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Advanced glycation endproduct

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https://www.readbyqxmd.com/read/30100446/naringenin-a-common-flavanone-inhibits-the-formation-of-ages-in-bread-and-attenuates-ages-induced-oxidative-stress-and-inflammation-in-raw264-7-cells
#1
Jing Teng, Yunlong Li, Wenzhe Yu, Yueliang Zhao, Xiaoqian Hu, Ning-Ping Tao, Mingfu Wang
Dietary flavonoids as popular food additives have attracted a wide range of research interests. Naringenin, a common flavanone, was evaluated of its impact on the formation of advanced glycation endproducts (AGEs) in bread crust. It was found that with the increase of naringenin content in bread (0.25-1% w/w), the formation of CML and total fluorescent AGEs were significantly inhibited (9.67-54.27% and 11.79-35.19%, respectively). In addition, the fortification with naringenin could also significantly inhibit the formation of acrylamide in bread crust, while enhancing the antioxidant and antibacterial activity of bread crumb without bringing undesirable changes to the bread quality attributes...
December 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/30094805/systemic-inflammation-changes-the-site-of-rage-expression-from-endothelial-cells-to-neurons-in-different-brain-areas
#2
Juciano Gasparotto, Camila Tiefensee Ribeiro, Helen Tais da Rosa-Silva, Rafael Calixto Bortolin, Thallita Kelly Rabelo, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Daniel Pens Gelain
The receptor for advanced glycation endproducts (RAGE) is a transmembrane, immunoglobulin-like receptor that interacts with a broad repertoire of extracellular ligands. RAGE belongs to a family of cell adhesion molecules and is considered a key receptor in the inflammation axis and a potential contributor to the neurodegeneration. The present study aimed to investigate the content and cell localization of RAGE in the brain of Wistar rats subjected to systemic inflammation induced by a single dose of lipopolysaccharide (LPS, 5 mg/kg, i...
August 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30047241/a-single-high-fat-meal-alters-human-soluble-rage-profiles-and-pbmc-rage-expression-with-no-effect-of-prior-aerobic-exercise
#3
Kelly N Z Fuller, Rudy J Valentine, Edwin R Miranda, Prabhakaran Kumar, Bellur S Prabhakar, Jacob M Haus
A high-fat diet can induce inflammation and metabolic diseases such as diabetes and atherosclerosis. The receptor for advanced glycation endproducts (RAGE) plays a critical role in metabolic disease pathophysiology and the soluble form of the receptor (sRAGE) can mitigate these effects. However, little is known about RAGE in the postprandial condition and the effect of exercise in this context. Thus, we aimed to determine the effects of a single high-fat meal (HFM) with and without prior exercise on peripheral blood mononuclear cell (PBMC) RAGE biology...
July 2018: Physiological Reports
https://www.readbyqxmd.com/read/30014221/structural-effects-of-methylglyoxal-glycation-a-study-on-the-model-protein-mnei
#4
Serena Leone, Jole Fonderico, Chiara Melchiorre, Andrea Carpentieri, Delia Picone
The reaction of free amino groups in proteins with reactive carbonyl species, known as glycation, leads to the formation of mixtures of products, collectively referred to as advanced glycation endproducts (AGEs). These compounds have been implicated in several important diseases, but their role in pathogenesis and clinical symptoms' development is still debated. Particularly, AGEs are often associated to the formation of amyloid deposits in conformational diseases, such as Alzheimer's and Parkinson's disease, and it has been suggested that they might influence the mechanisms and kinetics of protein aggregation...
July 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/30009284/phenolics-from-eugenia-jambolana-seeds-with-advanced-glycation-endproduct-formation-and-alpha-glucosidase-inhibitory-activities
#5
Feifei Liu, Hang Ma, Guihua Wang, Weixi Liu, Navindra P Seeram, Yu Mu, Yingjie Xu, Xueshi Huang, Liya Li
Published data suggest that dietary-derived phenolics exert beneficial effects against hyperglycemia-mediated diseases, such as diabetes, through inhibiting the formation of advanced glycation endproducts (AGEs) and carbohydrate hydrolyzing enzyme activities. In the course of our investigation on the edible berry, Eugenia jambolana (known as Jamun), 21 phenolics (1-21) were isolated and identified from its seeds. Among these, one compound (1) is new and eleven compounds (3, 6, 9-13, 17, and 19-21) are being reported from E...
July 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29977803/effect-of-a%C3%AE-protein-on-inhibiting-proliferation-and-promoting-apoptosis-of-retinal-pigment-epithelial-cells
#6
Zi Ye, Shou-Zhi He, Zhao-Hui Li
AIM: To identify the effect and regulatory mechanism of amyloid β (Aβ) protein on retinal pigment epithelial (RPE) cells in cell proliferation and apoptosis, and clarify Aβ role in the pathogenesis of age-related macular degeneration (AMD). METHODS: The model of Aβ25-35 protein cytotoxicity in RPE cell was successfully established to investigate the effect of Aβ protein on RPE cells in vitro . Based on Aβ protein, the specific inhibitors (HY-50682 or BAY11-7082) or activating agent (lipopolysaccharide) was used to analyze the regulatory mechanism of Aβ protein to RPE cells on cell proliferation and apoptosis by flow cytometry, real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay and dual-luciferase reporter gene assay...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29936054/traditional-medicines-used-by-q-eqchi-maya-to-treat-diabetic-symptoms-and-their-antiglycation-potential
#7
J Ferrier, A Saleem, A Carter Ramirez, R Liu, E Chen, T Pesek, V Cal, M Balick, J T Arnason
ETHNOPHARMACOLOGICAL RELEVANCE: Because of the recent increase in type 2 diabetes and the need for complementary treatments in remote communities in many parts of the world, we undertook a study of treatments for diabetic symptoms used by traditional Q'eqchi' Maya healers of Belize. We used quantitative ethnobotany to rank culturally important taxa and subsequent pharmacological and phytochemical studies to assess bioactivity. MATERIALS AND METHODS: Antidiabetic plants identified in field interviews with traditional healers were ranked by syndromic importance value (SIV) based on 15 symptoms of diabetes...
June 21, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29906314/gromwell-lithospermum-erythrorhizon-root-extract-protects-against-glycation-and-related-inflammatory-and-oxidative-stress-while-offering-uv-absorption-capability
#8
Kelly M Glynn, Penny Anderson, David J Fast, James Koedam, John F Rebhun, Rodney A Velliquette
Glycation and advanced glycation endproducts (AGE) damage skin which is compounded by AGE-induced oxidative stress and inflammation. Lip and facial skin could be susceptible to glycation damage as they are chronically stressed. As Gromwell (Lithospermum erythrorhizon) root (GR) has an extensive traditional medicine history that includes providing multiple skin benefits, our objective was to determine if GR extract and its base naphthoquinone, shikonin, might protect skin by inhibiting glycation, increasing oxidative defenses, suppressing inflammatory responses, and offering ultraviolet (UV) absorptive potential in lip and facial cosmetic matrices...
June 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29900561/rage-dependent-vcam-1-expression-in-the-lung-endothelium-mediates-il-33-induced-allergic-airway-inflammation
#9
Timothy N Perkins, Elizabeth A Oczypok, Pavle S Milutinovic, Regina E Dutz, Tim D Oury
BACKGROUND: The receptor for advanced glycation endproducts (RAGE) has been implicated as a critical molecule in the pathogenesis of experimental asthma/allergic airway inflammation (AAI). It has been previously shown that RAGE acts both upstream of interleukin-33 (IL-33) release and downstream of IL-33 release via RAGE-dependent IL-33 induced accumulation of type 2 innate lymphoid cells (ILC2s) in the lungs, which perpetuate type 2 inflammation and mucus metaplasia. However, the mechanism by which RAGE mediates downstream IL-33 induced type 2 inflammatory responses is unknown...
June 14, 2018: Allergy
https://www.readbyqxmd.com/read/29896433/apx3330-promotes-neurorestorative-effects-after-stroke-in-type-one-diabetic-rats
#10
Tao Yan, Poornima Venkat, Michael Chopp, Alex Zacharek, Peng Yu, Ruizhuo Ning, Xiaoxi Qiao, Mark R Kelley, Jieli Chen
APX3330 is a selective inhibitor of APE1/Ref-1 redox activity. In this study, we investigate the therapeutic effects and underlying mechanisms of APX3330 treatment in type one diabetes mellitus (T1DM) stroke rats. Adult male Wistar rats were induced with T1DM and subjected to transient middle cerebral artery occlusion (MCAo) and treated with either PBS or APX3330 (10mg/kg, oral gavage) starting at 24h after MCAo, and daily for 14 days. Rats were sacrificed at 14 days after MCAo and, blood brain barrier (BBB) permeability, ischemic lesion volume, immunohistochemistry, cell death assay, Western blot, real time PCR, and angiogenic ELISA array were performed...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29877948/inhibition-of-mir-25-aggravates-diabetic-peripheral-neuropathy
#11
Yanzhuo Zhang, Chunyu Song, Jing Liu, Yonghong Bi, Hao Li
The hyperglycemia-induced enhanced oxidative stress is a key factor of diabetic peripheral neuropathy implicated in the pathogenesis of diabetic neuropathy, and microRNA may be involved, playing promotion or protection roles. In this study, we aimed to investigate the function of miR-25 during the development of oxidative/nitrative stress and in subsequent neurological problems. We detected the oxidative stress effects and expression of miR-25 on sciatic nerves from db/db diabetic model mice and analyzed the expression of related genes by qPCR and Western blotting...
August 1, 2018: Neuroreport
https://www.readbyqxmd.com/read/29872802/steamed-bread-enriched-with-quercetin-as-an-antiglycative-food-product-its-quality-attributes-and-antioxidant-properties
#12
Jing Lin, Yuan Xin Gwyneth Tan, Lai Peng Leong, Weibiao Zhou
Quercetin, a natural antiglycative agent, was incorporated into steamed bread to produce a functional food that has high potential to lower the risk of diabetes. With the incorporation of quercetin at 1.20, 2.40, and 3.60%, the volume of steamed bread significantly decreased and the hardness of the crumb correspondingly increased with incremental quercetin content, while incorporation levels below 1.20% had no impact. Within this range of enrichment (1.2-3.6%), quercetin negatively affected the yeast activity with significantly less CO2 produced in dough during proofing...
June 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29851842/soluble-levels-of-receptor-for-advanced-glycation-endproducts-and-dysfunctional-high-density-lipoprotein-in-persons-infected-with-human-immunodeficiency-virus-actg-nwcs332
#13
Theodoros Kelesidis, Michelle A Kendall, Ann Danoff, Judith A Aberg, Judith S Currier, Ann Marie Schmidt
The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear. Both glycation and oxidation (HDLox) are major modifications of HDL that can alter its composition and function. Therefore, we explored the longitudinal association of HDLox with progression of glycation, as evaluated by measurement of circulating forms of receptor for AGE that predict morbidity (soluble Receptors for Advanced Glycation Endproducts [sRAGE], endogenous secretory Receptors for Advanced Glycation Endproducts [esRAGE]), in people with HIV-1 (PWH; HIV-1) and uninfected (HIV-1) individuals...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29806588/content-of-nitric-oxide-and-glycative-compounds-in-cured-meat-products-negative-impact-upon-health
#14
Ya-Chen Yang, Zhi-Hong Wang, Mei-Chin Yin
The content of nitric oxide (NO), 3-nitrotyrosine, advanced glycation endproducts (AGEs) and trans fatty acids (TFAs) in 16 kinds of cured meat products was examined. Results showed that NO and 3-nitrotyrosine levels were in the range of non-detectable to 4.6 μM/mg protein, and non-detectable to 0.49 nmol/mg protein, respectively. Carboxymethyllysine could be detected in 13 kinds of cured meat products; its content was in the range of 48-306 μg/100 g meat. Pentosidine was found in 14 kinds of meat products, in the range of 109-631 μg/100 g meat...
June 2018: BioMedicine
https://www.readbyqxmd.com/read/29803627/accumulation-of-advanced-glycation-endproducts-and-subclinical-inflammation-in-deep-tissues-of-adult-patients-with-and-without-diabetes
#15
Hang Hu, Hongfei Jiang, Liyan Zhu, Xiaodan Wu, Chunmao Han
OBJECTIVES: Advanced glycation endproducts (AGEs) play a key role in the development of foot complications in people with diabetes. Skin autofluorescence (AF) might noninvasively determine tissue accumulation of AGEs. This study evaluated the association between skin AF and AGE contents in the deep tissues of those with diabetes and the further consequences of such contents. METHODS: Between September 2014 and September 2015, we studied 33 patients, with and without diabetes, who had received lower-limb amputations...
January 10, 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29796842/srage-attenuates-angiotensin-ii-induced-cardiomyocyte-hypertrophy-by-inhibiting-rage-nf%C3%AE%C2%BAb-nlrp3-activation
#16
Soyeon Lim, Myung Eun Lee, Jisu Jeong, Jiye Lee, Soyoung Cho, Miran Seo, Sungha Park
OBJECTIVE AND DESIGN: The receptor for advanced glycation endproducts (RAGE) is an innate immunity receptor that has been implicated in the pathogenesis of atherosclerotic cardiovascular disease. However, the possibility that RAGE-mediated signaling is involved in angiotensin II (Ang II)-induced cardiac left ventricular hypertrophy has yet to be investigated. We therefore determined whether RAGE has a role in regulating pathological cardiac hypertrophy. MATERIALS AND SUBJECTS: Protein abundance was estimated using Western blotting and intracellular ROS level and phospho-p65 were detected using fluorescence microscopy...
August 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29796010/cxcr-4-expression-by-circulating-endothelial-progenitor-cells-and-sdf-1-serum-levels-are-elevated-in-septic-patients
#17
Christian Patry, Daniela Stamm, Christian Betzen, Burkhard Tönshoff, Benito A Yard, Grietje Ch Beck, Neysan Rafat
Background: Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clinical outcome. Methods: Peripheral blood mononuclear cells from septic patients ( n  = 30), ICU control patients ( n  = 11) and healthy volunteers ( n  = 15) were isolated by Ficoll density gradient centrifugation...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29794498/bone-health-in-type-1-diabetes
#18
Viral N Shah, R Dana Carpenter, Virginia L Ferguson, Ann V Schwartz
PURPOSE OF REVIEW: This article reviews recent publications on the effect of type 1 diabetes (T1D) on fracture risk, bone mineral density (BMD), bone structure, and bone tissue quality. Possible fracture prevention strategies for patients with T1D have also been reviewed. RECENT FINDINGS: T1D is associated with substantially elevated fracture risk and modestly low BMD at the femoral neck. However, BMD alone does not explain higher observed fracture risk in T1D. T1D also affects bone macro- and microstructure, characterized by thinner cortices and trabecular bone changes such as thinner and more widely spaced trabeculae...
August 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29782323/role-of-blood-brain-barrier-in-alzheimer-s-disease
#19
Zhiyou Cai, Pei-Feng Qiao, Cheng-Qun Wan, Min Cai, Nan-Kai Zhou, Qin Li
The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD). BBB is a highly selective semipermeable structural and chemical barrier which ensures a stable internal environment of the brain and prevents foreign objects invading the brain tissue. BBB dysfunction induces the failure of Aβ transport from brain to the peripheral circulation across the BBB. Especially, decreased levels of LRP-1 (low density lipoprotein receptor-related protein 1) and increased levels of RAGE (receptor for advanced glycation endproducts) at the BBB can cause the failure of Aβ transport...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29702605/advanced-glycation-endproducts-are-increased-in-the-animal-model-of-multiple-sclerosis-but-cannot-be-reduced-by-pyridoxamine-treatment-or-glyoxalase-1-overexpression
#20
Suzan Wetzels, Kristiaan Wouters, Toshio Miyata, Jean L J M Scheijen, Jerome J A Hendriks, Casper G Schalkwijk, Tim Vanmierlo
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS). The immune response in MS patients leads to the infiltration of immune cells in the CNS and their subsequent activation. Immune cell activation induces a switch towards glycolysis. During glycolysis, the dicarbonyl product methylglyoxal (MGO) is produced. MGO is a glycating agent that can rapidly form advanced glycation endproducts (AGEs). In turn, AGEs are able to induce inflammatory responses. The glyoxalase system is the endogenous defense system of the body to reduce the burden of MGO thereby reducing AGE formation...
April 27, 2018: International Journal of Molecular Sciences
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