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Work-related Asthma

Santiago Quirce, Joaquín Sastre
PURPOSE OF REVIEW: This review focuses on new findings in the clinical and inflammatory aspects that can help to better identify the different phenotypes of work-related asthma and the development of specific biomarkers useful in diagnosis and follow-up. RECENT FINDINGS: Studies on phenotyping of occupational asthma, a subtype of work-related asthma, have mainly compared the clinical, physiological, and inflammatory patterns associated with the type of agent causing occupational asthma, namely, high-molecular-weight and low-molecular-weight agents...
October 12, 2018: Current Opinion in Pulmonary Medicine
Conor P Kerley, Basil Elnazir, Peter Greally, David Coghlan
INTRODUCTION: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation. METHODS: We conducted post-hoc analysis of two double-blind, randomized, placebo-controlled trials (RCT) of vitamin D3 supplementation, one RCT involving children with ASD and another involving children with asthma...
October 10, 2018: Nutritional Neuroscience
Fraser W Gaspar, Catherine S Zaidel, Carolyn S Dewa
CONTEXT: Despite the high prevalence of work disability due to common mental disorders (CMD), no information exists on the rates and predictors of recurrence in a United States population. OBJECTIVE: To estimate recurrent work disability statistics and evaluate factors associated with recurrence due to CMDs including adjustment, anxiety, bipolar, and depressive disorders. METHODS: Recurrent work disability statistics were calculated using a nationwide database of disability claims...
2018: PloS One
Qihua Wang, Xijin Xu, Xiaowei Cong, Zhijun Zeng, Long Xu, Xia Huo
Asthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene-environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative stress and environment-gene interactions of asthma. EPHX1 (the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism...
October 6, 2018: Environmental Geochemistry and Health
Pablo Oliveira, Gustavo N O Costa, Andresa K A Damasceno, Fernando P Hartwig, George C G Barbosa, Camila A Figueiredo, Rita de C Ribeiro-Silva, Alexandre Pereira, M Fernanda Lima-Costa, Fernanda S Kehdy, Eduardo Tarazona-Santos, Bernardo L Horta, Laura C Rodrigues, Rosemeire L Fiaccone, Maurício L Barreto
The genetic architecture of asthma was relatively well explored. However, some work remains in the field to improve our understanding on asthma genetics, especially in non-Caucasian populations and with regards to commonly neglected genetic variants, such as Copy Number Variations (CNVs). In the present study, we investigated the contribution of CNVs on asthma risk among Latin Americans. CNVs were inferred from SNP genotyping data. Genome wide burden and association analyses were conducted to evaluate the impact of CNVs on asthma outcome...
September 27, 2018: Scientific Reports
Salma Hussain Abu-Grain, Sanaa Sadiq Alsaad, Dalia Yahia El Kheir
Background: Being the first in-line care providers, primary health-care (PHC) physicians may encounter all forms of emergencies, ranging from minor complaints to life-threatening events. This wide variation of cases challenges the physicians to be competent in emergency medicine. Informative literature describing and assessing the factors affecting PHC physicians' emergency medical services (EMS)-related practice is deficient (nationally and internationally). The aim of this study is to assess PHC physicians' practice related to EMS, the factors affecting it, as well as their learning needs and preferred methods of continuous training in emergency medicine...
July 2018: Journal of Family Medicine and Primary Care
David Knight, Andreas L Lopata, Natalie Nieuwenhuizen, Mohamed F Jeebhay
BACKGROUND: Cellulose is an insoluble plant polysaccharide produced from soft-wood pulp. Although chronic respiratory effects associated with high cellulose-based dust levels have been previously described, occupational asthma has not. A 37 year old machine operator in a sanitary pad production factory presented with new-onset work-related asthma symptoms for two years. METHODS: The worker underwent clinical, pulmonological and immunological (skin prick tests, serum specific IgE determinations) evaluation using standardised procedures...
September 19, 2018: American Journal of Industrial Medicine
Andrew Menzies-Gow, G-Walter Canonica, Tonya A Winders, Jaime Correia de Sousa, John W Upham, Antje-Henriette Fink-Wagner
Severe asthma is a subtype of asthma that is difficult to treat and control. By conservative estimates, severe asthma affects approximately 5-10% of patients with asthma worldwide. Severe asthma impairs patients' health-related quality of life, and patients are at risk of life-threatening asthma attacks. Severe asthma also accounts for the majority of health care expenditures associated with asthma. Guidelines recommend that patients with severe asthma be referred to a specialist respiratory team for correct diagnosis and expert management...
October 2018: Advances in Therapy
Solja T Nyberg, G David Batty, Jaana Pentti, Marianna Virtanen, Lars Alfredsson, Eleonor I Fransson, Marcel Goldberg, Katriina Heikkilä, Markus Jokela, Anders Knutsson, Markku Koskenvuo, Tea Lallukka, Constanze Leineweber, Joni V Lindbohm, Ida E H Madsen, Linda L Magnusson Hanson, Maria Nordin, Tuula Oksanen, Olli Pietiläinen, Ossi Rahkonen, Reiner Rugulies, Martin J Shipley, Sari Stenholm, Sakari Suominen, Töres Theorell, Jussi Vahtera, Peter J M Westerholm, Hugo Westerlund, Marie Zins, Mark Hamer, Archana Singh-Manoux, Joshua A Bell, Jane E Ferrie, Mika Kivimäki
BACKGROUND: Obesity increases the risk of several chronic diseases, but the extent to which the obesity-related loss of disease-free years varies by lifestyle category and across socioeconomic groups is unclear. We estimated the number of years free from major non-communicable diseases in adults who are overweight and obese, compared with those who are normal weight. METHODS: We pooled individual-level data on body-mass index (BMI) and non-communicable diseases from men and women with no initial evidence of these diseases in European cohort studies from the Individual-Participant-Data Meta-Analysis in Working Populations consortium...
October 2018: Lancet. Public Health
Kate H Choi, Melissa L Martinson
PURPOSE: Racial/ethnic disparities in rates of low birthweight (LBW) are well established, as are racial/ethnic differences in health outcomes over the life course. Yet, there is little empirical work examining whether the consequences of LBW for subsequent child health vary by race, ethnicity, and national origin. METHODS: Using data from the 1998-2016 National Health Interview Survey, we examined whether racial, ethnic, and national differences existed in the association between LBW and subsequent health outcomes, namely being diagnosed with a developmental disability, asthma diagnosis, and poorer general health...
October 2018: Annals of Epidemiology
Julia Litvinov, Walter C Spear, Igor Patrikeev, Massoud Motamedi, Bill T Ameredes
Sinus congestion resultant of allergic rhinosinusitis is associated with development and worsening of asthma and can result in difficulty breathing, headaches, and missed days of school and work. Quantification of sinus congestion is important in the understanding of allergic rhinosinusitis, and the development of new drugs for its treatment. Non-invasive micro-computed tomography (CT) was investigated in a Guinea pig model of allergic rhinosinusitis to determine if it could be used to accurately determine the degree of sinus congestion and resolution with anti-inflammatory drug administration...
August 30, 2018: Journal of Applied Physiology
I J Skypala, N W de Jong, E Angier, J Gardner, I Kull, D Ryan, C Venter, B J Vlieg-Boerstra, K Grimshaw
The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target patient population. The AHPs most often involved in allergy care are nurses and dietitians. Nurses are often involved in the care of patients with all types of allergy and also with asthma, whilst allergy-specialist dietitians provide vital nutritional and dietary support for the diagnosis and management of food allergy...
2018: Clinical and Translational Allergy
Hille Suojalehto, Joaquin Sastre, Emilia Merimaa, Irmeli Lindström, Katri Suuronen
BACKGROUND: Two-component epoxy resin systems (ERSs) composed of epoxy resin and polyamine hardeners are extensively used in industrial and construction coating. Triglycidyl isocyanurate (TGIC) is another type of epoxy derivative, mostly encountered in polyester powder paints. Epoxy compounds are well-known skin sensitizers, but their respiratory-sensitizing potential is largely unknown. OBJECTIVE: To report patients examined for occupational asthma (OA) from epoxy compounds...
August 1, 2018: Journal of Allergy and Clinical Immunology in Practice
K M Phillips, R W Bergmark, L P Hoehle, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: The frequency of chronic rhinosinusitis (CRS) exacerbations is an independent predictor of quality of life. The objective of this study was to evaluate if increased CRS exacerbations predict decreased productivity. METHODS: Cross-sectional study of adult CRS patients. Number of patient-reported CRS-related antibiotic and oral corticosteroids courses and sinus infections in the past three months were used as metrics for acute exacerbations of CRS (AECRS)...
July 25, 2018: Rhinology
J M Molina Aragonés, R Bausà Peris, R Carreras Valls, A Carrillo Castillo, F Fiblà Nicolau, E Gaynés Palou, J Guerrero Monge, J Inglés Torruella, J A López Muñoz, E Martinez Martínez-Carrasco, J Matllo Aguilar, J A Medina Lavela, M T Mestre Prad, P Peña García, S Rodriguez Vallecillos, G Tapias Oller, M Vilardell Ynaraja
The presence of formaldehyde at workplace remains significant. Exposure to it results in local irritation of the eye, nose and upper respiratory tract mucous membranes, and it has been chronically related to a higher risk of cancer development at the paranasal sinuses, naso-oropharynx and lungs. The aim of our work has been the updating of the bibliography and the categorization of the most up to date scientific evidence of formaldehyde effects on human body. Bibliographic search on the electronic database Medline / PubMed, restricted to the last 10 years through a combination of free and controlled language...
July 2018: Archivos de Prevención de Riesgos Laborales
Ewa Nowakowska-Świrta, Marta Wiszniewska, Jolanta Walusiak-Skorupa
Bronchial hyperresponsiveness (BHR) is the individual ability to respond with bronchoconstriction to a variety of specific and nonspecific stimuli which do not cause these symptoms among healthy subjects. Bronchial hyperresponsiveness is one of the hallmark features of asthma. The degree of bronchial hyperresponsiveness is variable among individuals with asthma and may correlate to its severity (the more severe asthma the higher bronchial hyperreactivity). Bronchial hyperresponsiveness is evaluated by performing bronchial provocation test (BPT)...
August 20, 2018: Medycyna Pracy
Carlos Melero, Santiago Quirce, Alicia Huerta, Estefany Uría, Maribel Cuesta
OBJECTIVE: Estimate the economic impact of severe asthma from the Spanish social perspective through the estimation of the associated annual direct and indirect costs. METHODS: Observational, longitudinal, retrospective study carried out in 20 Spanish secondary settings (Pulmonology and Allergy Services) among patients aged ≥18, diagnosed with severe asthma according to ERS/ATS consensus and who have not experienced an exacerbation in the previous 2 months. Asthma-related healthcare resource utilization as well as asthma-related days off work were collected over a retrospective 12-month period from medical records review (inclusion period: June to November 2016)...
July 13, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Javier Milagro, Eduardo Gil, Jesus Lazaro, Ville-Pekka Seppa, L Pekka Malmberg, Anna S Pelkonen, Anne Kotaniemi-Syrjanen, Mika J Makela, Jari Viik, Raquel Bailon
Asthma is a chronic lung disease that usually develops during childhood. Despite that symptoms can almost be controlled with medication, early diagnosis is desirable in order to reduce permanent airway obstruction risk. It has been suggested that abnormal parasympathetic nervous system (PSNS) activity might be closely related with the pathogenesis of asthma, and that this PSNS activity could be reflected in cardiac vagal control. In this work, an index to characterize the spectral distribution of the high frequency (HF) component of heart rate variability (HRV), named peakness ($\wp$), is proposed...
September 2018: IEEE Journal of Biomedical and Health Informatics
Giuliana Ferrante, Stefania La Grutta
Asthma is the most common chronic disease in children, imposing a consistent burden on health system. In recent years, prevalence of asthma symptoms became globally increased in children and adolescents, particularly in Low-Middle Income Countries (LMICs). Host (genetics, atopy) and environmental factors (microbial exposure, exposure to passive smoking and air pollution), seemed to contribute to this trend. The increased prevalence observed in metropolitan areas with respect to rural ones and, overall, in industrialized countries, highlighted the role of air pollution in asthma inception...
2018: Frontiers in Pediatrics
Sharon D Horner, Gayle M Timmerman, Bennie C McWilliams
PURPOSE: The purpose of this study is to test the feasibility of delivering an intervention that combines healthy lifestyle behaviors related to weight management with asthma self-management, the Living Healthy with Asthma intervention, to children who have asthma. METHODS AND DESIGN: Using a mixed design, the feasibility study of the 12-week Living Healthy with Asthma intervention was conducted with a single group of children diagnosed with asthma. Pretest and posttest data were collected on asthma-related (self-management, metered dose inhaler [MDI] skill, asthma severity, quality of life [QOL]), and healthy lifestyle variables (body mass index [BMI], dietary quality)...
July 4, 2018: Journal for Specialists in Pediatric Nursing: JSPN
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