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Antoine Bruneau-Voisine, Lenka Pallova, Stéphanie Bastin, Vincent César, Jean-Baptiste Sortais
The direct α-methylation of ketones with methanol under hydrogen borrowing conditions using a well-defined manganese PN3P complex as a pre-catalyst was, for the first time, achieved. The reactions typically proceed at 120 °C for 20 h with 3 mol% pre-catalyst loading and in the presence of NaOtBu (50 mol%) as base. The scope of the reaction was extended to the α-methylation of esters.
December 10, 2018: Chemical Communications: Chem Comm
Véronique de Goumoëns, Laura Marques Rio, Cécile Jaques, Anne-Sylvie Ramelet
OBJECTIVE: This scoping review sought to describe the literature on the different types of interventions to support families of patients with acquired brain injuries (ABIs) and their outcomes. INTRODUCTION: Acquired brain injuries are among the leading causes of disability in adults worldwide and have physical, cognitive or/and behavioral consequences not only for the patient, but also for the family. Several support interventions have been proposed in different contexts at different phases of recovery with various levels of evidence, yet no synthesis is available to date...
December 2018: JBI Database of Systematic Reviews and Implementation Reports
Rui Zhang, Yan Zhao, Kun-Ming Liu, Xin-Fang Duan
The serendipitous addition of a phenolate to FeCl3 /TMEDA/Ti(OEt)4 enables a strong Fe/Ti cooperativity that can efficiently catalyze a general and selective biaryl-coupling reaction. In the absence of phosphine or NHC ligands, various aryl chlorides, bromides, and iodides can couple with a variety of common and Knochel-type aryl Grignard reagents. A wide range of sensitive functional groups in either coupling partner can be tolerated. This bimetallic cocatalysis not only remarkably extends the scope of Fe-catalyzed biaryl couplings but also provides a solution to the problem of functional group compatibility of Grignard reagents...
December 7, 2018: Organic Letters
Xian Luo, Wenyue Xie, Ruijie Wang, Xiaoshuai Wu, Ling Yu, Yan Qiao
Microfluidic microbial fuel cells (MMFCs) are promising green power sources for future ultra-small electronic devices. The MMFCs with co-laminar microfluidic structure are superior to other MMFCs according to their low internal resistance and relative high power density. However, the area for interfacial electron transfer between the bacteria and the anode is quite limited in the typical Y-shaped device, which apparently restricts the current generation performance. In this study, we developed a membraneless MMFC with serpentine microchannel to enhance the interfacial electron transfer and promote the power generation of the device...
2018: Frontiers in Microbiology
Tomasz Kuder, Anat Bernstein, Faina Gelman
RATIONALE: Compound-specific isotope analysis (CSIA) is a valuable tool in environmental chemistry and in other fields of science. Currently, hydrogen CSIA of polar compounds containing exchangeable hydrogen is uncommon. To extend the scope of CSIA applications, we present an alternative method of analysis, bypassing the typical step of derivatization. The method is demonstrated for two environmental contaminants, 4-bromophenol (4BP) and 2,4,6-tribromophenol (TBP) METHODS: Net isotope ratios obtained by CSIA combine the isotope composition of nonexchangeable, carbon-bound hydrogen and the exchangeable hydroxyl hydrogen...
December 4, 2018: Rapid Communications in Mass Spectrometry: RCM
Travis W Sawyer, Swati Chandra, Photini F S Rice, Jennifer W Koevary, Jennifer K Barton
Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Optical coherence tomography (OCT) has been applied successfully to experimentally image the ovaries in vivo; however, a robust method for analysis is still required to provide quantitative diagnostic information. Recently, texture analysis has proved to be a useful tool for tissue characterization; unfortunately, existing work in the scope of OCT ovarian imaging is limited to only analyzing 2D sub-regions of the image data, discarding information encoded in the full image area, as well as in the depth dimension...
December 4, 2018: Physics in Medicine and Biology
Jan J Reinders, Wim P Krijnen, Katarina Jerković-Ćosić, Merlijn Lycklama À Nijeholt, Marjolein Ag van Offenbeek, Boudewijn Stegenga, Cees P van der Schans
BACKGROUND: In the Netherlands, the scope of dental hygiene practice was expanded in 2006. The objective of this study was to explore reasons among dentists and dental hygienists for supporting or opposing an extended scope of practice and to find explanatory factors. METHODS: A questionnaire containing pre-defined reasons and an open-ended question was distributed among 1,674 randomly selected members of two Dutch professional associations (874 dentists, 800 dental hygienists)...
2018: Journal of Allied Health
Udaysankar Chockanathan, Adora M DSouza, Anas Z Abidin, Giovanni Schifitto, Axel Wismüller
Resting-state functional MRI (rs-fMRI), coupled with advanced multivariate time-series analysis methods such as Granger causality, is a promising tool for the development of novel functional connectivity biomarkers of neurologic and psychiatric disease. Recently large-scale Granger causality (lsGC) has been proposed as an alternative to conventional Granger causality (cGC) that extends the scope of robust Granger causal analyses to high-dimensional systems such as the human brain. In this study, lsGC and cGC were comparatively evaluated on their ability to capture neurologic damage associated with HIV-associated neurocognitive disorders (HAND)...
February 2018: Proceedings of SPIE
John-Marc Chandonia, Naomi K Fox, Steven E Brenner
The SCOPe (Structural Classification of Proteins-extended, database hierarchically classifies domains from the majority of proteins of known structure according to their structural and evolutionary relationships. SCOPe also incorporates and updates the ASTRAL compendium, which provides multiple databases and tools to aid in the analysis of the sequences and structures of proteins classified in SCOPe. Protein structures are classified using a combination of manual curation and highly precise automated methods...
November 30, 2018: Nucleic Acids Research
Christel Daniel, Patricia Serre, Nina Orlova, Stéphane Bréant, Nicolas Paris, Nicolas Griffon
BACKGROUND AND OBJECTIVES: Data Quality (DQ) programs are recognized as a critical aspect of new-generation research platforms using electronic health record (EHR) data for building Learning Healthcare Systems. The AP-HP Clinical Data Repository aggregates EHR data from 37 hospitals to enable large-scale research and secondary data analysis. This paper describes the DQ program currently in place at AP-HP and the lessons learned from two DQ campaigns initiated in 2017. MATERIALS AND METHODS: As part of the AP-HP DQ program, two domains - patient identification (PI) and healthcare services (HS) - were selected for conducting DQ campaigns consisting of 5 phases: defining the scope, measuring, analyzing, improving and controlling DQ...
November 9, 2018: Computer Methods and Programs in Biomedicine
Ramsey Al-Hakim, Ryan Schenning
Thoracic endovascular aortic repair (TEVAR) is a rapidly growing and improving technique for the management of thoracic aortic aneurysms, dissections, and traumatic aortic injury. These disease processes were previously treated exclusively by surgery, but TEVAR has substantially improved patient outcomes including reduced mortality, reduced paraplegia rate, and shorter hospital and/or intensive care unit stay compared to open surgery. TEVAR was initially isolated to the descending thoracic aorta, but the advent of advanced techniques has extended the scope to well beyond the left subclavian artery and into Zone 0...
September 2018: Techniques in Vascular and Interventional Radiology
Judith Volmer, Hans-Georg Wolff
Although researchers have shown that networking is positively associated with numerous long-term outcomes (e. g., salary, promotion) investigations of proximal outcomes of networking are still scarce. Building on Conservation of Resources theory (COR; Hobfoll, 2001, 2011) and conducting a daily diary study over five consecutive working days ( N = 160 academics), we investigated short-term effects of networking on employees' career-related outcomes (i.e., career optimism and career satisfaction), job attitudes (i...
2018: Frontiers in Psychology
Hazem A Farouk, Mostafa Saladin, Wessam Abu Senna, Walid Ebeid
PURPOSE: Assessment of the functional and oncologic outcomes regarding endoscopic curettage of different benign bone tumor types within variable anatomic locations. PATIENTS AND METHODS: During the period between February 2012 and December 2016, 26 patients with symptomatic intra-osseous benign bony lesions were included. The age ranged from 3 up to 49 years (mean 20), of 14 females and 12 males. The follow-up duration ranged from 26 up to 58 months (mean 41). Functional scoring was done according to the Revised Musculoskeletal Tumour Society Rating Scale...
2018: SICOT-J
Michael Henke, Astrid Junker, Kerstin Neumann, Thomas Altmann, Evgeny Gladilin
Modern facilities for high-throughput phenotyping provide plant scientists with a large amount of multi-modal image data. Combination of different image modalities is advantageous for image segmentation, quantitative trait derivation, and assessment of a more accurate and extended plant phenotype. However, visible light (VIS), fluorescence (FLU), and near-infrared (NIR) images taken with different cameras from different view points in different spatial resolutions exhibit not only relative geometrical transformations but also considerable structural differences that hamper a straightforward alignment and combined analysis of multi-modal image data...
2018: Frontiers in Plant Science
Lynn A Jansen, Steven Wall, Franklin G Miller
Drawing the line on physician assistance in physician-assisted death (PAD) continues to be a contentious issue in many legal jurisdictions across the USA, Canada and Europe. PAD is a medical practice that occurs when physicians either prescribe or administer lethal medication to their patients. As more legal jurisdictions establish PAD for at least some class of patients, the question of the proper scope of this practice has become pressing. This paper presents an argument for restricting PAD to the terminally ill that can be accepted by defenders as well as critics of PAD for the terminally ill...
November 21, 2018: Journal of Medical Ethics
Katherine Stroebe, Tom Postmes, Carla A Roos
While injustice is widespread, collective action against it appears to be rare. This paper argues that this may be because research often focuses on a narrow range of outgroup-oriented actions, such as demonstrating, signing petitions, that are symbolic of a collective response to injustice. The present work takes a bottom-up approach to study a broad range of collective and individual actions that people undertake in response to collective injustice. Participants indicated actions they felt they could take (Study 1) and, via interviews, actually had taken (Study 2) in response to human-induced earthquakes...
November 21, 2018: British Journal of Social Psychology
Sherry A Glied, Jeanne M Lambrew
Democratic candidates for president in 2020 will likely include some type of public plan in their health care reform platforms. Existing public plans take many forms and often incorporate private elements, as do most proposals to extend such plans. We review the types of public plans in the current system. We describe and assess the range of proposals to extend these plans or elements of them to additional populations. We suggest questions that candidates could use to guide their decisions about the scope and content of their health policy proposals...
November 16, 2018: Health Affairs
James E Glazer, Nicholas J Kelley, Narun Pornpattananangkul, Robin Nusslock
Bipolar spectrum and unipolar depressive disorders have been associated with distinct and opposite profiles of reward-related neural activity. These opposite profiles may reflect a differential preexisting vulnerability for both types of disorders. In support, recent ERP studies find that, following reward feedback, a larger reward positivity (RewP) is associated with greater vulnerability for bipolar spectrum disorders, whereas a smaller RewP is associated with greater vulnerability for depression. However, prior studies have investigated only immediate rewards and have not examined dimensions of both bipolar disorder and unipolar depression within the same sample...
November 15, 2018: Psychophysiology
Robert Peckham, Ria Sinha
In recent years, research on the military deployment of unmanned aerial vehicles (UAVs), or drones, has proliferated. However, to date there has been little systematic study of how drones are being used for health surveillance and management, particularly in resource-constrained settings. In this paper, we draw on a number of case studies to explore how the biomedical drone is contributing to a re-spatialization of health and to a process of datafication that is set to fundamentally change the nature and scope of health governance...
November 15, 2018: Global Public Health
Brian Chiou, James R Connor
Ferritin, a ubiquitously expressed protein, has classically been considered the main iron cellular storage molecule in the body. Owing to the ferroxidase activity of the H-subunit and the nucleation ability of the L-subunit, ferritin can store a large amount of iron within its mineral core. However, recent evidence has demonstrated a range of abilities of ferritin that extends well beyond the scope of iron storage. This review aims to discuss novel functions and biomedical uses of ferritin in the processes of iron delivery, delivery of biologics such as chemotherapies and contrast agents, and the utility of ferritin as a biomarker in a number of neurological diseases...
November 13, 2018: Pharmaceuticals
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