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Cervical intervertebral disc

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https://www.readbyqxmd.com/read/29675672/low-virulence-bacterial-infections-in-cervical-intervertebral-discs-a-prospective-case-series
#1
Yilei Chen, Xianjun Wang, Xuyang Zhang, Hong Ren, Bao Huang, Jian Chen, Junhui Liu, Zhi Shan, Zhihai Zhu, Fengdong Zhao
STUDY DESIGN: A prospective cross-sectional case series study. OBJECTIVE: To investigate the prevalence of low virulence disc infection and its associations with characteristics of patients or discs in the cervical spine. BACKGROUND: Low virulence bacterial infections could be a possible cause of intervertebral disc degeneration and/or back pain. Controversies are continuing over whether these bacteria, predominantly Propionibacterium acnes (P...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29670903/apparent-diffusion-coefficient-of-diffusion-weighted-imaging-in-evaluation-of-cervical-intervertebral-disc-degeneration-an-observational-study-with-3-0-t-magnetic-resonance-imaging
#2
Pinjie Chen, Chunlei Wu, Minghua Huang, Guangjian Jin, Qinglei Shi, Zhihua Han, Chun Chen
Aims: To investigate the correlation between the apparent diffusion coefficient (ADC) value and cervical intervertebral disc degeneration in adult symptomatic patients. Methods: A total of 52 symptomatic and 40 healthy volunteers were included. DWI and routine MRI examinations were performed to their cervical spines. The cervical discs (from C2-C3 to C6-C7) were graded according to the Pfirrmann grading system, and ADC values of the nucleus pulposus (NP) were measured...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669576/modic-changes-in-the-cervical-endplate-of-patients-suffering-from-cervical-spondylotic-myelopathy
#3
Pan Qiao, Tian-Tong Xu, Wen Zhang, Rong Tian
BACKGROUND: The distribution and related factors of Modic changes (MC) in the lumbar spine has been evaluated. In the present study, the MC in the cervical endplate of patients with cervical spondylotic myelopathy (CSM) was investigated. METHODS: A total of 6422 cervical endplates of 539 patients suffered from CSM (259 males and 280 females) with mean age of 46 ± 5.2 years. All patients underwent MRI scans and X-ray for evaluating the distribution of MC. The clinical information were recorded...
April 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29658148/biochemical-and-biomechanical-characterization-of-equine-cervical-facet-joint-cartilage
#4
S A O'Leary, J L White, J C Hu, K A Athanasiou
BACKGROUND: The equine cervical facet joint is a site of significant pathology. Located bilaterally on the dorsal spine, these diarthrodial joints work in conjunction with the intervertebral disc to facilitate appropriate spinal motion. Despite the high prevalence of pathology in this joint, the facet joint is understudied and thus lacking in viable treatment options. OBJECTIVE: The goal of this study was to characterise equine facet joint cartilage and provide a comprehensive database describing the morphological, histological, biochemical, and biomechanical properties of this tissue...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29643538/-anterior-cervical-discectomy-and-fusion-to-treat-cervical-spondylosis-with-sympathetic-symptoms
#5
H Liu, L Yue, S L Chen, B Hu, C D Li, X D Yi, H Li, H L Lu, Y Wang, Z R Yu, H L Sun, S J Wang, Y Zhao, L T Qi, R Wang
OBJECTIVE: To investigate the clinical effectiveness of polytheretherketone (PEEK) cages assisted anterior cervical discetomy and fusion (ACDF) to treat cervical spondylosis with sympathetic symptoms. METHODS: Retrospective analysis was undertaken for 39 patients who were diagnosed as cervical spondylosis with sympathetic symptoms and underwent ACDF with PEEK cages. Radiographs obtained before surgery, after surgery, and at the final follow-up were assessed for quality of fusion...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29621987/distribution-of-ossified-spinal-lesions-in-patients-with-severe-ossification-of-the-posterior-longitudinal-ligament-and-prediction-of-ossification-at-each-segment-based-on-the-cervical-op-index-classification-a-multicenter-study-josl-ct-study
#6
Takashi Hirai, Toshitaka Yoshii, Narihito Nagoshi, Kazuhiro Takeuchi, Kanji Mori, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi
BACKGROUND: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29615017/clinical-and-radiographic-outcome-of-dynamic-cervical-implant-dci-arthroplasty-for-degenerative-cervical-disc-disease-a-minimal-five-year-follow-up
#7
Lin-Nan Wang, Bo-Wen Hu, Lei Wang, Yue-Ming Song, Xi Yang, Li-Min Liu, Hao Liu
BACKGROUND: To evaluate the mid- to long-term clinical and radiographic outcomes of anterior cervical discectomy and dynamic cervical implant (DCI) arthroplasty for degenerative cervical disc disease. METHODS: From April 2010 to October 2010, 38 patients with single- or double-level cervical disc herniation underwent anterior cervical discectomy and DCI arthroplasty. The clinical results and radiographic outcomes of these 38 patients (42 levels) were retrospectively evaluated...
April 4, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29599656/degenerative-cervical-myelopathy-a-clinical-review
#8
REVIEW
Justin Gibson, Aria Nouri, Bryan Krueger, Nikita Lakomkin, Rani Nasser, David Gimbel, Joseph Cheng
Degenerative Cervical Myelopathy (DCM) is the most common form of spinal cord impairment in adults and results in disability and reduced quality of life. DCM can present with a wide set of clinical and imaging findings, including: 1) pain and reduced range of motion of the neck, and motor and sensory deficits on clinical exam, and 2) cord compression due to static and dynamic injury mechanisms resulting from degenerative changes of the bone, ligaments, and intervertebral discs on MRI. The incidence and prevalence of DCM has been estimated at a minimum of 4...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29584503/influence-of-morphological-variations-on-cervical-spine-segmental-responses-from-inertial-loading
#9
Jobin D John, Narayan Yoganandan, Mike W J Arun, G Saravana Kumar
OBJECTIVES: The objective of this study was to investigate the influence of morphological variations in osteoligamentous lower cervical spinal segment responses under postero-anterior inertial loading. METHODS: A parametric finite element model of the C5-C6 spinal segment was used to generate models. Variations in the vertebral body and facet depth (anteroposterior), posterior process length, intervertebral disc height, facet articular process height and slope, segment orientation ranging from lordotic to straight, and segment size were parameterized...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29582673/effect-of-the-ccl5-releasing-fibrin-gel-for-intervertebral-disc-regeneration
#10
Zhiyu Zhou, Stephan Zeiter, Tanja Schmid, Daisuke Sakai, James C Iatridis, Guangqian Zhou, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li
Objective To explore if chemokine (C-C motif) ligand 5 (CCL5) delivery could recruit annulus fibrosus (AF) cells to the injury sites and facilitate the repair of ruptured AF. Design The effects of CCL5 on bovine AF cells in vitro were tested by transwell assay and quantitative real-time polymerase chain reaction. Fibrin gel containing CCL5 was used to treat annulotomized bovine caudal discs cultured under dynamic loading conditions. After 14 days of loading, the samples were collected for histological examination...
March 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29565943/an-update-of-the-systematic-appraisal-of-the-accuracy-and-utility-of-discography-in-chronic-spinal-pain
#11
Laxmaiah Manchikanti, Amol Soin, Ramsin M Benyamin, Vijay Singh, Frank Je Falco, Aaron K Calodney, Vahid Grami, Joshua A Hirsch
BACKGROUND: The intervertebral disc has been implicated as a major cause of chronic spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients, and in 16% to 53% of patients with pain in the cervical spine...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29548949/predictive-factors-of-successful-percutaneous-cervical-nucleoplasty-for-the-treatment-of-pain-with-cervical-herniated-disk
#12
Min Kyoung Kim, Sung Eun Sim, Yong-Chul Kim, Jung Soo Kim, Seok Min Kwon, Yongjae Yoo, Chang-Soon Lee, Jee Youn Moon
BACKGROUND: Percutaneous cervical nucleoplasty (PCN) is an effective treatment for cervical herniated intervertebral disc (C-HIVD). In this retrospective study, we evaluated clinical predictors that affect the successful outcome of PCN. METHODS: Fluoroscopy-guided PCN was conducted for C-HIVD by one pain physician. Successful outcome was defined as a combination of > 50% pain relief on the numerical rating scale (NRS) pain score, no increase in analgesics, and no cervical epidural steroid injection during the 3-month follow-up period...
March 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29530383/high-resolution-magnetization-transfer-mri-in-patients-with-cervical-spondylotic-myelopathy
#13
Linda I Suleiman, Kenneth A Weber, Brett D Rosenthal, Surabhi A Bhatt, Jason W Savage, Wellington K Hsu, Alpesh A Patel, Todd B Parrish
Magnetization transfer (MT) contrast has been established as a marker of myelin integrity, and cervical spondylotic myelopathy is known to cause demyelination. Ten patients with clinical and magnetic resonance imaging (MRI) manifestations of cervical spondylotic myelopathy (CSM) were compared to the MRIs of seven historic healthy controls, using the magnetization transfer ratio (MTR) and Nurick scores as the primary metrics. Transverse slices through the intervertebral discs of the cervical spine were acquired using a gradient echo sequence (MEDIC) with and without an MT saturation pulse on a 3 Tesla Siemens Prisma scanner (TR = 300 ms, TEeff  = 17 ms, flip angle = 30°, in-plane resolution = 0...
March 9, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29503686/reliability-and-accuracy-of-palpable-anterior-neck-landmarks-for-the-identification-of-cervical-spinal-levels
#14
Koopong Siribumrungwong, Chitpon Sinchai, Boonsin Tangtrakulwanich, Weera Chaiyamongkol
Study Design: A descriptive experimental study. Purpose: The purpose of this study was to describe the reliability and accuracy of palpable anterior neck landmarks (angle of the mandible, hyoid bone, thyroid cartilage, and cricoid cartilage) for the identification of cervical spinal levels in a slight neck-extended position as in anterior approach cervical spinal surgery. Overview of Literature: Standard, palpable anatomical landmarks for the identification of cervical spinal levels were described by Hoppenfeld using the midline palpable anterior structures (angle of the mandible [C2 body], hyoid bone [C3 body], thyroid cartilage [C4-C5 disc], cricoid cartilage [C6 body], and carotid tubercle [C6 body]) to determine the approximate level for skin incisions...
February 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29496723/normal-values-of-magnetic-relaxation-parameters-of-spine-components-with-the-synthetic-mri-sequence
#15
M Drake-Pérez, B M A Delattre, J Boto, A Fitsiori, K-O Lovblad, S Boudabbous, M I Vargas
BACKGROUND AND PURPOSE: SyMRI is a technique developed to perform quantitative MR imaging. Our aim was to analyze its potential use for measuring relaxation times of normal components of the spine and to compare them with values found in the literature using relaxometry and other techniques. MATERIALS AND METHODS: Thirty-two spine MR imaging studies (10 cervical, 5 dorsal, 17 lumbosacral) were included. A modified multiple-dynamic multiple-echo sequence was added and processed to obtain quantitative T1 (millisecond), T2 (millisecond), and proton density (percentage units [pu]) maps for each patient...
March 1, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29456709/anterior-spinal-instrumentation-combining-a-prosthetic-disc-nucleus-with-a-flexible-stabilization-device-manufacture-and-use-in-intervertebral-disc-repair
#16
Da Bao, Dawei Li
Artificial disc replacement alone is unable to completely cure cervical degenerative diseases; thus, a stabilization device markedly improves patient recovery. In order to meet this requirement, an anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device (ASI combining PDN/FD) was developed. An artificial disc was designed and manufactured using polyvinyl alcohol hydrogel (PVA-H) with a repeated freeze-melting technique, and subsequently the dehydration and swelling properties of the PVA-H were investigated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456172/effect-of-pediatric-growth-on-cervical-spine-kinematics-and-deformations-in-automotive-crashes
#17
Victor S Alvarez, Svein Kleiven
Finite element (FE) models are a powerful tool that can be used to understand injury mechanisms and develop better safety systems. This study aims to extend the understanding of pediatric spine biomechanics, where there is a paucity of studies available. A newly developed and continuously scalable FE model was validated and scaled to 1.5-, 3-, 6-, 10-, 14- and 18-year-old using a non-linear scaling technique, accounting for local topological changes. The oldest and youngest ages were also scaled using homogeneous geometric scaling...
February 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29427744/towards-the-scale-up-of-tissue-engineered-intervertebral-discs-for-clinical-application
#18
Sarah E Gullbrand, Dong Hwa Kim, Edward Bonnevie, Beth G Ashinsky, Lachlan J Smith, Dawn M Elliott, Robert L Mauck, Harvey E Smith
Replacement of the intervertebral disc with a viable, tissue-engineered construct that mimics native tissue structure and function is an attractive alternative to fusion or mechanical arthroplasty for the treatment of disc pathology. While a number of engineered discs have been developed, the average size of these constructs remains a fraction of the size of human intervertebral discs. In this study, we fabricated medium (3 mm height x 10 mm diameter) and large (6 mm height x 20 mm diameter) sized disc-like angle ply structures (DAPS), encompassing size scales from the rabbit lumbar spine to the human cervical spine...
February 7, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29409935/comparison-between-cervical-disc-arthroplasty-and-conservative-treatment-for-patients-with-single-level-cervical-radiculopathy-at-c5-6
#19
Axiang He, Dong Xie, Bo Qu, Xiaomin Cai, Qin Kong, Lili Yang, Xiongsheng Chen, Lianshun Jia
BACKGROUND: Cervical radiculopathy is a common disease that affects millions of people. Patients usually are managed by conservative therapy and surgical treatments. OBJECTIVE: To compare the clinical outcomes between cervical disc arthroplasty (CDA) and conservative management for patients with single level cervical radiculopathy at C5/6. METHODS: Seventy-two patients with cervical radiculopathy that only affect C5/6 joints were included and thirty-two of them received CDA surgery, and forty patients were treated with conservative management...
January 30, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29403240/only-spinal-fixation-as-treatment-of-prolapsed-cervical-intervertebral-disc-in-patients-presenting-with-myelopathy
#20
Atul Goel, Pralhad Dharurkar, Abhidha Shah, Sandeep Gore, Sandeep More, Shashi Ranjan
Aim: An alternative form of surgical treatment of prolapsed cervical intervertebral disc in patients presenting with symptoms related to myelopathy is discussed. The treatment involved fixation of the affected spinal segments and aimed at arthrodesis. No direct manipulation or handling of the disc was done. Materials and Methods: During the period August 2010 to June 2017, 16 patients presenting with symptoms attributed to myelopathy and diagnosed to have prolapsed cervical intervertebral disc were surgically treated by spinal stabilization...
October 2017: Journal of Craniovertebral Junction and Spine
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