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resynchronization electrocardiographic

John Gorcsan, Christopher P Anderson, Bhupendar Tayal, Masataka Sugahara, John Walmsley, Randall C Starling, Joost Lumens
OBJECTIVES: In this study, the authors tested the hypotheses that the systolic stretch index (SSI) developed by computer modeling and applied using echocardiographic strain imaging may characterize the electromechanical substrate predictive of outcome following cardiac resynchronization therapy (CRT). They included patients with QRS width 120 to 149 ms or non-left bundle branch block (LBBB), where clinical uncertainty for CRT exists. They further tested the hypothesis that global longitudinal strain (GLS) has additional prognostic value...
September 12, 2018: JACC. Cardiovascular Imaging
Kelley P Anderson
BACKGROUND: The clinical significance of left bundle branch block (LBBB) has recently expanded with the discovery of a strong association with better outcomes in patients receiving cardiac resynchronization therapy. METHODS: Several milestones have contributed to the current understanding on the role of LBBB in clinical practice. RESULT: Sunao Tawara described the arrangement of components of what he called the cardiac conduction system from the atrioventricular node to the terminal Purkinje fibers that connect to the working myocardium, and his hypotheses on how it functions remain current...
August 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Benjamin J Sieniewicz, Tom Jackson, Simon Claridge, Helder Pereira, Justin Gould, Baldeep Sidhu, Bradley Porter, Steve Niederer, Cheng Yao, Christopher A Rinaldi
BACKGROUND: Cardiac resynchronization therapy (CRT) is typically delivered via quadripolar leads that allow stimulation using either true bipolar pacing, where stimulation occurs between two electrodes (BP) on the quadripolar lead, or extended bipole (EBP) left ventricular (LV) pacing, with the quadripolar electrodes and right ventricular coil acting as the cathode and anode, respectively. True bipolar pacing is associated with reductions in mortality and it has been postulated that these differences are the result of enhanced electrical activation...
August 14, 2018: Journal of Cardiovascular Electrophysiology
Mihoko Kawabata, Masahiko Goya, Yoshihide Takahashi, Shingo Maeda, Atsuhiko Yagishita, Yasuhiro Shirai, Masakazu Kaneko, Shinya Shiohira, Kenzo Hirao
In patients requiring an implantable cardioverter defibrillator (ICD), the combined use of a prior pacemaker and a subcutaneous ICD (S-ICD) could be an alternative treatment option to implantation of new leads or upgrading of pacemakers to an ICD if vascular access is limited. Here, we assessed the prevalence of S-ICD's eligibility according to surface electrogram screening in those receiving cardiac resynchronization therapy (CRT). S-ICD's eligibility was assessed in patients with a CRT pacemaker or a CRT defibrillator using the S-ICD template screening tool...
September 26, 2018: International Heart Journal
Robbert Zusterzeel, Jose Vicente, Roberto Ochoa-Jimenez, Jun Zhu, Jean-Philippe Couderc, Esther Akinnagbe-Zusterzeel, David G Strauss
The presence of left bundle branch block (LBBB) is an important predictor of benefit from cardiac resynchronization therapy (CRT). New "strict" electrocardiographic (ECG) criteria for LBBB have been shown to better predict benefit from CRT. The "strict" LBBB criteria include: QRS duration ≥140 ms (men) or ≥130 ms (women), QS- or rS-configurations of the QRS complex in leads V1 and V2, and mid-QRS notching or slurring in ≥2 of leads V1, V2, V5, V6, I and aVL. The "strict" LBBB criteria are not regularly used and most hospital automated ECG systems and physicians still use more conventional LBBB criteria...
August 1, 2018: Journal of Electrocardiology
Helder Pereira, Tom A Jackson, Benjamin Sieniewicz, Justin Gould, Cheng Yao, Steven Niederer, Christopher A Rinaldi
BACKGROUND: Cardiac resynchronization therapy (CRT) is now generally delivered via quadripolar leads. Assessment of the effect of different vector programs from quadripolar leads on ventricular activation can be now done using non-invasive electrocardiographic mapping (ECM). MATERIAL AND METHODS: In nineteen patients with quadripolar LV leads, activation maps were constructed. The total ventricular activation time (TVaT) and the time for the bulk of ventricular activation (VaT10-90 ) were calculated...
July 2018: Journal of Electrocardiology
Casper Lund-Andersen, Helen H Petersen, Christian Jøns, Berit T Philbert, Michael Vinther, Jesper H Svendsen
No abstract text is available yet for this article.
July 2018: Journal of Electrocardiology
Sophie Giffard-Roisin, Herve Delingette, Thomas Jackson, Jessica Webb, Lauren Fovargue, Jack Lee, C Aldo Rinaldi, Reza Razavi, Nicholas Ayache, Maxime Sermesant
GOAL: Non-invasive cardiac electrophysiology (EP) model personalisation has raised interest for instance in the scope of predicting EP cardiac resynchronization therapy (CRT) response. However, the restricted clinical applicability of current methods is due in particular to the limitation to simple situations and the important computational cost. METHODS: We propose in this manuscript an approach to tackle these two issues. First, we analyse more complex propagation patterns (multiple onsets and scar tissue) using relevance vector regression and shape dimensionality reduction on a large simulated database...
May 23, 2018: IEEE Transactions on Bio-medical Engineering
Oliver I Brown, Theodora Nikolaidou, Gowan Beddoes, Angela Hoye, Andrew L Clark
GOAL: The HF-CGM is a proof-of-principle study to investigate whether cardiogoniometry (CGM), a three-dimensional electrocardiographic method, can differentiate between pacing modes in patients with cardiac resynchronization therapy (CRT). METHODS: At a tertiary cardiology center, CGM recordings were performed using four pacing modes: no pacing; right ventricular (RV) pacing; left ventricular (LV) pacing, and biventricular (BIV) pacing. Three orthogonal CGM planes orientated to the long axis (XY), the frontal plane (YZ), and the short axis (XZ) of the heart were constructed, and the direction of the QRS-axis was calculated for each pacing mode in each plane...
August 2018: IEEE Transactions on Bio-medical Engineering
Marc Strik, Sylvain Ploux, Peter R Huntjens, Uyên Châu Nguyên, Antionio Frontera, Romain Eschalier, Remi Dubois, Philippe Ritter, Nicholas Klotz, Kevin Vernooy, Michel Haïssaguerre, Harry J G M Crijns, Frits W Prinzen, Pierre Bordachar
BACKGROUND: Electrocardiographic mapping (ECM) expresses electrical substrate through magnitude and direction of the activation delay vector (ADV). We investigated to what extent the response to cardiac resynchronization therapy (CRT) is determined by baseline ADV and by ADV modification through CRT and optimization of left ventricular (LV) pacing site. METHODS: ECM was performed in 79 heart failure patients (4 RBBB, 12 QRS < 120 ms, 23 non-specific conduction delay [NICD] and 40 left bundle branch block [LBBB])...
November 1, 2018: International Journal of Cardiology
Maria A Baturova, Valentina Kutyifa, Scott McNitt, Bronislava Polonsky, Scott Solomon, Jonas Carlson, Wojciech Zareba, Pyotr G Platonov
Cardiac resynchronization therapy (CRT) has proven prognostic benefits in patients with heart failure (HF) with left bundle branch block (LBBB) QRS morphology. Electrocardiographic left atrial (LA) abnormality has been proposed as a noninvasive marker of atrial remodeling. We aimed to assess the impact of electrocardiographic LA abnormality for prognosis in patients with HF treated with CRT. Baseline resting 12-lead electrocardiograms recorded from 941 patients enrolled in the CRT arm of the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy was processed automatically using Glasgow algorithm, which included automated assessment of P-wave terminal force in lead V1 (PTF-V1 ) as a marker of LA abnormality...
July 15, 2018: American Journal of Cardiology
Marek Jastrzębski, Piotr Kukla, Roksana Kisiel, Kamil Fijorek, Paweł Moskal, Danuta Czarnecka
BACKGROUND: Left bundle branch block (LBBB) is considered an important prognostic parameter in cardiac resynchronization therapy (CRT). We aimed to evaluate, in a sizeable cohort of patients with CRT, long-term mortality, and morbidity according to four different electrocardiographic definitions of LBBB. METHODS: This longitudinal cohort study included consecutive patients who underwent CRT device implantation in our institution in years 2006-2014. Two endpoints were assessed: (a) death from any cause or urgent heart transplantation, and (b) death from any cause or heart failure admission...
September 2018: Annals of Noninvasive Electrocardiology
Emanuela T Locati, Giuseppe Bagliani, Alessio Testoni, Maurizio Lunati, Luigi Padeletti
Surface electrocardiograms, both resting 12-lead electrocardiographs and ambulatory electrocardiograph monitoring, play an essential role in establishing indications for cardiac implantable electronic devices (pacemakers, cardiac implantable defibrillators, and cardiac resynchronization therapies), and in the evaluation of patients already implanted. Current devices have prolonged memory capabilities (defined as Holter functions) and remote monitoring functions, to evaluate the electrical properties and the automatic detection of arrhythmias...
June 2018: Cardiac Electrophysiology Clinics
Angelo Auricchio, Frits W Prinzen
Cardiac resynchronization therapy (CRT) is an established nonpharmacological treatment for patients with heart failure (HF), reduced left ventricular (LV) ejection fraction, and a wide QRS complex. Although the therapy was developed 30 years ago and approved by the Food and Drug Administration in 2001, attempts to improve it have never stopped. Such improvements have been facilitated by combining knowledge from bench (basic science), bits (computer modeling), and bedside (clinical studies); these issues are addressed in the present review...
November 2017: JACC. Clinical Electrophysiology
Shaan Khurshid, Edmond Obeng-Gyimah, Gregory E Supple, Robert Schaller, David Lin, Anjali T Owens, Andrew E Epstein, Sanjay Dixit, Francis E Marchlinski, David S Frankel
OBJECTIVES: This study sought to determine the extent, time course, and predictors of improvement following cardiac resynchronization therapy (CRT) upgrade among pacing-induced cardiomyopathy (PICM) patients. BACKGROUND: PICM is an important cause of heart failure in patients exposed to frequent right ventricular (RV) pacing. CRT may reverse PICM. METHODS: We retrospectively studied 1,279 consecutive patients undergoing CRT procedures between 2003 and 2016...
February 2018: JACC. Clinical Electrophysiology
Yahya Kemal İçen, Yurdaer Dönmez, Hasan Koca, Mehmet Uğurlu, Mevlüt Koç
PURPOSE: Positive T wave polarity in lead aVR (TPaVR) is associated with a poor prognostic indicator in patients with heart failure reduce ejection fraction (HFrEF). Our aim was to investigate the relationship between positive TPaVR and mortality in patients with cardiac resynchronization therapy defibrillator (CRT-D). METHODS: We included retrospectively 224 HFrEF patients with CRT-D in sinus rhythm. Laboratory, electrocardiographic (ECG), and echocardiographic data were recorded...
October 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Mand J H Khidir, Rachid Abou, Dilek Yilmaz, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. OBJECTIVE: The purpose of this study was to evaluate the prognostic value of LV GLS in HF patients treated with cardiac resynchronization therapy (CRT). METHODS: The study included 829 HF patients (mean age 64.6 ± 10.4 years; 72% men) treated with CRT...
October 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Lidija Poposka, Vladimir Boskov, Dejan Risteski, Jane Taleski, Filip Janusevski, Elizabeta Srbinovska, Ljubica Georgievska-Ismail
INTRODUCTION: Although strict selection criteria are used to select patients for cardiac resynchronisation therapy, up to 30% of patients do not have a positive clinical response. PATIENTS: A total of 102 consecutive patients who had biventricular pacemaker/defibrillator (CRT-P or CRT-D) implanted were enrolled in this prospective observational study. RESULTS: During the average follow-up period of 24.3 months 5 patients died and 17 (16.7%) patients were hospitalised with the symptoms of heart failure; 75 (73...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
Alessandro Proclemer, Massimo Zecchin, Antonio D'Onofrio, Giuseppe Boriani, Domenico Facchin, Luca Rebellato, Marco Ghidina, Giulia Bianco, Emanuela Bernardelli, Elsa Pucher, Dario Gregori
BACKGROUND: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2016 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers. METHODS: The registry collects prospectively national PM and ICD implantation activity on the basis of European cards...
February 2018: Giornale Italiano di Cardiologia
Yoram Rudy
No abstract text is available yet for this article.
July 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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