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https://www.readbyqxmd.com/read/30554497/lennox-gastaut-syndrome-in-mitochondrial-disease
#1
Soonie Lee, Min Seong Baek, Young Mock Lee
PURPOSE: Previous studies have shown that neurologic symptoms are dominant in patients with mitochondrial diseases, and most of these patients have seizure-related disorders. The epileptic classification of these patients as Lennox-Gastaut syndrome (LGS) is as high as 25%. This study aimed to investigate the clinical manifestations, diagnoses, treatments, and epilepsy in LGS, which is associated with mitochondrial disease. MATERIALS AND METHODS: A retrospective study was conducted on 372 patients who were diagnosed with mitochondrial disease between 2006 and 2016...
January 2019: Yonsei Medical Journal
https://www.readbyqxmd.com/read/30552741/maternal-and-offspring-mthfr-genotypes-interact-in-a-mouse-model-to-induce-asd-like-behavior
#2
Noa Sadigurschi, Hava M Golan
Individuals with autism constitute a variable population whose members are spread along the autism spectrum. Sub-populations within that spectrum exhibit other conditions, such as anxiety, intellectual disabilities, hyperactivity and epilepsy, with different severities and co-occurrences. Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon metabolic pathway efficiency. The frequency of the MTHFR677TT homozygote is markedly higher among autism patients and their mothers than in the general population...
December 15, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/30549376/autostimulation-in-vagus-nerve-stimulator-treatment-modulating-neuromodulation
#3
Toni Kulju, Joonas Haapasalo, Sirpa Rainesalo, Kai Lehtimäki, Jukka Peltola
OBJECTIVES: Until now, the vagus nerve stimulation (VNS) treatment in epilepsy has consisted of two different modes: normal and magnet stimulation. A new vagus nerve stimulator model (106 AspireSR®, LivaNova, Houston, TX, USA) also allows automatic stimulation (AutoStim). The purpose of this study is to examine the effect of autostimulation on seizure frequencies together with energy consumption. MATERIALS AND METHODS: The study material consisted of 14 patients whose former stimulator model (102/103) was replaced with model 106...
December 14, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/30548850/sensory-coding-is-impaired-in-rat-absence-epilepsy
#4
Florian Studer, Emel Laghouati, Guillaume Jarre, Olivier David, Benoît Pouyatos, Antoine Depaulis
KEY POINTS: Absence epilepsy is characterized by the occurrence of spike-and-wave discharges concomitant with an alteration of consciousness and associated with cognitive comorbidities. In a genetic model of absence epilepsy in the rat, the GAERS, we showed that spike-and-wave discharges are initiated in the barrel field primary somatosensory cortex that codes whisker-related information therefore playing an essential role in rodents' interactions with their environment. Sensory-information processing is impaired in the epileptic barrel field primary somatosensory cortex of GAERS with a delayed sensory-evoked potential and a duplicated neuronal response to whisker-stimulation in in vivo extracellular recordings...
December 13, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30548727/health-related-stigma-of-noncommunicable-neurological-disease-in-rural-adult-populations-a-scoping-review
#5
REVIEW
Valerie L Elliot, Debra Morgan, Julie Kosteniuk, Amanda Froehlich Chow, Melanie Bayly
Stigma is a widely recognised public health issue. Many people with neurological disease and their families experience stigmatisation, adding to their burden of illness. Rural populations are typically small, lack anonymity, and often have a higher proportion of older adults with inadequate access to specialised services and resources. Although generally isolated, rural areas can offer benefits such as a sense of familiarity and interconnectedness. The purpose of this scoping review was to map the existing evidence on stigma associated with non-communicable neurological disease in rural adult populations and identify key findings and gaps in the literature...
December 12, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/30547864/-christmas-article-the-influence-of-lunar-phases-on-epilectic-seizures
#6
Malthe Folmer Genét, Nanette Mol Debes
An old myth asserts, that the lunar phases influence epileptic seizures. This Christmas article examines the assertion by reviewing four articles about the correlation between the lunar phases and the frequency of seizures in patients with epilepsy and in patients with non-epileptic seizures. Hypotheses suggest, that sleep disturbances, melatonin level and nocturnal illumination may play a role in the relation between lunar phases and epileptic seizures. However, because of inconsistency in the literature, we cannot conclude any relation between the occurrence of epileptic seizures and the lunar phases...
December 10, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/30546927/utility-of-magnetic-resonance-imaging-brain-epilepsy-protocol-in-new-onset-seizures-how-is-it-different-in-developing-countries
#7
Janardhana Ponnatapura, Suresh Vemanna, Sandeep Ballal, Avisha Singla
Introduction: Magnetic resonance imaging (MRI) is the current imaging tool of choice in the investigation of patients with seizures. The advent of high-resolution MRI with a dedicated seizure protocol has significantly increased the chances of identifying a cause, resulting in a positive clinical impact on the management of these patients. Aims: The aims of this study were to evaluate the diagnostic efficacy of standard MRI, identify whether there is an increase in the diagnostic yield with the addition of dedicated seizure protocol, and compare the diagnostic yields of MRI and electroencephalogram (EEG) individually and in combination...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/30546381/p53-sensitive-epileptic-behavior-and-inflammation-in-ft1-hypomorphic-mice
#8
Romina Burla, Mattia La Torre, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona Del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì, Isabella Saggio
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Among animal models, mouse mutants are particularly valuable since they allow conjoint behavioral, organismal, and genetic analyses. Along with this, since aging has been associated with higher frequency of seizures, prematurely aging mice, simulating human progeroid diseases, offer a further useful modeling element as they recapitulate aging over a short time-window...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30544358/ictal-networks-of-temporal-lobe-epilepsy-views-from-high-frequency-oscillations-in-stereoelectroencephalography
#9
(no author information available yet)
OBJECTIVEIn this study, the authors investigated high-frequency oscillation (HFO) networks during seizures in order to determine how HFOs spread from the focal cerebral cortex and become synchronized across various areas of the brain.METHODSAll data were obtained from stereoelectroencephalography (SEEG) signals in patients with drug-resistant temporal lobe epilepsy (TLE). The authors calculated intercontact cross-coefficients between all pairs of contacts to construct HFO networks in 20 seizures that occurred in 5 patients...
November 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30543665/auditory-stimulation-improves-motor-function-and-caretaker-burden-in-children-with-cerebral-palsy-a-randomized-double-blind-study
#10
Hilla Ben-Pazi, Adi Aran, Anand Pandyan, Nava Gelkop, Gary Ginsberg, Yehuda Pollak, Debby Elnatan
AIM: To investigate the impact of auditory stimulation on motor function in children with cerebral palsy (CP) and disabling hypertonia. METHOD: 9 matched pairs (age: 7y5m, SD 4y1m; 13 boys; gross-motor-functional-classification-scale: median 4; manual-ability-classification-system: median 4) were randomized to receive either auditory stimulation embedded in music (study, n = 9) or music alone (sham, control, n = 9) for at least 10 minutes 4 times a week for 4 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/30542266/astroglial-ca-2-dependent-hyperexcitability-requires-p2y-1-purinergic-receptors-and-pannexin-1-channel-activation-in-a-chronic-model-of-epilepsy
#11
Mario Wellmann, Carla Álvarez-Ferradas, Carola J Maturana, Juan C Sáez, Christian Bonansco
Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. The above suggests that alterations in astroglial Ca2+ -dependent excitability observed in the epileptic tissue could arise from changes in astrocyte-to-astrocyte signaling, which is mainly mediated by purines in physiological and pathological conditions...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30542259/imbalance-of-functional-connectivity-and-temporal-entropy-in-resting-state-networks-in-autism-spectrum-disorder-a-machine-learning-approach
#12
Robert X Smith, Kay Jann, Mirella Dapretto, Danny J J Wang
Background: Two approaches to understanding the etiology of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) involve network level functional connectivity (FC) and the dynamics of neuronal signaling. The former approach has revealed both increased and decreased FC in individuals with ASD. The latter approach has found high frequency EEG oscillations and higher levels of epilepsy in children with ASD. Together, these findings have led to the hypothesis that atypical excitatory-inhibitory neural signaling may lead to imbalanced association pathways...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30539418/atp-synthase-subunit-beta-immunostaining-is-reduced-in-the-sclerotic-hippocampus-of-epilepsy-patients
#13
Marcelo Vilas Boas Mota, Bruna Cunha Zaidan, Amanda Morato do Canto, Enrico Ghizoni, Helder Tedeschi, Luciano de Souza Queiroz, Marina K M Alvim, Fernando Cendes, Iscia Lopes-Cendes, André Almeida Schenka, André Schwambach Vieira, Fabio Rogerio
Epilepsy is a common disease presenting with recurrent seizures. Hippocampal sclerosis (HS) is the commonest histopathological alteration in patients with temporal lobe epilepsy (TLE) undergoing surgery. HS physiopathogenesis is debatable. We have recently studied, by using mass spectrometry-based proteomics, an experimental model of TLE induced by electrical stimulation. Specifically, protein expressions of both the beta subunit of mitochondrial ATP synthase (ATP5B) and of membrane ATPases were found to be reduced...
December 11, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/30539344/evaluation-of-dual-pathology-among-drug-resistant-epileptic-patients-with-hippocampal-sclerosis
#14
Jafar Mehvari Habibabadi, Shervin Badihian, Nasim Tabrizi, Navid Manouchehri, Mohammad Zare, Reza Basiratnia, Majid Barekatain, Houshang Moein, Amirali Mehvari Habibabadi, Payam Moein, Peyman Gookizadeh
PURPOSE: Dual pathology (DP) is defined as simultaneous presence of hippocampal sclerosis (HS) and any other pathology in the brain. Since this is a less probed concept, we aimed to evaluate the frequency and characteristics of DP among drug-resistant epileptic patients with HS. METHODS: This is a cross-sectional study conducted during 2007-2016 in Kashani Comprehensive Epilepsy Center, Isfahan, Iran. Patients with diagnosis of drug-resistant epilepsy and HS were enrolled in the study, and demographic data, seizure semiology, EEG findings, and MRI findings were collected...
December 11, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/30534869/-sudden-death-in-epilepsy
#15
Mauricio Velásquez, Alejandro De Marinis, Evelyn Benavides
The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. The physiopathological mechanism of SUDEP is not yet fully understood. Autonomic system abnormalities, as well as cardiac and respiratory changes have been found...
August 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/30530132/risk-factors-for-the-use-of-antiepileptic-drugs-in-patients-with-psychogenic-nonepileptic-seizures
#16
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice. METHODS: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included...
December 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30529718/age-dependent-semiology-of-frontal-lobe-seizures
#17
Mandy Hintz, Valentina Krenz, Andreas Schulze-Bonhage
INTRODUCTION: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far. MATERIAL AND METHODS: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24.9 years) with EEG/MR evidence for frontal lobe epilepsy undergoing video-EEG telemetry assessment between 1999 und 2016...
October 23, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30529399/tonic-thermonociceptive-stimulation-selectively-modulates-ongoing-neural-oscillations-in-the-human-posterior-insula-evidence-from-intracerebral-eeg
#18
Giulia Liberati, Maxime Algoet, Susana Ferrao Santos, Jose Geraldo Ribeiro-Vaz, Christian Raftopoulos, André Mouraux
The human insula is an important target for spinothalamic input, but there is still no consensus on its role in pain perception and nociception. In this study, we show that the human insula exhibits activity preferential for sustained thermonociception. Using intracerebral EEG recorded from the insula of 8 patients (2 females) undergoing a presurgical evaluation of focal epilepsy (53 contacts: 27 anterior, 26 posterior), we "frequency-tagged" the insular activity elicited by sustained thermonociceptive and vibrotactile stimuli, by periodically modulating stimulation intensity at a fixed frequency of 0...
December 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/30525185/quantitative-analysis-and-eeg-markers-of-kcnt1-epilepsy-of-infancy-with-migrating-focal-seizures
#19
Mathieu Kuchenbuch, Pascal Benquet, Anna Kaminska, Agathe Roubertie, Emilie Carme, Anne de Saint Martin, Edouard Hirsch, Fanny Dubois, Cécile Laroche, Giulia Barcia, Nicole Chemaly, Matthieu Milh, Nathalie Villeneuve, Paul Sauleau, Julien Modolo, Fabrice Wendling, Rima Nabbout
OBJECTIVE: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy. METHODS: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study...
December 7, 2018: Epilepsia
https://www.readbyqxmd.com/read/30525116/adjunctive-levetiracetam-in-the-treatment-of-chinese-and-japanese-adults-with-generalized-tonic-clonic-seizures-a-double-blind-randomized-placebo-controlled-trial
#20
Liwen Wu, Kazuichi Yagi, Zhen Hong, Weiping Liao, Xuefeng Wang, Dong Zhou, Yushi Inoue, Yoko Ohtsuka, Mutsuo Sasagawa, Kiyohito Terada, Xinlu Du, Yoshihiro Muramoto, Tomonobu Sano
Objective: To assess the efficacy, safety, and tolerability of adjunctive levetiracetam (LEV) in Chinese and Japanese adults with generalized tonic-clonic (GTC) seizures (N01159; NCT01228747). Methods: This double-blind, randomized, placebo-controlled, multicenter phase III trial comprised: 4-week retrospective and 4-week prospective baseline, 12-week dose-adjustment, and 16-week evaluation periods. Chinese and Japanese patients ≥16 years old with idiopathic generalized, symptomatic generalized, or undetermined epilepsy with GTC seizures received a single-blind placebo during the prospective baseline, and then were randomized 1:1 to placebo or LEV 1,000 mg/day administered twice daily...
December 2018: Epilepsia Open
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