Hongyi Ye, Lingqi Ye, Lingli Hu, Yuyu Yang, Yi Ge, Ruotong Chen, Shan Wang, Bo Jin, Wenjie Ming, Zhongjin Wang, Sha Xu, Cenglin Xu, Yi Wang, Yao Ding, Junming Zhu, Meiping Ding, Zhong Chen, Shuang Wang, Cong Chen
Interictal epileptiform discharges (IEDs) often co-occur across spatially-separated cortical regions, forming IED networks. However, the factors prompting IED propagation remain unelucidated. We hypothesized that slow oscillations (SOs) might facilitate IED propagation. Here, the amplitude and phase synchronization of SOs preceding propagating and non-propagating IEDs were compared in 22 patients with focal epilepsy undergoing intracranial electroencephalography (EEG) evaluation. Intracranial channels were categorized into the irritative zone (IZ) and normal zone (NOZ) regarding the presence of IEDs...
January 11, 2024: Neurobiology of Disease