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Infectional disease of pediatric

Enaam Raboei, Yazeed Owiwi, Alaa Ghallab, Ali Zeinelabdeen, Ameen Alsaggaf, Mazen Zaidan, Mohamed Fayez, Ahmad Alawi, Ahmed Atta, Ahmad Al Fageeh, Khalid Al Fifi, Murad Al Sayegh, Abdulaziz Banaja, Amani Haddad, Ziyad Al Nefai, Turki Aloufi, Shaima Alghamdi, Ibrahim Abdulrahim, Aljawhara Al Manea, Ibrahim Alharbi, Atef Sait, Reemah Fallatah
INTRODUCTION: Few centers worldwide have advanced single-incision pediatric endosurgery (SIPES) splenectomy. The safety and feasibility of SIPES performed by trainees were not assessed before. SIPES splenectomy is a demanding technique that needs high level of skills. This is the largest series of 39 SIPES splenectomies performed by 14 trainees in one single center. AIMS: To assess the safety, feasibility, and technical challenges of SIPES splenectomy performed by trainees and to compare it with other published series...
December 5, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Feyza Hüsrevoğlu-Esen, Yasemin Altuner-Torun, Çiğdem Karakükçü, Seçil Köse, Ahmet Şehriyaroğlu, Dilek Kafadar, Aydın Esen, Mehmet Köse
Hüsrevoğlu-Esen F. Altuner-Torun Y, Karakükçü Ç, Köse S, Şehriyaroğlu A, Kafadar D, Esen A, Köse M. Gelsolin levels in patients with bronchiolitis. Turk J Pediatr 2018; 60: 286-289. Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers can show severity of the disease and help in clinical management. In this study, the aim was to determine the clinical predictiveness of plasma gelsolin levels (pGSN) in acute bronchiolitis. From December 2013 to May 2014, 52 patients with bronchiolitis (aged < 24 months) were included in this study...
2018: Turkish Journal of Pediatrics
Necil Kutukculer, Ayca Aykut, Neslihan E Karaca, Asude Durmaz, Guzide Aksu, Ferah Genel, Erhan Pariltay, Özgür Cogulu, Elif Azarsız
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leukocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB (OMIM #300481) gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA (OMIM #608508), NCF1 (OMIM #608512), NCF2 (OMIM #608515) and NCF4 (OMIM #601488) genes encoding p22(phox), p47(phox), p67(phox), and p40(phox), respectively...
December 1, 2018: Scandinavian Journal of Immunology
Kunj R Sheth, Jeffrey T White, Andre F Perez-Orozco, Natalie D Debolske, Christopher R Hyde, Christine Geistkemper, David R Roth, Paul F Austin, Edmond T Gonzales, Nicolette K Janzen, Duong D Tu, Angela G Mittal, Chester J Koh, Sheila L Ryan, Carolina Jorgez, Abhishek Seth
Objective: While small non-obstructive stones in the adult population are usually observed with minimal follow-up, the same guidelines for management in the pediatric population have not been well-studied. We evaluate the clinical outcomes of small non-obstructing kidney stones in the pediatric population to better define the natural history of the disease. Methods: In this IRB-approved retrospective study, patients with a diagnosis of kidney stones from January 2011 to March 2017 were identified using ICD9 and ICD10 codes...
2018: Frontiers in Pediatrics
Barnali Mitra, Ajay Chopra, Krishna Talukdar, Neerja Saraswat, Debdeep Mitra, Joyjit Das
Herpes zoster (HZ) is a viral infection believed to be caused by the re activation of varicella zoster virus (VZV) or human herpes virus type 3 (HHV 3) that persists in the posterior nerve root ganglion. HZ is rarely reported in the pediatric age group with an intact immunity. Past infection with VZV and immunization with chickenpox vaccine are key markers in the onset of varicella zoster in children. Our aim was to study the clinicoepidemiological pattern of HZ infection in children aged less than 12 years and to start an early management to prevent long term complications...
November 2018: Indian Dermatology Online Journal
Helen J Madsen, Aparna Annam, Roger Harned, Taizo A Nakano, Lauren O Larroque, Ann M Kulungowski
BACKGROUND: Lymphatic malformations (LMs) are congenital and arise from errors in vascular embryogenesis. LMs are categorized by cyst size as microcystic, macrocystic, or combined. Abdominal LMs are rare. Surgical resection of abdominal LMs has been the mainstay of therapy, but recurrence and morbidity are high. We sought to determine the effectiveness of sclerotherapy treatment for abdominal LM. METHODS: A single-center, retrospective review from 2014 to 2018 was conducted evaluating pediatric patients with abdominal LM...
January 2019: Journal of Surgical Research
H Gil, B Bouldoires, B Bailly, N Meaux Ruault, S Humbert, N Magy-Bertrand
Since 1893, eosinopenia is a biological test to help a diagnosis of bacterial infection. Several publications have confirmed this hypothesis, particularly in the intensive care, pneumology and pediatric units. The value of this marker has been identified in vascular cerebral diseases and coronary bypass. Its contribution seems as relevant as procalcitonin, without extra cost. The diagnostic performance of this test was reinforced by a composite score (CIBLE score) that may improve its value in daily routine...
November 27, 2018: La Revue de Médecine Interne
Hui-Hui Song, Zheng-Ping Yu, Wen-Duo Heg, Jia-Hua Ding, Bao-An Chen
OBJECTIVE: To explore the clinical efficacy and safety of unrelated umbilical cord blood transplantation (UCBT) for the treatment of Wiskott-Aldrich syndrome(WAS). METHODS: Five pediatric patients with WAS received single UCBT were retrospectively analyzed. The median age of these male patients was 268 days (range, 3 days -695 days). Among them, 2 patients were transplanted with a 6/6 matched cord blood graft,the other 3 patients received a 5/6 matched cord blood graft...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Montserrat Fontanals, James D O'Leary, Christian Zaarour, Teresa Skelton, David Faraoni
BACKGROUND: Preoperative anemia is an important modifiable risk factor for red blood cell (RBC) transfusion in a variety of surgical populations. The primary objective of this study was to examine the association between preoperative anemia and i) transfusion of RBCs within 72 hours of surgery and ii) postoperative clinical outcomes in children undergoing spine arthrodesis surgery. STUDY DESIGN AND METHODS: We assembled a retrospective cohort of children included in the American College of Surgeons National Quality Improvement Program Pediatric database who underwent spine arthrodesis surgery from 2012 to 2016...
November 30, 2018: Transfusion
Marc Bardou, Kyle J Fortinsky, Nicolas Chapelle, Maxime Luu, Alan Barkun
Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population...
November 29, 2018: Expert Opinion on Pharmacotherapy
Khaled M Emara, Shady A Mahmoud, Ramy A Diab, Mahmoud A Elshobaky, Ahmed K Emara
The aim of this study was to assess the safety and efficacy of percutaneous low-energy osteotomy and casting in treatment of pathological coronal knee deformities in children equal or younger than 6 years. A prospective nonrandomized case series study was conducted. A total of 62 (109 limbs) patients with pathological coronal knee deformities were treated by percutaneous low-energy osteotomy and casting and observed over 3-10 years. The pathological nature was variable (rickets, Blount disease, dysplasia, after trauma, or after infection)...
November 21, 2018: Journal of Pediatric Orthopedics. Part B
Debrup Chakladar, Rakesh K Mondal, Tapas Kumar Sabui, Souravi Bhowmik, Tamoghna Biswas
OBJECTIVE: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established. METHODS: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years...
October 12, 2018: European Journal of Rheumatology
Todd Karsies, Melissa Moore-Clingenpeel, Mark Hall
Background: Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting high-risk GNR growth exist for critically ill children. We developed and validated a model for predicting high-risk GNR growth in critically ill children with suspected infection...
November 2018: Open Forum Infectious Diseases
Dimitri Poddighe, Vitaliy Sazonov
Acute acalculous cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during childhood. Although this pathology was originally described in critically ill or post-surgical patients, most pediatric cases have been observed during several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing AAC during viral illnesses (such as Epstein-Barr virus and hepatitis A virus infections)...
November 21, 2018: World Journal of Gastroenterology: WJG
Richard Taubert, Jana Diestelhorst, Norman Junge, Martha M Kirstein, Sven Pischke, Arndt Vogel, Heike Bantel, Ulrich Baumann, Michael P Manns, Heiner Wedemeyer, Elmar Jaeckel
Preceding viral infections have mostly been described in autoimmune hepatitis (AIH) in single cases. We aimed to identify viral infections that potentially trigger AIH, as suggested for hepatitis E virus (HEV) infections. Therefore, antibodies against hepatitis A (HAV), B, C and E viruses; hepatotropic herpesviruses; and parvovirus B19 (PVB19) were analyzed retrospectively in 219 AIH patients at diagnosis, 356 patients with other liver diseases and 89 children from our center. Untreated adult AIH (aAIH) patients showed higher anti-HEV seroprevalences at diagnosis than patients with other liver diseases...
November 28, 2018: Scientific Reports
Dongsub Kim, Sodam Lee, Sang-Hee Kang, Mi-Sun Park, So-Young Yoo, Tae Yeon Jeon, Joon-Sik Choi, Bora Kim, Jong Rim Choi, Sun Young Cho, Doo Ryeon Chung, Yon Ho Choe, Yae-Jean Kim
PURPOSE: Tuberculosis (TB) is one of the most important diseases that cause significant mortality and morbidity in young children. Data on TB transmission from an infected child are limited. Herein, we report a case of disseminated TB in a child and conducted a contact investigation among exposed individuals. METHODS: A 4-year-old child without Bacille Calmette-Guérin vaccination was diagnosed as having culture-proven disseminated TB. The child initially presented with symptoms of inflammatory bowel disease, and nosocomial and kindergarten exposures were reported...
November 2018: Korean Journal of Pediatrics
Jeremy D Kauffman, Christopher W Snyder, Paul D Danielson, Nicole M Chandler
BACKGROUND: Studies comparing pediatric laparoscopic and open total proctocolectomy with ileoanal anastomosis (TPC-IAA) are limited in size and number. This study utilized the adult and pediatric databases of the National Surgical Quality Improvement Project (NSQIP) to evaluate 30-day outcomes of these two techniques. MATERIALS AND METHODS: Patients younger than 21 years who underwent TPC-IAA from 2012 to 2016 were identified in both NSQIP databases. Simple and multivariate logistic regression was used to compare risk of reoperation, readmission, and postoperative occurrences between laparoscopic and open groups...
November 27, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Aamer Imdad, Maribeth R Nicholson, Emily E Tanner-Smith, Joseph P Zackular, Oscar G Gomez-Duarte, Dawn B Beaulieu, Sari Acra
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the gastrointestinal tract that is thought to be associated with a complex interplay between microbes and the immune system, leading to an abnormal inflammatory response in genetically susceptible individuals. Dysbiosis, characterized by the alteration of the composition of the resident commensal bacteria in a host compared to healthy individuals, is thought to play a major role in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD), two subtypes of IBD...
November 13, 2018: Cochrane Database of Systematic Reviews
Mohammed Lamorde, Arthur Mpimbaza, Richard Walwema, Moses Kamya, James Kapisi, Henry Kajumbula, Asadu Sserwanga, Jane Frances Namuganga, Abel Kusemererwa, Hannington Tasimwa, Issa Makumbi, John Kayiwa, Julius Lutwama, Prosper Behumbiize, Abner Tagoola, Jane Frances Nanteza, Gilbert Aniku, Meklit Workneh, Yukari Manabe, Jeff N Borchert, Vance Brown, Grace D Appiah, Eric D Mintz, Jaco Homsy, George S Odongo, Raymond L Ransom, Molly M Freeman, Robyn A Stoddard, Renee Galloway, Matthew Mikoleit, Cecilia Kato, Ronald Rosenberg, Eric C Mossel, Paul S Mead, Kiersten J Kugeler
Global health security depends on effective surveillance for infectious diseases. In Uganda, resources are inadequate to support collection and reporting of data necessary for an effective and responsive surveillance system. We used a cross-cutting approach to improve surveillance and laboratory capacity in Uganda by leveraging an existing pediatric inpatient malaria sentinel surveillance system to collect data on expanded causes of illness, facilitate development of real-time surveillance, and provide data on antimicrobial resistance...
2018: Health Security
Elio Castagnola, Paola Tatarelli, Alessio Mesini, Ivana Baldelli, Daniela La Masa, Roberto Biassoni, Roberto Bandettini
BACKGROUND: Little is known about epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in children. Aim of this study was to describe CPE epidemiology in a tertiary care pediatric hospital in Italy that admits patients coming from geographic areas with high diffusion of CPE. METHODS: Prospective evaluation of the proportion and rates per 100,000 hospital discharges (D) or hospitalization-days (HD) of invasive infections due to CPE from 2013 to 2017 and of CPE infections and colonizations from 2014 to 2017...
November 23, 2018: Journal of Infection and Public Health
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