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Ketone body

Hongjie Yi, Shichong Yu, Yanan Zhang, Runping Li, Dazhi Zhang, Dazhi Zhang, Weigang Xu
BACKGROUND: Recent studies indicated that ketone ester R,S-1,3-butanediol acetoacetate diester (BD-AcAc2 ) may be effective in preventing central nervous system oxygen toxicity (CNS-OT) and concomitant acute lung injury, a serious medical problem to be faced when breathing hyperbaric oxygen (HBO). This study aimed to further investigate the protective effects of BD-AcAc2 against CNS-OT and concomitant acute lung injury (ALI) in mice. METHODS: Mice were treated with BD-AcAc2 in peanut oil vehicle (2...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
D Marakushyn, I Karmazina, I Isaeva, N Hloba
The study was conducted as a part of research work "Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors". The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings...
October 2018: Georgian Medical News
Hae-Ryeon Choi, Jinmin Kim, Hyojung Lim, Yoo Kyoung Park
The ketogenic diet has long been recommended in patients with neurological disorders, and its protective effects on the cardiovascular system are of growing research interest. This study aimed to investigate the effects of two-week of low-calorie ketogenic nutrition drinks in obese adults. Subjects were randomized to consume drinks either a ketone-to-non-ketone ratio of 4:1 (KD 4:1), a drink partially complemented with protein at 1.7:1 (KD 1.7:1), or a balanced nutrition drink (BD). Changes in body weight, body composition, blood lipid profile, and blood ketone bodies were investigated...
December 3, 2018: Nutrients
Georgios Velonakis, Dimitrios Filippiadis, Stavros Spiliopoulos, Elias Brountzos, Nikolaos Kelekis, Alexis Kelekis
OBJECTIVES: The purposes of the study were to evaluate the safety and long-term efficacy of augmented vertebroplasty using a polyether ether ketone (PEEK) implant, for the treatment of lumbar or thoracic vertebral fractures (A2 according to the Magerl's AO classification) and to analyze pain reduction, height restoration, and complications during a 2-year follow-up period. METHODS: Prospective non-randomized evaluation was performed for 21 painful split vertebral fractures (20 patients, 14 females, 6 males; mean age 72...
December 3, 2018: European Radiology
Zhai Li, Jia Yulei, Ji Yaqing, Zou Jinmin, Liu Xinyong, Gao Jing, Liu Min
The aim of our study was to investigate the effects of a new synthetic compound (E) -1- (E) -1- (2- hydroxy -5- chlorophenyl) -3- (3, 5, 6- three methyl pyrazine -2- based) -2- propylene -1 ketone, Z-11, a tetramethylpyrazine analogue, on cerebral ischemia reperfusion injury and the underlying mechanism. 240~260g adult male Wistar rats were subjected to middle cerebral artery occlusion for 2h, followed by 22h of reperfusion. Z-11 (1.7, 3.4 and 6.8mg/kg, i.p.), Edaravone (3mg/kg, i.p.) and DMSO (1‰, i.p.) was administered at 2h after the onset of ischemia...
November 28, 2018: European Journal of Pharmacology
Azam Shakery, Katayoun Pourvali, Arman Ghorbani, Samira Sadat Fereidani, Hamid Zand
Background: Beta-hydroxybutyrate (BHB) as a ketone body is the metabolic fuel in oxidative phosphorylation pathway. So far the effects of BHB on the biology of tumor cells is contradictory. Therefore, we investigated the effect of BHB on viability, metabolism, proliferation and migration of 5FU treated SW480 colon cancer cell line. Methods: we treated the SW480 cells with IC50 dose of 5-fluorouracil (5FU) for 72 h to isolate a subpopulation of 5FU treated cells that were resistant to it. Effects of BHB on cell viability was investigated by MTT assay...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Brandon A Francis, Jennifer Fillenworth, Philip Gorelick, Kristina Karanec, Adriana Tanner
BACKGROUND: Status, refractory status and super refractory status epilepticus are common neurologic emergencies. The objective of this study is to investigate the feasibility, safety and effectiveness of a ketogenic diet (KD) for refractory status epilepticus (RSE) in adults in the intensive care unit (ICU). METHODS: We performed a retrospective, single-center study of patients between ages 18 and 80 years with RSE treated with a KD treatment algorithm from November 2016 through April 2018...
November 27, 2018: Neurocritical Care
Juan Wang, Meixiang Zhang, Zhenzhen Liu, Xiujie Wang, Yuanxin Pang, Ye Lu, Zhengqing Liu
BACKGROUND: To observe the clinical features of type 2 diabetes mellitus (T2DM) patients with ketosis as the initial symptom, and investigate its differences from clinical features of non-ketotic T2DM patients. METHODS: A total of 385 T2DM patients treated in our hospital from 2014 to 2017 were selected and divided into ketosis-prone T2DM group and non-ketotic T2DM group. Ketosis-prone T2DM patients refer to DM patients with the urine ketone body++ or above or the blood ketone body ≥1...
November 26, 2018: Minerva Endocrinologica
Yiwei Zhu, Guowen Liu, Xiliang Du, Zhen Shi, Meiyu Jin, Xueying Sha, Xiaobing Li, Zhe Wang, Xinwei Li
Dairy cows with ketosis are characterized by high blood concentrations of ketone bodies and hepatic lipid metabolism disorder. The discrepancies in the abundance of mRNA encoding a variety of hepatic candidate genes in varying degrees of ketotic cows represent specific responses of the liver to the challenge of fatty acids and ketone bodies. Importantly, the expression disorder of hepatic genes involved in lipid metabolism plays a promoting role in the onset and progression of ketosis. Thus, the aim of this study was to investigate the expression patterns of genes involved in the hepatic fatty acids uptake, transport, activation, β-oxidation, synthesis, and esterification in the cows with subclinical ketosis (SCK) or clinical ketosis (CK)...
November 21, 2018: Journal of Dairy Science
Shaoxia Pu, Kento Usuda, Kentaro Nagaoka, Gen Watanabe
High temperature induces various metabolic disturbances in animals. However, no comprehensive information is currently available on the metabolic pathway affected by high environmental temperature. The present study examined metabolite content in the serum of heat challenged quails using metabolomic analysis. In the present study, female quails with normal laying rate at 20 weeks kept in standard condition (control group) or exposed to 34°C 4 hr per day (12:00 hr to 16:00 hr) (heat group) for 10 consecutive days...
November 22, 2018: Journal of Veterinary Medical Science
Shunqin Zhu, Zhen Dong, Xiaoxue Ke, Jianbing Hou, Erhu Zhao, Kui Zhang, Feng Wang, Liqun Yang, Zhonghuai Xiang, Hongjuan Cui
Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying has not been fully elucidated. As a family of NAD+ dependent protein modifying enzyme, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase depalmitoylase, and/or mono-ADP-ribosyltransferase, and play important roles in regulating cell metabolism, especially in glucose and lipid metabolism, thereby exerting complex functions in either increasing or decreasing malignant characteristics in tumors...
November 16, 2018: Seminars in Cancer Biology
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, David Cameron-Smith, Maxim S Petrov
CONTEXT: Levels of ketone bodies are altered in both acute pancreatitis and type 1 and type 2 diabetes. However, the role of ketone bodies in the pathogenesis of abnormal glucose metabolism after pancreatitis is largely unknown. OBJECTIVE: To investigate the associations between ketone bodies and glucose homeostasis in individuals with post-pancreatitis prediabetes (PPP) versus normoglycaemia after pancreatitis (NAP). METHODS: Fasting blood samples were analysed for acetoacetate, β-hydroxybutyrate, and markers of glucose metabolism at a median of 26 months after acute pancreatitis...
November 19, 2018: Archives of Physiology and Biochemistry
Patrycja Puchalska, Shannon E Martin, Xiaojing Huang, Justin E Lengfeld, Bence Daniel, Mark J Graham, Xianlin Han, Laszlo Nagy, Gary J Patti, Peter A Crawford
Metabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue macrophage function remain unresolved. Here we apply a stable isotope tracing, mass spectrometry-based untargeted metabolomics approach to reveal the metabolome penetrated by hepatocyte-derived glucose and ketone bodies. In both classically and alternatively polarized macrophages, [13 C]acetoacetate (AcAc) labeled ∼200 chemical features, but its reduced form D-[13 C]β-hydroxybutyrate (D-βOHB) labeled almost none...
November 12, 2018: Cell Metabolism
Juliano Rodrigues Sangalli, Rafael Vilar Sampaio, Maite Del Collado, Juliano Coelho da Silveira, Tiago Henrique Camara De Bem, Felipe Perecin, Lawrence Charles Smith, Flávio Vieira Meirelles
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
November 16, 2018: Scientific Reports
Vasim Khan, Sumit Sharma, Uma Bhandari, Nishtha Sharma, Vikas Rishi, Syed Ehtaishamul Haque
The peroxisome proliferator-activated receptor-α (PPAR-α) controls the lipid and glucose metabolism and also affects inflammation, cell proliferation and apoptosis during cardiovascular disease. Raspberry ketone (RK) is a red raspberry (Rubusidaeus, Family-Rosaceae) plant constituent, which activates PPAR-α. This study was conducted to assess the cardioprotective action of RK against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups (six rats/group). Rats were orally administered with RK (50, 100 and 200 mg/kg, respectively) and fenofibrate (standard, 80 mg/kg) for 28 days and ISO was administered (85 mg/kg, subcutaneously) on 27th and 28th day...
October 26, 2018: European Journal of Pharmacology
Simon J Park, Chase P Smith, Ryan R Wilbur, Charles P Cain, Sankeerth R Kallu, Srijan Valasapalli, Arpit Sahoo, Maheedhara R Guda, Andrew J Tsung, Kiran K Velpula
Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins encoded by the SLC16 gene family found ubiquitously across mammalian species. Two members of this family, MCT1 and MCT4, have been linked to key roles in the metabolic activity of tissues through the proton-coupled transport of monocarboxylates, most notably L-lactate, ketone bodies, and pyruvate. This review aims to provide an overview of MCT1 and MCT4, followed by the implications of their expression in a multitude of cancers and in glioblastoma (GBM) specifically...
2018: American Journal of Cancer Research
Shahi Kiran, Fathiya Al Murshedi, Sheikha Al Jabri, Meka Nirmala Devi
BACKGROUND: Alpha-methylacetoacetic aciduria, an autosomal recessive disorder of isoleucine and ketone body metabolism, is caused by a mutation in the acetyl coenzyme A acetyltransferase-1 gene (ACAT1; 607809) on chromosome 11q22. Ketoacidotic episodes in such patients are triggered by stress situations with increased energy demands. Pregnancy, surgical procedures, and prolonged fasting are potential triggers for metabolic crisis in such cases. CASE: A young Rh-negative Omani woman with alpha-methylacetoacetic aciduria is described here during her second pregnancy...
November 5, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Jin Hee Kim, Minyoung Lee, Soo Hyun Kim, So Ra Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin Won Cho, Yong-Ho Lee
AIMS: Sodium-glucose transporter 2 inhibitors (SGLT2i), a new class of glucose-lowering medications for diabetes, increase serum ketone levels. Recent studies have reported that ketone has an anti-inflammatory function and extends longevity in animal models. However, the mechanisms by which various organs upregulate ketogenesis in response to SGLT2i have not been elucidated. We investigated SGLT2i-induced changes in ketogenic enzymes and transporters in normal and diabetic mice models...
November 8, 2018: Diabetes, Obesity & Metabolism
Ehsan Haghi, Mahmood Alimohammadi, Sahar Asadnejad, Fariba Razeghi, Parisa Sadighara
Nowadays, Melamine- containers is widely use to because of heat- resistant. Due to the effects of Melamine- on human health, constant and long-term usage of Melamine- containers can be a source of Melamine- exposure to human body. The objective of this research was to measure the levels of Melamine- migration from Melamine- ware-products into foods at different test conditions and Effect of food type and Time on it. Spectrophotometer UV/VIS method was used to detect the limits of Melamine- and the method was based on the in the complex of Melamine- formaldehyde and Uranin (a ketone group)...
December 2018: Data in Brief
Pengfei Wu, Guojun Dai, Fuxiang Chen, Lan Chen, Tao Zhang, Kaizhou Xie, Jinyu Wang, Genxi Zhang
Chicken is widely favored by consumers because of some unique features. The leg muscles occupy an important position in the market. However, the specific mechanism for regulating muscle growth speed is not clear. In this experiment, we used Jinghai yellow chickens with different body weights at 300 days as research subjects. The chickens were divided into fast- and slow-growing groups, and we collected leg muscles after slaughtering for use in RNA-seq. After comparing the two groups, 87 differentially expressed genes (DEGs) were identified (fold change ≥ 2 and FDR < 0...
2018: PloS One
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