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Work-related Asthma

Jasmin Khateeb, Eyal Fuchs, Mogher Khamaisi
BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer...
November 23, 2018: Review of Diabetic Studies: RDS
M Jansà, M J Bertran, J Vilardell, F Garcia, J Escarrabill
BACKGROUND AND OBJECTIVES: The application and monitoring of quality criteria in information and therapeutic patient education can identify areas to improve care. The objectives of this study were: (1) To analyze the characteristics of patient information materials, educational activities, and self-management programs, and (2) to determine health care provider (HCP) proposals on therapeutic patient education. MATERIALS AND METHODS: Using a cross-sectional study, an online questionnaire was sent to hospital departments in a high complexity reference hospital from September to December 2013 to record: (a) information materials, (b) patient educational activities, and self-management program characteristics, (c) HCP proposals...
November 24, 2018: Journal of healthcare quality research
Julia Litvinov, Walter C Spear, Igor Patrikeev, Massoud Motamedi, Bill T Ameredes
Sinus congestion resultant of allergic rhinosinusitis is associated with development and worsening of asthma and can result in difficulty breathing, headaches, and missed days of school and work. Quantification of sinus congestion is important in the understanding of allergic rhinosinusitis and the development of new drugs for its treatment. Noninvasive microcomputed tomography (micro-CT) was investigated in a guinea pig model of allergic rhinosinusitis to determine its utility to determine accurately the degree of sinus congestion and resolution with anti-inflammatory drug administration...
November 1, 2018: Journal of Applied Physiology
Ignacio Esteban-Gorgojo, Darío Antolín-Amérigo, Javier Domínguez-Ortega, Santiago Quirce
Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count <2% in sputum. NEA has been associated with environmental and/or host factors, such as smoking cigarettes, pollution, work-related agents, infections, and obesity...
2018: Journal of Asthma and Allergy
Christoffer Dharma, Diana L Lefebvre, Maxwell M Tran, Zihang Lu, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Theo J Moraes, Meghan B Azad, Malcolm R Sears
BACKGROUND: Persisting atopic dermatitis (AD) is known to be associated with more serious allergic diseases at later ages; however, making an accurate diagnosis during infancy is challenging. We assessed the diagnostic performance of questionnaire-based AD measures with criteria-based in-person clinical assessments at age 1 year and evaluated the ability of these diagnostic methods to predict asthma, allergic rhinitis and food allergies at age 5 years. METHODS: Data relate to 3014 children participating in the Canadian Healthy Infant Longitudinal Development (CHILD) Study who were directly observed in a clinical assessment by an experienced healthcare professional using the UK Working Party criteria...
November 2018: Paediatric and Perinatal Epidemiology
Chiara Bertoncello, Massimiliano Colucci, Tatjana Baldovin, Alessandra Buja, Vincenzo Baldo
INTRODUCTION: Definitive evidence of the effectiveness and cost-effectiveness of telemedicine home-interventions for the management of chronic diseases is still lacking. This study examines whether and how published reviews consider and discuss the influence on outcomes of different factors, including: setting, target, and intensity of intervention; patient engagement; the perspective of patients, caregivers and health professionals; the organizational model; patient education and support...
2018: PloS One
Kristin Wickens, Christine Barthow, Edwin A Mitchell, Janice Kang, Noleen van Zyl, Gordon Purdie, Thorsten Stanley, Penny Fitzharris, Rinki Murphy, Julian Crane
BACKGROUND: In a two-centre randomized placebo-controlled trial of Lactobacillus rhamnosus HN001 (HN001) (6 × 109 colony-forming units [cfu]) or Bifidobacterium lactis HN019 (HN019) (9 × 109 cfu) taken daily from 35-week gestation to 6 months' post-partum in mothers while breastfeeding and from birth to age 2 years in infants, we showed that HN001 significantly protected against eczema development at 2, 4 and 6 years and atopic sensitization at 6 years. There was no effect of HN019...
November 14, 2018: Pediatric Allergy and Immunology
R W H Li, J C Lipszyc, S Prasad, S M Tarlo
Background: Cleaning agents have been commonly implicated as causative or triggering factors in work-related asthma (WRA), mainly from epidemiologic studies. Relatively few clinical series have been reported. Aims: We aimed to compare socio-demographic and clinical features among tertiary clinic patients with WRA exposed to cleaning and non-cleaning products. Methods: Analyses were conducted on a patient database containing 208 patients with probable WRA referred to the asthma and airway centre at a tertiary centre hospital in Canada from 2000 to 2014...
November 13, 2018: Occupational Medicine
Cedric Bradbury, Anna Köttgen, Fabian Staubach
With recent advances in DNA sequencing technologies it has become feasible and cost effective to genotype larger marker sets for forensic purposes. Two technologies that make use of the larger marker sets have come into focus in forensic research and applications; inference of biogeographic ancestry (BGA) and forensic DNA phenotyping (FDP). These methods hold the promise to reveal information about a yet unknown perpetrator from a DNA sample. In contrast, DNA-profiling, that is a standard practice in case work, relies on matching DNA-profiles between crime scene material and suspects on a database of DNA-profiles...
October 15, 2018: Forensic Science International. Genetics
Reza Rahbarghazi, Rana Keyhanmanesh, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi Ahmadi
OBJECTIVES: Although excitements related to stem cell therapeutic outcomes have been highlighted enormously in asthma, the vast majority of works were conducted by researchers in animal models. Elucidating the mechanisms underlying the therapeutic effects of MSCs in asthmatic rats will provide a rational basis for assuring maximal safety of future clinical application of stem cells. In the current study, we sought to investigate the possible paracrine mechanism by which direct injection of MSCs and/or CM attenuate efficiently Th2-mediated inflammation in asthmatic lung tissues with the focus on ICAM-1 and VCAM-1 expression...
October 18, 2018: Microvascular Research
Santiago Quirce, Joaquín Sastre
PURPOSE OF REVIEW: This review focuses on new findings in the clinical and inflammatory aspects that can help to better identify the different phenotypes of work-related asthma and the development of specific biomarkers useful in diagnosis and follow-up. RECENT FINDINGS: Studies on phenotyping of occupational asthma, a subtype of work-related asthma, have mainly compared the clinical, physiological, and inflammatory patterns associated with the type of agent causing occupational asthma, namely, high-molecular-weight and low-molecular-weight agents...
January 2019: Current Opinion in Pulmonary Medicine
Conor P Kerley, Basil Elnazir, Peter Greally, David Coghlan
INTRODUCTION: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation. METHODS: We conducted post-hoc analysis of two double-blind, randomized, placebo-controlled trials (RCT) of vitamin D3 supplementation, one RCT involving children with ASD and another involving children with asthma...
October 10, 2018: Nutritional Neuroscience
Fraser W Gaspar, Catherine S Zaidel, Carolyn S Dewa
CONTEXT: Despite the high prevalence of work disability due to common mental disorders (CMD), no information exists on the rates and predictors of recurrence in a United States population. OBJECTIVE: To estimate recurrent work disability statistics and evaluate factors associated with recurrence due to CMDs including adjustment, anxiety, bipolar, and depressive disorders. METHODS: Recurrent work disability statistics were calculated using a nationwide database of disability claims...
2018: PloS One
Qihua Wang, Xijin Xu, Xiaowei Cong, Zhijun Zeng, Long Xu, Xia Huo
Asthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene-environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative stress and environment-gene interactions of asthma. EPHX1 (the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism...
October 6, 2018: Environmental Geochemistry and Health
Pablo Oliveira, Gustavo N O Costa, Andresa K A Damasceno, Fernando P Hartwig, George C G Barbosa, Camila A Figueiredo, Rita de C Ribeiro-Silva, Alexandre Pereira, M Fernanda Lima-Costa, Fernanda S Kehdy, Eduardo Tarazona-Santos, Bernardo L Horta, Laura C Rodrigues, Rosemeire L Fiaccone, Maurício L Barreto
The genetic architecture of asthma was relatively well explored. However, some work remains in the field to improve our understanding on asthma genetics, especially in non-Caucasian populations and with regards to commonly neglected genetic variants, such as Copy Number Variations (CNVs). In the present study, we investigated the contribution of CNVs on asthma risk among Latin Americans. CNVs were inferred from SNP genotyping data. Genome wide burden and association analyses were conducted to evaluate the impact of CNVs on asthma outcome...
September 27, 2018: Scientific Reports
Salma Hussain Abu-Grain, Sanaa Sadiq Alsaad, Dalia Yahia El Kheir
Background: Being the first in-line care providers, primary health-care (PHC) physicians may encounter all forms of emergencies, ranging from minor complaints to life-threatening events. This wide variation of cases challenges the physicians to be competent in emergency medicine. Informative literature describing and assessing the factors affecting PHC physicians' emergency medical services (EMS)-related practice is deficient (nationally and internationally). The aim of this study is to assess PHC physicians' practice related to EMS, the factors affecting it, as well as their learning needs and preferred methods of continuous training in emergency medicine...
July 2018: Journal of Family Medicine and Primary Care
David Knight, Andreas L Lopata, Natalie Nieuwenhuizen, Mohamed F Jeebhay
BACKGROUND: Cellulose is an insoluble plant polysaccharide produced from soft-wood pulp. Although chronic respiratory effects associated with high cellulose-based dust levels have been previously described, occupational asthma has not. A 37 year old machine operator in a sanitary pad production factory presented with new-onset work-related asthma symptoms for two years. METHODS: The worker underwent clinical, pulmonological and immunological (skin prick tests, serum specific IgE determinations) evaluation using standardised procedures...
September 19, 2018: American Journal of Industrial Medicine
Andrew Menzies-Gow, G-Walter Canonica, Tonya A Winders, Jaime Correia de Sousa, John W Upham, Antje-Henriette Fink-Wagner
Severe asthma is a subtype of asthma that is difficult to treat and control. By conservative estimates, severe asthma affects approximately 5-10% of patients with asthma worldwide. Severe asthma impairs patients' health-related quality of life, and patients are at risk of life-threatening asthma attacks. Severe asthma also accounts for the majority of health care expenditures associated with asthma. Guidelines recommend that patients with severe asthma be referred to a specialist respiratory team for correct diagnosis and expert management...
October 2018: Advances in Therapy
Solja T Nyberg, G David Batty, Jaana Pentti, Marianna Virtanen, Lars Alfredsson, Eleonor I Fransson, Marcel Goldberg, Katriina Heikkilä, Markus Jokela, Anders Knutsson, Markku Koskenvuo, Tea Lallukka, Constanze Leineweber, Joni V Lindbohm, Ida E H Madsen, Linda L Magnusson Hanson, Maria Nordin, Tuula Oksanen, Olli Pietiläinen, Ossi Rahkonen, Reiner Rugulies, Martin J Shipley, Sari Stenholm, Sakari Suominen, Töres Theorell, Jussi Vahtera, Peter J M Westerholm, Hugo Westerlund, Marie Zins, Mark Hamer, Archana Singh-Manoux, Joshua A Bell, Jane E Ferrie, Mika Kivimäki
BACKGROUND: Obesity increases the risk of several chronic diseases, but the extent to which the obesity-related loss of disease-free years varies by lifestyle category and across socioeconomic groups is unclear. We estimated the number of years free from major non-communicable diseases in adults who are overweight and obese, compared with those who are normal weight. METHODS: We pooled individual-level data on body-mass index (BMI) and non-communicable diseases from men and women with no initial evidence of these diseases in European cohort studies from the Individual-Participant-Data Meta-Analysis in Working Populations consortium...
October 2018: Lancet. Public Health
Kate H Choi, Melissa L Martinson
PURPOSE: Racial/ethnic disparities in rates of low birthweight (LBW) are well established, as are racial/ethnic differences in health outcomes over the life course. Yet, there is little empirical work examining whether the consequences of LBW for subsequent child health vary by race, ethnicity, and national origin. METHODS: Using data from the 1998-2016 National Health Interview Survey, we examined whether racial, ethnic, and national differences existed in the association between LBW and subsequent health outcomes, namely being diagnosed with a developmental disability, asthma diagnosis, and poorer general health...
October 2018: Annals of Epidemiology
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