Shigeto Nagao, Osamu Yokota, Reiko Nanba, Hiroshi Takata, Takashi Haraguchi, Hideki Ishizu, Chikako Ikeda, Naoya Takeda, Etsuko Oshima, Katsuaki Sakane, Seishi Terada, Yuetsu Ihara, Yosuke Uchitomi
We report an autopsy case of progressive supranuclear palsy (PSP) that clinically showed only slowly progressive and symmetric upper motor neuron syndrome over a disease course of 12 years. A female patient initially exhibited dysarthria at the age of 65, followed by gait disturbance and dysphagia. Neurological examination at age 67 disclosed pseudobulbar palsy, spastic gait, hyperreflexia, and presence of bilateral Hoffmann and Babinski signs. However, muscle atrophy, weakness, evidence of denervation on electromyography, vertical gaze palsy, parkinsonism, gait freezing, aphasia, speech apraxia, or dementia was not noted throughout the course...
December 15, 2012: Journal of the Neurological Sciences