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Daniela Ferreira, Diana C G A Pinto, Helena Silva, Ana Paula Girol, Maria de Lourdes Pereira
The growing importance of Salicornia plants as bioactive agents and health promoters associated with the continuous demand for alternative treatments for liver disorders, has stimulated us to evaluate the renal and hepatic effects of S. ramosissima seeds in mice under normal conditions and exposure to toxic products as carbon tetrachloride (CCl4 ). Thus, histopathological and lipid peroxidation evaluations of the liver and kidneys were performed. Powdered dried seeds of S. ramosissima (SRS) were administered orally for 22 days at a dose of 2000 mg/kg/day to male mice in three different settings: 1) seed effects, 2) protection against CCl4 acute toxicity (0...
August 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Anna C Beck, Paolo Goffredo, Imran Hassan, Sonia L Sugg, Geeta Lal, James R Howe, Ronald J Weigel
BACKGROUND: Readmissions represent a substantial burden to the health care system. Risk factors for 30-day readmission after adrenalectomy were examined. METHODS: Patients who underwent adrenalectomy were selected from the American College of Surgeons National Surgical Quality Improvement Program database from 2011 to 2015. RESULTS: Among 4,221 patients who underwent adrenalectomy, 216 (5.1%) were readmitted. On multivariate analysis, pre-operative predictive factors associated with readmission were American Society of Anesthesiologists classification (odds ratio [OR] 1...
August 7, 2018: Surgery
Egor Y Plotnikov, Anna A Brezgunova, Irina B Pevzner, Ljubava D Zorova, Vasily N Manskikh, Vasily A Popkov, Denis N Silachev, Dmitry B Zorov
Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is necessary to consider the individuality of an organism's response to systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated acute kidney injury model to study mechanisms of kidney cells damage in neonatal and adult rats. We found LPS-associated oxidative stress was more severe in adults compared to neonates, as judged by levels of carbonylated proteins and products of lipids peroxidation...
August 8, 2018: Antioxidants (Basel, Switzerland)
Heba Allah M Elbaghdady, Maha A Alwaili, Reda S El-Demerdash
The effect of bone marrow-derived mesenchymal stem cells on cadmium-induced liver and kidney damage was studied in Sprague Dawley rats. The study employed three animal groups: Group 1 served as control animals; Group 2 rats were dosed intra-peritoneally with 2 mg of cadmium chloride per kg body weight, and Group 3 rats were again dosed with a single intraperitoneal injection of 2 mg of cadmium chloride per kg body weight two doses of 106 cells each intravenously. Finally, the animals were killed using halothane inhalation anesthesia...
August 7, 2018: Ecotoxicology and Environmental Safety
Savannah Ross, Kristen Eisenman, Kelly W Maloney
Pediatric Burkitt lymphoma has historically been treated with intensive methotrexate-based chemotherapy, which improves patient survival while causing severe toxicities. Young patients typically have better outcomes with intensive therapies, while adults and immunocompromised patients have higher toxicities and worse outcomes. Newer treatment regimens, including etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab (EPOCH-R), show promise for these patients. However, few studies exist to demonstrate efficacy and improved toxicity profile with EPOCH-R...
August 8, 2018: Journal of Pediatric Hematology/oncology
Adela Urisarri, Marta Gil, Natalia Mandiá, Luís Aldamiz-Echevarría, Roca Iria, Domingo González-Lamuño, María-Luz Couce
To evaluate the prognostic significance of factors frequently associated with a reduction in renal mass, such as prematurity, low birth weight, and congenital anomalies of kidney and urinary tract (CAKUT), in patients with solitary functioning kidney (SFK) and investigate signs of early renal injury due to glomerular hyperfiltration damage or dysplasia in the remaining kidney.Retrospective observational study of congenital SFK diagnosed and followed at a tertiary care hospital over a period of 10 years in which 32,900 newborns underwent routine neonatal abdominal ultrasound screening...
August 2018: Medicine (Baltimore)
Yuxi Wang, Zhi Zhao, Weiqi Yang, Lin Li, Fengming Zhu, Guangchang Pei, Juan Yang, Han Zhu, Huzi Xu, Meng Wang, Qian Yang, Zhizhi Hu, Pengge Wang, Gang Xu, Rui Zeng, Ying Yao
Tamoxifen is used to activate tamoxifen-dependent Cre recombinase (CreER) to generate time- and tissue-specific genetically mutant mice. However, tamoxifen is also an active estrogen analogue that binds with higher affinity to estrogen receptors and exhibits anti-apoptosis, anti-inflammation, and antifibrotic properties. Renal ischemia reperfusion (I/R) injury is characterized by increased apoptosis and inflammation, so optimal utility of tamoxifen-inducible CreER genetic systems in I/R model is important. The purpose of this study was to optimize the tamoxifen dose and evaluate its safety and tolerability in the development of mouse I/R injury...
2018: American Journal of Translational Research
Satoshi Matsuyama, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
Macrophages are required during kidney development and appear in the initiation and propagation of renal injury. To establish baseline data, we analyzed the kinetics of the macrophage with different immunophenotypes in the developing rat kidney (fetus at 18 and 20 days, neonate at 1-21 days, and adult at 7-weeks old). Macrophages reacting to CD68, CD163, and MHC class II were identified in the cortex and medulla of the developing rat kidney. CD68+ macrophages appeared in the fetal kidney as early as fetal day 18, and the number increased gradually in the neonatal kidney, whereas MHC class II+ and CD163+ macrophages first appeared on neonatal days 4 and 8, respectively...
July 2018: Journal of Toxicologic Pathology
Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Liu
The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, in various models of kidney disease induced by unilateral ureteral obstruction, adriamycin or ischemia/reperfusion injury. In vitro, forced expression of CB2 or treatment with a CB2 agonist was sufficient to trigger matrix gene expression, whereas knockdown of CB2 by siRNA abolished transforming growth factor-β1-induced signaling and fibrogenic responses in kidney tubular cells...
August 6, 2018: Kidney International
Seyed Mohammad Owji, Elahe Nikeghbal, Seyed Mostafa Shid Moosavi
NEW FINDINGS: What is central question of this study? Acute kidney injury (AKI) in patients is usually due to renal artery hypoperfusion or occasionally vein thrombosis, but murine model of ischemic AKI is mostly induced via pedicle-clamping. Hence, the traditional renal pedicle-clamping model was compared with models of occluding renal artery or vein alone in rats. What is main finding and its importance? During renal venous occlusion, transmission of high arterial pressure into renal capillaries likely caused rupture of their walls and occurrence of hemorrhagic congestion that led to higher kidney tissue damage and dysfunction than pedicle and artery clamping...
August 9, 2018: Experimental Physiology
Adi Drori, Anna Permyakova, Rivka Hadar, Shiran Udi, Alina Nemirovski, Joseph Tam
AIMS: To evaluate the specific role of the endocannabinoid/CB1 R system in modulating mitochondrial dynamics in the metabolically active renal proximal tubular cells (RPTCs). MATERIALS AND METHODS: We utilized mitochondrialy-targeted GFP in live cells (wild-type and null for the CB1 R), and electron microscopy in kidney sections of RPTC-CB1 R-/- mice and their littermate controls. In both in vitro and in vivo conditions, we assessed the ability of CB1 R agonism or fatty acid flux to modulate mitochondrial architecture and function...
August 9, 2018: Diabetes, Obesity & Metabolism
Hassan Askari, Mohammad Foad Abazari, Pegah Ghoraeian, Sepehr Torabinejad, Maryam Nouri Aleagha, Reza Mirfallah Nassiri, Farshid Tahmasebi, Nairi Abedi, Sulail Fatima Rajani, Ali Salarian, Maryam Belaran, Mohammed Elshiekh, Nima Sanadgol
Chronic kidney disease (CKD) is a major public health problem worldwide and is associated with spatial learning deficits. The aim of the present study was to evaluate the protective effects of hydrogen sulfide (H2S) on CKD-mediated behavioral deficits with emphasis to the role of nitric oxide (NO) in these effects. Fifty rats were randomly allocated to five experimental groups including: sham, Five-sixth (5/6) nephrectomy (Nx), 5/6Nx + NaHS, 5/6Nx + NaHS+L-nitroarginine methyl ester (L-NAME), and 5/6Nx + NaHS+aminoguanidine (AMG)...
August 8, 2018: Metabolic Brain Disease
Justine Huart, Jean-Marie Krzesinski, François Jouret
Delayed graft function (DGF) is defined as the need for dialysis within 7 days following kidney transplantation (KTx). DGF is associated with increased costs, higher risk for acute rejection and decreased long-term graft function. Renal ischaemia/reperfusion (I/R) injury plays a major role in DGF occurrence. Single nucleotide polymorphisms (SNPs) in certain genes may aggravate kidney susceptibility to I/R injury, thereby worsening post-transplant outcomes. The present article proposes an extensive review of the literature about the putative impact of donor or recipient SNPs on DGF occurrence in kidney transplant recipients (KTRs)...
August 2018: Clinical Kidney Journal
Samuel Selorm Fiati Kenston, Hong Su, Zhou Li, Lu Kong, Yafei Wang, Xin Song, Yuanliang Gu, Tabatha Barber, Joni Aldinger, Qihang Hua, Zhen Li, Min Ding, Jinshun Zhao, Xialu Lin
To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). The eight most common detectable heavy metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, mixtures of these eight heavy metals were prepared using the compounds zinc sulfate heptahydrate, cupric sulfate, manganese dichloride, potassium dichromate, nickel dichloride, cadmium dichloride, lead acetate, and methyl mercury chloride with ion mass proportions of 1070...
May 8, 2018: Toxicology Research
Zaher Armaly, Jimmy E Jadaon, Adel Jabbour, Zaid A Abassi
Preeclampsia is a serious complication of pregnancy where it affects 5-8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidneys, liver, brain, and lung. Although, the pathogenesis of preeclampsia has not yet been fully understood, growing evidence suggests that aberrations in the angiogenic factors levels and coagulopathy are responsible for the clinical manifestations of the disease...
2018: Frontiers in Physiology
Khalid Al-Otaibi
Objectives: The aim of this study is to review the complications of laparoscopic urological procedures performed using a single surgeon during a 12-year period. Materials and Methods: From June 2004 to May 2017, a total of 411 abdominal urological procedures were performed using the author. They included 250 varicocele ligations, 94 nephrectomies (simple, partial, radical, and nephroureterectomy), 34 adrenalectomies, 22 renal cyst ablation, and 11 pelvic lymph node dissections...
July 2018: Urology Annals
Manmeet Singh, Gaurav Garg, S N Sankhwar, Manoj Kumar
Purpose: The purpose of this study is to evaluate our experience of laparoscopic ureteroneocystostomy for mid and lower ureteral stricture in a tertiary center in North India. Materials and Methods: A total of 20 laparoscopic ureteroneocystostomy were performed with or without bladder flap procedures in 20 patients (13 females and 7 males) with various etiologies such as ureteric stricture, ureterovaginal fistula, endometriosis, and distal ureteric tumor at our hospital in a time frame from August 2013 to January 2017...
July 2018: Urology Annals
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Dengue is a common arboviral infection with a diverse spectrum of clinical manifestations. Dengue hemorrhagic fever is a more severe form of infection characterized by plasma leak and hemoconcentration. Although hepatic dysfunction is common in dengue illness, massive liver necrosis is rarely reported. Lactic acidosis is a poor prognostic marker in liver failure related to dengue. Management of acute renal injury in dengue hemorrhagic fever due to prolonged shock is challenging as the fluid reabsorption during the recovery phase expands the intravascular volume and precipitates heart failure and pulmonary edema...
August 8, 2018: Journal of Medical Case Reports
Amar D Bansal, Nina R O'Connor, David J Casarett
BACKGROUND: Dialysis is often initiated in the hospital during episodes of acute kidney injury and critical illness. Little is known about how patients or their surrogate decision makers feel about dialysis initiation in the inpatient setting. METHODS: We conducted a prospective cohort study at a large academic center in the United States. All patients who initiated dialysis during a 30-day period in 2016 were approached for enrollment. Study participants were defined as individuals who provided consent for dialysis initiation - either the patient or a surrogate decision-maker...
August 8, 2018: BMC Nephrology
Kai Jiang, Tristan A Ponzo, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
The rodent model of folic acid (FA)-induced acute kidney injury (AKI) provides a useful model for studying human AKI, but little is known about longitudinal changes in renal hemodynamics and evolution of renal fibrosis in vivo. In this work, we aimed to longitudinally assess renal structural and functional changes using multi-parametric magnetic resonance imaging (MRI). Ten adult mice were injected with FA, after which multi-parametric MRI was used to measure kidney volume, hypoxia index R2 * , magnetization transfer ratio (MTR), perfusion, T1 , and glomerular filtration rate (GFR) at 2 weeks post-treatment...
August 8, 2018: American Journal of Physiology. Renal Physiology
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