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https://www.readbyqxmd.com/read/30334794/interactive-visualization-of-rna-and-dna-structures
#1
Norbert Lindow, Daniel Baum, Morgan Leborgne, Hans-Christian Hege
The analysis and visualization of nucleic acids (RNA and DNA) is playing an increasingly important role due to their fundamental importance for all forms of life and the growing number of known 3D structures of such molecules. The great complexity of these structures, in particular, those of RNA, demands interactive visualization to get deeper insights into the relationship between the 2D secondary structure motifs and their 3D tertiary structures. Over the last decades, a lot of research in molecular visualization has focused on the visual exploration of protein structures while nucleic acids have only been marginally addressed...
October 17, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/30334789/automatic-needle-segmentation-and-localization-in-mri-with-3d-convolutional-neural-networks-application-to-mri-targeted-prostate-biopsy
#2
Alireza Mehrtash, Mohsen Ghafoorian, Guillaume Pernelle, Alireza Ziaei, Friso G Heslinga, Kemal Tuncali, Andriy Fedorov, Ron Kikinis, Clare M Tempany, William M Wells, Purang Abolmaesumi, Tina Kapur
Image-guidance improves tissue sampling during biopsy by allowing the physician to visualize the tip and trajectory of the biopsy needle relative to the target in MRI, CT, ultrasound, or other relevant imagery. This paper reports a system for fast automatic needle tip and trajectory localization and visualization in MRI that has been developed and tested in the context of an active clinical research program in prostate biopsy. To the best of our knowledge, this is the first reported system for this clinical application, and also the first reported system that leverages deep neural networks for segmentation and localization of needles in MRI across biomedical applications...
October 18, 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/30334761/collaborative-large-scale-dense-3d-reconstruction-with-online-inter-agent-pose-optimisation
#3
Stuart Golodetz, Tommaso Cavallari, Nicholas A Lord, Victor A Prisacariu, David W Murray, Philip H S Torr
Reconstructing dense, volumetric models of real-world 3D scenes is important for many tasks, but capturing large scenes can take significant time, and the risk of transient changes to the scene goes up as the capture time increases. These are good reasons to want instead to capture several smaller sub-scenes that can be joined to make the whole scene. Achieving this has traditionally been difficult: joining sub-scenes that may never have been viewed from the same angle requires a high-quality camera relocaliser that can cope with novel poses, and tracking drift in each sub-scene can prevent them from being joined to make a consistent overall scene...
October 15, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/30334745/thermoacoustic-tomography-of-in-vivo-human-finger-joints
#4
Zihui Chi, Yuan Zhao, Jinge Yang, Tingting Li, Guang Zhang, Huabei Jiang
OBJECTIVE: The purpose of this study was to demonstrate the potential of thermoacoustic tomography (TAT) to reveal anatomic structures of in vivo human finger joints. METHODS: All the participating volunteers provided written informed consent. Eight healthy middle and index fingers from 5 volunteers were imaged in vivo by our TAT imaging system. Axial T1-weighted MR imaging (3.0T) was used to validate the TAT findings. Comparative analyses between TAT and MRI images were performed in two-dimension for all the fingers imaged...
October 16, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/30332718/prenatal-development-of-the-humpback-whale-growth-rate-tooth-loss-and-skull-shape-changes-in-an-evolutionary-framework
#5
Agnese Lanzetti, Annalisa Berta, Eric G Ekdale
Extant baleen whales (Mysticeti) share a distinct suite of extreme and unique adaptations to perform bulk filter feeding, such as a long, arched skull and mandible and the complete loss of adult dentition in favor of baleen plates. However, mysticetes still develop tooth germs during ontogeny. In the fossil record, multiple groups document the transition from ancestral raptorial feeding to filter feeding. Fetal specimens give us an extraordinary opportunity to observe when and how this macroevolutionary transition occurs during gestation...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30328614/development-of-three-dimensional-laryngostroboscopy-for-office-based-laryngeal-diagnostics-and-phonosurgical-therapy
#6
Philipp P Caffier, Tadeus Nawka, Ahmed Ibrahim-Nasr, Björn Thomas, Holger Müller, Seo-Rin Ko, Wen Song, Manfred Gross, Sebastian Weikert
OBJECTIVE: To develop a three-dimensional (3D) laryngostroboscopic examination unit, compare the optic playback quality in relation to established 2D procedures, and report the first case series using 3D rigid laryngostroboscopy for diagnosis and management of laryngotracheal diseases. STUDY DESIGN: Laboratory study, prospective case series. METHODS: The optical efficacy of newly developed rigid 3D endoscopes was examined in a laboratory setting...
October 17, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30327822/-reconstructive-orbital-surgery
#7
REVIEW
M E H Wagner, H Essig, M Rücker, T Gander
BACKGROUND: In complex orbital reconstructions ideal positioning of the bony buttress and surrounding soft tissue is a prerequisite for an aesthetic and functional result. The use of computer-assisted surgery can support the surgeon before and during the reconstruction procedure and facilitate quality control processes. This is illustrated using three clinical examples. MATERIAL AND METHODS: The areas of interest (bony defect areas, surrounding tissues) are segmented in a 3D image series...
October 16, 2018: HNO
https://www.readbyqxmd.com/read/30327804/near-field-infrared-nanospectroscopy-and-super-resolution-fluorescence-microscopy-enable-complementary-nanoscale-analyses-of-lymphocyte-nuclei
#8
Godwin C Ajaezi, Max Eisele, Fabio Contu, Sadhana Lal, Aline Rangel-Pozzo, Sabine Mai, Kathleen M Gough
Recent super-resolution fluorescence microscopy (3D-Structured Illumination Microscopy, 3D-SIM) studies have revealed significantly altered nuclear organization between normal lymphocyte nuclei and those of classical Hodgkin's Lymphoma. Similar changes have been found in Multiple Myeloma (MM) nuclei, as well as in a premalignant condition, Monoclonal Gammopathy of Unknown Significance (MGUS). Using 3D-SIM, an increase in DNA-poor and DNA-free voids was evident in reconstructed 3D-SIM images of diseased nuclei at 40 nm pixel resolution (x,y: 40 nm, z: 80 nm)...
October 17, 2018: Analyst
https://www.readbyqxmd.com/read/30325711/head-and-trunk-movements-during-turning-gait-in-children-with-cerebral-palsy
#9
Asa Bartonek, Cecilia Lidbeck, Kerstin Hellgren, Elena Gutierrez-Farewik
Thirty children with cerebral palsy (CP) and 22 typical developing (TD) were tested with 3D-gait analysis. At turning, trunk rotation was larger in CP2 (GMFCS II) than in TD and CP1 (GMFCS I), and head flexion was larger in CP3 (GMFCS III) than TD. Maximum head and trunk flexion values during the entire trial were larger in CP3 than in the other groups, and trunk flexion was larger in CP2 than in TD. Trial time increased with GMFCS-level. Less trunk rotation than TD and CP1 reflects spatial insecurity in CP2, which in CP3 is compensated by the walker...
October 16, 2018: Journal of Motor Behavior
https://www.readbyqxmd.com/read/30324599/livefly-a-toolbox-for-the-analysis-of-transcription-dynamics-in-live-drosophila-embryos
#10
Huy Tran, Carmina Angelica Perez-Romero, Teresa Ferraro, Cécile Fradin, Nathalie Dostatni, Mathieu Coppey, Aleksandra M Walczak
We present the LiveFly toolbox for quantitative analysis of transcription dynamics in live Drosophila embryos. The toolbox allows users to process two-color 3D confocal movies acquired using nuclei-labeling and the fluorescent RNA-tagging system described in the previous chapter and export the nuclei's position as a function of time, their lineages and the intensity traces of the active loci. The toolbox, which is tailored for the context of Drosophila early development, is semiautomatic, and requires minimal user intervention...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30322772/pre-procedural-fit-testing-of-tavr-valves-using-parametric-modeling-and-3d-printing
#11
Ahmed Hosny, Joshua D Dilley, Tatiana Kelil, Moses Mathur, Mason N Dean, James C Weaver, Beth Ripley
BACKGROUND: Successful transcatheter aortic valve replacement (TAVR) requires an understanding of how a prosthetic valve will interact with a patient's anatomy in advance of surgical deployment. To improve this understanding, we developed a benchtop workflow that allows for testing of physical interactions between prosthetic valves and patient-specific aortic root anatomy, including calcified leaflets, prior to actual prosthetic valve placement. METHODS: This was a retrospective study of 30 patients who underwent TAVR at a single high volume center...
October 2, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/30321744/photogrammetry-using-visible-infrared-hyperspectral-and-thermal-imaging-of-crime-scenes
#12
G J Edelman, M C Aalders
Photogrammetry is a method for obtaining virtual 3D models of objects and scenes. The technique is increasingly used to record the crime scene in its original, undisturbed state for mapping, analytical and reconstruction purposes. Recently, it was shown that it is possible to visualize and/or chemically analyze latent traces by using advanced cameras which either operate in wavelength ranges beyond the visible range, and/or are able to obtain spectrally resolved images. The combination of these advanced cameras and photogrammetric techniques enables the 3D registration of valuable information...
September 29, 2018: Forensic Science International
https://www.readbyqxmd.com/read/30320700/objectifying-micrognathia-using-three-dimensional-photogrammetric-analysis
#13
Hanneke Basart, Michael Suttie, Amel Ibrahim, Patrizia Ferretti, Chantal M A M van der Horst, Raoul C Hennekam, Peter Hammond
BACKGROUND: Micrognathia occurs isolated and as part of entities like Robin sequence (RS). An objective measurement of mandible size and growth is needed to determine the degree of micrognathia and enable a comparison of treatment outcomes. A pilot study was conducted to investigate the usability of 3-dimensional (3D) facial photogrammetry, a fast, noninvasive method, to estimate mandible size and growth in a small cohort of newborns and infants. METHODS: Exterior mandibular volume was estimated using a tetrahedron defined by 4 facial landmarks...
October 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30319671/non-destructive-plant-morphometric-and-color-analyses-using-an-optoelectronic-3d-color-microscope
#14
Hugo G Lazcano-Ramírez, Andrea Gómez-Felipe, David Díaz-Ramírez, Yolanda Durán-Medina, Lino Sánchez-Segura, Stefan de Folter, Nayelli Marsch-Martínez
Gene function discovery in plants, as other plant science quests, is aided by tools that image, document, and measure plant phenotypes. Tools that acquire images of plant organs and tissues at the microscopic level have evolved from qualitative documentation tools, to advanced tools where software-assisted analysis of images extracts quantitative information that allows statistical analyses. They are useful to perform morphometric studies that describe plant physical characteristics and quantify phenotypes, aiding gene function discovery...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30318501/three-dimensional-pseudo-continuous-arterial-spin-labeling-using-turbo-spin-echo-with-pseudo-steady-state-readout-a-comparison-with-other-major-readout-methods
#15
Suzuko Aoike, Hiroyuki Sugimori, Noriyuki Fujima, Yuriko Suzuki, Yukie Shimizu, Akira Suwa, Kinya Ishizaka, Kohsuke Kudo
We evaluated 3D pseudo-continuous arterial spin labeling (pCASL) using turbo spin echo with a pseudo-steady-state (PSS) readout in comparison with the other major readout methods of 3D spiral and 2D echo-planar imaging (EPI). 3D-PSS produced cerebral blood flow (CBF) values well correlated to those of the 3D spiral readout. By visual evaluation, the image quality of 3D-PSS pCASL was superior to that of 2D-EPI. The 3D-PSS technique was suggested useful as pCASL readout.
October 12, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/30316655/advantages-of-performing-mentoplasties-with-customized-guides-and-plates-generated-with-3d-planning-and-printing-results-from-a-series-of-23-cases
#16
Antoni Arcas, Gerard Vendrell, Frank Cuesta, Laura Bermejo
PURPOSE: To evaluate the benefits of performing mentoplasty using custom guides and plates in a series of 23 patients. PATIENTS AND METHODS: An 18-month observational study in 23 patients (16 women, 7 men) who underwent procedures for chin augmentation (n = 15), reduction and centering mentoplasty (n = 6), chin asymmetry correction (n = 1) and placement of a custom chin implant to correct esthetics (n = 1) was conducted in the Department of Oral and Maxillofacial Surgery of Hospital Universitario Dexeus (Barcelona, Spain)...
September 21, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/30316446/virginity-sparing-management-of-blind-hemivagina-in-obstructed-hemivagina-and-ipsilateral-renal-anomaly-syndrome
#17
Artur Ludwin, Inga Ludwin, Bala Bhagavath, Wellington P Martins, Steven R Lindheim
OBJECTIVES: To demonstrate the hymen-sparing management of a blind hemivagina in obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with the use of transrectal ultrasound (TRUS)-guided vaginoscopic septoplasty supported by pre- and postoperative diagnostics with the use of a novel ultrasound technique: 3-dimensional saline-solution infusion contrast sonovaginocervicography (3D-SVC) with virtual speculoscopy. DESIGN: Video presentation of surgical and ultrasound techniques...
October 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/30316112/precision-implantation-with-positional-confirmation-of-fine-wire-emg-electrodes-in-the-deep-posterior-neck-muscles
#18
Tim J L Raven, Lise R Lothe, Gunnar Sandbæk, Torsten Eken
Precise electrode placement is essential for obtaining useful electromyographic (EMG) recordings. Our aim was to develop a protocol for computerized-tomography (CT) guided fine-wire (FW) electrode placement that permits confirmation of the final electrode position in the deep posterior cervical multifidus (CM). FW-EMG electrodes were custom-made from three 50-µm diameter Teflon-insulated platinum/iridium wires. The electrodes were inserted bilaterally in the CM in 15 healthy adult subjects through a 45-mm cannula under CT guidance...
October 6, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/30315096/microtubule-structure-by-cryo-em-snapshots-of-dynamic-instability
#19
REVIEW
Szymon W Manka, Carolyn A Moores
The development of cryo-electron microscopy (cryo-EM) allowed microtubules to be captured in their solution-like state, enabling decades of insight into their dynamic mechanisms and interactions with binding partners. Cryo-EM micrographs provide 2D visualization of microtubules, and these 2D images can also be used to reconstruct the 3D structure of the polymer and any associated binding partners. In this way, the binding sites for numerous components of the microtubule cytoskeleton-including motor domains from many kinesin motors, and the microtubule-binding domains of dynein motors and an expanding collection of microtubule associated proteins-have been determined...
October 12, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/30312272/additional-sacroplasty-does-not-improve-clinical-outcome-in-minimal-invasive-navigation-assisted-screw-fixation-procedures-for-non-displaced-insufficiency-fractures-of-the-sacrum
#20
Horst Balling
STUDY DESIGN: Prospective single-center cohort study (non-inferiority study). OBJECTIVE: To compare clinical results of navigation-assisted screw fixation (NSF) to those of NSF with additional sacroplasty (NSF+SP) for immobilizing non-displaced insufficiency fractures of the sacrum. SUMMARY OF BACKGROUND DATA: Navigation-assisted screw fixation for sacral insufficiency fractures is a new, technically demanding procedure requiring surgical skills and experience...
October 11, 2018: Spine
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