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EEG epilepsy

Alberto Verrotti, Marco Greco, Gaia Varriale, Agnese Tamborino, Salvatore Savasta, Marco Carotenuto, Maurizio Elia, Francesca Operto, Lucia Margari, Vincenzo Belcastro, Angelo Selicorni, Elena Freri, Sara Matricardi, Tiziana Granata, Francesca Ragona, Giuseppe Capovilla, Alberto Spalice, Giangennaro Coppola, Pasquale Striano
OBJECTIVIES: Monosomy 1p36 syndrome is a recognized syndrome with multiple congenital anomalies; medical problems of this syndrome include developmental delay, facial dysmorphisms, hearing loss, short stature, brain anomalies, congenital heart defects. Epilepsy can be another feature but there are few data about the types of seizures and long term prognosis. The aim of this work was to analyse the electroclinical phenotype and the long-term outcome in patients with monosomy 1p36 syndrome and epilepsy...
August 14, 2018: Acta Neurologica Scandinavica
Abhijeet Gummadavelli, Hitten P Zaveri, Dennis D Spencer, Jason L Gerrard
Seizures have traditionally been considered hypersynchronous excitatory events and epilepsy has been separated into focal and generalized epilepsy based largely on the spatial distribution of brain regions involved at seizure onset. Epilepsy, however, is increasingly recognized as a complex network disorder that may be distributed and dynamic. Responsive neurostimulation (RNS) is a recent technology that utilizes intracranial electroencephalography (EEG) to detect seizures and delivers stimulation to cortical and subcortical brain structures for seizure control...
2018: Frontiers in Neuroscience
Maina P Kava, Annie Robertson, Lawrence Greed, Shanti Balasubramaniam
Nonketotic hyperglycinemia (NKH) is a devastating inborn error of glycine metabolism caused by deficient activity of the glycine cleavage enzyme. Classically, patients present with lethargy, hypotonia, myoclonic jerks, transient respiratory depression in the first week of life and often progress to death. Surviving infants have profound psychomotor retardation, refractory epilepsy and poor quality of life. Currently, no effective therapeutic avenues exist for severe NKH. Ketogenic diet (KD) has been trialled only in a small group of patients with neonatal NKH and early myoclonic encephalopathy, in whom significant improvements in seizure control were reported...
August 14, 2018: European Journal of Clinical Nutrition
Stanislas Lagarde, Nicolas Roehri, Isabelle Lambert, Agnès Trebuchon, Aileen McGonigal, Romain Carron, Didier Scavarda, Mathieu Milh, Francesca Pizzo, Bruno Colombet, Bernard Giusiano, Samuel Medina Villalon, Maxime Guye, Christian-G Bénar, Fabrice Bartolomei
Drug-refractory focal epilepsies are network diseases associated with functional connectivity alterations both during ictal and interictal periods. A large majority of studies on the interictal/resting state have focused on functional MRI-based functional connectivity. Few studies have used electrophysiology, despite its high temporal capacities. In particular, stereotactic-EEG is highly suitable to study functional connectivity because it permits direct intracranial electrophysiological recordings with relative large-scale sampling...
August 9, 2018: Brain: a Journal of Neurology
Yang Qiu, Weidong Zhou, Nana Yu, Peidong Du
Automatic seizure detection technology can automatic mark the EEG by using epileptic detection algorithm, which is helpful to the diagnosis and treatment of epileptic diseases. This paper presents an EEG classification framework based on the denoising sparse autoencoder. The denoising sparse autoencoder (DSAE) is an improved unsupervised deep neural network over sparse autoencoder and denoising autoencoder, which can learn the closest representation of the data. The sparsity constraint applied in the hidden layer of the network makes the expression of data as sparse as possible so as to obtain more efficient representation of EEG signals...
August 8, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Yanfeng Yang, Haixiang Wang, Wenjing Zhou, Tianyi Qian, Wei Sun, Guoguang Zhao
BACKGROUND: Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to characterize the electrophysiological properties and clinical features of seizures arising from the precuneus based on data from stereoelectroencephalography (SEEG). METHODS: The present retrospective study included 10 patients with medically intractable epilepsy, all of whom were diagnosed with precuneal epilepsy via stereoelectroencephalography (SEEG) at Yuquan Hospital and Xuan Wu Hospital between 2014 and 2016...
August 13, 2018: BMC Neurology
Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothée Proix, Michal Náhlík, Daniel B Grunberg, Chip Reuben, Gregory Worrell, Brian Litt, David T J Liley, David B Grayden, Mark J Cook
Accurate seizure prediction will transform epilepsy management by offering warnings to patients or triggering interventions. However, state-of-the-art algorithm design relies on accessing adequate long-term data. Crowd-sourcing ecosystems leverage quality data to enable cost-effective, rapid development of predictive algorithms. A crowd-sourcing ecosystem for seizure prediction is presented involving an international competition, a follow-up held-out data evaluation, and an online platform, Epilepsyecosystem...
August 8, 2018: Brain: a Journal of Neurology
Frank J van Schalkwijk, Monica Ricci, Armin Nikpour, Laurie A Miller
Disturbed sleep can negatively affect overnight memory retention as well as new learning the subsequent day. In healthy participants, positive associations between memory performance and sleep characteristics (e.g., time spent in slow-wave sleep [SWS]) have been detected. In a previous study, we found that SWS was much reduced in patients with focal seizures, but when correlations between memory complaints and various sleep characteristics were considered, the only significant relationship was with the time to onset of rapid eye movement (REM) sleep (i...
August 7, 2018: Epilepsy & Behavior: E&B
Jun T Park, Guadalupe Fernandez Baca Vaca, Rachel Tangen, Jonathan Miller
Resection of the hippocampus ipsilateral to the verbal memory-dominant hemisphere frequently results in severe memory deficits. In adults with epilepsy, multiple hippocampal transections (MHTs) have resulted in excellent seizure outcome with preservation of verbal memory. The authors report the first detailed case of a child undergoing MHTs for mesial temporal lobe epilepsy. A 13-year-old right-handed boy had intractable seizures characterized by epigastric discomfort evolving to unresponsiveness and chewing automatisms, lasting 1 minute and occurring 2-3 times weekly, sometimes ending in a generalized tonic-clonic seizure...
August 10, 2018: Journal of Neurosurgery. Pediatrics
Byung-Chul Son, Young-Min Shon, Seong Hoon Kim, Jiyeon Kim, Hak-Cheol Ko, Jin-Gyu Choi
Background and Purpose: Implantation of deep brain stimulation (DBS) electrodes in the anterior nucleus of the thalamus (ANT) or the centromedian nucleus (CM), for the treatment of refractory epilepsy, is technically demanding. To enhance the accuracy of electrode placement within the ANT and CM, we analyzed our experience with electrode revision surgery in ANT and CM DBS and investigated the cause of misplacement and verifying methods for accurate placement. Methods: A retrospective analysis of the medical records of 23 patients who underwent DBS for refractory epilepsy during the period from 2013 to 2016 was performed...
June 2018: Journal of Epilepsy Research
Jangho Park, Hae-Won Choi, Mi-Sun Yum, Tae-Sung Ko, Seung-Hyun Shon, Hyo-Won Kim
OBJECTIVES: We aimed to investigate the effectiveness and safety of methylphenidate (MPH), and especially its influence on seizures, in subjects with attention-deficit/hyperactivity disorder (ADHD) and epilepsy through a retrospective chart review of subjects treated with MPH in a clinical setting. We also evaluated factors that could affect seizure aggravation during MPH treatment. METHODS: From April 2004 to July 2011, MPH was prescribed to 105 subjects with ADHD and epilepsy...
August 8, 2018: Journal of Child and Adolescent Psychopharmacology
Brandon Frank, Landon Hurley, Travis M Scott, Pat Olsen, Patricia Dugan, William B Barr
In this study, we employed a kernel support vector machine to predict epilepsy localization and lateralization for patients with a diagnosis of epilepsy (n = 228). We assessed the accuracy to which indices of verbal memory, visual memory, verbal fluency, and naming would localize and lateralize seizure focus in comparison to standard electroencephalogram (EEG). Classification accuracy was defined as models that produced the least cross-validated error (CVϵ). In addition, we assessed whether the inclusion of norm-based standard scores, demographics, and emotional functioning data would reduce CVϵ...
August 3, 2018: Epilepsy & Behavior: E&B
Lara Wadi, Yasser Medlej, Makram Obeid
Hyperekplexia is a rare neurogenetic disorder characterized by startle. Accurate diagnosis of this notorious mimicker of epilepsy is important to prevent life-threatening apnoea. We report a novel case of concomitant GLRA1-related hyperkeplexia and myoclonic epilepsy. A toddler with daily paroxysms of head drops and falls presented with epileptic myoclonus on EEG, however, whole-exome sequencing revealed hyperekplexia-related GLRA1 mutation. The boy eventually developed spells induced by noise and surprise...
August 3, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
Yuki Amano, Ayataka Fujimoto, Tohru Okanishi, Mitsuyo Nishimura, Hideo Enoki
PURPOSE: Tuberous sclerosis complex (TSC) is a leading cause of epilepsy, with seizures affecting almost 80-90% of children. We used the concordance between magnetic resonance imaging (MRI) and dense array electroencephalography (dEEG) findings to detect epileptic focus in a patient with TSC. METHODS: A 9-year-old boy with TSC exhibited daily choking spells. As we could not detect the seizure onset area with conventional scalp electroencephalogram (EEG) and long-term video monitoring, we performed dEEG and captured his regular seizures...
August 1, 2018: Brain & Development
Zuyi Yu, Weidong Zhou, Fan Zhang, Fangzhou Xu, Shasha Yuan, Yan Leng, Yang Li, Qi Yuan
Visual inspection of electroencephalogram (EEG) recordings for epilepsy diagnosis is very time-consuming. Therefore, much research is devoted to developing a computer-assisted diagnostic system to relieve the workload of neurologists. In this study, a kernel version of the robust probabilistic collaborative representation-based classifier (R-ProCRC) is proposed for the detection of epileptic EEG signals. The kernel R-ProCRC jointly maximizes the likelihood that a test EEG sample belongs to each of the two classes (seizure and non-seizure), and uses the kernel function method to map the EEG samples into the higher dimensional space to relieve the problem that they are linearly non-separable in the original space...
August 4, 2018: Medical & Biological Engineering & Computing
Xinjian Zhu, Xiaolin Li, Mengyi Zhu, Kangni Xu, Li Yang, Bing Han, Rongrong Huang, Aifeng Zhang, Honghong Yao
BACKGROUND: Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domain-containing protein (Adam) family, has been involved in the neuroinflammation response. However, it remains unclear whether and how Adam10 modulates neuroinflammation responses in the context of an epileptic brain or whether Adam10 affects epileptogenesis via the neuroinflammation pathway...
August 4, 2018: Journal of Neuroinflammation
Nihan Çarçak, Melis Yavuz, Tuğba Eryiğit Karamahmutoğlu, Akif Hakan Kurt, Meral Urhan Küçük, Filiz Yılmaz Onat, Kansu Büyükafsar
Rho/Rho-kinase (ROCK) signaling contributes to neuroinflammation, epileptogenesis, and seizures in convulsive-type epilepsies. However, this pathway has not been investigated in absence epilepsy. We investigated RhoA activity in genetic absence epilepsy rats from Strasburg (GAERS) and the effects of ROCK inhibitors Y-27632 and fasudil on spike-and-wave discharges (SWDs) of GAERS. ROCK level and activity were measured by Western blot analysis in the brain areas involved in absence seizures (i.e., cortex and thalamus) and hippocampus...
August 2, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Brin Freund, John C Probasco, Eva K Ritzl
OBJECTIVE Delay in diagnosis and subsequent treatment of nonconvulsive seizures can lead to worsened outcomes. The gold standard in detecting nonconvulsive seizures is continuous video-electroencephalography (cEEG). Compared to routine, 30-minute EEG, the use of cEEG increases the likelihood of capturing intermittent nonconvulsive seizures. Studies of critically ill patients in intensive care units demonstrate a particularly high rate of nonconvulsive seizures. Some of these studies included postneurosurgical patients, but often subanalyses of specific populations were not done...
June 1, 2018: Journal of Neurosurgery
Ashalatha Radhakrishnan, Ramshekhar Menon, Sanjeev V Thomas, Mathew Abraham, George Vilanilam, Chandrashekharan Kesavadas, Bejoy Thomas, Ajith Cherian, Ravi Prasad Varma
OBJECTIVES: To explore the effect of duration of epilepsy and delay in surgery on seizure outcome in patients operated for drug-resistant temporal lobe epilepsy (TLE). MATERIALS & METHODS: 664 consecutive patients who underwent anterior temporal lobectomy (ATL) for TLE from 1995 to 2008 formed the study cohort. We divided them into two, one as seizure-free with or without antiepileptic drugs after ATL as "good outcome" (Engel Class I a) and seizures of any type, any time after surgery as "poor outcome"...
July 31, 2018: Acta Neurologica Scandinavica
Mei-Ying Wang, Yu-Chen Lai, Chi-Ling Chen, Yi-Yu Lin, Yen-Gan Chiou
BACKGROUND & PROBLEMS: A total of 20 cases of children with epilepsy implemented electroencephalography (EEG) recording examinations in our ward between January 1st and March 10th, 2016. Fifteen (75%) of the recordings were incompletely stored, indicating that the EEG recordings storage integrity in our unit was 25%. Incomplete storage of these recordings results in prolonged hospital stays and negatively affects the ability of doctors to provide accurate diagnoses. PURPOSE: This project was developed to increase the EEG recording storage integrity for epileptic children to 100%...
August 2018: Hu Li za Zhi the Journal of Nursing
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