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https://www.readbyqxmd.com/read/30114363/fecl3-catalyzed-regio-divergent-carbosulfenylation-of-unactivated-alkenes-construction-of-medium-sized-ring
#1
Leiyang Lv, Zhiping Li
A FeCl3-catalyzed regio-divergent carbosulfenylation of unactivated alkenes with electrophilic N-sulfenophthalimides has been developed. This protocol provides a straightforward and efficient access to various medium-sized rings, especially strained 7-and 8-membered carborings with sulfur atom attached. The endo/exo selectivity in the reaction depends on the atom number of the chain between arene and alkene. Broad substrate scope, high yields and gram-scale synthesis exemplified the utility and practicability of this protocol...
August 16, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/30106660/new-and-improved-21-st-century-cures-act-revisions-to-certificates-of-confidentiality
#2
Leslie E Wolf, Laura M Beskow
Certificates of Confidentiality ("Certificates") are a federal legal tool designed to protect sensitive, identifiable research data from compelled disclosure. Congress first authorized their use in 1970 to facilitate research on illegal drug use. The scope of their use was later expanded to cover mental health research and then again to apply broadly to identifiable, sensitive research data, regardless of topic. Certificates can be critical to enabling conduct of essential research on sensitive topics, such as effective interventions to curb the opioid epidemic or reduce HIV transmission among minority youth...
May 2018: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/30104557/rfid-technology-for-management-and-tracking-e-health-applications
#3
Yuri Álvarez López, Jacqueline Franssen, Guillermo Álvarez Narciandi, Janet Pagnozzi, Ignacio González-Pinto Arrillaga, Fernando Las-Heras Andrés
Radio frequency identification (RFID) has become a key technology in the logistics and management industry, thanks to distinctive features such as the low cost of RFID tags, and the easiness of the RFID tags' deployment and integration within the items to be tracked. In consequence, RFID plays a fundamental role in the so-called digital factory or 4.0 Industry, aiming to increase the level of automatization of industrial processes. In addition, RFID has also been found to be of great help in improving the tracking of patients, medicines, and medical assets in hospitals, where the digitalization of these operations improves their efficiency and safety...
August 13, 2018: Sensors
https://www.readbyqxmd.com/read/30104016/antiviral-therapies-for-herpesviruses-current-agents-and-new-directions
#4
REVIEW
Claudette L Poole, Scott H James
PURPOSE: The objective of this review was to summarize the recent literature describing the current burden of disease due to herpesviruses in the antiviral and transplant era; describe mechanisms of action of antiviral agents and the development of resistance; summarize the literature of recent antiviral agents brought to market as well as agents under development; and to present literature on future strategies for herpesvirus therapeutics. METHODS: An extensive search of the medical literature related to antiherpesviral therapy was conducted to compose this narrative review...
August 10, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/30101557/insights-into-mechanochemical-reactions-at-targetable-and-stable-sub-ambient-temperatures
#5
James Mack, Joel Andersen
We provide early insights into the effects of stable and verifiable, low-temperature conditions on mechanochemical reactions. These are made possible by modifications made to a SPEX 8000M Mixer/mill allowing dial-able and reliable, fine control of low-temperature mechanochemical reactions. Our initial insights into these unique conditions were obtained using the reduction of 4-tert-butylcyclohexanone as a model system. The diastereomeric product distribution bore a strong dependence on the selected temperature of the jar...
August 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30095960/entanglement-induced-interactions-in-binary-mixtures
#6
J Chen, J M Schurer, P Schmelcher
We establish a conceptual framework for the identification and the characterization of induced interactions in binary mixtures and reveal their intricate relation to entanglement between the components or species of the mixture. Exploiting an expansion in terms of the strength of the entanglement among the two species enables us to deduce an effective single-species description. In this way, we naturally incorporate the mutual feedback of the species and obtain induced interactions for both species which are effectively present among the particles of same type...
July 27, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30089214/lived-experiences-and-insights-into-the-advantages-important-to-rural-recruitment-and-retention-of-general-practitioners
#7
Daniel R Terry, Hoang B Nguyen, David Schmitz, Ed Baker
INTRODUCTION: Despite existing studies in this field, community factors behind recruiting and retaining rural general practitioners (GPs) are not fully understood. To address this issue, the Community Apgar Questionnaire (CAQ) was developed to extend the understanding of communities' assets and capabilities that impact GP recruitment and retention. However, more in-depth insights are vital to develop a comprehensive approach. METHODS: This mixed methods study was administered using face-to-face structured interviews with a total of 40 health service representatives...
August 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/30089202/synthesis-of-%C3%AE-arylated-cycloalkanones-from-congested-trisubstituted-spiro-epoxides-application-of-the-house-meinwald-rearrangement-for-ring-expansion
#8
Nagalakshmi Jeedimalla, Camille Jacquet, Diana Bahneva, Jean-Jacques Youte Tendoung, Stephane P Roche
A three-step sequence for the synthesis of α-arylated cyclohexanones and the most challenging cycloheptanones is reported. First, an efficient one-pot synthesis of β,β'-disubstituted benzylidene cycloalkanes (styrenes) using the palladium-catalyzed Barluenga reaction from readily available feedstock chemicals is described. Furthermore an epoxidation followed by the House-Meinwald rearrangement (HMR) of spiro-epoxides is reported to produce a number of α-arylated cycloalkanones upon ring expansion. Reactions catalyzed by bismuth triflate underwent quasi-exclusively ring expansion for all substrates (electronically poor and rich), with yields ranging from 15% to 95% thus demonstrating the difficulty to achieve the ring enlargement for electron deficient spiro-epoxides...
August 8, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/30087021/the-impact-of-the-use-of-video-based-educational-interventions-on-patient-outcomes-in-hospital-settings-a-scoping-review
#9
Murtaza Dahodwala, Rose Geransar, Julie Babion, Jill de Grood, Peter Sargious
OBJECTIVE: To summarize the literature on the impact of video-based educational interventions on patient outcomes in inpatient settings as compared to standard education techniques. METHODS: This review followed a scoping review methodology. English language articles were searched in Pubmed, Medline, Cochrane, and CINAHL databases. Inclusion criteria were: use of video-based educational interventions, and inpatient hospital settings. Abstracts were reviewed and selected according to predetermined criteria, followed by full-text scrutiny...
June 30, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/30084277/the-road-to-market-implantable-drug-delivery-systems-a-review-on-us-fda-s-regulatory-framework-and-quality-control-requirements
#10
Sana Al-Jawadi, Pier Capasso, Manisha Sharma
The scope of Implantable Drug Delivery systems (IDDSs) comprehends a variety of sterile therapeutic implements placed inside the body to exert a certain therapeutic action for extended duration. They are classified under different categories from pharmaceutical science and regulatory perspectives. The novelty and variety of IDDSs prevents the application of a uniform regulation for all IDDS products; therefore, sponsors face regulatory challenges to register and market their products. This review investigates pharmaceutical science literature and the United States Food and Drug Administration (US FDA) regulatory guidance to find how any IDDS is classified, regulated and introduce in the market...
August 7, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/30080697/advances-in-machine-perfusion-organ-preservation-and-cryobiology-potential-impact-on-vascularized-composite-allotransplantation
#11
Laura C Burlage, Shannon N Tessier, Joanna W Etra, Korkut Uygun, Gerald Brandacher
PURPOSE OF REVIEW: In this review, we discuss novel strategies that allow for extended preservation of vascularized composite allografts and their potential future clinical implications for the field of vascularized composite allotransplantation (VCA). RECENT FINDINGS: The current gold standard in tissue preservation - static cold preservation on ice - is insufficient to preserve VCA grafts for more than a few hours. Advancements in the field of VCA regarding matching and allocation, desensitization, and potential tolerance induction are all within reasonable reach to achieve; these are, however, constrained by limited preservation time of VCA grafts...
August 4, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/30074048/exploring-diversity-in-platinum-iv-n-heterocyclic-carbene-complexes-synthesis-characterization-reactivity-and-biological-evaluation
#12
Mathilde Bouché, Antoine Bonnefont, Thierry Achard, Stéphane Bellemin-Laponnaz
Platinum(iv) complexes stabilized by N-heterocyclic carbene ligands of the type [(NHC)PtX4L], where L is a neutral nitrogen-based ligand and X is a halide anion (Br, Cl), were prepared by using straightforward and high-yielding synthetic routes and the scope was extended to amphiphilic derivatives. The complexes were fully characterized and the molecular structure of the three derivatives was determined by single-crystal X-ray analyses. The complexes demonstrated in vitro antiproliferative activities against several cancer cell lines...
August 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30073756/mesoporous-metal-organic-frameworks-synthetic-strategies-and-emerging-applications
#13
REVIEW
Dingxin Liu, Dianting Zou, Haolin Zhu, Jianyong Zhang
Metal-organic frameworks (MOFs) have attracted much attention over the past two decades due to their highly promising applications not only in the fields of gas storage, separation, catalysis, drug delivery, and sensors, but also in relatively new fields such as electric, magnetic, and optical materials resulting from their extremely high surface areas, open channels and large pore cavities compared with traditional porous materials like carbon and inorganic zeolites. Particularly, MOFs involving pores within the mesoscopic scale possess unique textural properties, leading to a series of research in the design and applications of mesoporous MOFs...
August 2, 2018: Small
https://www.readbyqxmd.com/read/30058151/reversible-spatial-control-in-aqueous-media-by-visible-light-a-thioindigo-photoswitch-soluble-and-operating-efficiently-in-plain-water
#14
Benjamin Peter Koeppe, Florian Römpp
Aiming to extend the scope of indigoid photoswitches to polar protic environments, we have synthesized a sulfonated thioindigo derivative highly soluble in water. Studies by UV/Vis absorption, fluorescence and NMR spectroscopy indicate that, despite aggregation effects at micromolar concentrations, the novel dye offers satisfactory performance in aqueous solution in the absence of solvation aides. Enrichment of the metastable cis isomer by irradiation and its half life at room temperature may exceed 65 % and several hours, resp...
July 29, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30057508/characteristics-emergent-properties-and-functions-of-somato-dendritic-t-and-l-type-calcium-channels
#15
Corey L Cleland
The primary literature, as an adjunct to textbooks, lectures, problem sets, and laboratories, has become integral to most undergraduate neuroscience courses by extending learning to topics outside the scope of introductory textbooks, providing insight into experimental methods and design, and offering a platform for critical thinking, independent learning, and student presentations. While introductory and intermediate textbooks cover "Hodgkin-Huxley" (H-H) Na and K channels thoroughly, the characteristics of diverse calcium, chloride, and other sodium and potassium channels, and especially the resulting emergent cellular properties and their functional consequences, receive far less coverage...
2018: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/30054262/scholarly-influence-of-the-conference-and-labs-of-the-evaluation-forum-ehealth-initiative-review-and-bibliometric-study-of-the-2012-to-2017-outcomes
#16
Hanna Suominen, Liadh Kelly, Lorraine Goeuriot
BACKGROUND: The eHealth initiative of the Conference and Labs of the Evaluation Forum (CLEF) has aimed since 2012 to provide researchers working on health text analytics with annual workshops, shared development challenges and tasks, benchmark datasets, and software for processing and evaluation. In 2012, it ran as a scientific workshop with the aim of establishing an evaluation lab, and since 2013, this annual workshop has been supplemented with 3 or more preceding labs each year. An evaluation lab is an activity where the participating individuals or teams' goal is to solve the same problem, typically using the same dataset in a given time frame...
July 27, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30043814/single-molecule-fluorescence-enhancement-of-a-near-infrared-dye-by-gold-nanorods-using-dna-transient-binding
#17
Weichun Zhang, Martín Caldarola, Xuxing Lu, Biswajit Pradhan, Michel Orrit
Fluorescence enhancement by plasmonic nanostructures enables the optical detection of single molecules with weak fluorescence, extending the scope of molecular fluorescence imaging to new materials and systems. In this work, we study single-molecule fluorescence enhancement by individual gold nanorods exploiting a DNA-based transient binding technique. Single molecules are attached to short DNA oligomers that can reversibly hybridize to their complementary docking DNA strands immobilized on the surface of gold nanorods or the glass substrate next to gold nanorods...
August 8, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30043178/a-systematic-review-for-human-eeg-brain-signals-based-emotion-classification-feature-extraction-brain-condition-group-comparison
#18
REVIEW
Mohamed Hamada, B B Zaidan, A A Zaidan
The study of electroencephalography (EEG) signals is not a new topic. However, the analysis of human emotions upon exposure to music considered as important direction. Although distributed in various academic databases, research on this concept is limited. To extend research in this area, the researchers explored and analysed the academic articles published within the mentioned scope. Thus, in this paper a systematic review is carried out to map and draw the research scenery for EEG human emotion into a taxonomy...
July 24, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/30039300/oxygen-consumption-of-desert-pupfish-at-ecologically-relevant-temperatures-suggests-a-significant-role-for-anaerobic-metabolism
#19
Matt Heuton, Luis Ayala, Aldo Morante, Kyle Dayton, Alexander C Jones, Joseph R Hunt, Austin McKenna, Frank van Breukelen, Stanley Hillyard
Oxygen consumption is oftentimes used as a proxy for metabolic rate. However, pupfish acclimated to ecologically relevant temperatures may employ extended periods of anaerobism despite the availability of oxygen-a process we called paradoxical anaerobism. In this study, we evaluated data from pupfish exhibiting stable oxygen consumption. Routine oxygen consumption ([Formula: see text]) of a refuge population derived from Cyprinodon spp. acclimated to 28 and 33 °C was evaluated at the ecologically relevant assay temperatures of between 25 and 38 °C...
July 23, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/30020371/-the-reshaping-of-healthcare-systems-in-the-age-of-financialization-lessons-from-france-and-brazil
#20
Ana Carolina Cordilha, Lena Lavinas
Since the post-War period, social protection systems have experienced continuous reforms, either extending or, more often, reducing the scope and the scale of public provision. This paper seeks to present how healthcare systems have evolved both in France and in Brazil recently, in order to comprehend mechanisms through which financialization has been reshaping public care provision. This comparative analysis unveils distinct financialization dynamics of healthcare systems, built upon universalism principles...
July 2018: Ciência & Saúde Coletiva
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