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Work-related Asthma

Hille Suojalehto, Joaquin Sastre, Emilia Merimaa, Irmeli Lindström, Katri Suuronen
BACKGROUND: Two-component epoxy resin systems (ERS) composed of epoxy resin and polyamine hardeners are extensively used in industrial and construction coating. Triglycidyl isocyanurate (TGIC) is another type of epoxy derivative, mostly encountered in polyester powder paints. Epoxy compounds are well known skin sensitizers, but their respiratory sensitizing potential is largely unknown. OBJECTIVES: We report patients examined for occupational asthma from epoxy compounds...
July 31, 2018: Journal of Allergy and Clinical Immunology in Practice
K M Phillips, R W Bergmark, L P Hoehle, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: The frequency of chronic rhinosinusitis (CRS) exacerbations is an independent predictor of quality of life. The objective of this study was to evaluate if increased CRS exacerbations predict decreased productivity. METHODS: Cross-sectional study of adult CRS patients. Number of patient-reported CRS-related antibiotic and oral corticosteroids courses and sinus infections in the past three months were used as metrics for acute exacerbations of CRS (AECRS)...
July 25, 2018: Rhinology
J M Molina Aragonés, R Bausà Peris, R Carreras Valls, A Carrillo Castillo, F Fiblà Nicolau, E Gaynés Palou, J Guerrero Monge, J Inglés Torruella, J A López Muñoz, E Martinez Martínez-Carrasco, J Matllo Aguilar, J A Medina Lavela, M T Mestre Prad, P Peña García, S Rodriguez Vallecillos, G Tapias Oller, M Vilardell Ynaraja
The presence of formaldehyde at workplace remains significant. Exposure to it results in local irritation of the eye, nose and upper respiratory tract mucous membranes, and it has been chronically related to a higher risk of cancer development at the paranasal sinuses, naso-oropharynx and lungs. The aim of our work has been the updating of the bibliography and the categorization of the most up to date scientific evidence of formaldehyde effects on human body. Bibliographic search on the electronic database Medline / PubMed, restricted to the last 10 years through a combination of free and controlled language...
July 2018: Archivos de Prevención de Riesgos Laborales
Ewa Nowakowska-Świrta, Marta Wiszniewska, Jolanta Walusiak-Skorupa
Bronchial hyperresponsiveness (BHR) is the individual ability to respond with bronchoconstriction to a variety of specific and nonspecific stimuli which do not cause these symptoms among healthy subjects. Bronchial hyperresponsiveness is one of the hallmark features of asthma. The degree of bronchial hyperresponsiveness is variable among individuals with asthma and may correlate to its severity (the more severe asthma the higher bronchial hyperreactivity). Bronchial hyperresponsiveness is evaluated by performing bronchial provocation test (BPT)...
July 16, 2018: Medycyna Pracy
Carlos Melero, Santiago Quirce, Alicia Huerta, Estefany Uría, Maribel Cuesta
OBJECTIVE: Estimate the economic impact of severe asthma from the Spanish social perspective through the estimation of the associated annual direct and indirect costs. METHODS: Observational, longitudinal, retrospective study carried out in 20 Spanish secondary settings (Pulmonology and Allergy Services) among patients aged ≥18, diagnosed with severe asthma according to ERS/ATS consensus and who have not experienced an exacerbation in the previous 2 months. Asthma-related healthcare resource utilization as well as asthma-related days off work were collected over a retrospective 12-month period from medical records review (inclusion period: June to November 2016)...
July 13, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Javier Milagro, Eduardo Gil, Jesus Lazaro, Ville-Pekka Seppae, Leo Pekka Malmberg, Anna Susanna Pelkonen, Anne Kotaniemi-Syrjanen, Mika Makela, Jari Viik, Raquel Bailon
Asthma is a chronic lung disease that usually develops during chilhood. Despite that symptoms can almost be controlled with medication, early diagnosis is desirable in order to reduce permanent airway obstruction risk. It has been suggested that abnormal parasympathetic nervous system (PSNS) activity might be closely related with the pathogenesis of asthma, and that this PSNS activity could be reflected in cardiac vagal control. In this work, an index to measure the spectral regularity of the high frequency (HF) component of heart rate variability (HRV) spectrum, named peakness (P), is proposed...
November 17, 2017: IEEE Journal of Biomedical and Health Informatics
Giuliana Ferrante, Stefania La Grutta
Asthma is the most common chronic disease in children, imposing a consistent burden on health system. In recent years, prevalence of asthma symptoms became globally increased in children and adolescents, particularly in Low-Middle Income Countries (LMICs). Host (genetics, atopy) and environmental factors (microbial exposure, exposure to passive smoking and air pollution), seemed to contribute to this trend. The increased prevalence observed in metropolitan areas with respect to rural ones and, overall, in industrialized countries, highlighted the role of air pollution in asthma inception...
2018: Frontiers in Pediatrics
Sharon D Horner, Gayle M Timmerman, Bennie C McWilliams
PURPOSE: The purpose of this study is to test the feasibility of delivering an intervention that combines healthy lifestyle behaviors related to weight management with asthma self-management, the Living Healthy with Asthma intervention, to children who have asthma. METHODS AND DESIGN: Using a mixed design, the feasibility study of the 12-week Living Healthy with Asthma intervention was conducted with a single group of children diagnosed with asthma. Pretest and posttest data were collected on asthma-related (self-management, metered dose inhaler [MDI] skill, asthma severity, quality of life [QOL]), and healthy lifestyle variables (body mass index [BMI], dietary quality)...
July 4, 2018: Journal for Specialists in Pediatric Nursing: JSPN
Loretta Jacques, Nawar Diar Bakerly, John P New, Henrik Svedsater, James Lay-Flurrie, David A Leather
OBJECTIVE: The Asthma Salford Lung Study demonstrated the effectiveness of initiating once-daily fluticasone furoate/vilanterol (FF/VI) versus continuing usual care in asthma patients in UK primary care [1]. Here, we report a secondary analysis in a subset of patients with fluticasone propionate/salmeterol (FP/Salm) as their baseline intended maintenance therapy, to evaluate the relative effectiveness of initiating FF/VI versus continuing FP/Salm. METHODS: Adults with symptomatic asthma were randomised to initiate FF/VI 100[200]/25 µg or continue FP/Salm...
July 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
O Vandenplas, J Godet, L Hurdubaea, C Rifflart, H Suojalehto, M Wiszniewska, X Munoz, J Sastre, P Klusackova, V Moore, R Merget, D Talini, C Svanes, P Mason, M dell'Omo, P Cullinan, G Moscato, S Quirce, J Hoyle, D Sherson, P Kauppi, A Preisser, N Meyer, F de Blay
BACKGROUND: High-molecular-weight (HMW) proteins and low-molecular-weight (LMW) chemicals can cause occupational asthma (OA) although few studies have thoroughly compared the clinical, physiological, and inflammatory patterns associated with these different types of agents. The aim of this study was to determine whether OA induced by HMW and LMW agents show distinct phenotypic profiles. METHODS: Clinical and functional characteristics, and markers of airway inflammation were analyzed in an international, multicenter, retrospective cohort of subjects with OA ascertained by a positive inhalation challenge response to HMW (n=544) and LMW (n=635) agents...
June 28, 2018: Allergy
Xuehua Ke, Abhishek Kavati, Debra Wertz, Qing Huang, Liya Wang, Vincent J Willey, Judith J Stephenson, Benjamin Ortiz, Brandee Paknis, Jonathan A Bernstein, Lisa A Beck
BACKGROUND: Omalizumab is indicated for the management of chronic idiopathic urticaria (CIU) in patients aged 12 years or older with persistent hives that are not adequately controlled by H1 antihistamines. While its safety and efficacy in CIU patients have been evaluated in multiple clinical trials, real-world use of omalizaumab in CIU has not been well characterized. OBJECTIVE: To assess demographics, clinical characteristics, and treatment patterns of CIU patients who initiated omalizumab to better understand the usage of this agent in CIU management in the real world...
July 2018: Journal of Managed Care & Specialty Pharmacy
Rafael V Veiga, Helio J C Barbosa, Heder S Bernardino, João M Freitas, Caroline A Feitosa, Sheila M A Matos, Neuza M Alcântara-Neves, Maurício L Barreto
BACKGROUND: Asthma and allergies prevalence increased in recent decades, being a serious global health problem. They are complex diseases with strong contextual influence, so that the use of advanced machine learning tools such as genetic programming could be important for the understanding the causal mechanisms explaining those conditions. Here, we applied a multiobjective grammar-based genetic programming (MGGP) to a dataset composed by 1047 subjects. The dataset contains information on the environmental, psychosocial, socioeconomics, nutritional and infectious factors collected from participating children...
June 26, 2018: BMC Bioinformatics
Carlos García-Vásquez, María J Fernández-Aceñero, Soledad García Gómez-Heras, Carlos Pastor
The intestinal anastomotic failure is one of the most severe complications in gastrointestinal surgery. Despite the great surgical improvements during the last decade, anastomotic leak rates remain practically the same, with a dramatically high grade of morbidity for patients. Leakages are usually the final consequence of ischemia in the anastomosis, leading to tissue hypoxia. In response to hypoxia, the cell orchestrates a variety of coordinated responses in order to restore oxygen homeostasis. The molecular mechanism of hypoxia sensitivity involves oxygen sensing hydroxylases, prolyl-hydroxylases, orchestrating two main transcription factors related to induction of inflammation and angiogenesis, namely nuclear factor-κB and hypoxia-inducible factors...
June 2018: Experimental Biology and Medicine
Feng-Chiao Su, Melissa C Friesen, Aleksandr B Stefaniak, Paul K Henneberger, Ryan F LeBouf, Marcia L Stanton, Xiaoming Liang, Michael Humann, M Abbas Virji
Objectives: Use of cleaning and disinfecting products is associated with work-related asthma among healthcare workers, but the specific levels and factors that affect exposures remain unclear. The objective of this study was to evaluate the determinants of selected volatile organic compound (VOC) exposures in healthcare settings. Methods: Personal and mobile-area air measurements (n = 143) from 100 healthcare workers at four hospitals were used to model the determinants of ethanol, acetone, 2-propanol, d-limonene, α-pinene, and chloroform exposures...
June 21, 2018: Annals of Work Exposures and Health
Madelyn Welch, Thomas Ludden, Kathleen Mottus, Paul Bray, Lori Hendrickson, Jennifer Rees, Jacqueline Halladay, Hazel Tapp
OBJECTIVE: Poor outcomes and health disparities related to asthma result in part from difficulty disseminating new evidence such as shared decision making (SDM) into clinical practice. As part of a three-arm cluster randomized dissemination study, evaluation of the impact of different dissemination methods was studied. Here we evaluate themes from patient and provider focus groups to assess the impact of a facilitated, traditional dissemination approach, or no intervention, on patient and provider perspectives of asthma care...
June 21, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Gabriella Guarnieri
OBJECTIVES: An accurate diagnosis of occupational allergic respiratory diseases is crucial because they are related to disability, loss of work and worsening of psychosocial and economic status of workers. Early diagnosis is therefore essential to prevent the progression of allergic respiratory diseases and to implement preventive measures. The most frequent occupational allergic respiratory diseases are asthma (OA) and rhinitis (OR), less frequently hypersensitivity pneumonia (HP) and non-asthmatic eosinophilic bronchitis (NAEB)...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
Eun Lee, Young-Ho Kim, Hyun-Ju Cho, Ji-Sun Yoon, Sungsu Jung, Song-I Yang, Hyung Young Kim, Ji-Won Kwon, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Soo-Jong Hong
BACKGROUND: Bronchial hyperresponsiveness (BHR), one of the key features of asthma, shows a diverse natural course in school-aged children, but, studies on BHR phenotypes are lacking. OBJECTIVE: We classified BHR phenotypes according to onset age and persistence in children and investigated the characteristics and factors associated with each phenotype in a longitudinal study. METHODS: We analyzed 1,305 elementary school children from the Children's HEalth and Environmental Research (CHEER) study, a 4-year prospective follow-up study with 2-year intervals starting at a mean age of 7 years...
June 7, 2018: Annals of Allergy, Asthma & Immunology
Árpád Farkas, Alpár Horváth, Attila Kerekes, Attila Nagy, Szilvia Kugler, Lilla Tamási, Gábor Tomisa
Lack of coordination between the beginning of the inhalation and device triggering is one of the most frequent errors reported in connection with the use of pMDI devices. Earlier results suggested a significant loss in lung deposition as a consequence of late actuation. However, most of our knowledge on the effect of poor synchronization is based on earlier works on CFC devices emitting large particles with high initial velocities. The aim of this study was to apply numerical techniques to analyse the effect of late device actuation on the lung dose of a HFA pMDI drug emitting high fraction of extrafine particles used in current asthma and COPD therapy...
August 25, 2018: International Journal of Pharmaceutics
Stephen Wu, Sijia Liu, Sunghwan Sohn, Sungrim Moon, Chung-Il Wi, Young Juhn, Hongfang Liu
Sequences of events have often been modeled with computational techniques, but typical preprocessing steps and problem settings do not explicitly address the ramifications of timestamped events. Clinical data, such as is found in electronic health records (EHRs), typically comes with timestamp information. In this work, we define event sequences and their properties: synchronicity, evenness, and co-cardinality; we then show how asynchronous, uneven, and multi-cardinal problem settings can support explicit accountings of relative time...
July 2018: Journal of Biomedical Informatics
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