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https://www.readbyqxmd.com/read/30285177/effect-of-early-surgery-vs-physical-therapy-on-knee-function-among-patients-with-nonobstructive-meniscal-tears-the-escape-randomized-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
Victor A van de Graaf, Julia C A Noorduyn, Nienke W Willigenburg, Ise K Butter, Arthur de Gast, Ben W Mol, Daniel B F Saris, Jos W R Twisk, Rudolf W Poolman
Importance: Despite recent studies suggesting arthroscopic partial meniscectomy (APM) is not more effective than physical therapy (PT), the procedure is still frequently performed in patients with meniscal tears. Objective: To assess whether PT is noninferior to APM for improving patient-reported knee function in patients with meniscal tears. Design, Setting, and Participants: Noninferiority, multicenter, randomized clinical trial conducted in 9 hospitals in the Netherlands...
October 2, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/30276189/functional-resistance-training-can-increase-strength-knee-torque-ratio-and-functional-performance-in-elderly-women
#2
Ahlan Benezar Lima, Ewertton de Souza Bezerra, Lucas Bet da Rosa Orssatto, Ericles de Paiva Vieira, Luhan Ammy Andrade Picanço, João Otacilio Libardoni Dos Santos
Functional resistance training can increase strength, knee torque ratio, and functional performance in elderly women. The aim of the present study was to understand the effects of closed kinetic chain exercises with constant load on muscular strength, the knee torque conventional ratio (hamstring:quadriceps - H:Q), and functional capacity in the elderly. Nine untrained healthy elderly women participated in experimental resistance training. Ten-repetition maximum (10RM) for the deadlift, isokinetic maximum voluntary concentric contraction, and functional capacity were assessed before and after the 7-week resistance-training program...
August 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30260226/exploiting-intermolecular-interactions-between-alkyl-functionalized-redox-active-molecule-pairs-to-enhance-interfacial-electron-transfer
#3
Inseong Cho, Mizuho Koshika, Pawel Wagner, Nagatoshi Koumura, Peter C Innis, Shogo Mori, Attila J Mozer
Strategies to enhance electron transfer rates between redox active, light harvesting molecules attached to semiconductor surfaces and redox mediators in solution by modifying molecular structure are not fully investigated yet. Therefore, the design of molecules with controlled electron transfer rates remains a challenge. The aims of this work are to quantify the effect of long alkyl chain substitution on the electron transfer from cobalt (II/III) tris(2,2' - bipyridine), (Cobpy)2+3 to or-ganic molecules containing carbazole and thiophene and to demonstrate that alkyl chains can be used to enhance elec-tron transfer between donor acceptor pairs...
September 27, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30255917/understanding-chain-looping-kinetics-in-polymer-solutions-crowding-effects-of-microviscosity-and-collapse
#4
Yukun Bian, Xiuli Cao, Peng Li, Nanrong Zhao
A theoretical framework based on a generalized Langevin equation with fractional Gaussian noise is presented to describe the looping kinetics of chains in polymer solutions. Particular attention is paid to quantitatively revealing crowding effects on the loop formation rate in terms of microviscosity and collapse. By the aid of empirical relations for these two crowding associated physical quantities, we explicitly investigate the relationship between the looping rate and polymer concentration, the degree of polymerization, and system parameters...
October 10, 2018: Soft Matter
https://www.readbyqxmd.com/read/30215522/dynamics-of-structural-elements-of-gb1-%C3%AE-hairpin-revealed-by-tryptophan-cysteine-contact-formation-experiments
#5
Andrea Soranno, Francesca Cabassi, Maria Elena Orselli, Troy Cellmer, Alessandro Gori, Renato Longhi, Marco Buscaglia
Quenching of the triplet state of tryptophan by close contact with cysteine provides a tool for measuring the rate of intramolecular contact formation, one of the most elementary events in the folding process, in peptides and proteins using only natural probes. Here we present a study performed on a stabilized mutant of the second β-hairpin of the GB1 domain, where we combine steady-state fluorescence, laser-induced temperature-jump, and contact formation measurements to unveil the role of elementary structural components on hairpin dynamics and overall stability...
October 1, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30213860/a-versatile-insulin-analog-with-high-potency-for-both-insulin-and-insulin-like-growth-factor-1-receptors-structural-implications-for-receptor-binding
#6
Martina Chrudinová, Lenka Žáková, Aleš Marek, Ondřej Socha, Miloš Buděšínský, Martin Hubálek, Jan Pícha, Kateřina Macháčková, Jiří Jiráček, Irena Selicharová
Insulin and insulin-like growth factor 1 (IGF-1) are closely related hormones involved in the regulation of metabolism and growth. They elicit their functions through activation of tyrosine kinase-type receptors: insulin receptors (IR-A and IR-B) and IGF-1 receptor (IGF-1R). Despite similarity in primary and three-dimensional structures, insulin and IGF-1 bind the non-cognate receptor with substantially reduced affinity. We prepared [D-HisB24, GlyB31, TyrB32]-insulin, which binds all three receptors with high affinity (251 % or 338 % binding affinity to IR-A respective to IR-B relative to insulin, and 12...
September 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30192512/peptides-as-bio-inspired-electronic-materials-an-electrochemical-and-first-principles-perspective
#7
Jingxian Yu, John R Horsley, Andrew D Abell
Molecular electronics is at the forefront of interdisciplinary research, offering a significant extension of the capabilities of conventional silicon-based technology as well as providing a possible stand-alone alternative. Bio-inspired molecular electronics is a particularly intriguing paradigm, as charge transfer in proteins/peptides, for example, plays a critical role in the energy storage and conversion processes for all living organisms. However, the structure and conformation of even the simplest protein is extremely complex, and therefore, synthetic model peptides comprising well-defined geometry and predetermined functionality are ideal platforms to mimic nature for the elucidation of fundamental biological processes while also enhancing the design and development of single-peptide electronic components...
September 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30176414/performance-of-pb-ii-removal-by-an-activated-carbon-supported-nanoscale-zero-valent-iron-composite-at-ultralow-iron-content
#8
Xuejiao Liu, Dengguo Lai, Yin Wang
Activated carbon supported nanoscale zero-valent iron composite (NZVI/AC) at ultralow iron content was synthesized and used to remove Pb(II) from aqueous solution. The technical characterization revealed that the loaded amorphous NZVI nanoparticles had a chain-like shape in or close to pores and were found as individual nanospheres with size of approximately 10 nm on the outer surface. The NZVI/AC with the iron content of only 1.57% showed a highly efficient Pb(II) removal performance with 95% of Pb(II) eliminated within 5 min...
January 5, 2019: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30150392/multivalent-multiflavored-droplets-by-design
#9
Yin Zhang, Xiaojin He, Rebecca Zhuo, Ruojie Sha, Jasna Brujic, Nadrian C Seeman, Paul M Chaikin
Nature self-assembles functional materials by programming flexible linear arrangements of molecules and then folding them to make 2D and 3D objects. To understand and emulate this process, we have made emulsion droplets with specific recognition and controlled valence. Uniquely monovalent droplets form dimers: divalent lead to polymer-like chains, trivalent allow for branching, and programmed mixtures of different valences enable a variety of designed architectures and the ability to subsequently close and open structures...
September 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30140553/the-musculoskeletal-readiness-screening-tool-athlete-concern-for-injury-prior-injury-associated-with-future-injury
#10
Aspen C Terry, Mark D Thelen, Michael Crowell, Donald L Goss
Background: The Musculoskeletal Readiness Screening Tool (MRST) was developed in an effort to consistently predict injury among military personnel. Current injury prediction tools have not consistently predicted injury in this population. The MRST is comprised of the weight bearing forward lunge, modified deep squat, closed kinetic chain upper extremity stability test (CKCUEST), forward step down with eyes closed, stationary tuck jump, unilateral wall sit hold, and subjective, individual perceived level of risk for injury...
August 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30126110/kinetics-of-aggregation-and-magnetic-separation-of-multicore-iron-oxide-nanoparticles-effect-of-the-grafted-layer-thickness
#11
Hinda Ezzaier, Jéssica Alves Marins, Cyrille Claudet, Gauvin Hemery, Olivier Sandre, Pavel Kuzhir
In this work, we have studied field-induced aggregation and magnetic separation-realized in a microfluidic channel equipped with a single magnetizable micropillar-of multicore iron oxide nanoparticles (IONPs) also called "nanoflowers" of an average size of 27 ± 4 nm and covered by either a citrate or polyethylene (PEG) monolayer having a thickness of 0.2⁻1 nm and 3.4⁻7.8 nm, respectively. The thickness of the adsorbed molecular layer is shown to strongly affect the magnetic dipolar coupling parameter because thicker molecular layers result in larger separation distances between nanoparticle metal oxide multicores thus decreasing dipolar magnetic forces between them...
August 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30109905/inactive-individuals-with-chronic-neck-pain-have-changes-in-range-of-motion-and-functional-performance-of-the-shoulder
#12
Rafaela Maria da Silva, Mariana Alves Bezerra, Aldair Darlan Santos-de-Araújo, Cid André Fidelis de Paula Gomes, Cesário da Silva Souza, Priscila Helena Vanin Alves de Souza Matias, Almir Vieira Dibai-Filho
OBJECTIVE: To correlate the range of movement and functional performance of the shoulder with pain measures in inactive individuals with and without neck pain. In addition, comparisons were made between the groups. METHODS: The sample comprised two groups of inactive adults, aged 18-45 years: chronic neck pain (n = 30) and healthy subjects (n = 30). All participants had no clinical dysfunction in the shoulder joint. Aspects related to neck pain were evaluated with the Numerical Rating Scale, Neck Disability Index, and the Catastrophic Thoughts about Pain Scale...
August 15, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/30102855/native-chemical-ligation-for-cross-linking-of-flower-like-micelles
#13
Marzieh Najafi, Neda Kordalivand, Mohammad-Amin Moradi, Joep van den Dikkenberg, Remco Fokkink, Heiner Friedrich, Nico A J M Sommerdijk, Mathew Hembury, Tina Vermonden
In this study, native chemical ligation (NCL) was used as a selective cross-linking method to form core-cross-linked thermosensitive polymeric micelles for drug delivery applications. To this end, two complementary ABA triblock copolymers having polyethylene glycol (PEG) as midblock were synthesized by atom transfer radical polymerization (ATRP). The thermosensitive poly isopropylacrylamide (PNIPAM) outer blocks of the polymers were copolymerized with either N-(2-hydroxypropyl)methacrylamide-cysteine (HPMA-Cys), P(NIPAM- co-HPMA-Cys)-PEG-P(NIPAM- co-HPMA-Cys) (PNC) or N-(2-hydroxypropyl)methacrylamide-ethylthioglycolate succinic acid (HPMA-ETSA), P(NIPAM- co-HPMA-ETSA)-PEG-P(NIPAM- co-HPMA-ETSA) (PNE)...
September 10, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30090671/electromyography-of-the-hip-and-thigh-muscles-during-two-variations-of-the-lunge-exercise-a-cross-sectional-study
#14
David A Krause, Joshua J Elliott, Domenic F Fraboni, Taylor J McWilliams, Rachel L Rebhan, John H Hollman
Background: The lunge is a closed kinetic chain exercise that athletes frequently use as part of training and rehabilitative programs. While typically performed on a stable surface, modifications include the use of balance platforms to create an unstable surface and suspension equipment. Suspension training exercises are theorized to be higher demand exercises and may be considered a progression from exercises on stable surfaces. Comparison of muscle recruitment between the suspended lunge and the standard lunge has not been reported...
April 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30052294/redox-control-of-iodotyrosine-deiodinase
#15
Jimin Hu, Qi Su, Jamie L Schlessman, Steven E Rokita
The redox chemistry of flavoproteins is often gated by substrate and iodotyrosine deiodinase (IYD) has the additional ability to switch between reaction modes based on the substrate. Association of fluorotyrosine (F-Tyr), an inert substrate analog, stabilizes single electron transfer reactions of IYD that are not observed in the absence of this ligand. The co-crystal of F-Tyr and a T239A variant of human IYD have now been characterized to provide a structural basis for control of its flavin reactivity. Coordination of F-Tyr in the active site of this IYD closely mimics that of iodotyrosine and only minor perturbations are observed after replacement of an active site Thr with Ala...
July 27, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29995792/electromyographic-analysis-of-hip-and-knee-muscles-during-specific-exercise-movements-in-females-with-patellofemoral-pain-syndrome-an-observational-study
#16
Shuya Chen, Wen-Dien Chang, Jhih-Yun Wu, Yi-Chin Fong
Hip muscle strengthening and knee extensor strengthening are common training exercises for patellofemoral pain syndrome (PFPS). PFPS engendered by insufficient hip abductor and external rotator muscle strength has been of interest, but these exercise movements may increase the lateral vector force of the patella warrants clarification. So, the purpose of this study was to assess muscular activations of vastus lateralis (VL), vastus medialis oblique (VMO), and gluteus medius muscles in electromyographic analysis during hip abduction and external rotator movements and open and closed kinetic chain knee extension movements...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29994183/stable-il-1-activation-in-an-inflammasome-signalling-model-depends-on-positive-and-negative-feedbacks-and-tight-regulation-of-protein-production
#17
Fernando Lopez-Caamal, Huber Heinrich
INTRODUCTION: NLRP3-dependent inflammasome signalling is a key pathway during inflammatory processes and its deregulation is implicated in several diseases. NLRP3-inflammasome pathway activation leads to the rapid, hosphorylation-driven NFB-pathway signalling, subsequently proceeds via lower transcription/translation process for producing pro-enzymes, and finally leads to the medium-speed enzymatic activation of the central inflammatory ediator IL-1 [1]. We here were interested how the timing of the rate-limiting step of transcription/translation and the presence of a positive and negative auto-regulation would pose conditions for meaningful and stable IL-1-activation...
January 18, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29981540/collisional-excitation-of-interstellar-ccn-x-2-%C3%AE-induced-by-he
#18
A Chefai, F Khadri, K Hammami, F Lique
The CCN radical has been recently detected in the interstellar medium. Accurate modeling of its abundance in such media requires one to model its excitation by both radiation and collisions. Here, we report the first quantum mechanical close-coupling study of CCN-He collisions. Calculations of fine-structure resolved excitation cross sections of CCN(X2 Π) induced by collision with He are performed for kinetic energies below 500 cm-1 . The calculations are based on new two-dimensional potential energy surfaces obtained from coupled cluster approaches...
July 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29935476/a-molecular-dynamics-simulation-study-of-amino-acid-selectivity-of-leurs-editing-domain-from-thermus-thermophilus
#19
Alexey Rayevsky, Mohsen Sharifi, Michael Tukalo
The accuracy of protein synthesis is provided by the editing functions of aminoacyl-tRNA synthetases (aaRSs), a mechanism that eliminates misactivated amino acids or mischarged tRNAs. Despite research efforts, some molecular bases of these mechanisms are still unclear. The post-transfer editing pathway of leucyl-tRNA synthetase (LeuRS) carried out in a special insertion domain (the Connective Polypeptide 1 or CP1), as editing domain. Recently, it was shown by in vivo studies and was supported by mutagenesis, and the kinetics approaches that the CP1 domain of LeuRS has discriminatory power for different substrates...
September 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29912862/stochastic-shielding-and-edge-importance-for-markov-chains-with-timescale-separation
#20
Deena R Schmidt, Roberto F Galán, Peter J Thomas
Nerve cells produce electrical impulses ("spikes") through the coordinated opening and closing of ion channels. Markov processes with voltage-dependent transition rates capture the stochasticity of spike generation at the cost of complex, time-consuming simulations. Schmandt and Galán introduced a novel method, based on the stochastic shielding approximation, as a fast, accurate method for generating approximate sample paths with excellent first and second moment agreement to exact stochastic simulations...
June 2018: PLoS Computational Biology
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