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https://www.readbyqxmd.com/read/30408554/peptide-based-targeted-therapeutics-focus-on-cancer-treatment
#1
REVIEW
Fatemeh Araste, Khalil Abnous, Maryam Hashemi, Seyed Mohmmad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Therapeutic peptides are attracting increasing attention for biomedical applications. Peptides present promising opportunities in targeted drug delivery due to their high specificity, selectivity, small dimensions, ease of modification, and high biocompatibility. During the last decade, the potential of peptides as therapeutics or targeting ligands has been boomed in nanotechnology and cancer research. This review summarizes various peptides as therapeutics and targeting ligands in cancer therapy. At first, two categories of tumor homing and cell penetrating peptides (CPPs) are introduced and then we will discuss the modification of CPPs...
November 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30408085/correlation-of-vascular-endothelial-growth-factor-subtypes-and-their-receptors-with-melanoma-progression-a-next-generation-tissue-microarray-ngtma-automated-analysis
#2
S Morteza Seyed Jafari, Christina Wiedmer, Simone Cazzaniga, Živa Frangež, Maziar Shafighi, Helmut Beltraminelli, Benedikt Weber, Hans-Uwe Simon, Robert E Hunger
INTRODUCTION: Finding new markers to assess prognosis of melanoma without the necessity to perform a surgical interventions is an important goal in melanoma research. The current study aimed to assess the correlation of clinical course and prognosis of primary and metastatic melanoma with expression of VEGF family and their receptors. METHODS: A ngTMA block was made from the randomly selected paraffin tissue blocks of the patients with melanocytic nevi, primary and metastatic melanoma...
2018: PloS One
https://www.readbyqxmd.com/read/30407814/optimizing-non-bonded-interactions-of-the-opls-force-field-for-aqueous-solutions-of-carbohydrates-how-to-capture-both-thermodynamics-and-dynamics
#3
Seyed Hossein Jamali, Thijs van Westen, Othonas A Moultos, Thijs J H Vlugt
Knowledge on thermodynamic and transport properties of aqueous solutions of carbohydrates is of great interest for process and product design in the food, pharma- ceutical, and biotechnological industries. Molecular simulation is a powerful tool to calculate these properties, but current classical force fields cannot provide accurate es- timates for all properties of interest. The poor performance of the force fields is mainly observed for concentrated solutions, where solute-solute interactions are overestimated...
November 8, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/30406492/the-impact-of-spiritual-care-education-on-anxiety-in-family-caregivers-of-patients-with-heart-failure
#4
Milad Borji, Seyed Rahmatollah Mousavimoghadam, Ebrahim Salimi, Masoumeh Otaghi, Yosof Azizi
Heart failure (HF) has been emerging as a general health problem over recent decades. Spiritual care is a type of support service provided to patients suffering from HF. Spiritual care intervention in nursing is a unique aspect of care, which cannot be replaced by psychosocial care. Considering the importance of anxiety for caregivers of patients with HF, the present study aimed to examine the effect of spiritual intervention on anxiety in caregivers of patients with HF in Ilam, Iran. This research is a semi-experimental study, 71 caregivers of patients with HF were randomly assigned to experimental group (n = 34) and control (n = 37) group...
November 7, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/30405894/vitamin-d-and-its-receptor-polymorphisms-new-possible-prognostic-biomarkers-in-leukemias
#5
Seyed Mohammad Sadegh Pezeshki, Ali Amin Asnafi, Abbas Khosravi, Mohammad Shahjahani, Shirin Azizidoost, Saeid Shahrabi
Several factors such as chromosomal translocations, gene mutations, and polymorphisms are involved in the pathogenesis of leukemia/lymphoma. Recently, the role of vitamin D (VD) and vitamin D receptor (VDR) polymorphisms in hematologic malignancies has been considered. In this review, we examine the possible role of VD levels, as well as VDR polymorphisms as prognostic biomarkers in leukemia/lymphoma. Relevant English language literature were searched and retrieved from Google Scholar search engine (1985-2017)...
July 4, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30405064/active-food-packaging-coatings-based-on-hybrid-electrospun-gliadin-nanofibers-containing-ferulic-acid-hydroxypropyl-beta-cyclodextrin-inclusion-complexes
#6
Niloufar Sharif, Mohammad-Taghi Golmakani, Mehrdad Niakousari, Seyed Mohammad Hashem Hosseini, Behrouz Ghorani, Amparo Lopez-Rubio
In this work, hybrid gliadin electrospun fibers containing inclusion complexes of ferulic acid (FA) with hydroxypropyl-beta-cyclodextrins (FA/HP-β-CD-IC) were prepared as a strategy to increase the stability and solubility of the antioxidant FA. Inclusion complex formation between FA and HP-β-CD was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), and X-ray diffraction (XRD). After adjusting the electrospinning conditions, beaded-free fibers of gliadin incorporating FA/HP-β-CD-IC with average fiber diameters ranging from 269...
November 7, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30404943/the-genetic-diversity-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis-in-the-capital-of-iran-revealed-by-whole-genome-sequencing
#7
Farzam Vaziri, Thomas A Kohl, Hasan Ghajavand, Mansour Kargarpour Kamakoli, Matthias Merker, Shima Hadifar, Sharareh Khanipour, Abolfazl Fateh, Morteza Masoumi, Seyed Davar Siadat, Stefan Niemann
The emergence and spread of multidrug resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains is a critical global health problem. Between 2014 and 2018, 606 MTBC strains were isolated from 13,892 suspected pulmonary tuberculosis (TB) patients in Tehran, Iran, including 16 MDR-TB (2.6%) cases. A combination of phenotypic and genotypic methods (whole genome sequencing), was employed for the identification of additional drug resistances and strain-to-strain genetic distances as a marker for recent transmission events...
November 7, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30402809/safranal-protects-against-beta-amyloid-peptide-induced-cell-toxicity-in-pc12-cells-via-mapk-and-pi3-k-pathways
#8
Faezeh Rafieipour, Elham Hadipour, Seyed Ahmad Emami, Javad Asili, Zahra Tayarani-Najaran
Alzheimer's disease is a type of cerebrovascular problem with progressive mental disabilities for the patient. This study aimed to investigate the protective effect of safranal on toxicity and oxidative damage induced by beta-amyloid (Aβ) and hydrogen peroxide (H2 O2 ) in PC12 cells as an appropriate model of Alzheimer's cell damage. PC12 cells pretreated with saffron extract (2.5-40 μg/ml), essential oil (2.5-40 μg/ml), safranal (2.5-5-40 μM) and donepezil (5, 10 and 20 μM) for 120 min. Then exposed to either Aβ (25 μM) for 48 h or H2 O2 (150 μM) for 24 h...
November 6, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30402514/diagnostic-accuracy-of-rapid-ultrasound-in-shock-rush-exam-a-systematic-review-and-meta-analysis
#9
REVIEW
Mojtaba Keikha, Mohammad Salehi-Marzijarani, Reihane Soldoozi Nejat, Hojat Sheikh Motahar Vahedi, Seyed Mohammad Mirrezaie
Objective: To perform a diagnostic accuracy of the rapid ultrasound in shock (RUSH) to diagnose the etiology of undifferentiated shock in patients presenting to the emergency department (ED). Methods: We searched the Medline via PubMed, Scopus, and ISI Web of Knowledge till July 2017. Two independent reviewers screened studies for eligibility. Our study analysis is planned in accordance with the guidelines for meta-analysis of diagnostic studies. In the systematic search, of 397 references, 295 were excluded on the basis of the title and abstract...
October 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/30401643/prevalence-of-hepatitis-c-virus-ns5a-resistance-associated-substitutions-in-chronic-infection-with-genotype-1-a-pooled-analysis-based-on-deposited-sequences-in-genbank
#10
Heidar Sharafi, Saeideh Maleki, Seyed Moayed Alavian
INTRODUCTION: Resistance-associated substitutions (RASs) in the NS5A gene of hepatitis C virus (HCV) has been studied as one of the predictors of response to NS5A inhibitor-containing regimens. This study aimed to evaluate the prevalence of pre-treatment naturally-occurring NS5A RASs in HCV isolates from patients with chronic HCV genotype 1 (HCV-1) infection retrieved from GenBank. METHODS: In the search procedure, the studies with published HCV-1 NS5A sequence in GenBank were screened and evaluated for inclusion in the pooled analysis...
October 25, 2018: Virus Research
https://www.readbyqxmd.com/read/30399440/a-systematic-review-of-toxoplasma-gondii-antigens-to-find-the-best-vaccine-candidates-for-immunization
#11
REVIEW
Fatemeh Rezaei, Shahabeddin Sarvi, Mahdi Sharif, Seyed Hossein Hejazi, Abdol Sattar Pagheh, Sargis A Aghayan, Ahmad Daryani
At present, there is not any available accepted vaccine for prevention of Toxoplasma gondii (T. gondii) in human and animals. We conducted literature search through English (Google Scholar, PubMed, Science Direct, Scopus, EBSCO, ISI Web of Science) scientific paper databases to find the best vaccine candidates against toxoplasmosis among T. gondii antigens. Articles with information on infective stage, pathogenicity, immunogenicity and characterization of antigens were selected. We considered that the ideal and significant vaccines should include different antigens and been expressed in all infective stages of the parasite with a high pathogenicity and immunogenicity...
November 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30398505/catalytic-and-networking-effects-of-carbon-black-on-the-kinetics-and-conversion-of-sulfur-vulcanization-in-styrene-butadiene-rubber
#12
Seyed Mostaffa Hosseini, Mehdi Razzaghi-Kashani
The present work discusses the effects of carbon-black (CB) on the kinetics and conversion of sulfur vulcanization in styrene butadiene rubber (SBR) compounds. Kinetic studies revealed that the onset of the vulcanization reaction shortens monotonically by incorporation of CB, but the rate of vulcanization goes through a maximum at a critical loading of CB. It was demonstrated that CB has two roles in the kinetics of vulcanization: a catalytic effect on accelerating the initial reactions among vulcanization agents and a networking effect on retarding the crosslinking of macro-radicals...
November 6, 2018: Soft Matter
https://www.readbyqxmd.com/read/30398001/elevated-expression-of-mir-21-and-mir-155-in-peripheral-blood-mononuclear-cells-as-potential-biomarkers-for-lupus-nephritis
#13
Majid Khoshmirsafa, Nahid Kianmehr, Reza Falak, Seyed Javad Mowla, Farhad Seif, Behnaz Mirzaei, Mohadeseh Valizadeh, Mehdi Shekarabi
AIM: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). There is a great interest in using microRNAs (miRNAs) as diagnostic and prognostic biomarkers in autoimmune diseases. MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction...
November 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30397850/cellular-and-molecular-aspects-of-parkinson-treatment-future-therapeutic-perspectives
#14
REVIEW
Khosro Jamebozorgi, Eskandar Taghizadeh, Daryoush Rostami, Hosein Pormasoumi, George E Barreto, Seyed Mohammad Gheibi Hayat, Amirhossein Sahebkar
Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamine by passing through the blood-brain barrier. Although L-dopa is able to improve motor function and improve the quality of life in the patients, there is inter-individual variability and some patients do not achieve the therapeutic effect...
November 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30397582/numerical-study-on-the-impulsive-growth-of-a-gaseous-plug-inside-a-cylindrical-vein-with-compliant-coating
#15
Mohammad T Shervani-Tabar, Babak Farzaneh, Reza Ahrabi, Seyed E Razavi
Introduction : Employing of gaseous plugs inside a vein for preventing of blood flow to the damaged or cancerous tissues has been known as a gas embolism in the medicine. In this research, a numerical investigation has been carried out on the delivery of the liquid drug DDFP, encapsulated in the microlipidcoated spheres (MLCSs), to target the human vein for construction of the gaseous plug inside the veins. Methods : The encapsulated liquid drug DDFP were delivered to the vein by injection of an emulsion. Releasing of the liquid drug DDFP results in an explosive growth of a gaseous plug inside the vein...
2018: BioImpacts: BI
https://www.readbyqxmd.com/read/30396737/three-year-efficacy-and-patency-follow-up-of-decellularized-human-internal-mammary-artery-as-a-novel-vascular-graft-in-animal-models
#16
Abdol-Mohammad Kajbafzadeh, Reza Khorramirouz, Seyedeh Maryam Kameli, Kiarad Fendereski, Seyedeh Sima Daryabari, Seyed Mohammad Tavangar, Bahram Azizi Garajegayeh
BACKGROUND: Various investigations have reported that the internal mammary artery (IMA) is an efficient and functional choice of conduit for vascular graft surgeries, especially for coronary artery bypass grafts; however, the quest to find an ideal vascular substitute remains. We hypothesized that acellular IMA could be an appropriate graft for small-diameter vascular bypasses that could be used in various surgeries including coronary artery bypass grafting. METHODS: We decellularized human IMAs and performed histologic evaluations and scanning electron microscopy to confirm the decellularization process and the preservation of the extracellular matrix...
September 28, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30396620/the-effect-of-tai-chi-on-quality-of-life-in-male-older-people-a-randomized-controlled-clinical-trial
#17
Alireza Tajik, Nahid Rejeh, Majideh Heravi-Karimooi, Parvaneh Samday Kia, Seyed Davood Tadrisi, Tessa E Watts, Pauline Griffiths, Mojtaba Vaismoradi
BACKGROUND AND AIM: Physical activity can improve the mental and physical functioning of older people. This study investigated the impact of Tai Chi exercise on the quality of life of older men. METHODS: This randomized controlled clinical trial was conducted on 132 older men in an urban area of Iran. The subjects were randomly assigned into two groups: a Tai Chi intervention group and a control group (n = 66 per group). Quality of life was evaluated using the Leiden-Padua quality of life questionnaire before and after the intervention...
November 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/30396619/the-effect-of-guided-imagery-on-anxiety-depression-and-vital-signs-in-patients-on-hemodialysis
#18
Yaser Beizaee, Nahid Rejeh, Majideh Heravi-Karimooi, Seyed Davood Tadrisi, Pauline Griffiths, Mojtaba Vaismoradi
BACKGROUND AND PURPOSE: Patients on hemodialysis experience anxiety and depression. This study aimed to investigate the effect of guided imagery on anxiety, depression, and vital signs in patients on hemodialysis. MATERIALS AND METHODS: This randomized controlled clinical trial was conducted on 80 patients undergoing hemodialysis. The subjects were randomly assigned into two groups: a guided intervention group and a control group. Anxiety and depression were measured using the Hospital Anxiety and Depression Scale...
November 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/30392197/stress-assessment-by-means-of-heart-rate-derived-from-functional-near-infrared-spectroscopy
#19
Naser Hakimi, Seyed Kamaledin Setarehdan
Many studies have been carried out in order to detect and quantify the level of mental stress by means of different physiological signals. From the physiological point of view, stress promptly affects brain and cardiac function; therefore, stress can be assessed by analyzing the brain- and heart-related signals more efficiently. Signals produced by functional near-infrared spectroscopy (fNIRS) of the brain together with the heart rate (HR) are employed to assess the stress induced by the Montreal Imaging Stress Task...
November 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/30392136/metabolomics-analysis-revealed-metabolic-changes-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome-and-metabolic-responses-to-a-synbiotic-yogurt-intervention
#20
Hamid Noorbakhsh, Masoud Yavarmanesh, Seyed Ali Mortazavi, Peyman Adibi, Ali A Moazzami
PURPOSE: Irritable bowel syndrome is a gastrointestinal disorder which can influence human metabolism. It has been demonstrated that probiotics are beneficial in controlling IBS. Thus, the main objective of the present study was to determine metabolic changes in response to diarrhea predominant irritable bowel syndrome (IBS-D) and to investigate the metabolic effects of a synbiotic intervention on serum, urine, and stool samples from IBS-D patients and healthy controls using proton nuclear magnetic resonance (1 HNMR)...
November 3, 2018: European Journal of Nutrition
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