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https://www.readbyqxmd.com/read/30121964/insights-from-multidimensional-analyses-of-the-pan-cancer-dna-methylome-heterogeneity-and-the-uncanonical-cpg-gene-associations
#1
Yang Liu, Rongyao Huang, Yu Liu, Wanlu Song, Yuting Wang, Yang Yang, Shengcheng Dong, Xuerui Yang
Although the DNA methylome profiles have been available in large cancer cohorts such as The Cancer Genome Atlas (TCGA), integrative analysis of the DNA methylome architectures in a pan-cancer manner is still limited. In the present study, we aimed to systematically dissect the insightful features related to the inter-tumoral DNA methylome heterogeneity in a pan-cancer context of 21 cancers in TCGA. First, pan-cancer clustering of the DNA methylomes revealed convergence of cancers and, meanwhile, new classifications of cancer subtypes, which are often associated to prognostic differences...
August 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30121910/effects-mifepristone-on-aminotransferase-activities-in-the-liver-in-rats-with-streptozotocin-induced-diabetes-mellitus
#2
N A Pal'chikova, V G Selyatitskaya, O I Kuz'minova, K V Pasechnaya
The glucocorticoid status and activities of ALT, AST, and tyrosine aminotransferase in the liver are studied in rats with streptozotocin-induced diabetes mellitus in response to repeated intraperitoneal injections of mifepristone. Diabetic rats develop an increase of the blood corticosterone and liver aminotransferase levels in response to mifepristone. These results indicate that in diabetic animals the glucocorticoid hormones with high blood concentrations, increasing still more in response to mifepristone, overcome the receptor blockade, and realize their regulatory functions in hepatocytes...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121878/diagnostic-performance-of-f-18-fluorocholine-pet-ct-for-parathyroid-localization-in-hyperparathyroidism-a-systematic-review-and-meta-analysis
#3
Seong-Jang Kim, Sang-Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim
The purpose of the current study was to investigate the diagnostic performance of F-18 Fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) for localization of hyperfunctioning parathyroid gland in patients with hyperparathyroidism (HPT) through a systematic review and meta-analysis. The MEDLINE/PubMed and EMBASE database, from the earliest available date of indexing through April 30, 2018, were searched for studies evaluating the diagnostic performance of F-18 FCH PET/CT for localization of hyperfunctioning parathyroid gland in patients with HPT...
August 18, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/30121834/brain-activity-mapping-from-meg-data-via-a-hierarchical-bayesian-algorithm-with-automatic-depth-weighting
#4
Daniela Calvetti, Annalisa Pascarella, Francesca Pitolli, Erkki Somersalo, Barbara Vantaggi
A recently proposed iterated alternating sequential (IAS) MEG inverse solver algorithm, based on the coupling of a hierarchical Bayesian model with computationally efficient Krylov subspace linear solver, has been shown to perform well for both superficial and deep brain sources. However, a systematic study of its ability to correctly identify active brain regions is still missing. We propose novel statistical protocols to quantify the performance of MEG inverse solvers, focusing in particular on how their accuracy and precision at identifying active brain regions...
August 18, 2018: Brain Topography
https://www.readbyqxmd.com/read/30121786/-it-still-affects-our-economic-situation-long-term-economic-burden-of-breast-cancer-and-lymphedema
#5
Lorraine T Dean, Shadiya L Moss, Yusuf Ransome, Livia Frasso-Jaramillo, Yuehan Zhang, Kala Visvanathan, Lauren Hersch Nicholas, Kathryn H Schmitz
PURPOSE: Financial toxicity after breast cancer may be exacerbated by adverse treatment effects, like breast cancer-related lymphedema. As the first study of long-term out-of-pocket costs for breast cancer survivors in the USA with lymphedema, this mixed methods study compares out-of-pocket costs for breast cancer survivors with and without lymphedema. METHODS: In 2015, 129 breast cancer survivors from Pennsylvania and New Jersey completed surveys on demographics, economically burdensome events since cancer diagnosis, cancer treatment factors, insurance, and comorbidities; and prospective monthly out-of-pocket cost diaries over 12 months...
August 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30121771/detection-of-tris-2-3-dibromopropyl-phosphate-and-other-organophosphorous-compounds-in-arctic-rivers
#6
Ian J Allan, Øyvind A Garmo, Jan Thomas Rundberget, Petr Terentjev, Guttorm Christensen, Nikolay A Kashulin
The flame-retardant tris(2,3-dibromopropyl) phosphate (TDBrPP) was in the 1970s banned for uses in textiles that may be in contact with the skin, owing to strong suspicions that the substance was a human carcinogen. The substance is looked for but rarely detected in samples from the built and natural environments, but there are indications that TDBrPP is still in use. Here, we report the measurement of a polymer-water partition coefficient (Kpw ) for two types of silicone rubber (SR), allowing quantitative estimation of freely dissolved concentrations of TDBrPP by passive sampling in water...
August 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30121762/short-term-copper-exposure-as-a-selection-pressure-for-antibiotic-resistance-and-metal-resistance-in-an-agricultural-soil
#7
Wei Kang, Yu-Jing Zhang, Xiuzhen Shi, Ji-Zheng He, Hang-Wei Hu
Owing to the similar mechanisms of antibiotic and metal resistance, there is a growing concern that metal contamination may select for antibiotic resistance genes (ARGs) in the environment. Here, we constructed short-term laboratory microcosms to investigate the dynamics of a wide range of ARGs and two copper (Cu) resistance genes in an agricultural soil amended with a gradient of Cu concentrations (0~1000 mg kg-1 ). Mobile genetic elements (MGEs) were also quantified as a proxy for the horizontal gene transfer potential of ARGs...
August 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30121738/whose-blood-is-it-application-of-deparray%C3%A2-technology-for-the-identification-of-individual-s-who-contributed-blood-to-a-mixed-stain
#8
K Anslinger, B Bayer
The interpretation and statistical evaluation of mixed DNA profiles often presents a particular challenge in forensic DNA investigations. Only in specific combinations can single cellular components of a mixture be assigned to one contributor. In this study, the DEPArray™ technology, which enables image-assisted immunofluorescent-sorting of rare single cells using dielectrophoretic (DEP) forces, was applied together with different preliminary tests to identify the individual/s who contributed blood to a given mixture...
August 18, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/30121710/an-insight-into-paracetamol-and-its-metabolites-using-molecular-docking-and-molecular-dynamics-simulation
#9
Yuanqiang Wang, Weiwei Lin, Nan Wu, Xibing He, Junmei Wang, Zhiwei Feng, Xiang-Qun Xie
Paracetamol is a relatively safe analgesia/antipyretic drug without the risks of addiction, dependence, tolerance, and withdrawal when used alone. However, when administrated in an opioid/paracetamol combination product, which often contains a large quantity of paracetamol, it can be potentially dangerous due to the risk of hepatotoxicity. Paracetamol is known to be metabolized into N-(4-hydroxyphenyl)-arachidonamide (AM404) via fatty acid amide hydrolase (FAAH) and into N-acetyl-p-benzoquinone imine (NAPQI) via cytochrome P450 (CYP) enzymes...
August 18, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/30121648/mir-122-5p-inhibits-the-proliferation-invasion-and-growth-of-bile-duct-carcinoma-cells-by-targeting-aldoa
#10
Zhuo Xu, Guangchao Liu, Meng Zhang, Zhilei Zhang, Yuming Jia, Li Peng, Yanhong Zhu, Jianbin Hu, Runying Huang, Xiaonan Sun
BACKGROUND/AIMS: Bile duct cancer, although not among the most common tumors, still accounts for more and more worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues and cells and explore the underlying molecular mechanism regulated by miR-122-5p, this study was designed to provide a potential molecular target in bile duct cancer treatment. METHODS: Western blot and immunohistochemistry were performed to detect the ALDOA protein level in duct carcinoma tissues...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121641/il-1%C3%AE-mediated-up-regulation-of-wt1d-via-mir-144-3p-and-their-synergistic-effect-with-nf-%C3%AE%C2%BAb-cox-2-hif-1%C3%AE-pathway-on-cell-proliferation-in-luad
#11
Chen Wu, Xiaodong Li, Dachuan Zhang, Bin Xu, Wenwei Hu, Xiao Zheng, Danxia Zhu, Qi Zhou, Jingting Jiang, Changping Wu
BACKGROUND/AIMS: IL-1β is an important mediator of "inflammation-cancer" transformation through IL-1β/NF-κB/COX-2/HIF-1α signaling pathway, whereas certain portion of patients with lung adenocarcinoma (LUAD) still suffer from rapid tumor progression in clinical practice, indicating the occurrence of potential bypass. METHODS: Real-time polymerase chain reaction was applied to examine the expressions of mir-144-3p, WT1, NF-κB, COX2 and HIF-1α at the mRNA level in 127 LUAD samples and corresponding adjacent tissues...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121610/utilisation-willingness-for-institutional-care-by-the-elderly-a-comparative-study-of-empty-nesters-and-non-empty-nesters-in-shandong-china
#12
Yangyang Qian, Wen Qin, Chengchao Zhou, Dandan Ge, Li Zhang, Long Sun
INTRODUCTION: Institutional care has been strongly promoted in China to meet seniors' long-term care needs. Empty-nest elderly, in comparison with their counterparts, have less social support and fewer caring networks. This study aimed to compare the utilisation willingness for institutional care and its predictors between empty-nest and non-empty-nest seniors. METHODS: A total of 3923 seniors were included in the analysis. Binary logistic regression models were used to understand the association between the living arrangements of the elderly households and willingness for institutional care and to identify the predictors of the utilisation willingness for institutional care among empty nesters and non-empty nesters...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121590/development-of-a-population-pharmacokinetic-model-of-olanzapine-for-chinese-health-volunteers-and-patients-with-schizophrenia
#13
Anning Li, Shuangmin Ji, Weihua Yue, Hao Yan, Fang Dong, Canjun Ruan, Wenbiao Li, Wei Lu, Dai Zhang, Chuanyue Wang
OBJECTIVE: Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapine, and researchers continually strive to improve the handling of data from regular therapeutic drug monitoring (TDM). The objective of this study is to optimise the individualised treatment of olanzapine by establishing a population pharmacokinetics (PopPK) model in Chinese patients with schizophrenia...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121551/lncrna-zeb1-as1-was-suppressed-by-p53-for-renal-fibrosis-in-diabetic-nephropathy
#14
Juan Wang, Jian Pang, Huiling Li, Jie Long, Fang Fang, Junxiang Chen, Xuejin Zhu, Xudong Xiang, Dongshan Zhang
The role of p53 in renal fibrosis is still controversial, and its underlying mechanisms remain not clear. Here, we showed that the pharmacological inhibition and genetic deletion of p53 in proximal tubular cells can attenuate renal dysfunction, tubular epithelial disruption, and interstitial fibrosis in db/db and STZ-induced diabetic nephrology (DN) mice. In human renal proximal tubule (human kidney 2 [HK-2]) cells, inhibition of p53 by PIF reduced the high glucose (HG)-induced extracellular matrix (ECM) accumulation and reversed the inhibitory effect of HG on mRNA expression levels of lncRNA zinc finger E-box binding homeobox1-antisense RNA 1 (ZEB1-AS1) and ZEB1...
July 31, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30121540/low-numbers-of-microplastics-detected-in-drinking-water-from-ground-water-sources
#15
S M Mintenig, M G J Löder, S Primpke, G Gerdts
Microplastic particles have been detected in various natural habitats and the digestive tracts of several species. These particles have also been reported in commercially available seafood, salt or bottled water starting discussions on potential implications for human health. To be able to assess the related risks, exposure concentrations and pathways need to be known. Here, we analysed ground water and drinking water for the presence of microplastics (>20 μm) using FTIR imaging. Samples were taken at different positions within the drinking water supply chain...
August 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30121520/root-soil-structure-inspired-hydrogel-microspheres-with-high-dimensional-stability-and-anion-exchange-capacity
#16
Haifeng Ji, Xin Song, Chao He, Chengqiang Tang, Lian Xiong, Weifeng Zhao, Changsheng Zhao
Ion exchange materials show great advantages in water purification, food industry, pharmaceutical industry, etc. However, the ion exchange capacities of ion exchange materials, especially for anion-exchange materials, at present are still relatively low. Hydrogels own abundant functional groups and show high hydrophilicity, and thus are recognized as high-potential ion exchange materials, but may deform and even crush in use due to their low mechanical strength and unavoidable swelling behavior. In this study, inspired by the root-soil structure, novel poly(methacryloxyethyltrimethyl ammonium chloride) composite hydrogel microspheres with ultrahigh ion exchange capacity (more than 3...
August 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30121474/ultra-fast-zinc-ion-detection-in-living-cells-and-zebrafish-by-a-light-up-fluorescent-probe
#17
Zhengliang Lu, Yanan Lu, Wenlong Fan, Chunhua Fan, Yanan Li
As the second most abundant transition metal after iron in biological systems, Zn2+ takes part in various fundamental life processes such as cellular metabolism and apoptosis, neurotransmission. Thus, the development of analytical methods for fast detection of Zn2+ in biology and medicine has been attracting much attention but still remains a huge challenge. In this report, we develop a novel Zn2+ -specific light-up fluorescent probe based on intramolecular charge transfer combined with chelation enhanced fluorescence induced by structural transformation...
August 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30121381/comprehensive-analysis-of-wintersweet-flower-reveals-key-structural-genes-involved-in-flavonoid-biosynthetic-pathway
#18
Nan Yang, Kaige Zhao, Xiang Li, Rong Zhao, Muhammad Z Aslam, Li Yu, Longqing Chen
Wintersweet (Chimonanthus praecox L.), with an over-one-thousand-years long history in cultivation, is still a popular ornamental woody plant in China. The tepals of wintersweet flower are waxy in nature and the overall color of the flower is yellow, while the inner tepals range from yellow to red, which makes it an ideal plant to study floral color formation in ornamental shrubs. In our current work, HPLC analysis revealed that the principal pigments in tepals were the metabolite of flavonoids. All the tepals were containing quercetin, kaempferol 3‑O‑rutinoside and rutin while cyanidin‑3‑O‑glucoside and cyanidin‑3‑O‑rutinoside were only found in the in the red tepals...
August 16, 2018: Gene
https://www.readbyqxmd.com/read/30121373/a-critical-review-of-multifunctional-titanium-surfaces-new-frontiers-for-improving-osseointegration-and-host-response-avoiding-bacteria-contamination
#19
REVIEW
Silvia Spriano, Seiji Yamaguchi, Francesco Baino, Sara Ferraris
Evolution of metal implants progressively shifted the focus from adequate mechanical strength to improved biocompatibility and absence of toxicity and, finally, to fast osseointegration. Recently, new frontiers and challenges of Ti implants have been addressed to improvement of bioactivity, fighting of bacterial infection and biofilm formation, as well as modulation of inflammation. This is closely related to the clinical demand of multifunctional implants able to simultaneously have a number of specific responses with respect to body fluids, cells (osteoblasts, fibroblasts, macrophages) and pathogenic agents (bacteria, viruses)...
August 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30121367/protocadherin-gamma-a7-is-down-regulated-in-colorectal-cancer-and-associated-with-the-prognosis-in-patients-with-wild-type-kras
#20
Yingdi Liu, Kangsheng Peng, Ruting Xie, Jiayi Zheng, Jing Guo, Rong Wei, Huiqiong Yang, Chunmiao Cai, Qing Wei
Many clustered protocadherin genes (PCDHs) within chromosome 5q31 are frequently down-regulated in colorectal cancer (CRC) due to the hypermethylation of this region, and some of them have been identified as tumor suppressors. However, the association between the expression of the clustered PCDHs and prognosis of CRC patients is still unclear. Here, we identified multiple PCDHs that were significantly down-regulated in CRC by analyzing the RNA-seq data of the Cancer Genome Atlas (TCGA) cohort. Among them, one γ-PCDH subfamily member, PCDHGA7, was found to be associated with overall survival in the patients with wild-type KRAS...
August 16, 2018: Human Pathology
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