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Nicholas Di Mascio, Padraic MacMathuna, Sean Murphy, Eoin Carl Kavanagh
A 68-year-old gentleman was referred for elective upper gastrointestinal endoscopy on a background of dysphagia and esophageal candidiasis. A benign peptic stricture was noted, managed with balloon dilation without apparent immediate complication. At completion, however, the patient became confused and agitated, with no improvement despite the reversal of sedation. Two hours later, with all investigations for suspected complications including perforation, negative, he developed acute left-sided hemiparesis...
October 20, 2018: Clinical Journal of Gastroenterology
Ozgur Kuzukiran, Begum Yurdakok-Dikmen, Sedat Sevin, Ufuk Tansel Sireli, Guzin Iplikcioglu-Cil, Ayhan Filazi
An increasing amount of evidence suggests that phthalic acid esters (PAE), polychlorinated biphenyls (PCB), polybrominated diphenyl ethers (PBDE), and organochlorine pesticides (OCP) are related to mutagenic, carcinogenic, and endocrine disruptor effects (EDCs). These lipophilic compounds are highly resistant to breakdown processes, and consequently remain in the environment, followed by uptake into the food chain. Human exposure to lipophilic compounds results from the consumption of food containing EDCs, mainly foodstuffs of animal origin with a high fat content, since these contaminants accumulate in fatty tissues...
October 20, 2018: Environmental Science and Pollution Research International
Miho Hirai, Michiho Ito
The sedative effects of the essential oil released by living Ocimum basilicum (basil) plants were investigated using a mouse activity monitoring system. Ocimum basilicum plants were grown in a hydroponic chamber, and either the headspace air from the hydroponic chamber or the essential oil extracted from mature plants was administered by the inhalation route to mice in an open field test. The most effective dose of O. basilicum essential oil for reducing the locomotor activity of the mice was found to be 4...
October 20, 2018: Journal of Natural Medicines
Robert E Pyke
INTRODUCTION: Treatment of hypoactive sexual desire disorder (HSDD) remains unfulfilled. The only approved medication, flibanserin (FLI), is highly underused owing to concerns about central nervous system (CNS) depression and interactions. Trazodone (TRZ), which is not often used for sexual problems, has evidence suggesting efficacy but similar concerns. AIM: To explore whether the pharmacologic similarities between TRZ and FLI could allow treatment of HSDD without CNS depression...
October 17, 2018: Sexual Medicine Reviews
Fuxi Song, Chunmiao Ye, Feng Qi, Ping Zhang, Xuexiang Wang, Yanfeng Lü, Alejandro Fernandez-Escobar, Chao Zheng, Liang Li
BACKGROUND: Postoperative pain is one of the most common symptoms after surgery, which brings physical discomfort to patients. In addition, it may cause a series of complications, and even affect the long-term quality of life. The purpose of this prospective, randomized, double-blinded, controlled trial is to investigate the efficacy and safety of dexmedetomidine combined with sufentanil to attenuate postoperative pain in patients after laparoscopic nephrectomy. METHODS: Ninety patients undergoing laparoscopic nephrectomy were randomized into three groups: the control (sufentanil 0...
October 20, 2018: BMC Anesthesiology
F Proust, S Bracard, J-P Lejeune, L Thines, X Leclerc, G Penchet, J Bergé, X Morandi, J-Y Gauvrit, K Mourier, F Ricolfi, M Lonjon, J Sedat, B Bataille, J Droineau, T Civit, E Magro, I Pelissou-Guyotat, H Cebula, K Lallouche, P David, E Emery, P Courthéoux, J-R Vignes, J Bénichou, N Aghakani, P-H Roche, E Gay, P Bessou, J Guabrillargues, B Irthum
BACKGROUND: Current aging of the population with good physiological status and the increasing incidence of subarachnoid hemorrhage (SAH) in elderly patients has enhanced the benefit of treatment in terms of independence and long-term quality of life (QoL). METHODS: From November 1, 2008 to October 30, 2012, 351 patients aged 70 years or older with aneurysmal SAH underwent adapted treatment: endovascular coiling (EV) for 228 (65%) patients, microsurgical clipping (MS) for 75 (29...
October 16, 2018: Neuro-Chirurgie
Romina Brignardello-Petersen
No abstract text is available yet for this article.
October 12, 2018: Journal of the American Dental Association
Md Moniruzzaman, Md Abdul Mannan, Md Farhad Hossen Khan, Ariful Basher Abir, Mirola Afroze
BACKGROUND: Crataeva nurvala Buch-Hum is an indigenous herb, extensively used in traditional medicines of the South Asian countries to treat inflammation, rheumatic fever, gastric irritation, and constipation. Despite this wide range of uses, very little information is known regarding its effects on the central nervous system (CNS). Therefore, this study evaluated the neuropharmacological properties of methanolic extract of Crataeva nurvala leaves (MECN) using a number of behavioral models in animals...
October 19, 2018: BMC Complementary and Alternative Medicine
Shahnaz Mohammed Ayasrah
PURPOSE: To investigate pain levels and factors that are predictive of pain for mechanically ventilated patients during rest and during routine nursing procedures. MATERIAL AND METHODS: Pain levels were assessed using Behavioral Pain Scale (BPS) and physiological measures among 247 mechanically ventilated patients. RESULTS: At rest, 33.2% of patients suffered pain, with a BPS > 3; of these, 10% presented significant pain levels (BPS ≥ 5)...
October 13, 2018: Journal of Critical Care
Muzaffar Iqbal, Essam Ezzeldin, Nasr Y Khalil, Prawez Alam, Khalid A Al-Rashood
Suvorexant is a novel sedative/hypnotic drug approved for treatment of insomnia. It has significant forensic importance due to its hypnotic and depressant effects on central nervous system. In this study, a highly sensitive UPLC-MS/MS assay was developed and validated for the determination of suvorexant in urine sample. A simplified dispersive liquid-liquid microextraction followed by ultrasound assisted back extraction from solidified floating organic droplets was employed for sample preparation. The 20 μL of 1-undecanol and 200 μL of acetonitrile were used as extraction solvent and dispersive solvent, respectively...
October 4, 2018: Journal of Pharmaceutical and Biomedical Analysis
Boohwi Hong, Choonho Jung, Yumin Jo, Hyemin Kang, Woosuk Chung, Yoon-Hee Kim, ChaeSeong Lim, YoungKwon Ko
PURPOSE: Dexmedetomidine, an alpha 2 receptor agonist, prolongs nerve block duration when administered in conjunction with peripheral nerve blocks. We hypothesised that sedation with dexmedetomidine could also significantly prolong the analgesic duration of brachial plexus block (BPB) during orthopaedic surgery on the upper extremities. MATERIALS AND METHODS: One hundred and two patients received upper extremity surgery under BPB. The patients were randomly sedated with dexmedetomidine (D group) or midazolam (M group) following BPB using 25 ml of local anaesthetics (1:1 mixture of 1% lidocaine and 0...
October 16, 2018: Anaesthesia, Critical Care & Pain Medicine
Lynn J Miller, David P Fetterer, Nicole L Garza, Matthew G Lackemeyer, Ginger C Donnelly, Jesse T Steffens, Sean A Van Tongeren, Jimmy O Fiallos, Joshua L Moore, Shannon T Marko, Luis A Lugo-Roman, Greg Fedewa, Joseph L DeRisi, Jens H Kuhn, Scott J Stahl
Laboratory animals are commonly anesthetized to prevent pain and distress and to provide safe handling. Anesthesia procedures are well-developed for common laboratory mammals, but not as well established in reptiles. We assessed the performance of intramuscularly injected tiletamine (dissociative anesthetic) and zolazepam (benzodiazepine sedative) in fixed combination (2 mg/kg and 3 mg/kg) in comparison to 2 mg/kg of midazolam (benzodiazepine sedative) in ball pythons (Python regius). We measured heart and respiratory rates and quantified induction parameters (i...
2018: PloS One
Brenda T Pun, Michele C Balas, Mary Ann Barnes-Daly, Jennifer L Thompson, J Matthew Aldrich, Juliana Barr, Diane Byrum, Shannon S Carson, John W Devlin, Heidi J Engel, Cheryl L Esbrook, Ken D Hargett, Lori Harmon, Christina Hielsberg, James C Jackson, Tamra L Kelly, Vishakha Kumar, Lawson Millner, Alexandra Morse, Christiane S Perme, Patricia J Posa, Kathleen A Puntillo, William D Schweickert, Joanna L Stollings, Alai Tan, Lucy D'Agostino McGowan, E Wesley Ely
OBJECTIVE: Decades-old, common ICU practices including deep sedation, immobilization, and limited family access are being challenged. We endeavoured to evaluate the relationship between ABCDEF bundle performance and patient-centered outcomes in critical care. DESIGN: Prospective, multicenter, cohort study from a national quality improvement collaborative. SETTING: 68 academic, community, and federal ICUs collected data during a 20-month period...
October 18, 2018: Critical Care Medicine
Leslie Citrome
RBP-7000 (PERSERIS™ ) is a once-monthly subcutaneously administered formulation of risperidone that does not require oral supplementation when initiated. As with risperidone microspheres, RBP-7000 is required to be stored in a refrigerator. The injection kit, consisting of two syringes (one containing liquid polymer, the other containing risperidone powder), will need to come to room temperature prior to mixing their contents. RBP-7000 is administered in the abdomen using an 18 G 5/8-inch length needle. In an 8-week Phase 3 study in patients with acute schizophrenia, monthly RBP-7000 at doses of 90 mg (equivalent to oral risperidone 3 mg/day) and 120 mg (equivalent to oral risperidone 4 mg/day) were superior to placebo on changes in the PANSS total score...
2018: Clinical Schizophrenia & related Psychoses
Jorge Gómez-Arnau, María Martín-Larrégola, María F Rabito-Alcón, Helen Dolengevich-Segal, Leticia Gutiérrez-Velasco, Javier Correas-Lauffer
No abstract text is available yet for this article.
September 2018: Actas Españolas de Psiquiatría
Yan Wang, Yinghou Jiang, Hongning Wu, Runfeng Wang, Ying Wang, Cheng Du
AIM: First, the inferior vena cava dilatation index (DIVC) was measured by ultrasound, and then the reliability of DIVC as an indicator to predict volume responsiveness in patients undergoing mechanical ventilation after pneumonectomy was evaluated. METHODS: Pulse indicator continuous cardiac output (Picco) as gold standard was performed to sedated mechanically ventilated post-pneumonectomy patients in intensive care unit of Nanjing Thoracic Hospital from August 2014 to December 2016...
October 18, 2018: Echocardiography
Argyle V Bumanglag, Robert S Sloviter
OBJECTIVE: To determine when spontaneous granule cell epileptiform discharges first occur after hippocampal injury, and to identify the postinjury "latent" period as either a "silent" gestational state of epileptogenesis or a subtle epileptic state in gradual transition to a more obvious epileptic state. METHODS: Nonconvulsive status epilepticus evoked by perforant path stimulation in urethane-sedated rats produced selective and extensive hippocampal injury and a "latent" period that preceded the onset of the first clinically obvious epileptic seizures...
October 19, 2018: Epilepsia
Gordana Jovanović, Dea Karaba Jakovljević, Mirka Lukić-Šarkanović
Patients are admitted to the surgical intensive care (SICU) unit after emergency and elective surgery. After elective surgery, for further support, or to manage coexisting comorbidities. The implementation of the ERAS (Enhanced recovery after surgery) protocols in surgery should decrease the need for ICU beds, but there will always be unpredicted complications after surgery. These will require individual management. What we can do for our surgical patients in ICU to further enhance their recovery? To promote early enhanced recovery in surgical intensive care-SICU, three areas need to be addressed, sedation, analgesia, and delirium...
2018: Frontiers in Medicine
Onur Koyuncu, Sedat Hakimoglu, Mustafa Ugur, Cagla Akkurt, Selim Turhanoglu, Daniel Sessler, Alparslan Turan
OBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo...
2018: Annali Italiani di Chirurgia
Daniel J Shin, Allison L Germann, Douglas F Covey, Joseph H Steinbach, Gustav Akk
Under both physiological and clinical conditions the GABAA receptors are exposed to multiple agonists, including the transmitter GABA, endogenous or exogenous neuroactive steroids, and various GABAergic anesthetic and sedative drugs. The functional output of the receptor reflects the interplay among all active agents. We have investigated the activation of the concatemeric α1β2γ2L GABAA receptor by combinations of agonists. Simulations of receptor activity using the co-agonist model demonstrate that the response amplitude in the presence of agonist combinations is highly dependent on whether the paired agonists interact with the same or distinct sites...
October 18, 2018: Molecular Pharmacology
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