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https://www.readbyqxmd.com/read/30644730/cis-pt231-tau-drives-neurodegeneration-in-bipolar-disorder
#1
Roghayeh Naserkhaki, Selva Zamanzadeh, Hossein Baharvand, Seyed Massood Nabavi, Hossein Pakdaman, Sahba Shahbazi, Masood Vosough, Gholam Ghaedi, Abdolrazagh Barzegar, Davood Mirtorabi, Javad Hedayatshodeh, Ehsan Ehsani, Mojtaba Falahati, Mohammad Javad Hajipour, Koorosh Shahpasand
Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. Anyhow, it remains uncertain how tau hyperphosphorylation results in neurodegeneration upon the disease. Recent studies have demonstrated that phosphorylated tau at Thr231 exists in two distinct cis and trans conformations, in which cis pT231-tau is highly neurotoxic and acts as an early driver of tauopathy in several neurodegenerative diseases...
January 15, 2019: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30644567/mobile-health-tools-for-the-management-of-chronic-respiratory-diseases
#2
Kristien Sleurs, Sven Seys, Jean Bousquet, Wytske Fokkens, Senne Gorris, Benoit Pugin, Peter W Hellings
BACKGROUND: The market of mobile health (mHealth) technology is rapidly evolving, making new mobile technologies potentially available for health care systems. Patient empowerment through self-monitoring of symptoms, shared decision making with the physician and easily accessible education are important features extending the reach of mHealth technology beyond traditional care. METHODS: Two digital distribution platforms (Apple App Store and Google Play Store) were searched for currently available mobile applications (apps) for patients with chronic respiratory diseases (CRDs)...
January 15, 2019: Allergy
https://www.readbyqxmd.com/read/30644346/association-between-human-leukocyte-antigens-with-autoimmune-diseases-diagnostic-approach
#3
Elham Rajaei, Mohammad Taha Jalali, Saeid Shahrabi, Ali Amin Asnafi, Seyed Mohammad Sadegh Pezeshki
BACKGROUND: The process of antigen presentation to immune cells is an undeniable contributor to pathogenesis of autoimmune diseases. Different studies have indicated several factors that are related to autoimmunity. Human leukocyte antigens (HLAs) are among such factors, which have a key role in autoimmunity because of their involvement in antigen presentation process. METHODS: Relevant English language literature were searched and retrieved from Google Scholar search engine and PubMed database (1996-2018)...
January 15, 2019: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/30644249/analysis-of-prm1-and-prm2-polymorphisms-in-iranian-infertile-men-with-idiopathic-teratozoospermia
#4
Fatemeh Dehghanpour, Farzaneh Fesahat, Seyed Mohsen Miresmaeili, Ehsan Zare Mehrjardi, Ahmad Honarju, Ali Reza Talebi
Single nucleotide polymorphisms (SNPs) in a number of genes involved in sperm maturation are considered as one of the main factors for male infertility. The aim of the present case-control study was to examine the association of SNPs in protamine1 (PRM1) and protamine2 (PRM2) genes with idiopathic teratozoospermia. In this case-control study, some SNPs in PRM1 (c.49 C>T, c.102 G>T and c.230A>C) and PRM2 (rs545828790, rs115686767, rs201933708, rs2070923 and rs1646022) were investigated in 30 idiopathic infertile men with teratozoospermia (case group) in comparison with 35 fertile men (controls)...
April 2019: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/30644246/the-effects-of-olive-leaf-extract-on-the-testis-sperm-quality-and-testicular-germ-cell-apoptosis-in-male-rats-exposed-to-busulfan
#5
Sepideh Ganjalikhan Hakemi, Fariba Sharififar, Tahereh Haghpanah, Abdolreza Babaee, Seyed Hassan Eftekhar-Vaghefi
Background: Busulfan (BU) has a destructive effect on the male reproductive system. The goal of this study was to assess the effects of olive leaf extract (OLE) as a source of antioxidants and phenolic compounds, on BU-induced damages in rat testes. Materials and Methods: In this experimental study, 40 male Wistar rats were randomly divided into 5 groups. The control group (CTL) received a single intraperitoneal (i.p.) injection of dimethyl sulfoxide (DMSO), followed by oral administration of distilled water for 5 weeks...
April 2019: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/30644245/protective-effect-of-n-acetyl-cysteine-on-chlorpyrifos-induced-testicular-toxicity-in-mice
#6
Rasoul Kheradmandi, Seyed Gholam Ali Jorsaraei, Farideh Feizi, Ali Akbar Moghadamnia, Nahid Neamati
Background: Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N-Acetyl Cysteine (NAC), a potent antioxidant against testicular toxicity of CPF in male mice. Materials and Methods: In this experimental study, 42 adult male mice were divided into seven groups, CPF low (0...
April 2019: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/30643864/detection-of-4977-bp-deletion-of-mitochondrial-dna-in-in-vitro-fertilization-failure-women-a-case-control-study
#7
Seyed Hamidreza Mirabutalebi, Noorodin Karami, Hamid Reza Ashrafzadeh, Zhima Akhvansales, Maryam Tavakoli, Nasrin Ghasemi
Background: The quality of oocyte is often considered as a limiting factor for fertility, especially IVF. Some mitochondrial mutations, particularly the 4977-bp deletion increase with the age. Thus, this mutation can serve as a marker for cell aging, which indicates the reduced quality of the oocytes for fertilization. It has been suggested that this can also be investigated in the blood cells of women with IVF failure. Objective: 1-Determination of the frequency of 4977-bp deletion in women with IVF failure, 2-Investigation of the relationship between 4977-bp deletion and the age of patients...
September 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/30643856/relationship-between-mspi-polymorphism-of-cyp1a1-gene-and-the-risk-of-endometriosis-in-an-iranian-population-a-case-control-study
#8
Azam Babaki, Ehsan Zare Mehrjardi, Razieh Dehghani Firouzabadi, Abbas Aflatoonian, Seyed Morteza Seifati
Background: Endometriosis is a disease that affects women of reproductive age. This disease is characterized by the presence of endometrial-like tissues (endometrial or stromal glands) outside the uterus and shows significantly elevated prevalence in industrial regions. Additionally, an interaction between genetics and environmental factors is assumed for the disease. Enzymes belonging to the cytochrome P450 (CYP) family are participated in detoxification process of a wide range of environmental toxins and carcinogens...
October 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/30643853/aberrant-expression-of-micrornas-16-and-21-and-gene-targets-in-women-with-unexplained-recurrent-miscarriage-a-case-control-study
#9
Noorodin Karami, Seyed Hamidreza Mirabutalebi, Fatemeh Montazeri, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha, Maryam Eftekhar
No abstract text is available yet for this article.
October 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/30643831/effects-of-self-management-education-on-self-efficacy-and-quality-of-life-in-patients-with-ulcerative-colitis-a-randomized-controlled-clinical-trial
#10
Mahboobeh Magharei, Sakineh Jaafari, Parisa Mansouri, Alireza Safarpour, Seyed Alireza Taghavi
Background: Self-management (SM) as a dynamic process enables Ulcerative colitis (UC) patients to live with this chronic illness. The present study aimed to investigate the effect of SM education on self-efficacy (SE) and quality of life (QoL) in patients with UC. Methods: This randomized controlled clinical trial study was conducted on 64 patients with UC from December 2016 to February 2017 at Motahari clinic, Shiraz. Patients were randomly divided into two groups of intervention and control...
January 2019: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/30643271/immunoglobulin-deposition-on-biomolecule-corona-determines-complement-opsonization-efficiency-of-preclinical-and-clinical-nanoparticles
#11
Vivian P Vu, Geoffrey B Gifford, Fangfang Chen, Halli Benasutti, Guankui Wang, Ernest V Groman, Robert Scheinman, Laura Saba, Seyed Moein Moghimi, Dmitri Simberg
Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonization of superparamagnetic iron oxide (SPIO) nanoworms with the third complement protein (C3) was dependent on the biomolecule corona of the nanoparticles. Here we show that natural antibodies play a critical role in C3 opsonization of SPIO nanoworms and a range of clinically approved nanopharmaceuticals...
January 14, 2019: Nature Nanotechnology
https://www.readbyqxmd.com/read/30642275/a-novel-mutation-in-sepn1-causing-rigid-spine-muscular-dystrophy-1-a-case-report
#12
Fateme Ziyaee, Eslam Shorafa, Hassan Dastsooz, Parham Habibzadeh, Hamid Nemati, Amir Saeed, Mohammad Silawi, Mohammad Ali Farazi Fard, Mohammad Ali Faghihi, Seyed Alireza Dastgheib
BACKGROUND: Muscular dystrophies are a clinically and genetically heterogeneous group of disorders characterized by variable degrees of progressive muscle degeneration and weakness. There is a wide variability in the age of onset, symptoms and rate of progression in subtypes of these disorders. Herein, we present the results of our study conducted to identify the pathogenic genetic variation involved in our patient affected by rigid spine muscular dystrophy. CASE PRESENTATION: A 14-year-old boy, product of a first-cousin marriage, was enrolled in our study with failure to thrive, fatigue, muscular dystrophy, generalized muscular atrophy, kyphoscoliosis, and flexion contracture of the knees and elbows...
January 14, 2019: BMC Medical Genetics
https://www.readbyqxmd.com/read/30642131/navigating-virtual-environments-using-leg-poses-and-smartphone-sensors
#13
Georgios Tsaramirsis, Seyed M Buhari, Mohammed Basheri, Milos Stojmenovic
Realization of navigation in virtual environments remains a challenge as it involves complex operating conditions. Decomposition of such complexity is attainable by fusion of sensors and machine learning techniques. Identifying the right combination of sensory information and the appropriate machine learning technique is a vital ingredient for translating physical actions to virtual movements. The contributions of our work include: (i) Synchronization of actions and movements using suitable multiple sensor units, and (ii) selection of the significant features and an appropriate algorithm to process them...
January 13, 2019: Sensors
https://www.readbyqxmd.com/read/30641826/dose-vitamin-d-supplementations-improve-peripheral-diabetic-neuropathy-a-before-after-clinical-trial
#14
Akram Ghadiri-Anari, Zohre Mozafari, Somaye Gholami, Seyed-Ali Khodaei, Marzieh Aboutorabi-Zarchi, Fariba Sepehri, Azade Nadjarzade, Masoud Rahmanian, Nasim Namiranian
OBJECTIVE: Peripheral neuropathy is a common complication of diabetes mellitus. This study was set to assess the effect of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes (T2DM). MATERIALS AND METHODS: This study was a quasi-experimental trial in Yazd diabetic research center. Sixty T2DM subjects (30-65 years old) with painful diabetic neuropathy enrolled in this study from March 2017 till April 2018. Patients received weekly 50000 IU of vitamin D3 for 12 weeks orally...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641786/serum-vitamin-e-as-a-significant-prognostic-factor-in-patients-with-dyslipidemia-disorders
#15
Maral Barzegar-Amini, Hamideh Ghazizadeh, Seyed Mohammad Reza Seyedi, Hamid Reza Sadeghnia, Akram Mohammadi, Mahdi Hassanzade-Daloee, Elham Barati, Sara Kharazmi-Khorassani, Jasmin Kharazmi-Khorassani, Maryam Mohammadi-Bajgiran, Shima Tavallaie, Gordon A Ferns, Mohsen Mouhebati, Mahmoud Ebrahimi, Maryam Tayefi, Majid Ghayour-Mobarhan
OBJECTIVES: Obesity and overweight are among the main causes of cardiovascular disease (CVD) mortality. Dyslipidemia, fatty liver index, is strongly related to CVD. Vitamin E as an antioxidant protects the hepatic cells against oxidative stress and prevents fatty liver disease. The aim of the current study is to evaluate the relationship between anthropometric parameters and fasted lipid profile with serum vitamin E levels. STUDY DESIGN: A randomized trial was designed based on data from the Mashhad stroke and heart atherosclerotic disorders (MASHAD: 2010-2020)...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641773/the-prevalence-of-peyronie-s-disease-in-diabetic-patients-2018-yazd
#16
Maryam Askari, Seyed Ali Mohamad Mirjalili, Mina Bozorg, Reyhane Azizi, Nasim Namiranian
INTRODUCTION: Peyronie's disease (PD) is the fibrous scar tissue inside the penis that causes curved and painful erections. PD is associated with, diabetes, hypertension, dyslipidemia and low testosterone. PD causes erectile dysfunction (ED). The aim of this study was to evaluate the prevalence of PD in type 2 diabetic (T2DM) patients in Yazd. METHODS: This cross-sectional study was conducted on 317 patients with T2DM referred to the Diabetes Research Center of Yazd...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641734/body-mass-index-growth-trajectories-from-birth-through-24-months-in-iranian-infants-of-mothers-with-gestational-diabetes-mellitus
#17
Sedigheh Nouhjah, Hajieh Shahbazian, Seyed Mahmoud Latifi, Reza Azizi Malamiri, Niloofar Ghodrati
AIMS: Child growth is one of the important health indicators in pediatric care. Few studies focused on the impact of prenatal exposure to gestational diabetes mellitus (GDM) on growth trajectories particular in early years of childhood. The aim of this study was identifying growth pattern of GDM exposed offspring's, comparison with new WHO child growth standards. METHODS AND MATERIALS: In a population-based Longitudinal study 438 infants exposed to gestational diabetes in utero, aged 0-24 months, born between 2014 and 2016 with at least 9 visits in first 2 years of life were enrolled...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641703/vitamin-d-level-in-non-diabetic-adult-people-with-metabolic-syndrome
#18
Bahman Ghaderian, Zivar Shirinpour, Armaghan Moravej Aleali, Seyed Mahmoud Latifi, Seyed Peyman Payami, Reza Amani, Marzieh Ghasemi, Mitra Zaheri Birgani
AIMS: The aim of this study is comparison the level of Vitamin D deficiency in non-diabetic adult people with metabolic syndrome in Ahvaz. MATERIAL & METHODS: This descriptive study investigation carried out on a population of individuals with metabolic syndrome. ATPIII criteria were used for metabolic syndrome. Serum concentration of 25 (OH Vit D) of below 5 ng/ml was considered as severe deficiency, 5-10 ng/ml as average deficiency, 10-20 ng/ml as slight deficiency, and above 20 ng/ml as normal...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641697/incidence-of-obesity-overweight-and-hypertension-in-children-and-adolescents-in-ahvaz-southwest-of-iran-five-years-study
#19
Homeira Rashidi, Azam Erfanifar, Seyed Mahmoud Latifi, Seyed Peyman Payami, Armaghan Moravej Aleali
OBJECTIVE: The purpose of this study was to investigate the incidence of obesity, overweight and hypertension in children and adolescents aged 10-15 in Ahvaz. METHODS: This is a epidemiologic study performed on 176 people aged 10-15 in Ahvaz. In 2009, 300 people underwent weight, height and blood pressure measurements. Five years later, the same people were reassessed for obesity, overweight and hypertension, of whom a total of 176 people agreed to repeat the procedure...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30641110/heroin-based-crack-induces-hyperalgesia-through-%C3%AE-arrestin-2-redistribution-and-phosphorylation-of-erk1-2-and-jnk-in-the-periaqueductal-gray-area
#20
Seyed Mohsen Aberoumandi, Nasim Vousooghi, Bahram Amoughli Tabrizi, Pouran Karimi
Continuous use of crack induces hyperalgesia which is related to drug tolerance. Despite cumulative evidence based on the growth rate of crack abuse, no serious study has been focused on the mechanisms of crack-induced hyperalgesia. This study aimed to elucidate whether extracellular signal-regulated kinases (Erk1/2)/β-arrestin pathways are involved in the crack-induced hyperalgesia. Fifty adult male Wistar rats were randomly divided into five groups: normal saline (NS), crack (0.9 mg/kg/day), heroin (1 mg/kg/day), crack + barbadin (100 μM), and heroin + barbadin groups, which received their intraperitoneal (i...
January 11, 2019: Neuroscience Letters
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