Francesca Lavatelli, Antonino Natalello, Loredana Marchese, Diletta Ami, Alessandra Corazza, Sara Raimondi, Maria Chiara Mimmi, Silvia Malinverni, P Patrizia Mangione, Manel Terrones Palmer, Alessio Lampis, Monica Concardi, Guglielmo Verona, Diana Canetti, Eloisa Arbustini, Vittorio Bellotti, Sofia Giorgetti
AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. Whilst the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and structural amyloidogenicity of individual light chains have in the disease pathogenesis. AL natural deposits contain both full-length light chains and fragments encompassing the variable domain (VL ) as well as different length segments of the constant region (CL ), thus highlighting the relevance that proteolysis may have in the fibrillogenesis pathway...
March 16, 2024: Journal of Biological Chemistry