keyword
https://read.qxmd.com/read/38513688/prevalence-of-occupational-co-exposure-to-biomechanical-factors-and-neurotoxic-chemicals-in-french-workers
#21
JOURNAL ARTICLE
Julie Bodin, Jessica Babin, Mélanie Bertin, Nathalie Bonvallot, Yves Roquelaure
OBJECTIVES: Little is known about occupational co-exposure. The objective was to assess the prevalence of exposure and co-exposure to biomechanical factors and neurotoxic chemicals in French workers in 2017. METHODS: Data from the French representative survey SUMER 2017 (SUrveillance Médicale des Expositions aux Risques professionnels) were analyzed. A total of 25 118 workers were included. Exposure to 4 biomechanical factors (manual handling of loads, forceful joint exertion, repetitive movements, and hand-arm transmitted vibrations) and 18 neurotoxic chemicals (n-hexane, perchloroethylene, trichloroethylene, etc...
March 21, 2024: Annals of Work Exposures and Health
https://read.qxmd.com/read/38513420/synergistic-utility-of-nbd-cl-fluorogenic-loading-activity-and-salting-out-assisted-liquid-liquid-extraction-as-sample-pretreatment-in-rasagiline-tracking-in-different-matrices
#22
JOURNAL ARTICLE
Ahmed A Abu-Hassan, Bassam Shaaban Mohammed, Wael A Mahdi, Sultan Alshehri, Mohamed A El Hamd
A typical drug used to treat Parkinson's disease is called rasagiline. It belongs to an assortment of drugs known as monoamine oxidase inhibitors, which function by raising dopamine levels in the brain. This work created a unique spectrofluorimetric method for the analytical assay of rasagiline for the first time. The approach utilized the synergistic utility of the fluorogenic properties of benzofurazan and salting-out assisted liquid-liquid extraction. By combining these techniques an ultrasensitive, and highly selective methodology for the assay of rasagiline was established...
March 16, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38513407/z-scheme-heterojunction-photocatalyst-formed-by-mof-derived-c-tio-2-and-bi-2-wo-6-for-enhancing-degradation-of-oxytetracycline-mechanistic-insights-and-toxicity-evaluation-in-the-presence-of-a-single-active-species
#23
JOURNAL ARTICLE
Jianhui Shi, Ting Zhao, Tiantian Yang, Kaikai Pu, Jiating Shi, Aijuan Zhou, Houfen Li, Sufang Wang, Jinbo Xue
In the work, Bi2 WO6 /C-TiO2 photocatalyst was successfully synthesized for the first time by loading narrow bandgap semiconductor Bi2 WO6 on MOF-derived carboxyl modified TiO2 . The phase structure, morphology, photoelectric properties, surface chemical states and photocatalytic performance of the prepared photocatalysts were systematically investigated using various characterization tools. The degradation efficiency of oxytetracycline by 6BT Z-scheme heterojunction photocatalyst under visible light could reach 93...
March 15, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38513312/mechanical-properties-of-clot-made-from-human-and-bovine-whole-blood-differ-significantly
#24
JOURNAL ARTICLE
Gabriella P Sugerman, Grace N Bechtel, Zuzanna Malinowska, Sapun H Parekh, Manuel K Rausch
Thromboembolism - that is, clot formation and the subsequent fragmentation of clot - is a leading cause of death worldwide. Clots' mechanical properties are critical determinants of both the embolization process and the pathophysiological consequences thereof. Thus, understanding and quantifying the mechanical properties of clots is important to our ability to treat and prevent thromboembolic disease. However, assessing these properties from in vivo clots is experimentally challenging. Therefore, we and others have turned to studying in vitro clot mimics instead...
March 15, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38508339/preparation-characterization-and-in-vitro-evaluation-of-insulin-phbv-nanoparticles-alginate-hydrogel-composite-system-for-prolonged-delivery-of-insulin
#25
JOURNAL ARTICLE
Samane Bayrami, Mehdi Chamani, SaeidReza JamaliMoghadamSiahkali, SeyedAhmad SeyedAlinaghi, Leila Rezaie Shirmard, Sepide Bayrami, Hamid Akbari Javar, Mohammad Hossein Ghahremani, Mohsen Amini, Morteza Rafiee Tehrani, Shadab Shahsavari, Farid Abedin Dorkoosh
PURPOSE: In the present study, biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) containing insulin were loaded in sodium alginate/jeffamine (ALG/jeff) hydrogel for prolonged delivery of insulin. The main aim of this work was to fabricate an efficient insulin delivery system to improve patient adherence by decreasing the repetition of injections. METHODS: Swelling and morphological properties and crosslinking efficiency of ALG/jeff hydrogel were assessed...
March 18, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38506805/artificial-intelligence-generated-draft-replies-to-patient-inbox-messages
#26
JOURNAL ARTICLE
Patricia Garcia, Stephen P Ma, Shreya Shah, Margaret Smith, Yejin Jeong, Anna Devon-Sand, Ming Tai-Seale, Kevin Takazawa, Danyelle Clutter, Kyle Vogt, Carlene Lugtu, Matthew Rojo, Steven Lin, Tait Shanafelt, Michael A Pfeffer, Christopher Sharp
IMPORTANCE: The emergence and promise of generative artificial intelligence (AI) represent a turning point for health care. Rigorous evaluation of generative AI deployment in clinical practice is needed to inform strategic decision-making. OBJECTIVE: To evaluate the implementation of a large language model used to draft responses to patient messages in the electronic inbox. DESIGN, SETTING, AND PARTICIPANTS: A 5-week, prospective, single-group quality improvement study was conducted from July 10 through August 13, 2023, at a single academic medical center (Stanford Health Care)...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38503185/metamodeling-based-reliability-analysis-framework-for-activated-sludge-processes
#27
JOURNAL ARTICLE
R A Borobio-Castillo, J M Cabrera-Miranda, B Corona-Vásquez
The reliability of activated sludge processes will be adversely affected by alterations in wastewater production and pollutant loading foreseen due to population growth, urbanization, and climate change, as well as the tendency to amend environmental regulations to mandate stricter effluent quality standards to alleviate water pollution. Until now, there was no framework capable of effectively managing these multifaceted challenges in reliability analysis. Previous attempts conducted a low number of simulations leading to insufficient statistical significance to properly validate reliability quantification...
March 9, 2024: Water Research
https://read.qxmd.com/read/38500763/effect-of-aromatic-substituents-on-thermoresponsive-functional-polycaprolactone-micellar-carriers-for-doxorubicin-delivery
#28
JOURNAL ARTICLE
Hanghang Wang, Himanshu Polara, Abhi Bhadran, Tejas Shah, Godwin Kweku Babanyinah, Ziyuan Ma, Erika L Calubaquib, Justin T Miller, Michael C Biewer, Mihaela C Stefan
Amphiphilic functional polycaprolactone (PCL) diblock copolymers are excellent candidates for micellar drug delivery. The functional groups on the backbone significantly affect the properties of PCL. A systematic investigation of the effect of aromatic substituents on the self-assembly of γ-functionalized PCLs and the delivery of doxorubicin (DOX) is presented in this work. Three thermoresponsive amphiphilic diblock copolymers with poly(γ-benzyloxy-ε-caprolactone) (PBnCL), poly(γ-phenyl- ε-caprolactone) (PPhCL), poly(γ-(4-ethoxyphenyl)-ε-caprolactone) (PEtOPhCL), respectively, as hydrophobic block and γ-tri(ethylene glycol) functionalized PCL (PME3 CL) as hydrophilic block were prepared through ring-opening polymerization (ROP)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38496278/work-ability-index-psychometric-testing-in-aeronautical-industry-workers
#29
JOURNAL ARTICLE
María Eugenia González-Domínguez, Elena Fernández-García, Olga Paloma-Castro, Regina María González-López, María Paz Rivas Pérez, Luis López-Molina, Jesús García-Jiménez, José Manuel Romero-Sánchez
BACKGROUND: The Work Ability Index (WAI) is an instrument that measures work ability. The wide dispersion of the WAI internationally has led to its adaptation for use in different countries. This study aimed to evaluate the psychometric properties of the Spanish version of the WAI. METHODS: A methodological design was used over an opportunistic sample of 233 workers in the aeronautical industry in Spain. Reliability was evaluated through internal consistency. Factorial validity, known groups, and convergent validity were tested...
March 2024: Safety and Health At Work
https://read.qxmd.com/read/38494981/the-use-of-cognitive-load-theory-to-assist-in-the-teaching-of-electrocardiogram-interpretation-within-paramedical-science-education
#30
JOURNAL ARTICLE
Marc Gildas Thomas
BACKGROUND: Paramedics are expected to record electrocardiograms (ECGs) as part of their clinical assessment; however, it is an extremely difficult skill to learn and understand as it has a high intrinsic cognitive load which can also be challenging to teach effectively. AIMS: This article will explore the use of cognitive load theory to assist in the teaching of ECG interpretation within the context of paramedical education. DESCRIPTION: Cognitive load theory can be useful to aid teaching within complex medical and health science domains including clinical skills teaching...
March 18, 2024: Clinical Teacher
https://read.qxmd.com/read/38493843/enhancing-oral-bioavailability-of-an-antifungal-thiazolylhydrazone-derivative-development-and-characterization-of-a-self-emulsifying-drug-delivery-system
#31
JOURNAL ARTICLE
Iara Rinco Silva, Mateus Araújo Castro E Souza, Renes Resende Machado, Renata Barbosa de Oliveira, Elaine Amaral Leite, Isabela da Costa César
RN104 (2-[2-(cyclohexylmethylene)hydrazinyl)]-4-phenylthiazole) is a thiazolylhydrazone derivative with prominent antifungal activity. This work aimed to develop a self-emulsifying drug delivery system (SEDDS) loaded with RN104 to improve its biopharmaceutical properties and enhance its oral bioavailability. Medium chain triglycerides, sorbitan monooleate, and polysorbate 80 were selected as components for the SEDDS formulation based on solubility determination and a pseudo-ternary phase diagram. The formulation was optimized using the central composite design in response surface methodology...
March 15, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38493753/drug-deconjugation-assisted-peptide-mapping-by-lc-ms-ms-to-identify-conjugation-sites-and-quantify-site-occupancy-for-antibody-drug-conjugates
#32
JOURNAL ARTICLE
Tongdan Wang, Zi-Ao Huang, Moyin Zhou, Ruxin Wang, Yufei Li, Longyun Guo, Xiaolin Cao, Jincui Huang
Antibody-drug conjugates (ADCs) are a heterogeneous mixture of conjugated species with varied drug loadings. Depending on conjugation sites, linkers and drugs can exhibit different stability as influenced by the solvent-accessibility and local charge, resulting in different ADC efficacy, pharmacokinetics, and toxicity. Conjugation site analysis is critical for ADC structural characterization to assure product quality and consistency. It enables early conjugation studies at site-specific levels, confirms the absence of unexpected products to support conjugation process development, and aids in ensuring lot-to-lot consistency for comparability studies...
March 7, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38492754/enhanced-visible-light-driven-photodegradation-of-rifampicin-and-cr-vi-reduction-activity-of-ultra-thin-zno-nanosheets-cuco-2-s-4-qds-a-mechanistic-insights-degradation-pathway-and-toxicity-assessment
#33
JOURNAL ARTICLE
S Sudheer Khan, S Kokilavani, Tahani Awad Alahmadi, Mohammad Javed Ansari
In this study, we focused on fabrication of porous ultra-thin ZnO nanosheet (PUNs)/CuCo2 S4 quantum dots (CCS QDs) for visible light driven photodegradation of rifampicin (RIF) and Cr(VI) reduction. The morphology, structural, optical and textural properties of fabricated photocatalyst were critically analyzed with different analytical and spectroscopic techniques. An exceptionally high RIF degradation (99.97%) and maximum hexavalent Cr(VI) reduction (96.17%) under visible light was achieved at 10 wt% CCS QDs loading on ZnO, which is 213% and 517% greater than ZnO PUNs...
March 14, 2024: Environmental Pollution
https://read.qxmd.com/read/38492527/the-role-of-visual-conditions-and-aircraft-type-on-different-aspects-of-pilot-workload
#34
JOURNAL ARTICLE
Marcin Piotr Biernacki, Rafał Lewkowicz
OBJECTIVE: The objective of our work was to assess the impact of flight conditions by aircraft type on the workload estimated using NASA-Task Load Index (NASA-TLX). BACKGROUND: Learning about subjective workload is important for assessing the impact of a pilot's work environment on their performance in the cockpit. This is an important element of flight safety and includes the prevention of aviation accidents. METHODS: The study included 146 military pilots that fly the following aircrafts: flying fast-jet (21), fixed-wing (24), and rotary-wing (101)...
March 15, 2024: Applied Ergonomics
https://read.qxmd.com/read/38483209/hip-osteoarthritis-and-occupational-mechanical-exposures-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Alexander Jahn, Johan Hviid Andersen, Andreas Seidler, David Høyrup Christiansen, Annett Dalbøge
OBJECTIVES: The aim was to conduct a systematic review and meta-analysis investigating the association between occupational mechanical exposures and hip osteoarthritis. METHODS: The study was registered in PROSPERO. A systematic literature search was conducted in six databases to identify relevant articles. Two authors independently excluded articles, extracted data, assessed the risk of bias of each included article, and graded the level of evidence. We conducted a meta-analysis using random-effects model and performed a sensitivity analysis stratifying articles based on the risk of bias assessment, study design, and the outcome measurement...
March 14, 2024: Scandinavian Journal of Work, Environment & Health
https://read.qxmd.com/read/38482628/deformable-vesicles-with-edge-activators-for-the-transdermal-delivery-of-non-psychoactive-cannabinoids
#36
JOURNAL ARTICLE
Elisa Vettorato, Marisa Fiordelisi, Silvia Ferro, Desirè Zanin, Erica Franceschinis, Giovanni Marzaro, Nicola Realdon
BACKGROUND: Transdermal delivery of highly lipophilic molecules is challenging due to the strong barrier function of the skin. Vesicles with penetration enhancers are safe and efficient systems that could improve the transdermal delivery of non-psychoactive cannabinoids such as cannabidiol and desoxy-cannabidiol. In the last decades, research interest in desoxy-cannabidiol as a potent drug with anti-nociceptive properties has risen. Still, its scarce market availability poses a limit for both research and clinical applications...
March 12, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38475937/pemetrexed-loaded-gold-nanoparticles-as-cytotoxic-and-apoptosis-inducers-in-lung-cancer-cells-through-ros-generation-and-mitochondrial-dysfunction-pathway
#37
JOURNAL ARTICLE
Baby Shakila P, Tamilmani Periasamy, Abdullah A Alarfaj, Palanisamy Arulselvan, Rajeswari Ravindran, Jagadeesh Suriyaprakash, Indumathi Thangavelu
Supramolecular nanoparticles containing peptides and drugs have recently gained recognition as an effective tumor treatment drug delivery system. A multitarget drug termed pemetrexed is effective against various cancers, including nonsmall cell lung cancer. The work aims to establish the capability of pemetrexed gold nanoparticles (PEM-AuNPs) to induce apoptosis and explore molecular changes. X-ray diffraction, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, scanning electron microscope, and transmission electron microscope were used to investigate the synthesized nanoparticles...
March 12, 2024: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/38475116/assessing-sensor-integrity-for-nuclear-waste-monitoring-using-graph-neural-networks
#38
JOURNAL ARTICLE
Pierre Hembert, Chady Ghnatios, Julien Cotton, Francisco Chinesta
A deep geological repository for radioactive waste, such as Andra's Cigéo project, requires long-term (persistent) monitoring. To achieve this goal, data from a network of sensors are acquired. This network is subject to deterioration over time due to environmental effects (radioactivity, mechanical deterioration of the cell, etc.), and it is paramount to assess each sensor's integrity and ensure data consistency to enable the precise monitoring of the facilities. Graph neural networks (GNNs) are suitable for detecting faulty sensors in complex networks because they accurately depict physical phenomena that occur in a system and take the sensor network's local structure into consideration in the predictions...
February 29, 2024: Sensors
https://read.qxmd.com/read/38474980/biomechanical-effects-of-using-a-passive-exoskeleton-for-the-upper-limb-in-industrial-manufacturing-activities-a-pilot-study
#39
JOURNAL ARTICLE
Armando Coccia, Edda Maria Capodaglio, Federica Amitrano, Vittorio Gabba, Monica Panigazzi, Gaetano Pagano, Giovanni D'Addio
This study investigates the biomechanical impact of a passive Arm-Support Exoskeleton (ASE) on workers in wool textile processing. Eight workers, equipped with surface electrodes for electromyography (EMG) recording, performed three industrial tasks, with and without the exoskeleton. All tasks were performed in an upright stance involving repetitive upper limbs actions and overhead work, each presenting different physical demands in terms of cycle duration, load handling and percentage of cycle time with shoulder flexion over 80°...
February 23, 2024: Sensors
https://read.qxmd.com/read/38474976/exploring-the-beam-squint-effects-on-reflectarray-performance-a-comprehensive-analysis-of-the-specular-and-scattered-reflection-of-the-unit-cell
#40
JOURNAL ARTICLE
Manzoor Elahi, Amir Altaf, Slawomir Koziel, Anna Pietrenko-Dabrowska
In this article, the phenomena of beam deviation in reflectarray is discussed. The radiation pattern of the unit cell, which plays a vital role in shaping the beam of the reflectarray, is analyzed by considering undesired specular and scattered reflections. These unwanted reflections adversely affect the pattern of the single unit cell, thereby reducing the overall performance of the reflectarray. To conduct our investigations, three cases of reflectarray-i.e., (i) a center-fed with broadside beam (Case-I), (ii) a center-fed with the beam at 30° (Case-II), and (iii) off-center-fed with the beam at 30° reciprocal to feed position with reference to the broadside direction (Case-III)-are simulated...
February 23, 2024: Sensors
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