case group), or from children ≤5 years of age without diarrhea from Longtan Community Medical Service Center, Beijing (control group)...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Frank M van der Sande, Karlien J A Ter Meulen, Peter Kotanko, Jeroen P Kooman
BACKGROUND: Calcium (Ca) is an essential element that plays a critical role in many biological processes. In dialysis patients, the regulation of Ca balance is highly complex, given the absence of kidney function, endocrine disturbances and the use of drugs such as phosphate binders, vitamin D analogues, and calcimimetics. Also, the use of different dialysate Ca (DCa) baths has profound effect on Ca balance, which depends both on the difference between the Ca concentration in the bath and the serum of the patients, as on the ultrafiltration volume...
December 5, 2018: Blood Purification
Mateusz K Hołda, Mateusz Koziej
BACKGROUND: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach. METHODS: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control...
December 5, 2018: Cerebrovascular Diseases
Alexander J Martin, Christopher I Price
BACKGROUND: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. SUMMARY: Electronic searches from January 1990 to March 2017 identified studies reporting a blood/cerebrospinal fluid (CSF)/urine biomarker measurement within 24 h of acute stroke and at least 2 serial assessments of clinical neurological status (< 24 h and < 7 days)...
December 5, 2018: Cerebrovascular Diseases
Charles Chazot, Guillaume Jean
Recently the concept that prescription of chronic hemodialysis (HD) start should be tailored based on residual renal function (RRF) and urine output (UO) has been revived from the past and called infrequent or incremental dialysis. It mainly consists in prescribing 1 or 2 HD sessions per week instead of what has become the standard thrice-weekly HD. It is both surprising and fascinating that almost 60 years after the first end-stage kidney disease patient was treated by Scribner et al. [Trans Am Soc Artif Intern Organs 1960; 6: 114-122], the nephrology community still questions the best way to start HD therapy...
December 5, 2018: Blood Purification
Guanghua Xiong, Lufang Zou, Yunyun Deng, Yunlong Meng, Xinjun Liao, Huiqiang Lu
Clethodim is one of the most widely used herbicides in agriculture, but its potential negative effects on aquatic organisms are still poorly understood. This study examined the effects of clethodim on zebrafish at aspects of early stage embryonic development, immune toxicity, cell apoptosis and locomotor behavior. Firstly, clethodim exposure markedly decreased the survival rate, body length, and heart rate and resulted in a series of morphological abnormalities, primarily spinal deformities (SD) and yolk sac edema, in zebrafish larvae...
December 2, 2018: Fish & Shellfish Immunology
Young Je Lee, Soo-Jung Kim, Matthew B Amrofell, Tae Seok Moon
Recent advances in our understanding of RNA folding and functions have facilitated the use of regulatory RNAs such as synthetic antisense RNAs (asRNAs) to modulate gene expression. However, despite the simple and universal complementarity rule, predictable asRNA-mediated repression is still challenging due to the intrinsic complexity of native asRNA-mediated gene regulation. To address this issue, we present a multivariate model, based on the change in free energy of complex formation (ΔGCF) and percent mismatch of the target binding region, which can predict synthetic asRNA-mediated repression efficiency in diverse contexts...
December 5, 2018: ACS Synthetic Biology
Paolo Armando Gagliardi, Luca Primo
Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCKα) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by proteases. How caspases acquired the ability to control these proteins during evolution of vertebrates is still unknown. Here, we report a phylogenetic and molecular study on the acquisition of caspase-cleavage sites in the family of Rho-activated kinases (RaKs). We demonstrate that the acquisition of such sites has more frequently occurred in identifiable intrinsically disordered regions (IDRs) within or flanking the coiled-coil domain...
December 4, 2018: Molecular Biology and Evolution
Samer Tannus, Yoni Cohen, Sara Henderson, Na'ama Al Ma'mari, Tal Shavit, Weon-Young Son, Michael H Dahan
STUDY QUESTION: In IVF cycles in which the entire embryo cohort is slow growing, is it optimal to perform fresh transfer in Day 5 or to extend the culture and transfer in subsequent vitrified-warmed cycles? SUMMARY ANSWER: The outcomes depend on the degree of embryo development on Day 5. WHAT IS KNOWN ALREADY: Slow-growing blastocysts have lower implantation potential when transferred in fresh cycles. It has been suggested that embryo-endometrial asynchrony could explain this finding...
December 4, 2018: Human Reproduction
Nikolaos Settas, Rebecca Persky, Fabio R Faucz, Nicole Sheanon, Antonis Voutetakis, Maya Lodish, Louise A Metherell, Constantine A Stratakis
Context: Multiple autosomal recessive genes have been etiologically linked to Primary Adrenal Insufficiency (PAI). Recently, SGPL1 gene mutations were recognized as causes of steroid-resistant nephrotic syndrome type 14 (NPHS14), a sphingolipidosis with multisystemic manifestations including PAI. Interestingly, this is the only monogenetic form of nephrotic syndrome (NS) and the sole sphingolipidosis causing adrenal disease. Objective: To understand if SGPL1 mutations are involved in the pathogenesis of PAI in patients who do not exhibit NS...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
Yuan Yuan, Qingyun Mai, Jiaxuan Ma, Mingfen Deng, Yanwen Xu, Guanglun Zhuang, Canquan Zhou
STUDY QUESTION: Do human embryos survive long-term cryopreservation (CP) (≥12 years) and implant after frozen embryo transfer (ET)? SUMMARY ANSWER: Human embryos remain usable after long-term CP. WHAT IS KNOWN ALREADY: Several cohort studies have reported the live birth rate or neonatal outcomes of human embryos after CP for up to 5 years. Only a few case reports have described successful live births from human embryos after long-term CP up to 12 years...
December 4, 2018: Human Reproduction
Carolyn H Still, Nicholas M Pajewski, Gordon J Chelune, Stephen R Rapp, Kaycee M Sink, Virginia G Wadley, Jeff D Williamson, Alan J Lerner
Objective: To examine the association of global cognitive function assessed via the Montreal Cognitive Assessment (MoCA) and deficiencies in instrumental activities of daily living (IADL) on the Functional Activity Questionnaire (FAQ) in hypertensive older adults in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods: In cross-sectional analysis, 9,296 SPRINT participants completed the MoCA at baseline. The FAQ was obtained from 2,705 informants for SPRINT participants scoring <21 or <22 on the MoCA, depending on education...
December 5, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Alfredo Borda-Olivas, Ángel Florián Florián, Edgar Montalvan Santillan, María Dedios Alegría, César Cabezas Sánchez, Fernando Donaires Toscano
The objective of the study was to determine compliance with hepatitis-B virus (HBV) in newborns in Lima and Callao. A descriptive, cross-sectional, multicenter-design study was conducted in high level public and private hospitals. Information on vaccination corresponds to newborns during one week of 2015 and was obtained through consultations with parents and review of health service reports. The study was conducted in 12 health facilities including 935 mothers and newborns. Vaccination coverage within 24 hours of life was 85...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Javier Vargas-Herrera, Karim Pardo Ruiz, Gladys Garro Nuñez, Janet Miki Ohno, José Enrique Pérez-Lu, William Valdez Huarcaya, Benjamin Clapham, Juan Cortez-Escalante
Peru has a low coverage of deaths with a cause of death (54%) and a poor-quality registration of causes of death, as about 30% of causes of death are classified as poorly-defined or not very useful for the formulation of public policies. In response to these problems, the Ministry of Health, together with other government agencies, with the support of the Bloomberg Philanthropies "Data for Health Initiative," is implementing the National Death Registry Information System (SINADEF). The objective of this article is to describe the process of strengthening the mortality information system in Peru, focused on the implementation of SINADEF...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Mike R Bueno, Carlos Estrela, Brunno C Azevedo, Anibal Diogenes
Cone-beam computed tomography (CBCT) has promoted changes in approaches in Endodontics, and enhanced decision-making in complex clinical cases. Despite the technological advancements in CBCT hardware, the interpretation of the acquired images is still compromised by viewing software packages that often have limited navigational tools and lack adequate filters to overcome some challenges of the CBCT technology such as artefacts. This study reviews the current limitations of CBCT and the potential of a new CBCT software package (e-Vol DX, CDT- Brazil) to overcome these aspects and support diagnosing, planning and managing of endodontic cases...
November 2018: Brazilian Dental Journal
Flávia Carvalho Malta Mello, Deborah Carvalho Malta, Maria Goreth Santos, Marta Maria Alves da Silva, Marta Angélica Iossi Silva
INTRODUCTION: The purpose of this paper was to compare the tendency of bullying across Brazilian capitals, considering the editions of National Scholl Health Survey (PeNSE) 2009, 2012 and 2015, and to describe the prevalence of bullying by sex, age and administrative dependence of the school in the 2015 sample. METHODOLOGY: The prevalence of bullying and its 95% confidence interval (95%CI) were assessed per State capital and for all capitals. 95%CI was used to check for differences in the period...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Max Moura de Oliveira, Silvânia Suely Caribé de Araújo Andrade, Sheila Rizzato Stopa, Deborah Carvalho Malta
INTRODUCTION: Knowing the profile of individuals who demand health services or professionals could help in the improvement and reorganization of services. However, this subject is still underexplored among adolescents. This study aimed to describe and identify characteristics related to the demand for health services or professionals by Brazilian students. METHODS: Using data from the 2015 National School Health Survey, the prevalence and respective 95% confidence intervals (95%CI) of the demand for health services or professionals among students were estimated, and Poisson regression adjusted by age and region of residence was used to identify the associated factors...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Mariana Borsa Mallmann, Antonio Fernando Boing, Yaná Tamara Tomasi, Juliana Cristine Dos Anjos, Alexandra Crispim Boing
OBJECTIVE: to analyze evolution as to conducting seven or more prenatal consultations with pregnant women in Brazil, in the period 2000-2015 according to maternal education level and race/skin color of the newborn baby. METHODS: this was a time series study based on Live Births Information System (SINASC) data; relative and absolute inequalities were investigated, adjusted for maternal age and gestational week in which childbirth occurred. RESULTS: we analyzed approximately 48 million births; the proportion of seven or more prenatal consultations increased nationally (from 46...
November 29, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Grasielle Camisão Ribeiro, Maria Clara Padoveze
OBJECTIVE: To conduct a situational diagnosis of the Nursing Care Systematization (NCS) in a Basic Health Unit from the perception of the nursing team. METHOD: This was a quantitative, descriptive-exploratory study, conducted in a Basic Health Unit in the interior of São Paulo state, Brazil. A structured questionnaire containing Likert scale was used for data collection, previously validated by specialists. RESULTS: The questionnaire was applied to 21 nursing professionals...
December 3, 2018: Revista da Escola de Enfermagem da U S P
Pedro Bichaff, Karina T Setani, Emiliana H G Motta, Artur F Delgado, Werther B Carvalho, Michele Luglio
OBJECTIVE: Opioid abstinence syndrome is common in the pediatric intensive care environment because sedation is often needed during the children's treatment. There is no specific guideline regarding the management of these patients; and lately, methadone is an important drug for the prevention of abstinence symptoms during the weaning of opioids. This study gathers the available research to establish the initial dose of methadone, the rate of taper and tools to recognize this syndrome and act promptly...
October 2018: Revista da Associação Médica Brasileira
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