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Betânia Souza Monteiro, Bianka Souza Dos Santos, Bruna Lopes de Almeida, Emy Hiura, Wagner Alexey Back Fiorio, Gisele Pereira Valdetaro, Dariele Vieira Gonçalves, Caroline Saraiva Silva, Tatiana Champion, Daniela Campagnol
PURPOSE: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell. METHODS: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal)...
November 2018: Acta Cirúrgica Brasileira
Kátia Alves Ramos, Cristiane Bitencourt Dias
INTRODUCTION: Among patients undergoing cardiac surgery, the occurrence of acute renal injury appears to be associated with worse prognosis and increased mortality. The objective of this study was to evaluate risk factors and the impact this complication on mortality and survival after cardiac surgery among patients without chronic kidney disease. METHODS: In this retrospective study, we reviewed the medical records of 142 patients who underwent elective coronary artery bypass grafting, valve replacement (single or multiple), or both (simultaneously) at a tertiary care hospital...
September 2018: Brazilian Journal of Cardiovascular Surgery
Tim Rahmel, Hartmuth Nowak, Katharina Rump, Winfried Siffert, Jürgen Peters, Michael Adamzik
BACKGROUND: Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that prevail in sepsis and ARDS. Thus, the functionally relevant AQP5 -1364A/C promoter single nucleotide polymorphism could impact on the development and resolution of acute kidney injury (AKI). Accordingly, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated with AKI in patients suffering from pneumonia evoked ARDS...
2018: PloS One
Paula S Mantula, Tuula K Outinen, Pia Jaatinen, Mari Hämäläinen, Heini Huhtala, Ilkka H Pörsti, Antti Vaheri, Jukka T Mustonen, Satu M Mäkelä
BACKGROUND: Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. METHODS: This study included 79 patients hospitalized due to acute PUUV infection. Plasma resistin, leptin, adiponectin, as well as IL-6 and CRP, were measured at the acute phase, recovery phase and one year after hospitalization...
2018: PloS One
Jamie R Privratksy, Nian Wang, Yi Qi, Jiafa Ren, Benjamin T Morris, John C Hunting, G Allan Johnson, Steven D Crowley
Acute kidney injury (AKI) is a common cause of morbidity and mortality in hospitalized patients. Nevertheless, there is limited ability to diagnose AKI in its earliest stages through the collection of structural and functional information. Imaging modalities such as magnetic resonance imaging (MRI) are increasingly being utilized to provide structural and functional data that characterize the injured kidney. Dynamic contrast-enhanced (DCE) MRI is an imaging modality that measures changes in kidney structure and contrast transit times; however, its ability to detect these parameters following AKI has not been determined...
December 5, 2018: American Journal of Physiology. Renal Physiology
Consuelo Pasten, Cristóbal Alvarado, Jocelyn Rocco, Luis Contreras, Paula Aracena, Jéssica Liberona, Cristian Suazo, Luis Fernando Michea, Carlos E Irarrázabal
Upon renal ischemia-reperfusion (IR) injury, recruitment of neutrophils during the inflammatory process promotes local generation of oxygen and nitrogen reactive species which, in turn, are likely to exacerbate tissue damage. The mechanism by which iNOS is involved in IR has not been completely elucidated. In this work, the selective iNOS inhibitor L-N6 -(1-iminoethyl)lysine (L-NIL) and the NOS substrate L-Arginine (L-Arg), were employed to understand the role of NOS activity on the expression of particular target genes and the oxidative stress elicited after a 30 min of bilateral renal ischemia, followed by 48h reperfusion in BALB/c mice...
December 5, 2018: American Journal of Physiology. Renal Physiology
Lecticia Barbosa Jorge, Fernanda Oliveira Coelho, Talita Rojas Sanches, Denise M A C Malheiros, Leandro Ezaquiel de Souza, Fernando Dos Santos, Larissa de Sá Lima, Cristóforo Scavone, Maria Claudia Irigoyen, Makoto Kuro-O, Lucia Andrade
Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous Klotho-haploinsufficient mice and their wild-type littermates (CLP-Kl+/- and CLP-WT mice, respectively)...
December 5, 2018: American Journal of Physiology. Renal Physiology
Tzevat Tefik, Salvatore Buttice, Bhaskar Somani, Selçuk Erdem, Tayfun Oktar, Faruk Özcan, Taner Koçak, İsmet Nane, Olivier Traxer
BACKGROUND: Ureteral access sheaths (UASs) are commonly used in retrograde intra-renal surgery (RIRS). Despite their advantages, there is a risk of ureteral trauma during their placement and subsequent stricture following surgery. The aim of this study was to evaluate the UAS force of insertion (FOI) during placement and its impact on ureteral trauma. METHODS: Seven female patients who underwent RIRS for kidney stones were included in the study. A digital force gauge (Chatillon DFX II; Ametek Test and Calibration Instruments, Largo, Florida, USA) was connected to the distal end of the UAS and the UAS FOI was continuously measured during insertion...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Yu Wang, Hongjing Zhao, Menghao Guo, Yizhi Shao, Juanjuan Liu, Guangshun Jiang, Mingwei Xing
The kidney is the most crucial site for the excretion of arsenic and its metabolites. In this study, Hy-line chickens exposed to different toxicologically relevant doses of arsenic (0, 7.5, 15 and 30 mg kg-1 diet) presented marked renal injury as evidenced by the increased leakage of blood urea nitrogen (up to 2.6 folds) and creatinine (up to 2.3 folds). Furthermore, increased content of renal arsenic (up to 30 folds) and malondialdehyde restrained anti-hydroxyl radical ability, and the activities of antioxidant enzymes (glutathione peroxidase, catalase) further corroborated extensive renal damage...
December 5, 2018: Metallomics: Integrated Biometal Science
Shan Huang, Yong Xu, Xiaoxu Ge, Bojin Xu, Wenfang Peng, Xiaohong Jiang, Lisha Shen, Lili Xia
Accumulating evidence has indicated the significant roles of long noncoding RNAs (lncRNAs) in the pathophysiology of diabetic nephropathy (DN). LncRNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to exert a key role in the progression of several diseases including diabetes. However, the role of NEAT1 in the regulation of DP progression remains barely known. Therefore, our study aimed to investigate the role of NEAT1 in a streptozotocin-induced diabetes model (DM) of rats and glucose-induced mouse mesangial cell models...
December 4, 2018: Journal of Cellular Physiology
Chi Liu, Ping Zhu, Masayuki Fujino, Yoshitaka Isaka, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Jian Zhuang, Xiao-Kang Li
BACKGROUND: Cyclosporine-A (CsA) is an immunosuppressant indicated for various immunological diseases; however, it can induce chronic kidney injury. Oxidative stress and apoptosis play a crucial role in CsA-induced nephrotoxicity. The present study evaluated the protective effect of combining 5-aminolaevulinic acid with iron (5-ALA/SFC), a precursor of heme synthesis, to enhance HO-1 activity against CsA-induced chronic nephrotoxicity. METHODS: Mice were divided into three groups: the control group (using olive oil as a vehicle), CsA-only group, and CsA+5-ALA/SFC group...
December 1, 2018: Biochemical and Biophysical Research Communications
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Rie Takashima, Masaki Morishita, Toshiyasu Sakane, Akira Yamamoto
l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia/reperfusion injury. Ser-PAMAM-Cys effectively scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and ROS (hydrogen peroxide and hydroxyl radical) in phosphate-buffered saline (PBS). In addition, ~64% of 111 In-labeled Ser-PAMAM-Cys accumulated in mouse kidney 3 h after intravenous administration...
December 1, 2018: Pharmaceutics
Monika Kamianowska, Marek Szczepański, Elżbieta Ewa Kulikowska, Barbara Bebko, Anna Wasilewska
BACKGROUND: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. OBJECTIVES: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1)...
December 4, 2018: Neonatology
Shuangtao Ma, Chunqi Qian, Donna H Wang
No abstract text is available yet for this article.
December 1, 2018: American Journal of Physiology. Renal Physiology
Evangelos Oikonomou, Sotiris Tsalamandris, Dimitris Karlis, Gerasimos Siasos, Christina Chrysohoou, Georgia Vogiatzi, Stathis Dimitropoulos, Georgios Charalambous, Evangelia Kouskouni, Dimitris Tousoulis
AIM: The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with Galectin-3 in patients with chronic HF. METHODS: We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Serum levels of Galectin-3, b-type natriuretic peptide and NGAL were measured. RESULTS: NGAL levels were positively correlated with Galectin-3 (rho = 0.26; p = 0...
December 4, 2018: Biomarkers in Medicine
Anton Lund, Mette B Damholt, Jørgen Wiis, Jesper Kelsen, Ditte G Strange, Kirsten Møller
BACKGROUND: Because osmotic fluid shifts may occur over the blood-brain barrier, patients with acute brain injury are theoretically at risk of surges in intracranial pressure (ICP) during hemodialysis. However, this remains poorly investigated. We studied changes in ICP during hemodialysis in such patients. METHODS: We performed a retrospective study of patients with acute brain injury admitted to Rigshospitalet (Copenhagen, Denmark) from 2012 to 2016 who received intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT) while undergoing ICP monitoring...
December 3, 2018: Acta Anaesthesiologica Scandinavica
Samir A Salama, Hany H Arab, Ibrahim A Maghrabi
Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas species. The clinical use of gentamycin is substantially limited by its side effects particularly acute kidney injury (AKI). The aim of the current study was to investigate the protective effect of the plant flavonoid troxerutin (150 mg kg-1 day-1 for 15 days) against gentamycin-induced AKI using Wistar rats as an experimental mammalian model...
December 4, 2018: Food & Function
Syed Rizwan A Bokhari, Faisal Inayat, Mah Jabeen, Zumar Sardar, Sara Saeed, Ayesha M Malik, Sabin Nasir, Amtul Zareen, Hafiz Ijaz Ahmad
Introduction Acute kidney injury (AKI) continues to be a cause of increased morbidity and mortality in pregnant women. While studies have been conducted on the incidence and etiology of this complication, the outcomes of obstetric AKI have not been extensively investigated. The primary focus of this prospective observational study was to analyze the risk factors, etiologies as well as maternal and fetal outcomes of AKI in pregnant females in Pakistan. Methods A total of 56 patients with obstetric AKI were recruited...
September 26, 2018: Curēus
Houmin Luo, Caiyun Gu, Chuanxin Liu, Yuming Wang, Hao Wang, Yubo Li
Both Strychnos nux-vomica Linn. (SNV) and Tripterygium wilfordii Hook F (TwHF) have received extensive attention due to their excellent clinical efficacies. However, clinical applications of SNV and TwHF have been limited by their narrow therapeutic windows and severe kidney toxicities. In this paper, based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS), endogenous metabolites after administration of SNV and TwHF extracts were detected, and biomarkers were screened successfully...
November 1, 2018: Toxicology Research
Azade Tarashande Foumani, Forouzan Elyasi
Background: The prevalence of using anabolic steroids such as oxymetholone is increasing. This highlights the need for closely monitoring side effects of this drug. Acute renal failure (ARF) has been reported as a complication of rhabdomyolysis in anabolic steroids users. Case presentation: We present one 33-year-old man complaining of decreased urine volume, urine color change, and lower abdominal pain. He is engaged with a rare side effect of oxymetholone abuse...
2018: Caspian Journal of Internal Medicine
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