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https://www.readbyqxmd.com/read/30114709/metabolic-shift-induced-by-%C3%AF-3-pufas-and-rapamycin-lead-to-cancer-cell-death
#1
Shenglong Zhu, Ninghan Feng, Guangxiao Lin, Yuelin Tong, Xuan Jiang, Qin Yang, Shunhe Wang, Wei Chen, Zhao He, Yong Q Chen
BACKGROUND/AIMS: Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders and drug resistance reduce its efficacy. Epidemiological, clinical, and experimental studies have demonstrated that omega-3 polyunsaturated fatty acids (ω-3 PUFAs) significantly reduce the incidence and mortality of breast cancer and improve metabolic disorders. METHODS: Three breast cancer cell lines and immunocompetent and immunodeficient mice were used to evaluate the therapeutic effects of Rp plus ω-3 PUFA treatment...
August 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30114704/pci29732-a-bruton-s-tyrosine-kinase-inhibitor-enhanced-the-efficacy-of-conventional-chemotherapeutic-agents-in-abcg2-overexpressing-cancer-cells
#2
Chunlei Ge, Fang Wang, Chaochu Cui, Xiaodong Su, Kenneth Kin Wah To, Xiaokun Wang, Hui Zhang, Xin Song, Liwu Fu
BACKGROUND/AIMS: Multidrug resistance (MDR) induced by the ABC transporter subfamily B member 1 (ABCB1) and subfamilyG member 2 (ABCG2) limits successful cancer chemotherapy and no commercially available MDR modulator is used in the clinic. In the current study, we aimed to investigate the effects of PCI29732 on the enhancement of chemotherapeutic agents. METHODS: Cell cytotoxicity and reversal effect were measured with MTT assay. Additionally, flow cytometry was employed to detect the accumulation and efflux of the drugs...
August 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30114633/inhalational-supplementation-of-metformin-butyrate-a-strategy-for-prevention-and-cure-of-various-pulmonary-disorders
#3
REVIEW
Kunal Maniar, Vandana Singh, Amal Moideen, Rajasri Bhattacharyya, Amitava Chakrabarti, Dibyajyoti Banerjee
The management of chronic lung diseases such as cancer, asthma, COPD and pulmonary hypertension remains unsatisfactory till date, and several strategies are being tried to control the same. Metformin, a popular anti-diabetic drug has shown promising effects in pre-clinical studies and has been subject to several trials in patients with debilitating pulmonary diseases. However, the clinical evidence for the use of metformin in these conditions is disappointing. Recent observations suggest that metformin use in diabetic patients is associated with an increase in butyrate-producing bacteria in the gut microbiome...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30114477/nqo1-regulates-mitotic-progression-and-response-to-mitotic-stress-through-modulating-sirt2-activity
#4
Hong-Jun Kang, Ha Yong Song, Yang Guo, Mohamed A Ahmed, Mingming Zhang, Chuyu Chen, Massimo Cristofanilli, Dai Horiuchi, Athanassios Vassilopoulos
Previous studies have shown that SIRT2 plays a role in mitosis through deacetylating specific downstream targets. However, the upstream regulation of SIRT2 activity has been relatively unexplored. In this study, we provide evidence that NAD(P)H:quinone oxidoreductase 1 (NQO1) interacts with and activates SIRT2 in an NAD-dependent manner. Strong protein-protein interaction and co-localization of the two proteins during mitosis is required to maintain an active NQO1-SIRT2 axis which is critical for successful completion of mitosis...
August 13, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30114438/ets-1-induces-sorafenib-resistance-in-hepatocellular-carcinoma-cells-via-regulating-transcription-factor-activity-of-pxr
#5
Zhiyi Shao, Yibo Li, Wenjie Dai, Hui Jia, Yingshi Zhang, Qiyu Jiang, Yantao Chai, Xiaojuan Li, Huiwei Sun, Ruichuang Yang, Yu Cao, Fan Feng, Yingjie Guo
Transcription factor E26 transformation specific sequence 1 (ETS-1) is a primary regulator in the metastasis of human cancer cells, especially hepatocellular carcinoma (HCC) cells; and it would affect the prognosis of HCC patients who received chemotherapies. However, the regulatory role of ETS-1 in the resistance of HCC cells to molecular-targeting agent remains poorly understood. In the present work, we demonstrate that high ETS-1 expression correlates with poor prognosis of advanced HCC patients received Sorafenib treatment...
August 13, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30113432/anti-pd-1-drug-nivolumab-may-induce-acute-and-life-threatening-pancreatitis-in-lung-cancer-patient-a-case-report
#6
Rong Jiang, Li Xu, Yun Huang, Chen Fang, Heming Guo, Sicheng Li, Jianwu Wu, Ziyan Du
No abstract text is available yet for this article.
September 2018: Pancreas
https://www.readbyqxmd.com/read/30112986/preclinical-pharmacokinetics-of-triptolide-a-potential-antitumor-drug
#7
Wei Song, Meilin Liu, Junjun Wu, Hong Zhai, Yong Chen, Zhihong Peng
Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong anti-proliferative activity on all 60-national cancer institute (NCI) cancer cell lines. The antitumor property of triptolide has made it become a promising anti-cancer drug. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. All the toxic characteristics of triptolide are associated with the pharmacokinetics especially its distribution and accumulation in the target organ...
August 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/30112590/bioactive-lipid-metabolism-in-platelet-first-responder-and-cancer-biology
#8
Preeti Kanikarla-Marie, Scott Kopetz, Ernest T Hawk, Steven W Millward, Anil K Sood, Paolo Gresele, Michael Overman, Kenneth Honn, David G Menter
Platelets can serve as "first responders" in cancer and metastasis. This is partly due to bioactive lipid metabolism that drives both platelet and cancer biology. The two primary eicosanoid metabolites that maintain platelet rapid response homeostasis are prostacyclin made by endothelial cells that inhibits platelet function, which is counterbalanced by thromboxane produced by platelets during activation, aggregation, and platelet recruitment. Both of these arachidonic acid metabolites are inherently unstable due to their chemical structure...
August 15, 2018: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/30112527/half-sandwich-os-ii-and-ru-ii-bathophenanthroline-complexes-anticancer-drug-candidates-with-unusual-potency-and-a-cellular-activity-profile-in-highly-invasive-triple-negative-breast-cancer-cells
#9
Jitka Pracharova, Vojtech Novohradsky, Hana Kostrhunova, Pavel Štarha, Zdeněk Trávníček, Jana Kasparkova, Viktor Brabec
There is an urgent need to discover new, selective compounds to add to the limited arsenal of chemotherapeutics displaying selective toxicity for aggressive triple-negative breast cancer (TNBC) cells. The effect of two, recently developed metal-based half-sandwich complexes [Os(η6-pcym)(bphen)(dca)]PF6 (Os-dca) and [Ru(η6-pcym)(bphen)(dca)]PF6 (Ru-dca) [pcym = 1-methyl-4-(propan-2-yl)benzene (p-cymene); bphen = 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline); dca = dichloroacetate] on triple-negative breast cancer cells MDA-MB-231 is reported...
August 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30112118/protection-from-chemotherapy-and-antibiotic-mediated-dysbiosis-of-the-gut-microbiota-by-a-probiotic-with-digestive-enzymes-supplement
#10
Thomas E Ichim, Santosh Kesari, Kim Shafer
There are numerous downstream consequences of marketed drugs like antineoplastic agents on the gut microbiome, an effect that is suggested to contribute to adverse event profiles and may also influence drug responses. In cancer, progress is needed toward modulation of the host microbiome to prevent off-target side effects of drugs such as gastrointestinal mucositis that result from gut dysbiosis. The objective of this study was evaluation of the bioactivity of a supplement consisting of capsules with a blend of 9 probiotic organisms of the genera Lactobacillus and Bifidobacterium plus 10 digestive enzymes, in protecting the human gastrointestinal tract from chemotherapy and an antibiotic...
July 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/30112045/liver-targeted-delivery-of-liposome-encapsulated-curcumol-using-galactosylated-stearate
#11
Wen-Jie Li, You-Wen Lian, Quan-Sheng Guan, Ning Li, Wen-Jun Liang, Wen-Xin Liu, Yong-Bin Huang, Yi Cheng, Hui Luo
Liver-targeted drug delivery improves the efficacy of anti-liver cancer agents and reduces systemic toxicity by limiting the bioavailability of these drugs to within tumors. Liver targeting reagents with galactose residues, which selectively combine to asialoglyco protein receptors, have previously been used to improve liposome-encapsulated drug accumulation within liver cells. They lead to a reduction in liver cancer cell growth and have been used to cure certain hepatic diseases. In the present study, curcumol, which is the primary active component of Chinese traditional medicine Rhizoma zedoariae, was encapsulated in galactosylated-liposomes to enhance its anti-liver cancer efficacy...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30112023/in-vitro-screening-of-cytotoxic-activity-of-euphol-from-euphorbia-tirucalli-on-a-large-panel-of-human-cancer-derived-cell-lines
#12
Viviane Aline Oliveira Silva, Marcela Nunes Rosa, Aline Tansini, Renato J S Oliveira, Olga Martinho, João Paulo Lima, Luiz F Pianowski, Rui M Reis
A large number of classic antineoplastic agents are derived from plants. Euphorbia tirucalli L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of E. tirucalli in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic cells was also assessed...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111763/rutacecarpine-inhibits-angiogenesis-by-targeting-the-vegfr2-and-vegfr2-mediated-akt-mtor-p70s6k-signaling-pathway
#13
Lijun Ji, Mingfei Wu, Zeng Li
This study aimed to investigate the effect of Ru (Rut) on angiogenesis, and the underlying regulation mechanism of signal transduction. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, adhesion inhibition experiment, migration inhibition experiment, and chick embryo chorioallantoic membrane (CAM) assays were performed on models of angiogenesis. The potential targets of rutaecarpine (Ru) were reverse screened with Discovery Studio 2017. The interaction between the compound and target were detected by surface plasmon resonance (SPR), enzyme-activity experiment, and Western blot assay...
August 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30111018/-preparation-of-hispidulin-chitosan-microsphere-and-its-antiproliferation-effect-in-vitro
#14
Xia Li, Ya-Hua Wang, Tian-Ci Yan, Hao-Lun Xu, He-Lu Yan, Lan-Yu He, Lan-Yu He, Xue Ying
Hispidulin(HPDL) chitosan microspheres were prepared in this study to deliver HPDL to the lesion sitevia intravenous injection, and further evaluate their anticancer effects in vitro and the growth inhibition effect on A549 cells spheroids. HPDL chitosan microspheres were prepared by emulsion crosslinking method with chitosan as a drug carrier and the amount of HPDL was determined by high performance liquid chromatography (HPLC). The morphology of microspheres was observed under laser scanning confocal microscope...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30110677/kidney-protection-effect-of-ginsenoside-re-and-its-underlying-mechanisms-on-cisplatin-induced-kidney-injury
#15
Zi Wang, Yan-Fei Li, Xin-Yue Han, Yin-Shi Sun, Lian-Xue Zhang, Wei Liu, Xiang-Xiang Liu, Wei Li, Ying-Ying Liu
BACKGROUND/AIMS: Cisplatin (CDDP) was the first platinum-containing anti-cancer drug. However, CDDP causes nephrotoxicity as a side effect, which limits its clinic application. The aim of this study was to investigate the renoprotective effect of ginsenoside Re (G-Re) in a murine model of CDDP-induced acute kidney injury. METHODS: Male ICR mice were divided into 4 groups. G-Re was administered to the mice by oral gavage once a day at a dose of 25 mg/kg for 10 days...
August 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30110619/carcinoembryonic-antigen-targeted-nanoparticles-potentiate-the-delivery-of-anticancer-drugs-to-colorectal-cancer-cells
#16
Inês Pereira, Flávia Sousa, Patrick Kennedy, Bruno Sarmento
Bioengineered functionalized nanoparticles have extensively been proposed in recent years to efficiently deliver anti-cancer drugs to the tumour site, by targeting the cancer cells and improving the therapeutic efficiency of active molecules. In this work, polymeric poly (lactic-co- glycolic)-polyethyleneglycol (PLGA-PEG) nanoparticles were produced by nanoprecipitation and loaded with paclitaxel, following surface-functionalized with a monoclonal antibody targeting the carcinoembryonic antigen (CEA) of intestinal epithelial cells...
August 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30110551/sialic-acid-anchored-micelles-a-hierarchical-targeting-device-for-enhanced-tumor-tissue-accumulation-and-cellular-internalization
#17
Meng-Lu Zhu, Xiao-Ling Xu, Xiao-Juan Wang, Nan-Nan Zhang, Kong-Jun Lu, Jing Qi, Fei-Yang Jin, Di Liu, Yong-Zhong Du
Targeted Drug Delivery Systems (TDDS) have attracted wide attention with reduced drug side effects and improved anti-tumor efficacy in comparison with traditional preparations. While targeting moiety in existing TDDS principally focused on recognition of receptors on the surface of tumor cells, accumulation into tumor tissue only could be performed by enhanced permeability and retention effect and active transportation into tumor cells. Doxorubicin (DOX)-loaded sialic acid-dextran (Dex)-octadecanoic acid (OA) micelles (SA-Dex-OA/DOX) were designed for targeting hepatocellular carcinoma effectively...
August 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30110148/lactobionic-folate-dual-targeted-amphiphilic-maltodextrin-based-micelles-for-targeted-co-delivery-of-sulfasalazine-and-resveratrol-to-hepatocellular-carcinoma
#18
Doaa M Anwar, Sherine Nabil Khattab, Maged W Helmy, Mohamed K Kamal, Adnan A Bekhit, Kadria A Elkhodairy, Ahmed O Elzoghby
In this study, promising approaches of dual-targeted micelles and drug-polymer conjugation were combined to enable injection of poorly soluble anti-cancer drugs together with site-specific drug release. Ursodeoxycholic acid (UDCA) as a hepatoprotective agent was grafted to maltodextrin (MD) via carbodiimide coupling to develop amphiphilic maltodextrin-ursodeoxycholic acid (MDCA)-based micelles. Sulfasalazine (SSZ), as a novel anti-cancer agent, was conjugated via a tumor-cleavable ester bond to MD backbone to obtain tumor-specific release whereas resveratrol (RSV) was physically entrapped within the hydrophobic micellar core...
August 15, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/30110124/antihypertensive-drugs-and-prostate-cancer-survival-after-radical-prostatectomy-in-finland-a-nationwide-cohort-study
#19
Eerik Ee Santala, Antti Rannikko, Teemu J Murtola
Antihypertensive (anti-HT) drugs targeting renin-angiotensin-aldosterone (RAA)- system have been associated with improved prostate cancer (PCa)-specific survival. Challenge is that often multiple drugs are used simultaneously. We evaluated the association between use of anti-HT drugs and PCa survival among 14,422 surgically treated Finnish PCa patients. Information on drug purchases was obtained from a national prescription database. We used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of PCa death and initiation of androgen deprivation therapy (ADT) with adjustment for age, tumor extent, use of statins and for Charlson Comorbidity Index...
August 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30109812/novel-isatin-derived-molecules-activate-p53-via-interference-with-mdm2-to-promote-apoptosis
#20
Olga Fedorova, Alexandra Daks, Varvara Petrova, Alexey Petukhov, Larissa Lezina, Oleg Shuvalov, Pavel Davidovich, Darya Kriger, Ekaterina Lomert, Dmitry Tentler, Victor Kartsev, Burhan Uyanik, Vyacheslav Tribulovich, Oleg Demidov, Gerry Melino, Nickolai A Barlev
The p53 protein is a key tumor suppressor in mammals. In response to various forms of genotoxic stress p53 stimulates expression of genes whose products induce cell cycle arrest and/or apoptosis. An E3-ubiquitin ligase, Mdm2 (mouse-double-minute 2) and its human ortholog Hdm2, physically interact with the amino-terminus of p53 to mediate its ubiquitin-mediated degradation via the proteasome. Thus, pharmacological inhibition of the p53-Mdm2 interaction leads to overall stabilization of p53 and stimulation of its anti-tumorigenic activity...
August 15, 2018: Cell Cycle
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