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https://www.readbyqxmd.com/read/30096484/lithium-affects-rat-hippocampal-electrophysiology-and-epileptic-seizures-in-a-dose-dependent-manner
#1
Guohui Jiang, Tianqiang Pu, Zhimin Li, Xiaodong Zhang, Ruijiao Zhou, Xing Cao, Juming Yu, Xiaoming Wang
Lithium, a classic mood stabilizer, prevents apoptosis-dependent cellular death and has garnered considerable interest as a neuroprotective agent that is efficacious in the treatment of many neurological diseases. However, the effects of lithium in epilepsy remain controversial. We found that different doses of lithium affect epileptic seizure activity and bidirectionally modulate the susceptibility to and severity of seizures induced by pilocarpine in rats. Recently, it has been demonstrated that systematically administered lithium affects the powers of hippocampal gamma and theta oscillations in baseline electroencephalograms...
July 29, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30077870/visually-validated-semi-automatic-high-frequency-oscillation-detection-aides-the-delineation-of-epileptogenic-regions-during-intra-operative-electrocorticography
#2
Shennan Aibel Weiss, Brent Berry, Inna Chervoneva, Zachary Waldman, Jonathan Guba, Mark Bower, Michal Kucewicz, Benjamin Brinkmann, Vaclav Kremen, Fatemeh Khadjevand, Yogatheesan Varatharajah, Hari Guragain, Ashwini Sharan, Chengyuan Wu, Richard Staba, Jerome Engel, Michael Sperling, Gregory Worrell
OBJECTIVE: To test the utility of a novel semi-automated method for detecting, validating, and quantifying high-frequency oscillations (HFOs): ripples (80-200 Hz) and fast ripples (200-600 Hz) in intra-operative electrocorticography (ECoG) recordings. METHODS: Sixteen adult patients with temporal lobe epilepsy (TLE) had intra-operative ECoG recordings at the time of resection. The computer-annotated ECoG recordings were visually inspected and false positive detections were removed...
July 20, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30057733/link-prediction-investigation-of-dynamic-information-flow-in-epilepsy
#3
Yan He, Fan Yang, Yunli Yu, Celso Grebogi
As a brain disorder, epilepsy is characterized with abnormal hypersynchronous neural firings. It is known that seizures initiate and propagate in different brain regions. Long-term intracranial multichannel electroencephalography (EEG) reflects broadband ictal activity under seizure occurrence. Network-based techniques are efficient in discovering brain dynamics and offering finger-print features for specific individuals. In this study, we adopt link prediction for proposing a novel workflow aiming to quantify seizure dynamics and uncover pathological mechanisms of epilepsy...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/30051505/high-frequency-oscillations-in-the-normal-human-brain
#4
Birgit Frauscher, Nicolás von Ellenrieder, Rina Zelmann, Christine Rogers, Dang Khoa Nguyen, Philippe Kahane, François Dubeau, Jean Gotman
OBJECTIVE: High-frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. It has not been possible however to differentiate physiological from pathological HFOs, and baseline rates of HFO occurrence vary substantially across brain regions. This project establishes region-specific normative values for physiological HFOs and high-frequency activity (HFA). METHODS: Intracerebral stereo-encephalography recordings with channels displaying normal physiological activity and from non-lesional tissue were selected from two tertiary epilepsy centers...
July 26, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/30050424/epinetlab-a-software-for-seizure-onset-zone-identification-from-intracranial-eeg-signal-in-epilepsy
#5
Lucia R Quitadamo, Elaine Foley, Roberto Mai, Luca de Palma, Nicola Specchio, Stefano Seri
The pre-operative workup of patients with drug-resistant epilepsy requires in some candidates the identification from intracranial EEG (iEEG) of the seizure-onset zone (SOZ), defined as the area responsible of the generation of the seizure and therefore candidate for resection. High-frequency oscillations (HFOs) contained in the iEEG signal have been proposed as biomarker of the SOZ. Their visual identification is a very onerous process and an automated detection tool could be an extremely valuable aid for clinicians, reducing operator-dependent bias, and computational time...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/30048931/frequency-specific-alterations-in-the-amplitude-and-synchronization-of-resting-state-spontaneous-low-frequency-oscillations-in-benign-childhood-epilepsy-with-centrotemporal-spikes
#6
Ge Tan, Fenglai Xiao, Sihan Chen, Haijiao Wang, Deng Chen, Lina Zhu, Da Xu, Dong Zhou, Ling Liu
OBJECTIVES: Spontaneous low-frequency oscillations in different frequency bands have diverse physiological meanings. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in different frequency bands in Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) are unknown and worth exploring. METHOD: Resting-state functional magnetic resonance imaging data were collected in 51 drug-naïve BECTS patients and 76 healthy controls. The ALFF was calculated for the typical (0...
September 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30009381/altered-circadian-rhythms-and-oscillation-of-clock-genes-and-sirtuin-1-in-a-model-of-sudden-unexpected-death-in-epilepsy
#7
Eli Wallace, Samantha Wright, Barry Schoenike, Avtar Roopra, Jong M Rho, Rama K Maganti
OBJECTIVES: Circadian rhythms are affected in many neurological disorders. Although sleep disturbances are known in epilepsy, data on circadian rhythm disturbances in epilepsy are sparse. Here, we examined diurnal and circadian rest-activity and sleep-wake patterns in Kcna1-null mice, which exhibit spontaneous recurrent seizures and are a model of sudden unexpected death in epilepsy. Furthermore, we sought to determine whether seizures or aberrant oscillation of core clock genes and a regulator, sirtuin 1 (Sirt1), is associated with disrupted rhythms...
July 15, 2018: Epilepsia
https://www.readbyqxmd.com/read/30005220/enhancement-and-bilateral-synchronization-of-ripples-in-atypical-benign-epilepsy-of-childhood-with-centrotemporal-spikes
#8
Satoru Ikemoto, Shin-Ichiro Hamano, Susumu Yokota, Reiko Koichihara, Yuko Hirata, Ryuki Matsuura
OBJECTIVE: To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS. METHODS: Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized...
September 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30005212/small-sharp-spikes-as-eeg-markers-of-mesiotemporal-lobe-epilepsy
#9
Naoum P Issa, Shasha Wu, Sandra Rose, Vernon L Towle, Peter C Warnke, James X Tao
OBJECTIVE: Mesial temporal lobe epilepsy (mTLE) is the most common type of focal epilepsy, but often lacks scalp EEG correlates. We ask if hippocampal epileptiform discharges that are characteristic of mTLE are associated with small sharp spikes (SSS) recorded on scalp EEG. SSS are considered benign waveforms, so are not currently used as markers of epilepsy. METHODS: To determine if there is a relationship between SSS and hippocampal discharges, simultaneous scalp and hippocampal depth electrode EEGs were recorded from 27 patients being evaluated for possible mTLE...
September 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30003857/diagnostic-biomarkers-of-epilepsy
#10
Chiara Sueri, Sara Gasparini, Simona Balestrini, Angelo Labate, Antonio Gambardella, Emilio Russo, Antonio Leo, Silvia Casarotto, Francesca Pittau, Michele Trimboli, Vittoria Cianci, Michele Ascoli, Salvatore M Cavalli, Giulia Ferrigno, Umberto Aguglia, Edoardo Ferlazzo
BACKGROUND: diagnostic biomarkers of epilepsy are objectively measurable variables associated to the development of epilepsy or the propensity to generate seizures. Identification of biomarkers could be helpful for differential diagnosis and for tailored therapeutic approaches. OBJECTIVE: this review focuses on diagnostic biomarkers of epilepsy, including genetic, serological, neuroimaging and electrophysiological variables. METHODS: references were mainly identified through PubMed search until December 2017 and backtracking of references in pertinent studies...
July 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30002645/generalizability-of-high-frequency-oscillation-evaluations-in-the-ripple-band
#11
Aaron M Spring, Daniel J Pittman, Yahya Aghakhani, Jeffrey Jirsch, Neelan Pillay, Luis E Bello-Espinosa, Colin Josephson, Paolo Federico
Objective: We examined the interrater reliability and generalizability of high-frequency oscillation (HFO) visual evaluations in the ripple (80-250 Hz) band, and established a framework for the transition of HFO analysis to routine clinical care. We were interested in the interrater reliability or epoch generalizability to describe how similar the evaluations were between reviewers, and in the reviewer generalizability to represent the consistency of the internal threshold each individual reviewer. Methods: We studied 41 adult epilepsy patients (mean age: 35...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29994761/a-stacked-sparse-autoencoder-based-detector-for-automatic-identification-of-neuromagnetic-high-frequency-oscillations-in-epilepsy
#12
Jiayang Guo, Kun Yang, Hongyi Liu, Chunli Yin, Jing Xiang, Hailong Li, Rongrong Ji, Yue Gao
High-frequency oscillations (HFOs) are spontaneous magnetoencephalography (MEG) patterns that have been acknowledged as a putative biomarker to identify epileptic foci. Correct detection of HFOs in the MEG signals is crucial for accurate and timely clinical evaluation. Since the visual examination of HFOs is time-consuming, error-prone and with poor inter-reviewer reliability, an automatic HFOs detector is highly desirable in clinical practice. However, existing approaches for HFOs detection may not be applicable for MEG signals with noisy background activity...
May 15, 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29985998/high-frequency-stimulation-of-anterior-nucleus-of-thalamus-desynchronizes-epileptic-network-in-humans
#13
Tao Yu, Xueyuan Wang, Yongjie Li, Guojun Zhang, Gregory Worrell, Patrick Chauvel, Duanyu Ni, Liang Qiao, Chang Liu, Liping Li, Liankun Ren, Yuping Wang
Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced neuronal excitability and synchronization. Although it has been described since antiquity, there are still significant challenges achieving the therapeutic goal of seizure freedom. Deep brain stimulation of the anterior nucleus of the thalamus has emerged as a promising therapy for focal drug-resistant epilepsy; the basic mechanism of action, however, remains unclear. Here, we show that desynchronization is a potential mechanism of deep brain stimulation of the anterior nucleus of the thalamus by studying local field potentials recordings from the cortex during high-frequency stimulation (130 Hz) of the anterior nucleus of the thalamus in nine patients with drug-resistant focal epilepsy...
July 6, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29981424/theta-oscillations-underlie-retrieval-success-effects-in-the-nucleus-accumbens-and-anterior-thalamus-evidence-from-human-intracranial-recordings
#14
Eva M Bauch, Nico Bunzeck, Hermann Hinrichs, Friedhelm C Schmitt, Jürgen Voges, Hans-Jochen Heinze, Tino Zaehle
Previous imaging studies independently highlighted the role of the anterior thalamus (ANT) and nucleus accumbens (NAcc) in successful memory retrieval. While these findings accord with theoretical models, the precise temporal, oscillatory and network dynamics as well as the interplay between the NAcc and ANT in successfully retrieving information from long-term memory are largely unknown. We addressed this issue by recording intracranial electroencephalography in human epilepsy patients from the NAcc (n = 5) and ANT (n = 4) during an old/new recognition test...
July 4, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29967583/quantitative-analysis-of-the-antiepileptogenic-effects-of-low-frequency-stimulation-applied-prior-or-after-kindling-stimulation-in-rats
#15
Mostafa Jalilifar, Ali Yadollahpour, Ahmad Ali Moazedi, Zohreh Ghotbeddin
Background and Objective: Developing quantitative measures based on spectral analysis of electroencephalograph (EEG) recordings of neural activities plays an important role in developing efficient treatments for epilepsy. Such biomarkers can be used for developing open or closed loop approaches for seizure prediction or prevention. This study aims to quantitatively evaluate antiepileptogenic effects of low frequency stimulation (LFS) applied immediately before or after kindling stimulations using spectral power analysis of extracellular EEG in rat...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29960405/synchronous-high-frequency-oscillations-in-inhibitory-dominant-network-motifs-consisting-of-three-dentate-gyrus-ca3-systems
#16
Liyuan Zhang, Denggui Fan, Qingyun Wang
Studies on the structural-functional connectomes of the human brain have demonstrated the existence of synchronous firings in a specific brain network motif. In particular, synchronization of high-frequency oscillations (HFOs) has been observed in the experimental data sets of temporal lobe epilepsy (TLE). In addition, both clinical and experimental evidences have accumulated to demonstrate the effect of electrical stimulation on TLE, which, however, remains largely unexplored. In this work, we first employ our previously proposed dentate gyrus (DG)-CA3 network model to investigate the influence of an external electrical stimulus on the HFO transitions...
June 2018: Chaos
https://www.readbyqxmd.com/read/29952700/theta-phase-synchronization-between-the-human-hippocampus-and-prefrontal-cortex-increases-during-encoding-of-unexpected-information-a-case-study
#17
Matthias J Gruber, Liang-Tien Hsieh, Bernhard P Staresina, Christian E Elger, Juergen Fell, Nikolai Axmacher, Charan Ranganath
Events that violate predictions are thought to not only modulate activity within the hippocampus and prefrontal cortex (PFC) but also enhance communication between the two regions. Scalp and intracranial EEG studies have shown that oscillations in the theta frequency band are enhanced during processing of contextually unexpected information. Some theories suggest that the hippocampus and PFC interact during processing of unexpected events, and it is possible that theta oscillations may mediate these interactions...
June 28, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29947131/genome-wide-association-analysis-links-multiple-psychiatric-liability-genes-to-oscillatory-brain-activity
#18
Dirk J A Smit, Margaret J Wright, Jacquelyn L Meyers, Nicholas G Martin, Yvonne Y W Ho, Stephen M Malone, Jian Zhang, Scott J Burwell, David B Chorlian, Eco J C de Geus, Damiaan Denys, Narelle K Hansell, Jouke-Jan Hottenga, Matt McGue, Catharina E M van Beijsterveldt, Neda Jahanshad, Paul M Thompson, Christopher D Whelan, Sarah E Medland, Bernice Porjesz, William G Lacono, Dorret I Boomsma
Oscillatory activity is crucial for information processing in the brain, and has a long history as a biomarker for psychopathology. Variation in oscillatory activity is highly heritable, but current understanding of specific genetic influences remains limited. We performed the largest genome-wide association study to date of oscillatory power during eyes-closed resting electroencephalogram (EEG) across a range of frequencies (delta 1-3.75 Hz, theta 4-7.75 Hz, alpha 8-12.75 Hz, and beta 13-30 Hz) in 8,425 subjects...
June 26, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29937441/ictal-intracranial-electroencephalography-using-wavelet-analysis-of-high-frequency-oscillations-in-chinese-patients-with-refractory-epilepsy
#19
H W Leung, W S Poon, P Kl Kwan, C Ht Lui, T L Poon, E Ly Chan, S C Yuen
No abstract text is available yet for this article.
June 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29909157/fullerenol-c-60-oh-36-at-relatively-high-concentrations-impairs-hippocampal-theta-oscillations-in-vivo-and-in-vitro-and-triggers-epilepsy-in-vitro-a-dose-response-study
#20
Paulina Kazmierska-Grebowska, Anna Kobrzycka, Renata Bocian, Tomasz Kowalczyk, Anita Krokosz, Jacek Grebowski
Since the first identification of fullerenes (C60 ) and their synthesis in 1985, those compounds have been extensively studied in the biomedical field. In particular, their water-soluble derivatives, fullerenols (C60 (OH)n, n = 2-48), have recently been the subject of numerous investigations concerning their antioxidant and prooxidant properties in biological systems. A small fraction of that research has focused on the possible use of C60 and C60 (OH)n in neuroscience and the therapy of pathologies such as dementia, amyloid-β (Aβ) formation, and Parkinson's disease...
August 2018: Experimental and Molecular Pathology
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