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Anorexia Nervosa: The Diagnosis

Katarzyna Górowska-Kowolik, Agata Chobot, Jarosław Kwiecień
BACKGROUND: Anorexia nervosa (AN) concerns approximately up to 1.8% of the pediatric female population. One of the complications that can occur in the course of this disease is acute liver failure. This study's objective was to assess the usefulness of the 13 C labeled Methacetin Breath Test (MBT) in the diagnostics of the liver function in girls with eating disorders. METHODS: For the study 81 girls aged 12 to 17 years were recruited, including 41 patients with confirmed diagnosis of AN (mean age 14...
August 13, 2018: BMC Gastroenterology
Mariana Santos, Eva Osório, Sarah Finnegan, Matt Clarkson, Sertório Timóteo, Isabel Brandão, António Roma-Torres, Nick C Fox, António J Bastos-Leite
We aimed to determine whether variation in the body mass index (BMI)-a marker of anorexia nervosa (AN) severity-is associated with brain volume changes longitudinally estimated using registration-based methods on serial high-resolution T1-weighted magnetic resonance images (MRI). Fifteen female patients (mean age = 21 years; standard deviation [SD] = 5.7; range: 15-33 years) with the diagnosis of AN of the restricting type (AN-r)-according to the Diagnostic and Statistic Manual of Mental Disorders, 5th edition criteria-underwent T1-weighted MRI at baseline and after a mean follow-up period of 11 months (SD = 6...
July 9, 2018: Psychiatry research. Neuroimaging
Johnny Berona, Rebekah Richmond, Renee D Rienecke
Early response to treatment has been shown to predict good outcome in family-based treatment, but little is known about who responds quickly. OBJECTIVE: The purpose of the current study was to examine the short-term weight gain trajectories among youth receiving partial hospitalization program services for anorexia nervosa (AN), and to identify predictors of these trajectories. METHOD: Adolescent and young adults (n = 102) with AN or subthreshold AN completed semi-structured interviews and self-report measures on admission to a family-based partial hospitalization program...
July 29, 2018: International Journal of Eating Disorders
Neda Razaz, Sven Cnattingius
BACKGROUND: The etiology of anorexia nervosa is poorly understood. Although genetic factors play a major role, maternal factors, and obstetric complications are possible environmental causes. We investigated the association between maternal overweight and obesity in early pregnancy and risk of anorexia nervosa in daughters. METHODS: A retrospective cohort study including all live singleton females born in Sweden from 1992 through 2002. Anorexia nervosa diagnosis was identified by using the nation-wide Swedish Patient and Cause of Death Registers...
July 26, 2018: International Journal of Eating Disorders
Bronwyn C Raykos, David M Erceg-Hurn, Peter M McEvoy, Anthea Fursland, Glenn Waller
OBJECTIVE: The present study aimed to examine whether Anorexia Nervosa (AN) illness severity or duration is associated with retention or treatment response in outpatient, enhanced cognitive-behavioral therapy (CBT-E). METHOD: Patients with a confirmed AN diagnosis (N = 134) completed measures of eating disorder symptoms and quality of life, and had their BMI objectively measured before, during, and after treatment. We evaluated whether illness severity or duration predicted treatment outcomes, using longitudinal regression models...
August 2018: Journal of Consulting and Clinical Psychology
Mauro Bozzola, Elena Bozzola, Chiara Montalbano, Filomena Andreina Stamati, Pietro Ferrara, Alberto Villani
Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal maturation. A family history of the subject comprising the timing of puberty in the parents and physical examination may provide clues regarding the cause of DP. Delayed onset of puberty is rarely considered a disease in either sex. In fact, DP usually represents a common normal variant in pubertal timing, with favorable outcomes for final height and future reproductive capacity...
June 2018: Annals of Pediatric Endocrinology & Metabolism
Jason M Nagata, Jennifer L Carlson, Neville H Golden, Stuart B Murray, Jin Long, Mary B Leonard, Rebecka Peebles
OBJECTIVE: To identify the effect of duration of weight-bearing exercise and team sports participation on bone mineral density (BMD) and body composition among adolescents with anorexia nervosa (AN). METHOD: We retrospectively reviewed electronic medical records of all patients 9-20 years old with a DSM-5 diagnosis of AN evaluated by the Stanford Eating Disorders Program (1997-2011) who underwent dual-energy X-ray absorptiometry. RESULTS: A total of 188 adolescents with AN were included (178 females and 10 males)...
June 8, 2018: Eating and Weight Disorders: EWD
Bethan Dalton, Savani Bartholdy, Lauren Robinson, Marco Solmi, Mohammad A A Ibrahim, Gerome Breen, Ulrike Schmidt, Hubertus Himmerich
Cytokines are signalling molecules, which play an important role in both immune system function and brain development and function, and subsequently mental states and behaviour. Cytokines have been implicated in eating disorders (EDs) due to their role in psychological health, body weight and appetite regulation. This meta-analysis examined cross-sectional and longitudinal studies measuring concentrations of cytokines in individuals with EDs. Using PRISMA guidelines, we systematically reviewed relevant articles in PubMed, Web of Science, and MEDLINE...
August 2018: Journal of Psychiatric Research
Briana Sacco, Urszula Kelley
Recognizing eating disorders in the pediatric population can be challenging for outpatient providers. With the high prevalence of these disorders in children and adolescents, it is critical that pediatricians recognize these disorders and connect these children and families with available treatments. This article provides a review of the current diagnostic criteria for pica, rumination disorder, anorexia nervosa, bulimia nervosa, avoidant restrictive food intake disorder, binge-eating disorder, other specified feeding or eating disorder, and unspecified feeding or eating disorder as described in The Diagnostic and Statistical Manual of Mental Disorders, fifth edition...
June 1, 2018: Pediatric Annals
Karuna Mizusaki, Daniel Gih, Christina LaRosa, Rebekah Richmond, Renee D Rienecke
PURPOSE: To assess psychotropic use patterns and possible associations with age, eating disorder diagnosis and psychiatric comorbidity in adolescents and young adults with a primary eating disorder. METHODS: A retrospective chart review of 86 consecutive patients with a primary eating disorder from August 2012 to December 2014 was conducted. Patients presented for a multidisciplinary evaluation at a United States-based academic program for eating disorders. RESULTS: Nearly half (45...
June 7, 2018: Eating and Weight Disorders: EWD
Sinem Akgül, Ayfer Alikaşifoğlu, Alev Özon, Nazlı Gönç, Yasemin Düzçeker, Sine Örs, Orhan Derman, Nuray Kanbur
Background Adolescents with type 1 diabetes mellitus (T1DM) are at an increased risk of eating disturbances. The aim of this study was to evaluate whether the risk of a disordered eating behavior (DEB) also applies to the well sibling sharing the same environment. Methods Well siblings were included if they were 10-18 years old, had a sibling with a T1DM diagnosis for at least 6 months and lived with the sibling during the illness. The control group was comprised of healthy participants recruited from the outpatient clinic with no family history of T1DM...
July 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Tomoko Udo, Carlos M Grilo
BACKGROUND: Few population-based data on the prevalence of eating disorders exist, and such data are especially needed because of changes to diagnoses in the DSM-5. This study aimed to provide lifetime and 12-month prevalence estimates of DSM-5-defined anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED) from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. METHODS: A national sample of 36,306 U.S. adults completed structured diagnostic interviews (Alcohol Use Disorder and Associated Disabilities Interview Schedule-5)...
April 17, 2018: Biological Psychiatry
Jake Linardon, Andrea Phillipou, Richard Newton, Matthew Fuller-Tyszkiewicz, Zoe Jenkins, Leonardo L Cistullo, David Castle
Although empirical evidence identifies dietary restraint as a transdiagnostic eating disorder maintaining mechanism, the distinctiveness and significance of the different behavioural and cognitive components of dietary restraint are poorly understood. The present study examined the relative associations of the purportedly distinct dietary restraint components (intention to restrict, delayed eating, food avoidance, and diet rules) with measures of psychological distress (depression, anxiety, and stress), disability, and core eating disorder symptoms (overvaluation and binge eating) in patients with anorexia nervosa (AN) and bulimia nervosa (BN)...
September 1, 2018: Appetite
Masahiro Takeshima, Hiroyasu Ishikawa, Akihiro Kitadate, Ryo Sasaki, Takahiro Kobayashi, Hiroshi Nanjyo, Takashi Kanbayashi, Tetsuo Shimizu
BACKGROUND: Patients with anorexia nervosa (AN) often present with pancytopenia. In most cases described in the literature, AN with pancytopenia demonstrates gelatinous marrow transformation (GMT), which is a typical bone marrow feature of malnutrition. Differentiation of AN-associated pancytopenia from other types of pancytopenia, especially idiopathic aplastic anemia (IAA), has not been studied. We encountered a case of pancytopenia in a patient with AN and relatively poor nutritional status, whose hematological findings mimicked those of IAA, specifically fatty bone marrow and absence of GMT...
May 25, 2018: BMC Psychiatry
Hyoun S Kim, Kristin M von Ranson, David C Hodgins, Daniel S McGrath, Hermano Tavares
Preliminary evidence suggests that binge/purge type eating disorders and gambling disorder may commonly co-occur. However, this dual-diagnosis population remains understudied. The present research examined the prevalence rates and correlates of binge/purge type eating disorders (i.e., bulimia nervosa, binge-eating disorder, and anorexia nervosa binge/purge type) among adults seeking treatment for their gambling (N = 349). In total, 11.5% of the sample (n = 40) met criteria for a binge/purge type eating disorder, most commonly bulimia nervosa (n = 33)...
May 24, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
Aurélie Letranchant, Bénédicte Pigneur, Martine Flament, Nathalie Godart
Marine was a fourteen and a half-year-old adolescent female hospitalized for an eating disorder (ED) of the anorexic type with purging behaviors. She has had a complicated life course, made up of disruptions and discontinuities, both family and school. Since the age of five, Marine had been intermittently treated in psychiatry for a diagnosis of oppositional defiant disorder. The current illness started with spontaneous and induced vomiting associated with major weight loss (body mass index, 15.27 kg m-2 )...
May 17, 2018: Eating and Weight Disorders: EWD
Nadine P G Paans, Mariska Bot, Ingeborg A Brouwer, Marjolein Visser, Brenda W J H Penninx
Depression and body mass index (BMI) are known to be associated with body image, however, their independent or joint effects on body image in adults are largely unknown. Therefore, we studied associations of depression diagnosis, severity, and BMI with perceptual body size (PBS) and body image dissatisfaction (BID). Cross-sectional data from 882 remitted depressed patients, 242 currently depressed patients and 325 healthy controls from the Netherlands Study of Depression and Anxiety were used. Depressive disorders (DSM-IV based psychiatric interview), standardized self-reported depressive symptoms (Inventory of Depressive Symptomatology) and BMI were separately and simultaneously related to body image (the Stunkard Figure Rating scale) using linear regression analyses...
August 2018: Journal of Psychiatric Research
Emel Ataş Berksoy, Gonca Özyurt, Murat Anıl, Özlem Üzüm, Yeliz Çağan Appak
INTRODUCTION: this article examines a boy who was diagnosed with anorexia nervosa at eight years old. Pediatricians and family physicians encountered difficulties during the diagnosis and treatment stages due to the fact that early onset of the disease is rare. CASE REPORT: a boy aged eight years and four months presented with bradicardia, malnutrition and dehydration as far away from the preliminary diagnosis of anorexia nervosa investigated for possible organic pathologies at the pediatric ward...
February 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Maja Popovic, Costanza Pizzi, Franca Rusconi, Luigi Gagliardi, Claudia Galassi, Morena Trevisan, Franco Merletti, Lorenzo Richiardi
OBJECTIVE: This study evaluates associations of maternal eating disorders (bulimia nervosa, anorexia nervosa, and purging behaviors) with infant wheezing and examines the effects of eating disorders on several wheezing determinants. METHOD: We studied 5,150 singletons from the NINFEA birth cohort. Maternal bulimia nervosa and anorexia nervosa diagnoses were ascertained from the questionnaires completed in pregnancy and 6 months after delivery, and were analyzed as: ever diagnosis, only before pregnancy, and during pregnancy...
May 2, 2018: International Journal of Eating Disorders
Alessandro Leone, Miguel Ángel Martínez-González, Francisca Lahortiga-Ramos, Patricio Molero Santos, Simona Bertoli, Alberto Battezzati, Maira Bes-Rastrollo
OBJECTIVE: To our knowledge, no study has yet assessed the association between dietary patterns and incidence of eating disorders. This study aimed to assess the association between adherence to the Mediterranean dietary pattern (MDP) and incident risk of anorexia (AN) and bulimia nervosa (BN). METHODS: We conducted a prospective cohort study of 11 800 women from the Seguimiento Universidad de Navarra follow-up project. Participants were classified as having incident AN or BN if they were free of AN or BN at baseline and reported a physician-made diagnosis of AN or BN during the follow-up period...
March 21, 2018: Nutrition
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