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Biopolymer AND self Healing

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https://www.readbyqxmd.com/read/30525150/microtubule-self-healing-and-defect-creation-investigated-by-in-line-force-measurements-during-high-speed-atomic-force-microscopy-imaging
#1
Christian Ganser, Takayuki Uchihashi
Microtubules are biopolymers composed of tubulin and play diverse roles in a wide variety of biological processes such as cell division, migration and intracellular transport in eukaryotic cells. To perform their functions, microtubules are mechanically stressed and, thereby, susceptible to structural defects. Local variations in mechanical properties caused by these defects modulate their biological functions, including binding and transportation of microtubule-associated proteins. Therefore, assessing the local mechanical properties of microtubules and analyzing their dynamic response to mechanical stimuli provide insight into fundamental processes...
December 7, 2018: Nanoscale
https://www.readbyqxmd.com/read/30276958/furfuryl-and-maleimido-polysaccharides-synthetic-strategies-toward-functional-biomaterials
#2
REVIEW
Thomas Elschner, Franziska Obst, Thomas Heinze
In context with facile and efficient syntheses of functional polymeric materials, the combination of polysaccharides and functional moieties based on renewable resources is a sustainable and valuable approach. This review presents alternatives to prominent click reactions utilizing biopolymer derivatives with furfuryl and maleimide groups. On the one hand, the cross-linking by Diels-Alder reaction of these polymers enables the synthesis of novel materials in the fields of self-healing polymers, tissue engineering, and drug delivery...
October 1, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/30023901/gelatin-based-hydrogels-blended-with-gellan-as-an-injectable-wound-dressing
#3
Yueyuan Zheng, Yuqing Liang, Depan Zhang, Xiaoyi Sun, Li Liang, Juan Li, You-Nian Liu
Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network...
May 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/29736513/free-standing-three-dimensional-hollow-bacterial-cellulose-structures-with-controlled-geometry-via-patterned-superhydrophobic-hydrophilic-surfaces
#4
Anna Laromaine, Tina Tronser, Ivana Pini, Sebastià Parets, Pavel A Levkin, Anna Roig
Bacteria can produce cellulose, one of the most abundant biopolymer on earth, and emerge as an interesting candidate to fabricate advanced materials. Cellulose produced by Komagataeibacter Xylinus, a bacterial strain, is a pure water insoluble biopolymer, without hemicellulose or lignin. Bacterial cellulose (BC) exhibits a nanofibrous porous network microstructure with high strength, low density and high biocompatibility and it has been proposed as cell scaffold and wound healing material. The formation of three dimensional (3D) cellulose self-standing structures is not simple...
May 16, 2018: Soft Matter
https://www.readbyqxmd.com/read/29644843/noncovalently-assembled-electroconductive-hydrogel
#5
Yong Xu, Xuegeng Yang, Alvin Kuriakose Thomas, Panagiotis A Patsis, Thomas Kurth, Martin Kräter, Kerstin Eckert, Martin Bornhäuser, Yixin Zhang
Cross-linking biomolecules with electroconductive nanostructures through noncovalent interactions can result in modular networks with defined biological functions and physical properties such as electric conductivity and viscoelasticity. Moreover, the resulting matrices can exhibit interesting features caused by the dynamic assembly process, such as self-healing and molecular ordering. In this paper, we present a physical hydrogel system formed by mixing peptide-polyethylene glycol and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29642447/mitoq-loaded-chitosan-hyaluronan-composite-membranes-for-wound-healing
#6
Tamer M Tamer, Maurice N Collins, Katarina Valachová, Mohamed A Hassan, Ahmed M Omer, Mohamed S Mohy-Eldin, Karol Švík, Rastislav Jurčík, Ľubomír Ondruška, Csaba Biró, Ahmad B Albadarin, Ladislav Šoltés
Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant-MitoQ-was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods...
April 7, 2018: Materials
https://www.readbyqxmd.com/read/29542910/composite-hydrogels-using-bioinspired-approach-with-in-situ-fast-gelation-and-self-healing-ability-as-future-injectable-biomaterial
#7
Musammir Khan, Janne T Koivisto, Terttu I Hukka, Mikko Hokka, Minna Kellomäki
Biopolymers are attractive candidates to fabricate biocompatible hydrogels, but the low water solubility of most of them at physiological pH has hindered their applications. To prepare a water-soluble derivative of chitosan (WSC) biopolymer, it was grafted with a small anionic amino acid, l-glutamic acid, using a single-step 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide coupling reaction. This resulted in a zwitterion-tethered structure onto the polymer backbone. The degree of substitution range was 13-16 ± 1...
April 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336146/coordination-triggered-hierarchical-folate-zinc-supramolecular-hydrogels-leading-to-printable-biomaterials
#8
Kaerdun Liu, Shihao Zang, Rongrong Xue, Jinghui Yang, Lizhi Wang, Jianbin Huang, Yun Yan
Printable hydrogels desired in bioengineering have extremely high demands on biocompatibility and mechanic strength, which can hardly be achieved in conventional hydrogels made with biopolymers. Here, we show that on employment of the strategy of coordination-triggered hierarchical self-assembly of naturally occurring small-molecule folic acid, supramolecular hydrogels with robust mechanical elastic modulus comparable to synthetic double-network polymer gels can be made at concentrations below 1%. A sequence of hierarchical steps are involved in the formation of this extraordinary hydrogel: petrin rings on folate form tetramers through hydrogen bonding, tetramers stack into nanofibers by π-π stacking, and zinc ions cross-link the nanofibers into larger-scale fibrils and further cross-link the fibril network to gel water...
February 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29281172/moldable-hyaluronan-hydrogel-enabled-by-dynamic-metal-bisphosphonate-coordination-chemistry-for-wound-healing
#9
Liyang Shi, Yannan Zhao, Qifan Xie, Caixia Fan, Jöns Hilborn, Jianwu Dai, Dmitri A Ossipov
Biomaterial-based regenerative approaches would allow for cost-effective off-the-shelf solution for the treatment of wounds. Hyaluronan (HA)-based hydrogel is one attractive biomaterial candidate because it is involved in natural healing processes, including inflammation, granulation, and reepithelialization. Herein, dynamic metal-ligand coordination bonds are used to fabricate moldable supramolecular HA hydrogels with self-healing properties. To achieve reversible crosslinking of HA chains, the biopolymer is modified with pendant bisphosphonate (BP) ligands using carbodiimide coupling and chemoselective "click" reactions...
March 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29103512/stimuli-responsive-ion-gels-based-on-polysaccharides-and-other-polymers-prepared-using-ionic-liquids-and-deep-eutectic-solvents
#10
REVIEW
Kamalesh Prasad, Dibyendu Mondal, Mukesh Sharma, Mara G Freire, Chandrakant Mukesh, Jitkumar Bhatt
Ion gels and self-healing gels prepared using ionic liquids (ILs) and deep eutectic solvents (DESs) have been largely investigated in the past years due to their remarkable applications in different research areas. Herewith we provide an overview on the ILs and DESs used for the preparation of ion gels, highlight the preparation and physicochemical characteristics of stimuli responsive gel materials based on co-polymers and biopolymers, with special emphasis on polysaccharides and discuss their applications...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29055701/self-healing-and-tough-hydrogels-with-physically-cross-linked-triple-networks-based-on-agar-pva-graphene
#11
Navid Samadi, Mohammad Sabzi, Masoud Babaahmadi
The aim of this work was to prepare polyvinyl alcohol (PVA)/Agar/Graphene nanocomposite hydrogels through a one-pot and green solution mixing method using water as solvent. Herein a novel strategy for designing stiff, tough and self-healing triple network (TN) hydrogels was proposed. The prepared TN hydrogels composed of strong Agar polysaccharide as the first network, tough PVA biopolymer gel as the second network, and graphene nanoplatelets as the third network. Interestingly, similar to natural biomaterials, all of the networks of the nanocomposite hydrogel were physically cross-linked via dynamic hydrogen bonding associations, i...
February 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28963020/nanocomposite-hydrogels-stabilized-by-self-assembled-multivalent-bisphosphonate-magnesium-nanoparticles-mediate-sustained-release-of-magnesium-ion-and-promote-in-situ-bone-regeneration
#12
Kunyu Zhang, Sien Lin, Qian Feng, Chaoqun Dong, Yanhua Yang, Gang Li, Liming Bian
Hydrogels are appealing biomaterials for applications in regenerative medicine due to their tunable physical and bioactive properties. Meanwhile, therapeutic metal ions, such as magnesium ion (Mg2+ ), not only regulate the cellular behaviors but also stimulate local bone formation and healing. However, the effective delivery and tailored release of Mg2+ remains a challenge, with few reports on hydrogels being used for Mg2+ delivery. Bisphosphonate exhibits a variety of specific bioactivities and excellent binding affinity to multivalent cations such as Mg2+ ...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28772449/self-healing-materials-for-ecotribology
#13
Shih-Chen Shi, Teng-Feng Huang
Hydroxypropyl methylcellulose (HPMC) is a biopolymer that is biodegradable, environmentally friendly, and bio-friendly. Owing to its unique chemical structure, HPMC can reduce the coefficient of friction (COF) and frictional wear and thus possesses excellent lubrication properties. HPMC has good dissolvability in specific solvents. The present research focuses on the reversible dissolution reaction subsequent to the film formation of HPMC, with a view to the healing and lubrication properties of thin films...
January 22, 2017: Materials
https://www.readbyqxmd.com/read/28528863/cross-linking-of-a-biopolymer-peptide-co-assembling-system
#14
Karla E Inostroza-Brito, Estelle C Collin, Anna Majkowska, Sherif Elsharkawy, Alistair Rice, Armando E Del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
The ability to guide molecular self-assembly at the nanoscale into complex macroscopic structures could enable the development of functional synthetic materials that exhibit properties of natural tissues such as hierarchy, adaptability, and self-healing. However, the stability and structural integrity of these kinds of materials remains a challenge for many practical applications. We have recently developed a dynamic biopolymer-peptide co-assembly system with the capacity to grow and undergo morphogenesis into complex shapes...
August 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28254307/bioinspired-fully-physically-cross-linked-double-network-hydrogels-with-a-robust-tough-and-self-healing-structure
#15
Mohammad Sabzi, Navid Samadi, Farhang Abbasi, Gholam Reza Mahdavinia, Masoud Babaahmadi
The conventional covalently cross-linked double network (DN) hydrogels with high stiffness often show low toughness and self-healing property due to the irreversible bond breakages in their networks. Therefore, scarcity of hydrogels that possess simultaneous features of stiffness, toughness, and autonomous self-healing properties at the same time remains a great challenge and seriously limits their biomedical applications. While, many natural materials acquire these features from their dynamic sacrificial bonds...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27550535/-smart-drug-loaded-nanoparticle-delivery-from-a-self-healing-hydrogel-enabled-by-dynamic-magnesium-biopolymer-chemistry
#16
Liyang Shi, Yuanyuan Han, Jöns Hilborn, Dmitri Ossipov
We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
September 25, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27527229/tissue-regeneration-a-silk-road
#17
REVIEW
Dave Jao, Xiaoyang Mou, Xiao Hu
Silk proteins are natural biopolymers that have extensive structural possibilities for chemical and mechanical modifications to facilitate novel properties, functions, and applications in the biomedical field. The versatile processability of silk fibroins (SF) into different forms such as gels, films, foams, membranes, scaffolds, and nanofibers makes it appealing in a variety of applications that require mechanically superior, biocompatible, biodegradable, and functionalizable biomaterials. There is no doubt that nature is the world's best biological engineer, with simple, exquisite but powerful designs that have inspired novel technologies...
August 5, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/26651064/water-assisted-self-healing-and-property-recovery-in-a-natural-dermal-armor-of-pangolin-scales
#18
Z Q Liu, D Jiao, Z Y Weng, Z F Zhang
Self-healing capacity, of which the inspiration comes from biological systems, is significant for restoring the mechanical properties of materials by autonomically repairing damages. Clarifying the naturally occurring self-healing behaviors and mechanisms may provide valuable inspiration for designing synthetic self-healing materials. In this study, water-assisted self-healing behavior was revealed in a natural dermal armor of pangolin scales. The indentation damages which imitate the injury caused by predatory attack can be continuously mitigated through hydration...
March 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/26280813/functionalized-agarose-self-healing-ionogels-suitable-for-supercapacitors
#19
Tushar J Trivedi, Dhrubajyoti Bhattacharjya, Jong-Sung Yu, Arvind Kumar
Agarose has been functionalized (acetylated/carbanilated) in an ionic liquid (IL) medium of 1-butyl-3-methylimidazolium acetate at ambient conditions. The acetylated agarose showed a highly hydrophobic nature, whereas the carbanilated agarose could be dissolved in water as well as in the IL medium. Thermoreversible ionogels were obtained by cooling the IL sols of carbanilated agarose at room temperature. The ionogel prepared from a protic-aprotic mixed-IL system (1-butyl-3-methylimidazolium chloride and N-(2-hydroxyethyl)ammonium formate) demonstrated a superior self-healing property, as confirmed from rheological measurements...
October 12, 2015: ChemSusChem
https://www.readbyqxmd.com/read/26095789/hierarchical-nacre-mimetics-with-synergistic-mechanical-properties-by-control-of-molecular-interactions-in-self-healing-polymers
#20
Baolei Zhu, Nils Jasinski, Alejandro Benitez, Manuel Noack, Daesung Park, Anja S Goldmann, Christopher Barner-Kowollik, Andreas Walther
Designing the reversible interactions of biopolymers remains a grand challenge for an integral mimicry of mechanically superior biological composites. Yet, they are the key to synergistic combinations of stiffness and toughness by providing sacrificial bonds with hidden length scales. To address this challenge, dynamic polymers were designed with low glass-transition temperature T(g) and bonded by quadruple hydrogen-bonding motifs, and subsequently assembled with high-aspect-ratio synthetic nanoclays to generate nacre-mimetic films...
July 20, 2015: Angewandte Chemie
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