Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao, Binhui Chen
BACKGROUND: Although cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an animal model of cervical disc degeneration and discogenic neck pain induced by a low concentration of Propionibacterium acnes (P. acnes-L) is investigated to explore the possible mechanisms of cervical discogenic pain. METHODS: Cervical IVD degeneration and discitis was induced in 8-week-old male rats in C3-C6 IVDs through the anterior intervertebral puncture with intradiscal injections of low and high concentrations of P...
January 31, 2024: Arthritis Research & Therapy