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Alonso G P Guedes, Julie M Meadows, Bruno H Pypendop, Eric G Johnson, Bianca Zaffarano
OBJECTIVE Toevaluate effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life (QOL) in osteoarthritic geriatric cats. DESIGN Blinded, placebo-controlled, randomized crossover-design study. ANIMALS 20 osteoarthritic cats (≥ 10 years old). PROCEDURES Cats received gabapentin (10 mg/kg [4.5 mg/lb]) or placebo treatment, PO, every 12 hours for 2 weeks, followed by the alternate treatment (with no washout period). Activity was assessed with a collar-mounted accelerometer...
September 1, 2018: Journal of the American Veterinary Medical Association
Jorge Alberto Arroyo Vázquez, Maria Bergström, Stephen Bligh, Barry P McMahon, Per-Ola Park
BACKGROUND: Perforated duodenal ulcers can be treated with a covered stent. Stent migration is a severe complication, sometimes requiring surgery. Pyloric physiology during stent treatment has not been studied and mechanisms for migration are unknown. The aim of this study was to investigate the pyloric response to distention, mimicking stent treatment, using the EndoFLIP. METHODS: A nonsurvival study in five pigs was carried out, followed by a pilot study in one volunteer...
August 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Lionel Sebbag, Rachel A Allbaugh, Rachel A Strauss, Travis D Strong, Rita F Wehrman, Braidee C Foote, Gil Ben-Shlomo
OBJECTIVE: To describe the clinical application and effect of MicroPulse™ transscleral cyclophotocoagulation (MP-TSCPC) in dogs with glaucoma. ANIMALS STUDIED: Twelve dogs with primary (n = 8) or secondary (n = 4) glaucoma, aged 2-13 years (mean ± SD, 7.2 ± 3.8 years). PROCEDURES: MP-TSCPC was performed under sedation or general anesthesia. Laser duty cycle was 31.3%, laser power varied from 2000-2800 mW, and each hemisphere was treated for 90-180 seconds...
August 15, 2018: Veterinary Ophthalmology
Thiago Alegre Coelho Ferreira, Gabrielle Fornazari, André Saldanha, Bruno Lunardeli, Bret A Moore, Fabiano Montiani-Ferreira
BACKGROUND: The pecten oculi is a vascular and pigmented structure localized within the posterior segment of all avian eyes. Its primary function is not fully understood yet. OBJECTIVE: As ultrasonography (US) is a useful imaging modality for evaluation of the pecten oculi, the objective of this study was to investigate the utility of an intravenous contrast solution of sulfur hexafluoride (SF6) microbubbles as a means of enhancing visualization of the pecten oculi in normal birds...
August 15, 2018: Veterinary Ophthalmology
Anthony A Bavry, Seyed Hossein Aalaei-Andabili, Ki E Park, Calvin Y Choi, Eddie W Manning Iii, Wade W Stinson
INTRODUCTION: When transcatheter aortic valve replacement (TAVR) was introduced, pre-implantation balloon aortic valvuloplasty (BAV) was a routine part of the procedure. Smaller device profiles have resulted in selective use of BAV; however, there is a paucity of data about the trend in use of direct TAVR and the safety of this strategy. METHODS: All patients who underwent TAVR at a Veterans Affairs Medical Center from September 2013 to November 2016 were included in this retrospective analysis...
August 14, 2018: Cardiology and Therapy
Jerzy Gawor, Michał Jank, Katarzyna Jodkowska, Emilia Klim, Ulla K Svensson
The objective of this placebo-controlled, double-blind, randomized study (designed according to evidence based medicine standards) was to determine the effect of 90-day administration of edible treats containing the brown algae, Ascophyllum nodosum , on plaque and dental calculus accumulation on the teeth of dogs, as well as on other parameters characterizing canine oral health status, including: plaque index (PI), calculus index (CI), oral health index (OHI), gingival bleeding index (GBI), and volatile sulfur compound (VSC) concentration...
2018: Frontiers in Veterinary Science
Mehmet Sedat Durmaz, Bora Özbakır
Molybdenum cofactor deficiency is an extremely rare and fatal metabolic disorder that should be considered in the differential diagnosis of hypoxic-ischemic encephalopathy. Magnetic resonance imaging findings are useful in diagnosis. The short-echo-time magnetic resonance spectrum was characterized by a total loss of signal and lipid and lactate peaks. In this case, conventional magnetic resonance imaging and magnetic resonance spectroscopy findings of this extremely rare disease whose pathophysiology was not known were presented...
June 2018: Radiology Case Reports
Gianfranco Frojo, Aaron Dotson, Kara Christopher, Sumesh Kaswan, Herluf Lund
Background: Anesthesia for elective ambulatory procedures must provide appropriate pain control while minimizing perioperative risk. Local anesthesia in combination with oral sedation provides a safe office-based method of anesthesia for rhytidectomy. Objectives: The purpose of this analysis was to identify the incidence of traditional outcome parameters in ambulatory rhytidectomy performed with local anesthesia and oral sedation. Methods: A retrospective chart review was performed on all patients who underwent office-based rhytidectomy under local anesthesia with oral sedation from February 2011 to May 2017...
August 13, 2018: Aesthetic Surgery Journal
B Vestal, P Russell, R A Radcliffe, L Bemis, L M Saba, K Kechris
INTRODUCTION: Studying innate sensitivity to ethanol can be an important first step toward understanding alcohol use disorders. In brain, we investigated transcripts, with evidence of miRNA modulation related to a predisposition to the hypnotic effect of ethanol, as measured by loss of righting reflex (LORR). METHODS: Expression of miRNAs (12 samples) and expression of mRNAs (353 samples) in brain were independently analyzed for an association with LORR in mice from the LXS recombinant inbred panel gathered across several small studies...
June 2018: Brain and Behavior
Sara Hocker, Elanagan Nagarajan, Mark Rubin, Eelco F M Wijdicks
Background: We sought to identify clinical associations and potential triggers of Guillain-Barré syndrome (GBS) within 6 weeks of surgery. Methods: We retrospectively reviewed consecutive patients diagnosed with GBS within 6 weeks of a surgery between January 1995 and June 2014 at Mayo Clinic. Postsurgical GBS was defined as symptom onset within 6 weeks of surgery. Patients with postsurgical GBS were compared with patients who did not have a surgery prior to GBS onset to determine differences between groups...
June 2018: Neurology. Clinical Practice
Shiue-Chin Liou, Chen-Ming Hsu, Chit Chen, Ming-Yao Su, Cheng-Tang Chiu
Background: Subjects with obstructive sleep apnea (OSA) are vulnerable to sedation-related complications during endoscopic procedures. A significant portion of subjects undergoing routine endoscopy is at high risk of OSA, but most are undiagnosed. The purpose of this study was to estimate the prevalence of high risk for OSA among Chinese subjects undergoing deep sedation for screening gastrointestinal endoscopy and to evaluate the hypoxemia risk of these examinees stratified by Berlin Questionnaire (BQ)...
2018: Therapeutics and Clinical Risk Management
Tapas Kumar Singh, Sandeep Sahu, Anil Agarwal, Devendra Gupta, Prabhaker Mishra
Background and Aims: Catheter-related bladder discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Mayank Gupta, Priyanka Gupta
Background and Aims: Etomidate induced myoclonus (EM) is a common and hazardous sequel. Premedication with a number of opioids has been shown to effectively attenuate EM. However, there is no reported literature evaluating the effect of nalbuphine pretreatment on EM. The present study was designed to evaluate the efficacy of 0.2 mg/kg nalbuphine intravenous (IV) pretreatment for prevention of EM. Material and Methods: This prospective randomized double-blind and placebo controlled study was conducted in a medical college associated tertiary hospital...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Mohamed M Abu Elyazed, Mohammad A Abdullah
Background and Aims: Percutaneous radiofrequency ablation (PRFA) is a minimally invasive treatment for hepatic tumors. We assessed and compared the efficacy of right thoracic paravertebral block (TPVB) with that of local anesthetic infiltration for the anesthetic management of PRFA of liver tumors. Material and Methods: Sixty patients with hepatic tumors aged 50-80 years were randomly allocated into two groups. Group I received local anesthetic infiltration along the path of the ablation device with sedation...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
William T Ralvenius, Elena Neumann, Martina Pagani, Mario A Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacological targeting of inhibitory α2 and α3GABAA receptors reduces acute histaminergic and non-histaminergic itch in mice. Systemic treatment with an α2/α3GABAA receptor selective modulator alleviates also chronic itch in a mouse model of atopic dermatitis and in dogs sensitized to house dust mites, without inducing sedation, motor dysfunction, or loss of antipruritic activity after prolonged treatment...
August 13, 2018: Nature Communications
Lauren Stummer, Marija Markovic, Megan E Maroney
Background: Symptoms of sleep disorders, such as disturbances in sleep initiation and continuity, are commonly reported in patients with schizophrenia, especially in the acute phase of illness. Studies have shown that up to 80% of patients diagnosed with schizophrenia report symptoms of insomnia. Sleep disturbances have been shown to increase the risk of cognitive dysfunction and relapse in patients with schizophrenia. Currently, there are no medications approved specifically for the treatment of insomnia in patients with schizophrenia...
August 11, 2018: Medicines (Basel, Switzerland)
Berna Bulut Çakmak, Güler Özkula, Sedat Işıklı, İbrahim Özkan Göncüoğlu, Serkan Öcal, Ali Ercan Altınöz, Nilgün Taşkıntuna
Previous studies have identified a link between anger and somatization. However, little is known about the associations between anger and the development and progression of Functional Gastrointestinal Disorders (FGID). The study aim was to determine the associations between FGID and anger, anxiety, and depression. Participants in this cross-sectional observational study were 109 consecutive patients aged 18-64 years with FGID at Gastroenterology Clinic of Başkent University Hospital. A control group comprised of 96 individuals with no chronic gastrointestinal disorders recruited via snowball sampling...
July 30, 2018: Psychiatry Research
Tarık Acar, Gülsüm Alkan, Hüseyin Çaksen, Birsen Ertekin, Mehmet Ergin, Sedat Koçak, Başar Cander
Acar T, Alkan G, Çaksen H, Ertekin B, Ergin M, Koçak S, Cander B. Phenytoin induced dystonia. Turk J Pediatr 2018; 60: 111-112. The abnormalities of dopaminergic activity in the basal ganglia have been emphasized to be effective in dystonia. We hereby report a case of a 2.5-year-old male patient who presented with tonic-clonic sezures and who developed dystonia after being given phenytoin. Biperidene hydrochloride was administered intramuscularly; primidone was added to the treatment regimen. After a 7-day-follow-up at the hospital, the patient had no dystonia and was discharged...
2018: Turkish Journal of Pediatrics
Sedat Işıkay, Nurgül Işıkay, Hüseyin Per, Kürşat Bora Çarman, Halil Kocamaz
Işıkay S, Işıkay N, Per H, Çarman KB, Kocamaz H. Restless leg syndrome in children with celiac disease. Turk J Pediatr 2018; 60: 70-75. Celiac disease (CD) is an immune-mediated enteropathy triggered by ingestion of dietary gluten in genetically predisposed individuals. The aim of the study was to determine the prevalence of restless leg syndrome (RLS) in children with CD and to investigate the associated factors for RLS. Totally 494 children with the ages ranging between 11-18 years were included. Among those, 226 were under follow-up with CD and constituted the study group while other 268 children did not have any symptoms or signs associated with CD and established the control group...
2018: Turkish Journal of Pediatrics
Yong Zhang, Xuan Wang, Zhaoguo Liu, Lingzhi Yu
Dexmedetomidine (Dex) is an agonist of α2-adrenergic receptors, and it is used as an anxiety reducing, sedative, and pain medication in clinical. Studies have shown that dexmedetomidine protects against lipopolysaccharide (LPS)-induced acute lung injury; however, the underlying mechanism is still unclear. To investigate, an acute lung injury mouse model was induced by intraperitoneal injection of LPS. Histopathological changes were determined by hematoxylin and eosin staining. Enzyme-linked immunosorbent assay was used to detect cytokines in serum...
August 13, 2018: Journal of Biochemical and Molecular Toxicology
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