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https://www.readbyqxmd.com/read/30109905/inactive-individuals-with-chronic-neck-pain-have-changes-in-range-of-motion-and-functional-performance-of-the-shoulder
#1
Rafaela Maria da Silva, Mariana Alves Bezerra, Aldair Darlan Santos-de-Araújo, Cid André Fidelis de Paula Gomes, Cesário da Silva Souza, Priscila Helena Vanin Alves de Souza Matias, Almir Vieira Dibai-Filho
OBJECTIVE: To correlate the range of movement and functional performance of the shoulder with pain measures in inactive individuals with and without neck pain. In addition, comparisons were made between the groups. METHODS: The sample comprised two groups of inactive adults, aged 18-45 years: chronic neck pain (n = 30) and healthy subjects (n = 30). All participants had no clinical dysfunction in the shoulder joint. Aspects related to neck pain were evaluated with the Numerical Rating Scale, Neck Disability Index, and the Catastrophic Thoughts about Pain Scale...
August 15, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/30102855/native-chemical-ligation-for-crosslinking-of-flower-like-micelles
#2
Marzieh Najafi, Neda Kordalivand, Mohammad-Amin Moradi, Joep van den Dikkenberg, Remco Fokkink, Heiner Friedrich, Nico A J M Sommerdijk, Mathew Hembury, Tina Vermonden
In this study, native chemical ligation (NCL) was used as a selective crosslinking method to form core-crosslinked thermosensitive polymeric micelles for drug delivery applications. To this end, two complementary ABA triblock copolymers having polyethylene glycol (PEG) as midblock were synthesized by atom transfer radical polymerization (ATRP). The thermosensitive poly isopropyl acrylamide (PNIPAM) outer blocks of the polymers were co-polymerized with either N-(2-hydroxypropyl)methacrylamide-cysteine (HPMA-Cys), P(NIPAM-co-HPMA-Cys)-PEG-P(NIPAM-co-HPMA-Cys) (PNC), or N-(2-hydroxypropyl)methacrylamide-ethylthioglycolate succinic acid (HPMA-ETSA), P(NIPAM-co-HPMA-ETSA)-PEG-P(NIPAM-co-HPMA-ETSA) (PNE)...
August 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30090671/electromyography-of-the-hip-and-thigh-muscles-during-two-variations-of-the-lunge-exercise-a-cross-sectional-study
#3
David A Krause, Joshua J Elliott, Domenic F Fraboni, Taylor J McWilliams, Rachel L Rebhan, John H Hollman
Background: The lunge is a closed kinetic chain exercise that athletes frequently use as part of training and rehabilitative programs. While typically performed on a stable surface, modifications include the use of balance platforms to create an unstable surface and suspension equipment. Suspension training exercises are theorized to be higher demand exercises and may be considered a progression from exercises on stable surfaces. Comparison of muscle recruitment between the suspended lunge and the standard lunge has not been reported...
April 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30052294/redox-control-of-iodotyrosine-deiodinase
#4
Jimin Hu, Qi Su, Jamie Schlessman, Steven E Rokita
The redox chemistry of flavoproteins is often gated by substrate and iodotyrosine deiodinase (IYD) has the additional ability to switch between reaction modes based on substrate. Association of fluorotyrosine (F-Tyr), an inert substrate analog, stabilizes single electron transfer reactions of IYD that are not observed in the absence of this ligand. The co-crystal of F-Tyr and a T239A variant of human IYD has now been characterized to provide a structural basis for control of its flavin reactivity. Coordination of F-Tyr in the active site of this IYD closely mimics that of iodotyrosine and only minor perturbations are observed after replacement of an active site Thr with Ala...
July 27, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29995792/electromyographic-analysis-of-hip-and-knee-muscles-during-specific-exercise-movements-in-females-with-patellofemoral-pain-syndrome-an-observational-study
#5
Shuya Chen, Wen-Dien Chang, Jhih-Yun Wu, Yi-Chin Fong
Hip muscle strengthening and knee extensor strengthening are common training exercises for patellofemoral pain syndrome (PFPS). PFPS engendered by insufficient hip abductor and external rotator muscle strength has been of interest, but these exercise movements may increase the lateral vector force of the patella warrants clarification. So, the purpose of this study was to assess muscular activations of vastus lateralis (VL), vastus medialis oblique (VMO), and gluteus medius muscles in electromyographic analysis during hip abduction and external rotator movements and open and closed kinetic chain knee extension movements...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29994183/stable-il-1-activation-in-an-inflammasome-signalling-model-depends-on-positive-and-negative-feedbacks-and-tight-regulation-of-protein-production
#6
Fernando Lopez-Caamal, Huber Heinrich
INTRODUCTION: NLRP3-dependent inflammasome signalling is a key pathway during inflammatory processes and its deregulation is implicated in several diseases. NLRP3-inflammasome pathway activation leads to the rapid, hosphorylation-driven NFB-pathway signalling, subsequently proceeds via lower transcription/translation process for producing pro-enzymes, and finally leads to the medium-speed enzymatic activation of the central inflammatory ediator IL-1 [1]. We here were interested how the timing of the rate-limiting step of transcription/translation and the presence of a positive and negative auto-regulation would pose conditions for meaningful and stable IL-1-activation...
January 18, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29981540/collisional-excitation-of-interstellar-ccn-x-2-%C3%AE-induced-by-he
#7
A Chefai, F Khadri, K Hammami, F Lique
The CCN radical has been recently detected in the interstellar medium. Accurate modeling of its abundance in such media requires one to model its excitation by both radiation and collisions. Here, we report the first quantum mechanical close-coupling study of CCN-He collisions. Calculations of fine-structure resolved excitation cross sections of CCN(X2 Π) induced by collision with He are performed for kinetic energies below 500 cm-1 . The calculations are based on new two-dimensional potential energy surfaces obtained from coupled cluster approaches...
July 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29935476/a-molecular-dynamics-simulation-study-of-amino-acid-selectivity-of-leurs-editing-domain-from-thermus-thermophilus
#8
Alexey Rayevsky, Mohsen Sharifi, Michael Tukalo
The accuracy of protein synthesis is provided by the editing functions of aminoacyl-tRNA synthetases (aaRSs), a mechanism that eliminates misactivated amino acids or mischarged tRNAs. Despite research efforts, some molecular bases of these mechanisms are still unclear. The post-transfer editing pathway of leucyl-tRNA synthetase (LeuRS) carried out in a special insertion domain (the Connective Polypeptide 1 or CP1), as editing domain. Recently, it was shown by in vivo studies and was supported by mutagenesis, and the kinetics approaches that the CP1 domain of LeuRS has discriminatory power for different substrates...
June 18, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29912862/stochastic-shielding-and-edge-importance-for-markov-chains-with-timescale-separation
#9
Deena R Schmidt, Roberto F Galán, Peter J Thomas
Nerve cells produce electrical impulses ("spikes") through the coordinated opening and closing of ion channels. Markov processes with voltage-dependent transition rates capture the stochasticity of spike generation at the cost of complex, time-consuming simulations. Schmandt and Galán introduced a novel method, based on the stochastic shielding approximation, as a fast, accurate method for generating approximate sample paths with excellent first and second moment agreement to exact stochastic simulations...
June 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29804980/effect-of-polysaccharide-chain-conformation-on-ultrasonic-degradation-of-curdlan-in-alkaline-solution
#10
Yi-Ching Cheung, Junyi Yin, Jian-Yong Wu
This study was to investigate the effects of polysaccharide chain conformation on ultrasonic degradation of curdlan, a high MW β-glucan with wide applications. The ultrasonic degradation was performed in alkaline solution at 0.1 M and 0.3 M NaOH, in which the curdlan chain was mainly in triple helical conformation and random coil form, respectively. The degradation rate was represented by the kinetic model, 1/Mt  - 1/Mo  = kt, with the rate constant k increasing with the ultrasonic power. The degradation rate was much higher in 0...
September 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29799301/using-flow-cytometry-to-monitor-glycoprotein-iib-iiia-activation
#11
Andrew L Frelinger
Platelet-to-platelet aggregation is critical to the formation of hemostatic thrombi which limit bleeding following vascular injury and also contributes to obstructive thrombi in acute myocardial infarction, stroke, or other thrombotic diseases. Platelet aggregation is mediated by platelet surface glycoprotein (GP) IIb-IIIa (integrin αIIbβ3, CD41/61) on adjacent platelets. Upon platelet activation by adenosine diphosphate (ADP), thrombin, or other platelet agonists, GPIIb-IIIa undergoes conformational changes from a "resting" bent conformation to an "activated" extended conformation...
May 25, 2018: Platelets
https://www.readbyqxmd.com/read/29757625/structure-and-kinetics-of-the-s-1-amino-2-propanol-dehydrogenase-from-the-rmm-microcompartment-of-mycobacterium-smegmatis
#12
Evan Mallette, Matthew S Kimber
S-(+)-1-Amino-2-propanol dehydrogenase (APDH) is a short-chain dehydrogenase/reductase associated with the incompletely characterized Rhodococcus and Mycobacterium bacterial microcompartment (RMM). We enzymatically characterized the APDH from M. smegmatis and showed it is highly selective, with a low micromolar Km for S-(+)-1-amino-2-propanol and specificity for NADP(H). A paralogous enzyme from a nonmicrocompartment-associated operon in the same organism was also shown to have a similar activity. We determined the structure of APDH in both apo form (at 1...
July 3, 2018: Biochemistry
https://www.readbyqxmd.com/read/29735473/exercise-therapy-interventions-in-patients-with-hip-osteoarthritis-comparison-of-the-effects-of-dvd-and-website-based-interventions
#13
Yuko Uesugi, Junichiro Koyanagi, Keishi Takagi, Ryota Yamaguchi, Shinya Hayashi, Takashi Nishii
BACKGROUND: Prevalence of developmental hip dysplasia is high in Japan. Exercise therapy has been proven effective to treat certain aspects of hip osteoarthritis. Moreover, therapy provided via digital video discs (DVDs) and websites allows patients to exercise in the comfort of their own homes. However, no studies have evaluated the effectiveness of visual instructions in patients with hip disorders. OBJECTIVE: This study aimed to compare the effectiveness of exercise therapy administered via DVD and that administered via a website...
May 7, 2018: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29725124/active-site-gate-dynamics-modulate-the-catalytic-activity-of-the-ubiquitination-enzyme-e2-25k
#14
Manoj K Rout, Brian L Lee, Aiyang Lin, Wei Xiao, Leo Spyracopoulos
The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps by a three-component enzyme system. Ubiquitination, or E2 enzymes, catalyze the central step by facilitating reaction of a target protein lysine with the C-terminus of Ub that is attached to the active site cysteine of the E2 through a thioester bond...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29706893/determinants-of-isoform-specific-gating-kinetics-of-herg1-channel-combined-experimental-and-simulation-study
#15
Laura L Perissinotti, Pablo M De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C Lee, Colleen E Clancy, Henry J Duff, Sergei Y Noskov
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in humans are linked to functional modifications in the Kv11.1 (hERG) ion channel and potentially life threatening arrhythmias. There is little doubt now that hERG-related component of IKr in the heart depends on the tetrameric (homo- or hetero-) channels formed by two alternatively processed isoforms of hERG, termed hERG1a and hERG1b...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29704707/unravelling-the-reactivity-of-bifenazate-in-water-and-on-vegetables-kinetics-and-byproducts
#16
Samar Hamdache, Mohamad Sleiman, Pascal de Sainte-Claire, Farouk Jaber, Claire Richard
In this study, we aimed to better understand the transformation mechanisms of bifenazate, a biphenyl hydrazine derivative insecticide poorly studied up to now. For this, we compared its reactivity in the dark and under simulated solar light irradiation in different media (water, non-aqueous polar solvent, surface of apolar wax films, skin of vegetable). In air-saturated pH = 5.7 water, bifenazate underwent both autoxidation in the dark (t1/2  = 34 h) and photolysis (t1/2  = 17 h). In an aprotic polar solvent such as acetonitrile, bifenazate was stable in the dark but was quickly photodegraded in the presence of oxygen (t1/2  = 2 h)...
September 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29701209/time-dependent-changes-in-the-growth-of-ultrathin-ionic-liquid-films-on-ag-111
#17
Matthias Lexow, Timo Talwar, Bettina S J Heller, Benjamin May, Radha G Bhuin, Florian Maier, Hans-Peter Steinrück
Various amounts of the ionic liquids (ILs) [C1C1Im][Tf2N] and [C8C1Im][Tf2N] were deposited in vacuo by physical vapour deposition (PVD) on single crystalline Ag(111) at room temperature and subsequently monitored by angle-resolved X-ray photoelectron spectroscopy (ARXPS) as a function of time. For very low coverages of up to one closed molecular layer, an initial wetting layer was rapidly formed for both ILs. Deposition of higher amounts of [C1C1Im][Tf2N] revealed an initial three-dimensional film morphology...
May 9, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29685058/the-effect-of-open-versus-closed-kinetic-chain-exercises-on-anterior-tibial-laxity-strength-and-function-following-anterior-cruciate-ligament-reconstruction-a-systematic-review-and-meta-analysis
#18
Alyssa Perriman, Edmund Leahy, Adam Ivan Semciw
Background There is controversy surrounding the early use of open-kinetic-chain (OKC) quadriceps-strengthening exercises following anterior cruciate ligament reconstruction (ACLR) due to the belief that increased strain on the graft could cause damage. Objectives To determine whether OKC quadriceps exercises result in differences in anterior tibial laxity, strength, function, quality of life, or adverse events in the ACLR population, when compared to closed-kinetic-chain (CKC) quadriceps exercises. Methods Seven electronic databases (MEDLINE, Embase, AMED, CINAHL, SPORTDiscus, PEDro, and the Cochrane Central Register of Controlled Trials) were searched through April 2017...
July 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29669418/termination-of-biological-function-at-low-temperatures-glass-or-structural-transition
#19
Salman Seyedi, Dmitry V Matyushov
Energy of life is produced by electron transfer in energy chains of respiration or photosynthesis. A small input of free energy available to biology puts significant restrictions on how much free energy can be lost in each electron-transfer reaction. We advocate the view that breaking ergodicity, leading to violation of the fluctuation-dissipation theorem (FDT), is how proteins achieve high reaction rates without sacrificing the reaction free energy. Here we show that a significant level of nonergodicity, represented by a large extent of the configurational temperature over the kinetic temperature, is maintained in the entire physiological range for the cytochrome c electron transfer protein...
May 3, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29617564/method-unifying-view-of-loop-formation-kinetics-in-peptide-and-protein-folding
#20
Maik H Jacob, Roy N D'Souza, Thomas Schwarzlose, Xiaojuan Wang, Fang Huang, Elisha Haas, Werner M Nau
Protein folding can be described as a probabilistic succession of events in which the peptide chain forms loops closed by specific amino acid residue contacts, herein referred to as loop nodes. To measure loop rates, several photophysical methods have been introduced where a pair of optically active probes is incorporated at selected chain positions and the excited probe undergoes contact quenching (CQ) upon collision with the second probe. The quenching mechanisms involved triplet-triplet energy transfer, photoinduced electron transfer, and collision-induced fluorescence quenching, where the fluorescence of Dbo, an asparagine residue conjugated to 2,3-diazabicyclo[2...
April 26, 2018: Journal of Physical Chemistry. B
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