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neonatal kidney

Egor Y Plotnikov, Anna A Brezgunova, Irina B Pevzner, Ljubava D Zorova, Vasily N Manskikh, Vasily A Popkov, Denis N Silachev, Dmitry B Zorov
Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is necessary to consider the individuality of an organism's response to systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated acute kidney injury model to study mechanisms of kidney cells damage in neonatal and adult rats. We found LPS-associated oxidative stress was more severe in adults compared to neonates, as judged by levels of carbonylated proteins and products of lipids peroxidation...
August 8, 2018: Antioxidants (Basel, Switzerland)
Adela Urisarri, Marta Gil, Natalia Mandiá, Luís Aldamiz-Echevarría, Roca Iria, Domingo González-Lamuño, María-Luz Couce
To evaluate the prognostic significance of factors frequently associated with a reduction in renal mass, such as prematurity, low birth weight, and congenital anomalies of kidney and urinary tract (CAKUT), in patients with solitary functioning kidney (SFK) and investigate signs of early renal injury due to glomerular hyperfiltration damage or dysplasia in the remaining kidney.Retrospective observational study of congenital SFK diagnosed and followed at a tertiary care hospital over a period of 10 years in which 32,900 newborns underwent routine neonatal abdominal ultrasound screening...
August 2018: Medicine (Baltimore)
Satoshi Matsuyama, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
Macrophages are required during kidney development and appear in the initiation and propagation of renal injury. To establish baseline data, we analyzed the kinetics of the macrophage with different immunophenotypes in the developing rat kidney (fetus at 18 and 20 days, neonate at 1-21 days, and adult at 7-weeks old). Macrophages reacting to CD68, CD163, and MHC class II were identified in the cortex and medulla of the developing rat kidney. CD68+ macrophages appeared in the fetal kidney as early as fetal day 18, and the number increased gradually in the neonatal kidney, whereas MHC class II+ and CD163+ macrophages first appeared on neonatal days 4 and 8, respectively...
July 2018: Journal of Toxicologic Pathology
Vishal Gupta, Aakash Pandita, Astha Panghal, Venkat Kallem
We report a case of a term baby presenting with neonatal cholestasis and upper limb flexion deformity on day 4 of life. On further evaluation, high gamma glutamyl transpeptidase (GGT) levels and absent left kidney were found. A diagnosis of arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome was made which is a rare autosomal recessive disorder with primarily clinical diagnosis. Outcome of this condition is dismal. It has a large spectrum of clinical manifestations, but association with high GGT levels and absent kidney is quite rare...
August 9, 2018: BMJ Case Reports
Emily J Kraut, Louis J Boohaker, David J Askenazi, Jeffery Fletcher, Alison L Kent
Text for Correction.
August 8, 2018: Pediatric Research
Aleksandra Mikołajczak, Anna Tytkowska, Agata Jaworska, Alicja Wesołowska, Maria Katarzyna Borszewska-Kornacka, Renata Bokiniec
OBJECTIVES: Renal vein thrombosis in newborns is a rare but serious and acute disease. Clinical representations of RVT can vary from discrete symptoms to life-threatening conditions. Therefore imaging, and in particular sonography, plays an important role in the diagnosis of RVT in neonates. Gray-scale, color and spectral/power Doppler ultrasound are all used in the diagnosis of RVT. MATERIAL AND METHODS: We present retrospective sequential ultrasonic imaging of three patients (two term and one preterm infant) with findings characteristic of RVT...
2018: Ginekologia Polska
Sharon R Lewis, Michael W Pritchard, David Jw Evans, Andrew R Butler, Phil Alderson, Andrew F Smith, Ian Roberts
BACKGROUND: Critically ill people may lose fluid because of serious conditions, infections (e.g. sepsis), trauma, or burns, and need additional fluids urgently to prevent dehydration or kidney failure. Colloid or crystalloid solutions may be used for this purpose. Crystalloids have small molecules, are cheap, easy to use, and provide immediate fluid resuscitation, but may increase oedema. Colloids have larger molecules, cost more, and may provide swifter volume expansion in the intravascular space, but may induce allergic reactions, blood clotting disorders, and kidney failure...
August 3, 2018: Cochrane Database of Systematic Reviews
Anderson Pedroza, Diorginis Soares Ferreira, David F Santana, Pedro Thiago da Silva, Francisco Carlos Amanajás de Aguiar Júnior, Donald F Sellitti, Cláudia J Lagranha
There is a strong correlation between inadequate gestational and postpartum nutrition with the occurrence of cardiovascular diseases. The present study investigates the effects of maternal low-protein and neonatal overfeeding on the oxidative balance and morphology of the renal cortex of male Wistar rats. Two independent protocols were used. First, pregnant Wistar rats received diets containing either 17% (normal protein) or 8% (low protein) casein throughout pregnancy and lactation. Second, the litter size was reduced by one-third on the third postnatal day to induce overnourishment in offspring...
July 30, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Ioannis Bellos, Georgia Fitrou, Georgios Daskalakis, Despina N Perrea, Vasilios Pergialiotis
There is growing evidence that neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of acute kidney injury. The objective of this meta-analysis is to determine the accuracy of serum and urinary NGAL in the detection of acute kidney injury in neonates with perinatal asphyxia. Medline (1966-2018), Scopus (2004-2018), EMBASE (1980-2018), (2008-2018), and Google Scholar (2004-2018) databases, along with the reference lists of the electronically retrieved articles, were systematically searched...
July 26, 2018: European Journal of Pediatrics
Joan B Soriano, David Rojas-Rueda, Jordi Alonso, Josep M Antó, Pere-Joan Cardona, Esteve Fernández, Alberto L Garcia-Basteiro, Fernando G Benavides, Scott D Glenn, Varsha Krish, Jeffrey V Lazarus, José Martínez-Raga, Maria F Masana, Mark J Nieuwenhuijsen, Alberto Ortiz, Maria Dolores Sánchez-Niño, Antoni Serrano-Blanco, Miguel Tortajada-Girbés, Stefanos Tyrovolas, Josep Maria Haro, Mohsen Naghavi, Christopher J L Murray
BACKGROUND AND OBJECTIVES: The global burden of disease (GBD) project measures the health of populations worldwide on an annual basis, and results are available by country. We used the estimates of the GBD to summarise the state of health in Spain in 2016 and report trends in mortality and morbidity from 1990 to 2016. MATERIAL AND METHODS: GBD 2016 estimated disease burden due to 333 diseases and injuries, and 84 risk factors. The GBD list of causes is hierarchical and includes 3 top level categories, namely: 1) communicable, maternal, neonatal, and nutritional diseases; 2) non-communicable diseases (NCDs), and 3) injuries...
July 20, 2018: Medicina Clínica
Jeffrey T White, Kunj R Sheth, Aylin E Bilgutay, David R Roth, Paul F Austin, Edmond T Gonzales, Nicolette K Janzen, Duong D Tu, Angela G Mittal, Chester J Koh, Sheila L Ryan, Carolina Jorgez, Abhishek Seth
Objective: Review outcomes of Prune Belly Syndrome (PBS) with the hypothesis that contemporary management improves mortality. Methods: A retrospective chart review of inpatient and outpatient PBS patients referred between 2000 and 2018 was conducted to assess outcomes at our institution. Data collected included age at diagnosis, concomitant medical conditions, imaging, operative management, length of follow-up, and renal function. Results: Forty-five PBS patients presented during these 18 years. Prenatal diagnoses were made in 17 (39%); 65% of these patients underwent prenatal intervention...
2018: Frontiers in Pediatrics
Maja Thim Larsen, Helen Rawsthorne, Karen Kræmmer Schelde, Frederik Dagnæs-Hansen, Jason Cameron, Kenneth A Howard
Recombinant albumin-drug genetic fusions are an effective technology to prolong the serum half-life of therapeutics that has resulted in marketed products. Indirect evidence suggests albumin fusions' long circulation is controlled by engagement with the cellular recycling neonatal Fc receptor (FcRn) in addition to reduced kidney filtration. In this work, we have used a panel of recombinant fusions, engineered with different human FcRn (hFcRn) affinity, including a novel high binding albumin variant (HBII), to directly define and importantly, control the intracellular mechanism as a half-life extension tuning method...
July 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jing Chen, Marina Gálvez-Peralta, Xiang Zhang, Jingyuan Deng, Zijuan Liu, Daniel W Nebert
Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+ , Mn2+ and Fe2+ . Slc39a8(neo/neo) knockdown mice exhibit 10-15% of wild-type ZIP8 mRNA and protein levels, and show pleiotropic phenotype of stunted growth, neonatal lethality, multi-organ dysmorphogenesis, and dysregulated hematopoiesis manifested as severe anemia. Herein we performed RNA-seq analysis of gestational day (GD)13.5 yolk sac and placenta, and GD16...
July 16, 2018: Scientific Reports
Michele Losurdo, Giulia Dowgier, Maria Stella Lucente, Mario Cinone, Michele Camero, Maria Loredana Colaianni, Giuseppe Passantino, Gianluca Ventriglia, Domenico Buonavoglia, Nicola Decaro
The long-term shedding of Canine alphaherpesvirus 1 (CaHV-1) by neonatal pups with natural infection is reported. The pups belonged to a litter of 11 pointers of a breeding kennel in southern Italy, 9 of which developed a fatal form of systemic infection, as resulted by the detection of CaHV-1 in internal organs (kidney, liver, lung and brain) of one of this dogs and in the vaginal swab of their mother. The two remaining animals displayed a milder form of disease, with one pup showing ocular involvement, and underwent a progressive recovery...
July 6, 2018: Research in Veterinary Science
Imeshi Wijetunga, Clare Ecuyer, Sonsoles Martinez-Lopez, Muhammad Jameel, Richard J Baker, Matthew Wellberry-Smith, Chirag Patel, Michael Weston, Niaz Ahmad
Kidney transplants from young paediatric donors are uncommonly performed in the UK. Published literature of kidney transplant from donors under 5kg in weight is sparse. We present our initial experience of en bloc kidney transplantation (EKT) from donors under 20kg in weight including neonatal donors. All recipients undergoing EKT from donors under 20kg at our centre from January 2005 to October 2016 were included. Donor and recipient details were recorded from a prospective database. Electronic patient records were examined for follow-up data...
July 7, 2018: American Journal of Transplantation
Jacek Hawiger
Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulnerable patients, with these groups suffering from the highest sepsis mortality. In both groups, many survivors respectively display serious developmental disabilities and cognitive decline. The National Institute of Health National Heart Lung and Blood Institute Panel redefined sepsis as a "severe endothelial dysfunction syndrome in response to intravascular and extravascular infections causing reversible or irreversible injury to the microcirculation responsible for multiple organ failure...
July 12, 2018: Kardiologia Polska
Andrea M Lencina, Thierry Franza, Matthew J Sullivan, Glen C Ulett, Deepak S Ipe, Philippe Gaudu, Robert B Gennis, Lici A Schurig-Briccio
The opportunistic pathogen Streptococcus agalactiae is the major cause of meningitis and sepsis in a newborn's first week, as well as a considerable cause of pneumonia, urinary tract infections, and sepsis in immunocompromised adults. This pathogen respires aerobically if heme and quinone are available in the environment, and a functional respiratory chain is required for full virulence. Remarkably, it is shown here that the entire respiratory chain of S. agalactiae consists of only two enzymes, a type 2 NADH dehydrogenase (NDH-2) and a cytochrome bd oxygen reductase...
July 3, 2018: MBio
David G Lehenbauer, Charles D Fraser, Todd C Crawford, Naru Hibino, Susan Aucott, Joshua C Grimm, Nishant Patel, J Trent Magruder, Duke E Cameron, Luca Vricella
OBJECTIVE: The safety of surgical closure of patent ductus arteriosus (PDA) in very low birth weight premature neonates has been questioned because of associated morbidities. However, these studies are vulnerable to significant bias as surgical ligation has historically been utilized as "rescue" therapy. The objective of this study was to review our institutions' outcomes of surgical PDA ligation. METHODS: All neonates with operative weight of ≤1.00 kg undergoing surgical PDA ligation from 2003 to 2015 were analyzed...
July 2018: World Journal for Pediatric & Congenital Heart Surgery
I B Pevzner, T A Pavlenko, V A Popkov, N V Andrianova, L D Zorova, A A Brezgunova, S D Zorov, S S Yankauskas, D N Silachev, D B Zorov, E Yu Plotnikov
Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion...
June 19, 2018: Bulletin of Experimental Biology and Medicine
Illja J Diets, Trine Prescott, Neena L Champaigne, Grazia M S Mancini, Bård Krossnes, Radek Frič, Kristina Kocsis, Marjolijn C J Jongmans, Tjitske Kleefstra
PURPOSE: SMARCB1 encodes a subunit of the SWI/SNF complex involved in chromatin remodeling. Pathogenic variants (PV) in this gene can give rise to three conditions. Heterozygous loss-of-function germline PV cause rhabdoid tumor predisposition syndrome and schwannomatosis. Missense PV and small in-frame deletions in exons 8 and 9 result in Coffin-Siris syndrome, which is characterized by intellectual disability (ID), coarse facial features, and fifth digit anomalies. METHODS: By a gene matching approach, individuals with a similar SMARCB1 PV were identified...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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