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Yan Jun Ma, Chun Xiao Sun, Jian Wen Wang
Hypocrellin A (HA), a promising photosensitizer for anticancer photodynamic therapy (PDT), is a fungal perylenequinone pigment from the fruiting body of Shiraia bambusicola, a traditional Chinese medicine for treating skin diseases. The mycelial cultures are becoming a biotechnological alternative for HA production. In this study, light of different wavelengths was investigated to develop an effective eliciting strategy for HA production in the cultures. Under red LED light (627 nm) at 200 lux, the maximum HA production (175...
October 19, 2018: Photochemistry and Photobiology
Jae Sik Yu, Hyun-Soo Roh, Kwan-Hyuck Baek, Seul Lee, Sil Kim, Hae Min So, Eunjung Moon, Changhyun Pang, Tae Su Jang, Ki Hyun Kim
Background: Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung adenocarcinoma cells. Methods: Bioactivity-guided fractionation and preparative/semipreparative HPLC purification were used with LC/MS analysis to separate the bioactive constituents. Cell viability and apoptosis in human lung cancer cell lines (A549, H1264, H1299, and Calu-6) after treatment with KRG extract fractions and constituents thereof were assessed using the water-soluble tetrazolium salt (WST-1) assay and terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, respectively...
October 2018: Journal of Ginseng Research
Jason Lanoue, Evangelos D Leonardos, Shalin Khosla, Xiuming Hao, Bernard Grodzinski
In controlled environment plant production facilities, elevating either light or CO2 levels generally has led to increased biomass and yield due to enhanced canopy photosynthesis. Today, advancements in light-emitting diodes (LEDs) have made this technology a viable option for both supplementary lighting in greenhouses and a sole lighting source in controlled environment chambers. Our study used tomato plants grown under both ambient CO2 (AC) and elevated CO2 (EC) conditions then exposed them to various CO2 and lighting treatments during both whole plant and leaf level measurements...
2018: PloS One
Jun-Bo Chen, Cen Zhou, Ru-Qiang Lu, Xin-Chang Wang, Hang Qu, Mithu Saha, Hao-Liang Liu, Hui Zhang, Xiao-Yu Cao
Triindolo-truxene, a C3-symmetric molecule with a large π-conjugated plane, has six methylene carbon atoms and three aromatic carbon atoms which can be facilely functionalized. Herein, we introduce butyl, carbonyl, cyano, and/or malononitrile groups into six methylene carbon atoms (6-, 14-, 22-, or 8-, 16-, 24-positions) and/or three aromatic carbon atoms (2-, 10-, and 18-positions) of triindolo-truxene to produce eight derivatives. Their photophysical and electrochemical properties, and molecular assembly can be effectively modulated by substituents and substitution patterns...
October 17, 2018: Chemistry: a European Journal
Laura J Schmertmann, Kate Bodley, Wieland Meyer, Richard Malik, Mark B Krockenberger
A systematic investigation into environmental sources of infection was conducted at an Australian zoological park after cryptococcosis, caused by Cryptococcus gattii VGI, was diagnosed in a red-tailed black cockatoo (Calyptorhynchus banksii) residing in a large aviary with a diverse range of other avian species. A single tree with an extensive hollow was identified as the likely source of infection based on heavy culture of C. gattii VGI, multi-locus sequence typing and phylogenetic analysis of environmental and disease-related isolates...
October 16, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Abiodun O Adewuya, Tomilola Adewumi, Olufisayo Momodu, Olushola Olibamoyo, Olabanji Adesoji, Adedayo Adegbokun, Suraju Adeyemo, Olufikunayo Manuwa, Dapo Adegbaju
BACKGROUND: This study aimed to develop and test the feasibility of a primary care worker-led psychological intervention as the main feature of a collaborative stepped care for depression that is effective, affordable, culturally acceptable, tailored to patients' clinical condition and easily integrate-able into the primary care schedule in Nigeria. METHODS: Using the Medical Research Council framework, in the first stage (modelling/theoretical development), experts reviewed and distilled evidence from literature to form the intervention components...
October 17, 2018: Psychological Medicine
Fug Akogou, T S Canoy, App Kayode, Hmw den Besten, A R Linnemann, V Fogliano
BACKGROUND: The "clean label" trend is pushing the food industry to replace synthetic colorants by plant-based colorants. However, technological efficacy and undesirable side effects restrict the use of plant-based colorants in industrial applications. This research studied the production of fermented maize dough coloured by apigeninidin-rich red sorghum biocolorant, as practiced for centuries in West Africa, as a model to assess the impact of the biocolorant on nutritional and sensorial quality of foods...
October 16, 2018: Journal of the Science of Food and Agriculture
Min Jiang, Tianqi Wang, Xueming Yan, Zhuochao Liu, Yufei Yan, Kai Yang, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu, Xiaobing Xi, Chunhao Yang, Lianfu Deng
Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodelling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target-directed agents that inhibit excessive bone resorption and increase bone formation is considered an efficient strategy for developing new osteoporosis treatments. Rhein, a natural anthraquinone, can be isolated from various Asian herbal medicines. Rhein and its derivatives have been reported to have various beneficial pharmacological effects, especially their bone-targeting ability and anti-osteoclastogenesis activity...
October 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Bin Li, G Annadurai, Liangling Sun, Jia Liang, Shaoying Wang, Qi Sun, Xiaoyong Huang
In this work, Ce3+ -activated Ba3 Lu2 B6 O15 (BLBO) blue-emitting phosphors were prepared, and their photoluminescence properties were studied. It was found that these phosphors can be excited over a broad excitation band range from 300 nm to 430 nm and generated a blue emission band in the 400-550 nm range with a maximum peak at 443 nm. The full width at half maximum of the blue emission band was about 68 nm. The optimal doping concentration of Ce3+ ions was determined to be 3 mol. %, and the BLBO:0...
October 15, 2018: Optics Letters
Delphine Sarafian, Claire Maufrais, Jean-Pierre Montani
Aim: Red wine is usually ingested as an unmixed drink. However, mixtures of wine with juices and/or sucrose (mixed wine) are becoming more and more popular and could be ingested at either cold or hot temperature. Although the temperature effects on the cardiovascular system have been described for water and tea, with greater energy expenditure (EE) and lower cardiac workload with a colder drink, little information is available on the impact of temperature of alcoholic beverages on alcoholemia and cardiometabolic parameters...
2018: Frontiers in Physiology
Francisco J Rivero, M José Jara-Palacios, Belén Gordillo, Francisco J Heredia, M Lourdes González-Miret
With the purpose of modulating the copigmentation equilibria of red wines, an environmentally sustainable process was performed based on post-fermentative addition of overripe seeds (OS). Simple (SW) and double (DW) addition were performed to produce different enrichment of phenolics from seeds, hence different copigmentation/polymerization ratios. The determination of the phenolic composition showed different global increases in OS-macerates wines (catechin, epicatechin, gallic acid and procyanidins B1 and B2)...
January 30, 2019: Food Chemistry
Catherine E Amiot, Guy El Hajj Boutros, Ksenia Sukhanova, Antony D Karelis
Both epidemiological studies and randomised controlled trials have shown that meat-eating can be harmful to human health. Meat-eating is also considered to be a moral issue, impacting negatively on the environment and the welfare of animals. To date, very little scientific research has aimed to reduce this dietary behavior. Therefore, the current research tests the effectiveness of a 4-week multicomponent intervention designed to reduce meat-eating. Using a randomised controlled trial procedure, thirty-two young men (mean age: 23...
2018: PloS One
H A Olanrewaju, J L Purswell, S D Collier, S L Branton
Replacing outdated incandescent light sources provides the opportunity to modify lighting systems according to the needs of different species and according to their spectral sensitivity. Providing a lighting environment geared towards poultry vision may improve bird welfare and blood physiological homeostasis. The influence of two LED light sources (red-supplemented vs. un-supplemented) adjusted to either human spectral sensitivity (lux) or poultry spectral sensitivity (CLUX) was investigated on selected blood physiological variables of male broilers...
October 10, 2018: Poultry Science
Kebin Lin, Jun Xing, Li Na Quan, F Pelayo García de Arquer, Xiwen Gong, Jianxun Lu, Liqiang Xie, Weijie Zhao, Di Zhang, Chuanzhong Yan, Wenqiang Li, Xinyi Liu, Yan Lu, Jeffrey Kirman, Edward H Sargent, Qihua Xiong, Zhanhua Wei
Metal halide perovskite materials are an emerging class of solution-processable semiconductors with considerable potential for use in optoelectronic devices1-3 . For example, light-emitting diodes (LEDs) based on these materials could see application in flat-panel displays and solid-state lighting, owing to their potential to be made at low cost via facile solution processing, and could provide tunable colours and narrow emission line widths at high photoluminescence quantum yields4-8 . However, the highest reported external quantum efficiencies of green- and red-light-emitting perovskite LEDs are around 14 per cent7,9 and 12 per cent8 , respectively-still well behind the performance of organic LEDs10-12 and inorganic quantum dot LEDs13 ...
October 2018: Nature
Kerry F Pedley, Ajay K Pandey, Amy Ruck, Lori M Lincoln, Steven A Whitham, Michelle A Graham
Phakopsora pachyrhizi is the causal agent of Asian soybean rust. Susceptible soybean plants infected by virulent isolates of P. pachyrhizi are characterized by tan-colored lesions and erumpent uredinia on the leaf surface. Germplasm screening and genetic analyses have led to the identification of seven loci, Rpp1 - Rpp7, that provide varying degrees of resistance to P. pachyrhizi (Rpp). Two genes, Rpp1 and Rpp1b, map to the same region on soybean chromosome 18. Rpp1 is unique among the Rpp genes in that it confers an immune response (IR) to avirulent P...
October 10, 2018: Molecular Plant-microbe Interactions: MPMI
Arielle Cimeno, Rolf N Barth, John C LaMattina
PURPOSE OF REVIEW: This review highlights advances in liver xenotransplantation, focusing on immunologic barriers and mechanisms underlying graft failure and recipient demise, and discussion of recent in-vivo results. RECENT FINDINGS: Pig to primate models of liver xenotransplantation have been plagued by thrombocytopenia, anemia, and coagulopathy. It is now known that platelet sequestration is mediated by liver sinusoidal endothelial cells and Kupffer cells in part by asialoglycoprotein receptor 1-driven mechanisms...
October 8, 2018: Current Opinion in Organ Transplantation
Maria Stefania Lepanto, Luigi Rosa, Antimo Cutone, Maria Pia Conte, Rosalba Paesano, Piera Valenti
The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a hormone peptide able to bind to ferroportin, leading to its degradation. Therefore, new efficient therapeutic interventions acting on hepcidin and ferroportin are imperative to manage anemia and AI. Bovine milk derivative lactoferrin (bLf), a glycoprotein able to chelate two ferric ions per molecule, is emerging as a natural anti-inflammatory substance able to modulate hepcidin and ferroportin synthesis through the down-regulation of interleukin-6 (IL-6)...
2018: Frontiers in Immunology
Xiuxia Ren, Ya Liu, Hai Kyoung Jeong, Byoung Ryong Jeong
Codonopsis lanceolata is widely used in traditional medicine and diets. However, there is no optimal protocol for the commercial production of C. lanceolata seedlings. This study was carried out to find the optimum supplementary light source for the production of C. lanceolata seedlings. Seedlings were grown for four weeks in a glasshouse with an average daily light intensity of 490 μmol·m-2 ·s-1 photosynthetic photon flux density (PPFD) coming from the sun and a 16-h daily supplementary lighting at 120 μmol·m-2 ·s-1 PPFD from either high-pressure sodium (HPS), metal halide (MH), far-red (FR), white LED (LED-w), or mixed (white: red: blue = 1:2:1) LEDs (LED-mix)...
October 8, 2018: International Journal of Molecular Sciences
Kanwal Iqbal, Anam Iqbal, Alexander M Kirillov, Weisheng Liu, Yu Tang
Nanoscale metal-organic frameworks (NMOFs) represent a unique class of solids with superior adsorption, mass transport, and catalytic properties. In this study, a facile and novel approach was developed for the generation of hybrid Cu-NMOF/Ce-doped-Mg-Al-LDH nanocatalyst through in situ self-assembly and solvothermal synthesis of a 2D Cu-NMOF, [Cu2 (μ-OH)(μ4 -btc)(phen)2 ] n ·5 nH2 O {H3 btc, trimesic acid; phen, 1,10-phenanthroline}, on a cerium-doped Mg-Al layered double hydroxide (Ce-doped-Mg-Al-LDH) matrix...
October 8, 2018: Inorganic Chemistry
Zhaopei Guo, Lin Lin, Jie Chen, Xingzhi Zhou, Hon Fai Chan, Xuesi Chen, Huayu Tian, Meiwan Chen
To improve gene transfection efficiency in vitro and in vivo, we first grafted polyglycine (PGly) onto branched polyethyleneimine (PEI) (molecular weight MW 25 kDa) to obtain a novel gene vector PGly-PEI (PPG), before complexing it with poly(ethylene glycol)-poly-l-glutamate (PEG-PLG) for adjusting the charge density of PEI. We named the resulting nano-polyplex PG/PPG. The PPGs demonstrated improved gene transfection efficiency after grafting with polyglycine, and the efficiency could be further increased with the introduction of PEG-PLG...
October 5, 2018: Biomaterials Science
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