Wei Ouyang, Wei Lu, Yamin Zhang, Yiming Liu, Jong Uk Kim, Haixu Shen, Yunyun Wu, Haiwen Luan, Keith Kilner, Stephen P Lee, Yinsheng Lu, Yiyuan Yang, Jin Wang, Yongjoon Yu, Amy J Wegener, Justin A Moreno, Zhaoqian Xie, Yixin Wu, Sang Min Won, Kyeongha Kwon, Changsheng Wu, Wubin Bai, Hexia Guo, Tzu-Li Liu, Hedan Bai, Giuditta Monti, Jason Zhu, Surabhi R Madhvapathy, Jacob Trueb, Maria Stanslaski, Elizabeth M Higbee-Dempsey, Iwona Stepien, Nayereh Ghoreishi-Haack, Chad R Haney, Tae-Il Kim, Yonggang Huang, Roozbeh Ghaffari, Anthony R Banks, Thomas C Jhou, Cameron H Good, John A Rogers
Fully implantable wireless systems for the recording and modulation of neural circuits that do not require physical tethers or batteries allow for studies that demand the use of unconstrained and freely behaving animals in isolation or in social groups. Moreover, feedback-control algorithms that can be executed within such devices without the need for remote computing eliminate virtual tethers and any associated latencies. Here we report a wireless and battery-less technology of this type, implanted subdermally along the back of freely moving small animals, for the autonomous recording of electroencephalograms, electromyograms and body temperature, and for closed-loop neuromodulation via optogenetics and pharmacology...
April 27, 2023: Nature Biomedical Engineering