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EEG epilepsy

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https://www.readbyqxmd.com/read/30343368/altered-s100-calcium-binding-protein-b-and-matrix-metallopeptidase-9-as-biomarkers-of-mesial-temporal-lobe-epilepsy-with-hippocampus-sclerosis
#1
Nagwa A Meguid, Hatem Samir, Geir Bjørklund, Mona Anwar, Adel Hashish, Farouk Koura, Salvatore Chirumbolo, Saher Hashem, Mona A El-Bana, Hebatalla S Hashem
Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt...
October 20, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/30340903/eeg-endophenotypes-in-autism-spectrum-disorder
#2
Jamie K Capal, Christopher Carosella, Elora Corbin, Paul S Horn, Rebecca Caine, Patricia Manning-Courtney
OBJECTIVES: The association between autism spectrum disorder (ASD) and epilepsy is well-known. Abnormalities on electroencephalography (EEG) results have been reported in patients with ASD without a history of seizures. However, little is known about the relationship between abnormalities on EEG results and the core features of ASD. The purpose of the study was to determine the relationship between the presence of epilepsy and/or abnormalities on EEG results and disease-associated impairments in young children with ASD...
October 16, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30340473/clinical-and-genetic-rett-syndrome-variants-are-defined-by-stable-electrophysiological-profiles
#3
Conor Keogh, Giorgio Pini, Adam H Dyer, Stefania Bigoni, Pietro DiMarco, Ilaria Gemo, Richard Reilly, Daniela Tropea
BACKGROUND: Rett Syndrome (RTT) is a complex neurodevelopmental disorder, frequently associated with epilepsy. Despite increasing recognition of the clinical heterogeneity of RTT and its variants (e.g Classical, Hanefeld and PSV(Preserved Speech Variant)), the link between causative mutations and observed clinical phenotypes remains unclear. Quantitative analysis of electroencephalogram (EEG) recordings may further elucidate important differences between the different clinical and genetic forms of RTT...
October 19, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30338512/epilepsy-surgery-in-panama-establishment-of-a-successful-hybrid-program-as-a-model-for-small-middle-income-countries
#4
Ruben Kuzniecky, Carmen Baez, Guzmán Aranda, Eveline Teresa Hidalgo, Ameeta Grover, Cordelia Orillac, Yvonne Zelenka, Howard L Weiner
OBJECTIVE: The majority of the 65 million people worldwide with epilepsy live in low- and middle-income countries. Many of these countries have inadequate resources to serve the large patient population affected by epilepsy. Panama is a middle-income country that currently has only 2 facilities that can provide basic epilepsy services and no epilepsy surgery services. To address this need, a group of Panamanian physicians partnered with U.S. epilepsy health care providers to test a hybrid epilepsy surgery program, combining resources and expertise...
October 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/30337131/clinical-features-at-the-time-of-diagnosis-of-benign-epilepsy-with-centrotemporal-spikes-do-not-predict-subsequent-seizures
#5
Nathan Watemberg, Sveta Afunevitz, Esther Ganelin-Cohen, Muhammad Mahajnah
BACKGROUND: Benign epilepsy with centrotemporal spikes (BECTs) usually follows a self-limited course, with a single or few seizures. Assessing the likelihood of a second seizure after the first event may help establishing the need for antiepileptic drug therapy at the time of diagnosis. We aimed at identifying clinical and/or electrographic features that could predict the occurrence of a second seizure. METHODS: We reviewed the clinical and electroencephalographic (EEG) data of children diagnosed with BECTs between 2006 and 2012...
September 5, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/30336400/perineal-stimulation-triggering-seizures-in-a-child-with-dravet-syndrome
#6
Puneet Jain, Pratima Gulati, Daad Alsowat, Miguel A Cortez, O Carter Snead, Robyn Whitney
The reported case demonstrates the clinical and EEG features of an interesting seizure precipitant in a child with Dravet Syndrome. It also showed exacerbation of preexisting epilepsy by mild head injury.
October 9, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30334378/lacosamide-on-background-eeg-activity-in-brain-tumor-related-epilepsy-patients-a-case-series-study
#7
Marta Maschio, Alessia Zarabla, Andrea Maialetti, Francesca Sperati, Loredana Dinapoli, Sabrina Dispenza, Gianluca Petreri, Tonino Cantelmi
OBJECTIVE: Therapeutic doses of antiepileptic drugs (AEDs) may alter EEG background activity, which is considered an index of the functional state of the brain. Quantitative analysis (qEEG) of EEG background activity is a valid instrument to assess the effects of many centrally active drugs on the central nervous system, including AEDs. Lacosamide (LCM) is a new AED that could be a valid therapeutic choice in patients with brain tumor-related epilepsy (BTRE). METHODS: We used qEEG to analyze the possible effect of LCM as an add-on, on background EEG activity after 4 months in patients with BTRE...
October 17, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/30333740/global-epileptic-seizure-identification-with-affinity-propagation-clustering-partition-mutual-information-using-cross-layer-fully-connected-neural-network
#8
Fengqin Wang, Hengjin Ke
A longstanding challenge in epilepsy research and practice is the need to classify synchronization patterns hidden in multivariate electroencephalography (EEG) data that is routinely superimposed with intensive noise. It is essential to select a suitable feature extraction method to achieve high recognition performance. A typical approach is to extract the mutual information (MI) between pairs of channels. This calculation, which considers the differences between the sequence pairs to build a reasonable partition, can improve the classification performance...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/30332659/clinical-and-electrographic-characteristics-of-seizures-in-lgi1-antibody-encephalitis
#9
Li-Hao Li, Cong-Cong Ma, Hai-Feng Zhang, Ya-Jun Lian
PURPOSE: The purpose of this study was to analyze the clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis. METHODS: The methods utilized in this study were prospective analysis of the clinical manifestations, types of seizures, electroencephalogram (EEG), adjuvant examination, treatment and prognosis of 19 cases of LGI1-antibody encephalitis diagnosed from January 2017 to February 2018 in First Affiliated Hospital of Zhengzhou University, and reviewed related literatures...
October 14, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30332347/seizure-forecasting-using-single-robust-linear-feature-as-correlation-vector-of-seizure-like-events-in-brain-slices-preparation-in-vitro
#10
Muhammad Khizar Abbas, Muhammad Liaquat Raza, Syed Sajjad Haider Zaidi, Bilal Muhammad Khan, Uwe Heinemann
Epilepsy is a neurological disorder affecting 50 million individuals globally. Modern research has inspected the likelihood of forecasting epileptic seizures. Algorithmic investigations are giving promising results for seizure prediction. Though mostly seizure prediction algorithm uses pre-ictal (prodromal symptoms) events for prediction. On the contrary, prodromal symptoms may not necessarily be present in every patient or subject. This paper focuses on seizure forecasting regardless of the presence of pre-ictal (prodromal symptoms) using the single robust feature with maximum accuracy...
October 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/30327227/episodic-gaze-deviation-in-multiple-sclerosis-versive-seizures-or-oculogyric-crises
#11
Shirin Jamal Omidi, Guadalupe Fernandez BacaVaca, Nuria Lacuey, Aasef G Shaikh, Michael Morgan, Samden D Lhatoo
Ictal gaze deviation and oculogyric crisis (OGC) can show identical clinical manifestations. We report a case of repeated drug induced OGCs in a 38 year old patient with secondary progressive multiple sclerosis. He was referred to our center for treatment of "intractable" epilepsy manifesting as episodic eye and head deviations with apparent unresponsiveness. In the epilepsy monitoring unit, ten typical spells were captured without epileptiform electroencephalographic correlates, but we discovered chronic exposure to metoclopramide...
October 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30327223/pathophysiology-of-corticobasal-degeneration-insights-from-neurophysiological-studies
#12
REVIEW
Raffaele Nardone, Francesco Brigo, Viviana Versace, Luca Sebastianelli, Monica Christova, Stefan Golaszewski, Leopold Saltuari, Eugen Trinka
BACKGROUND: Several studies have applied electrophysiological techniques to physiologically characterize corticobasal degeneration (CBD). METHODS: We performed a systematic literature search of these studies and reviewed all 25 identified articles. RESULTS: Conventional electroencephalography (EEG) is usually normal even in the late stages of disease. Quantitative EEG (qEEG) with spectral analysis revealed mainly lateralized abnormalities, such as an increase of slow wave activity and occasionally the occurrence of sharp waves, and a significant increase of coherence between left parietal-right premotor areas...
October 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30325068/comparison-of-electroencephalographic-findings-with-hippocampal-magnetic-resonance-imaging-volumetry-in-dogs-with-idiopathic-epilepsy
#13
Adriana Czerwik, Marta Płonek, Przemyslaw Podgórski, Marcin Wrzosek
BACKGROUND: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS). OBJECTIVES: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. ANIMALS: An EEG examination, brain magnetic resonance imaging, and volumetric assessment of the hippocampus were performed in 16 nonepileptic and 41 epileptic dogs...
October 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30324037/low-power-and-low-cost-dedicated-bit-serial-hardware-neural-network-for-epileptic-seizure-prediction-system
#14
Si Mon Kueh, Tom J Kazmierski
This paper presents results of using a simple bit-serial architecture as a method of designing an extremely low-power and low-cost neural network processor for epilepsy seizure prediction. The proposed concept is based on a novel bit-serial data processing unit (DPU) which implements the functionality of a complete neuron and uses bit-serial arithmetic. Arrays of DPUs are controlled by simple finite state machines. We show that epilepsy detection through such dedicated neural hardware is feasible and may facilitate development of wearable, low-cost and low-energy personalized seizure prediction equipment...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/30323874/microglial-activation-an-important-process-in-the-onset-of-epilepsy
#15
Hu Zhao, Changgeng Zhu, Donghui Huang
This study aimed to investigate the effects of microglial activation on the onset of epilepsy. Microglias cultured in vitro were stimulated with different concentrations of coriaria lactone (CL), and the effects on cell cycle and apoptosis were examined using flow cytometry. Then microglia were stimulated with 5×10-5 mol/L CL, and levels of cyclin D1 and interleukin-1β (IL-1β) mRNA were measured by fluorescence quantitative PCR; tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in supernatant were detected by radioimmunoassay...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30319527/post-ictal-modulation-of-baroreflex-sensitivity-in-patients-with-intractable-epilepsy
#16
Behnaz Esmaeili, Farhad Kaffashi, Wanchat Theeranaew, Aman Dabir, Samden D Lhatoo, Kenneth A Loparo
Objective: Seizure-related autonomic dysregulation occurs in epilepsy patients and may contribute to Sudden Unexpected Death in Epilepsy (SUDEP). We tested how different types of seizures affect baroreflex sensitivity (BRS) and heart rate variability (HRV). We hypothesized that BRS and HRV would be reduced after bilateral convulsive seizures (BCS). Methods: We recorded blood pressure (BP), electrocardiogram (ECG) and oxygen saturation continuously in patients ( n = 18) with intractable epilepsy undergoing video-EEG monitoring...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30318350/hexadirectional-modulation-of-theta-power-in-human-entorhinal-cortex-during-spatial-navigation
#17
Dong Chen, Lukas Kunz, Wenjing Wang, Hui Zhang, Wen-Xu Wang, Andreas Schulze-Bonhage, Peter C Reinacher, Wenjing Zhou, Shuli Liang, Nikolai Axmacher, Liang Wang
Grid cells and theta oscillations are fundamental components of the brain's navigation system. Grid cells provide animals [1, 2] and humans [3, 4] with a spatial map of the environment by exhibiting multiple firing fields arranged in a regular grid of equilateral triangles. This unique firing pattern presumably constitutes the neural basis for path integration [5-8] and may also enable navigation in visual and conceptual spaces [9-12]. Theta frequency oscillations are a prominent mesoscopic network phenomenon during navigation in both rodents and humans [13, 14] and encode movement speed [15-17], distance traveled [18], and proximity to spatial boundaries [19]...
September 14, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/30317059/automated-seizure-prediction
#18
REVIEW
U Rajendra Acharya, Yuki Hagiwara, Hojjat Adeli
In the past two decades, significant advances have been made on automated electroencephalogram (EEG)-based diagnosis of epilepsy and seizure detection. A number of innovative algorithms have been introduced that can aid in epilepsy diagnosis with a high degree of accuracy. In recent years, the frontiers of computational epilepsy research have moved to seizure prediction, a more challenging problem. While antiepileptic medication can result in complete seizure freedom in many patients with epilepsy, up to one-third of patients living with epilepsy will have medically intractable epilepsy, where medications reduce seizure frequency but do not completely control seizures...
October 11, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30316048/can-home-videos-made-on-smartphones-complement-video-eeg-in-diagnosing-psychogenic-nonepileptic-seizures
#19
Bhargavi Ramanujam, Deepa Dash, Manjari Tripathi
PURPOSE: To assess the contribution home-videos made on mobile phones can make to the diagnosis of Psychogenic Nonepileptic Seizures (PNES). METHODS: Consecutive patients 10-50 years old, with episodes of altered behavior or abnormal movements, unresponsiveness, or falls, were recruited after they had obtained 'good' or 'fair' quality (quality of video scale (QOV)) home-videos of their episodes on personal mobile phones; these subjects underwent video-electroencephalography (VEEG)...
October 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30315907/bold-mapping-of-human-epileptic-spikes-recorded-during-simultaneous-intracranial-eeg-fmri-the-impact-of-automated-spike-classification
#20
Niraj K Sharma, Carlos Pedreira, Umair J Chaudhary, Maria Centeno, David W Carmichael, Tinonkorn Yadee, Teresa Murta, Beate Diehl, Louis Lemieux
OBJECTIVES: Simultaneous intracranial EEG and functional MRI (icEEG-fMRI) can be used to map the haemodynamic (BOLD) changes associated with the generation of IEDs. Unlike scalp EEG-fMRI, in most patients who undergo icEEG-fMRI, IEDs recorded intracranially are numerous and show variability in terms of field amplitude and morphology. Therefore, visual marking can be highly subjective and time consuming. In this study, we applied an automated spike classification algorithm, Wave_clus (WC), to IEDs marked visually on icEEG data acquired during simultaneous fMRI acquisition...
October 10, 2018: NeuroImage
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