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Christian Schubert, Carmen Hagen
This "integrative single-case study" investigated the bidirectional cause and effect relations between various emotional states (i.e., mood, irritation, mental activity) and urinary IL-6 levels in a 49-year-old female breast cancer survivor (woman) under conditions of "life as it is lived." During a period of 28 days, the patient collected her entire urine in 12-h intervals for IL-6 measurement and completed each morning and evening a list of adjectives regarding mood, irritation, and mental activity (55 measurements in total)...
2018: Frontiers in Neuroscience
Mravec Boris, Tibenský Miroslav, Horváthová Ľubica
BACKGROUND: Gallen observed that psychosocial factors influence tumor incidence. Findings of the last decades have enabled us to understand the mechanisms and pathways responsible for this influence. Ader, Solomon, Besedovsky, and other pioneers of psychoneuroimmunology demonstrated that the nervous system can regulate the activity of immune cells. Based on their findings, the mechanisms via which psychosocial stressors potentiate tumor growth indirectly through inhibition of anti-tumor immune cells have been reported...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Stefanie Stanzer, Elisabeth Andritsch, Silke Zloklikovits, Verena Ladinek, Clemens Farkas, Thomas Augustin, Barbara Obermayer-Pietsch, Hellmut Samonigg, Thomas Bauernhofer
OBJECTIVE: The aim of this study was to determine a potential benefit of the specific psycho-educational intervention "Learning to Live with Cancer" (LTLWC) for patients with operated non-metastatic breast cancer, with respect to psychological variables and endocrine and immune parameters. METHODS: Fifty-two postmenopausal women with operated stage I - III breast cancer were randomized to either a breast cancer intervention group (BCIG, n=30) who immediately began participating in the LTLWC intervention program or to a breast cancer control group (BCCG, n=22)...
November 27, 2018: Psychosomatic Medicine
Danielle Tometich, Brent J Small, Judith E Carroll, Wanting Zhai, George Luta, Xingtao Zhou, Lindsay C Kobayashi, Tim Ahles, Andrew J Saykin, Jonathan D Clapp, Heather S L Jim, Paul B Jacobsen, Arti Hurria, Deena Graham, Brenna C McDonald, Neelima Denduluri, Martine Extermann, Claudine Isaacs, Asma Dilawari, James Root, Christine Rini, Jeanne S Mandelblatt
CONTEXT: Symptoms affect quality of life (QOL), functional status, and cognitive function in cancer survivors, but older survivors are understudied. OBJECTIVES: To identify prototypical pre-systemic therapy psychoneurological symptom clusters among older breast cancer survivors, and determine whether these symptom clusters predicted cognition and QOL over time. METHODS: Women with newly diagnosed non-metastatic breast cancer (n=319) and matched non-cancer controls (n=347) aged 60+ completed questionnaires and neuropsychological tests before systemic therapy and 12- and 24-months later...
November 22, 2018: Journal of Pain and Symptom Management
Yaroslava Yu Marunkevych
OBJECTIVE: Introduction: Suicidal behavior in schizophrenia is one of the most urgent problems of modern psychiatry. The aim of the study was to study the suicidal activity of patients with paranoid schizophrenia in the context of clinical symptoms. PATIENTS AND METHODS: Materials and methods: The medical documentation of 407 men and 409 women who were diagnosed as "paranoid schizophrenia" in the period 1967-2017 on the basis of the Vinnytsia Regional Psychoneurological Hospital was studied by the method of continuous analysis; the prevalence of separate symptoms was analyzed in accordance with the standard ICD-10 criteria in the context of the presence of suicidal thoughts and suicidal actions...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Sandra Zänkert, Silja Bellingrath, Stefan Wüst, Brigitte M Kudielka
Stress is an ubiquitous phenomenon with significant impact on human physiology when it lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the mechanisms linking stress exposure with health and disease is an important endeavor in psychoneuroendocrine research. Empirical evidence so far revealed large intra- as well as inter-individual variability in hypothalamic-pituitary-adrenal (HPA) axis responses to acute psychosocial stress, showing that the HPA axis is a highly adaptive system...
October 29, 2018: Psychoneuroendocrinology
Gee Su Yang, Sreelakshmy Kumar, Susan G Dorsey, Angela R Starkweather, Debra Lynch Kelly, Debra E Lyon
PURPOSE: Psychoneurological (PN) symptoms, such as anxiety, cognitive impairment, depression, fatigue, sleep disturbances, and pain, are highly prevalent in breast cancer patients undergoing cancer treatment. Emerging evidence suggests that genetic polymorphisms may contribute to differential symptom susceptibility. We aimed to systematically review associations between genetic polymorphisms and PN symptoms during or after cancer treatment for early-stage breast cancer. METHODS: Twenty-six eligible articles published until October 2017 were identified in PubMed, PsycINFO, Web of Science, and additional records...
October 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Laurent Tatu, Julien Bogousslavsky
The issue of First World War shell shock has been documented mainly from a medical perspective. Many medical texts dealing with war psychoneuroses and their aggressive treatments, such as electrotherapy, were published during the war. Accounts from shell-shocked soldiers are rare. Nevertheless, shell shock was described from a non-medical point of view by a few writers who had undergone or witnessed this pathology. Their texts deal mainly with the psychiatric forms, the most striking ones, but also with the more common concepts of commotion, emotion and pathological fear...
2018: Frontiers of Neurology and Neuroscience
Bruce S McEwen
Dirk Hellhammer and his colleagues have played a major role in creating the field of psychoneuroendocrinology from their roots in psychology. In this review, using examples from the history of the McEwen laboratory and neuroscience and neuroendocrinology colleagues, I summarize my own perspective as to how the fields of neuroscience and neuroendocrinology have contributed to psychoneuroendocrinology and how they converged with the contributions from Dirk Hellhammer and his colleagues.
September 12, 2018: Psychoneuroendocrinology
Nathalie Peiris, Maxie Blasini, Thelma Wright, Luana Colloca
The placebo effect is a complex phenomenon that can be described from neurobiological, psychosocial, and epistemological perspectives. Different leaders in the field have proposed multiple theories and models that attempt to describe both the nature and the mechanisms of action underlying placebo effects. This article focuses on the most relevant psychological models that have been suggested for characterizing the different mechanisms underlying the placebo effect. We outline how the dynamic psychoneurobiological aspects of the placebo phenomenon can be a potential reliable and useful tool in daily clinical practice for illness and symptom management within a wide variety of specialties and health-care practices...
2018: Perspectives in Biology and Medicine
Avshalom Galil, Jessica Yarmolovsky, Maor Gidron, Ronny Geva
Children's cheating and factors supporting honesty are not well understood. The current work explored variables involved in children's cheating through eye-tracking and an implicit manipulation in which extrinsic awareness of the effects of one's behaviors on others was primed. Participants played a computer game with the option for a monetary gain in which they could earn more if they selectively erred in response to more profitable stimuli. Results show that children cheat by making selective effort toward more profitable errors; however, extrinsic awareness inhibits these cheating behaviors...
October 3, 2018: Journal of Experimental Child Psychology
Gunther Meinlschmidt, Esther Stalujanis, Marion Tegethoff
Using vehicles with engaged automated driving systems (ADS) ('highly automated driving', HAD) will substantially impact on future society's mobility, yet the current understanding of human psychobiology related to HAD is still limited. Hence, we synthesized evidence on the psychobiology of subjects using HAD, informing an integrative model of the psychobiology of HAD, and providing guidance for reporting future research on this topic. We included (non-)randomized studies assessing human peripheral biology markers of in-vehicle-users in real or simulated driving environments, using vehicles with vs...
September 22, 2018: Psychoneuroendocrinology
Susen Heimbürge, Ellen Kanitz, Winfried Otten
The hair cortisol concentration (HCC) is assumed to be a retrospective marker of integrated cortisol secretion and stress over longer periods of time. Its quantification is increasingly used in psychoneuroendocrinological studies in humans, but also in animal stress and welfare research. The measurement of HCCs for the assessment of stress offers many considerable benefits for use in domesticated and wild animals, especially due to the easy and minimally invasive sampling procedure and the representation of longer time periods in one sample...
October 1, 2018: General and Comparative Endocrinology
Antti Huotarinen, Riku Kivisaari, Marwan Hariz
BACKGROUND: The widespread use of deep brain stimulation (DBS) for movement disorders has renewed the interest in DBS for psychiatric disorders. Lauri Laitinen was a pioneer of stereotactic psychosurgery in the 1950s to 1970s, especially by introducing the subgenual cingulotomy. Our aim here was to verify the anatomical target used by Laitinen, to report on a patient who underwent this procedure, and to review the literature. MATERIALS AND METHODS: The records of Helsinki University Hospital were searched for psychosurgical cases performed between 1970 and 1974...
October 2, 2018: Stereotactic and Functional Neurosurgery
Massimo Fioranelli, Anna G Bottaccioli, Francesco Bottaccioli, Maria Bianchi, Miriam Rovesti, Maria G Roccia
Recent findings have deeply changed the current view of coronary heart disease, going beyond the simplistic model of atherosclerosis as a passive process involving cholesterol build-up in the subintimal space of the arteries until their final occlusion and/or thrombosis and instead focusing on the key roles of inflammation and the immune system in plaque formation and destabilization. Chronic inflammation is a typical hallmark of cardiac disease, worsening outcomes irrespective of serum cholesterol levels. Low-grade chronic inflammation correlates with higher incidence of several non-cardiac diseases, including depression, and chronic depression is now listed among the most important cardiovascular risk factors for poor prognosis among patients with myocardial infarction...
2018: Frontiers in Immunology
Jens Hoebel, Thomas Lampert
Since the early 2000s, evidence has been accumulating that subjective social status - a person's sense of their own position on the social ladder - affects health above and beyond objective socioeconomic status. To date, however, little is known about how these distinct health effects of subjective social status can be explained. This article narratively reviews different explanatory approaches and key methodological challenges, backed up by empirical findings and supplemented by the authors' own reflections...
September 19, 2018: Journal of Health Psychology
Yeon-Hee Lee, Suk Chon
OBJECTIVE: The aim of this study was to investigate possible relationships among hematologic factors, psychological dimensions, the presence of self-reported sleep problems, and clinical characteristics in patients with burning mouth syndrome (BMS). METHODS: Twenty-five postmenopausal female patients with primary BMS (aged 55.2 ± 9.6 years) were included. All participants underwent clinical and psychological evaluations and blood sampling. The patients were subdivided according to the absence or presence of the self-reported sleep problems...
August 31, 2018: Cranio: the Journal of Craniomandibular Practice
Saideh Masafi, Seyed Hassan Saadat, Katayoun Tehranchi, Roohollah Olya, Mostafa Heidari, Saied Malihialzackerini, Mahdi Jafari, Ehsan Rajabi
BACKGROUND: Psychoneuroimmunology (PNI) is the study of the interaction between psychological processes and the nervous and immune systems of the human body. The impact of psychological factors on the immune system and the role of this system in Coronary Artery Disease (CAD) are confirmed. Coronary Heart Disease (CHD) is arisen due to the failure of blood and oxygen to the heart tissues. AIM: The present study aimed to describe psychoneuroimmunological processes which contribute to CAD and CHD progression...
August 20, 2018: Open Access Macedonian Journal of Medical Sciences
Andrew D Grotzinger, Daniel A Briley, Laura E Engelhardt, Frank D Mann, Megan W Patterson, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
No abstract text is available yet for this article.
December 2018: Psychoneuroendocrinology
Jens Gaab
Placebos are usually employed deceptively in clinical trials in order to control for non-specific effects. However, since placebos themselves have been found to cause clinically relevant changes and in some cases are indistinguishable from the verum they are tested against, this theoretically inert, but practically effective intervention has become a scientific discipline in its own right. In this review, it is argued that placebos are generic and genuine biopsychosocial interventions and as such are highly interesting candidates for a psychoneuroendocrinological perspective...
August 3, 2018: Psychoneuroendocrinology
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