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https://www.readbyqxmd.com/read/30214140/intracameral-cefuroxime-in-combined-pars-plana-vitrectomy-and-phacoemulsification-a-study-of-safety
#1
Gianluca Besozzi, Attilio Di Salvatore, Daniele Cardillo, Alessandro Finzi, Joseph Sajish Pinackatt, Andrea Baldi, Alessandro Monfardini, Valeria Forioli, Rino Frisina, Barbara Parolini
Background: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease. Methods: The charts of 152 patients who underwent combined phacoemulsification, intraocular lens implant and pars plana vitrectomy were reviewed. The final tamponade was chosen among fluid, air, gas or silicone oil, based on the requirement of each single case...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30129402/deranged-metabolic-profile-and-identification-of-biomarkers-in-the-vitreous-humour-of-patients-with-proliferative-diabetic-retinopathy
#2
Nikhil Shri Sahajpal, Vipan Kumar Vig, Rajbir Singh, Harshinder Singh, Alka Chaubey, Kanwardeep Singh, Rajesh Kumar Goel, Subheet Kumar Jain
Systemic biochemical disarray has been implicated in the pathogenesis and progression of diabetes and its complications. The objective of the present study was to investigate the modifications in the metabolic state of the retina and its microenvironment in response to the systemic metabolic mal-function to understand the different pathways and biomarkers that may be involved in the patho-genesis and progression of proliferative diabetic retinopathy (PDR). The vitreous humour and plas-ma samples from 38 PDR, 7 proliferative vitreo retinopathy (PVR) and 17 control patients undergo-ing pars plana vitrectomy were analysed for sixteen different biomarkers...
August 21, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29452885/somatolactogens-and-diabetic-retinopathy
#3
REVIEW
Kevin Christian Bermea, Alejandro Rodríguez-García, Andrew Tsin, Hugo Alberto Barrera-Saldaña
IMPORTANCE: Diabetic retinopathy (DR) is one of the most common of all diabetic complications. The number of people with DR in the United States is expected to increase to 16 million by 2050. DR is the leading cause of blindness among working-age adults in many different countries, including the United States. In later DR stages, neovascularization is associated with extensive retinal capillary non-perfusion and vitreo-proliferation leading to retinal detachment. This neovascularization is orchestrated by an imbalance of growth factors in the retina from which somatolactogens (pituitary growth hormone, GH-N; placental growth hormone, GH-V; prolactin, PRL; and placental lactogen, PL, also referred as chorionic somatomammotropin, CSH), may play an important role...
August 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28799561/retinal-detachment-repair-and-cataract-surgery-in-patients-with-atopic-dermatitis
#4
V Gnana Jothi, S McGimpsey, J A Sharkey, W C Chan
PurposeThe aim of this study is to report a case series of ocular complications including retinal detachment (RD) and cataract in atopic dermatitis (AD) and surgical management involving a majority of Caucasian patients.Patients and methodsThis study is an observational case series, originally designed as an audit. It involves detailed discussion of history, clinical features, and surgical management of patients presenting with retinal detachment and cataracts secondary to severe AD. Six consecutive patients with diagnosis of severe AD requiring posterior segment and cataract surgery were included in the study...
September 2017: Eye
https://www.readbyqxmd.com/read/28790571/retinal-vasculitis-and-its-management-in-serving-soldiers-long-term-follow-up-study
#5
Ajay Banarji, D P Vats, R G Dash, S Patra, P R Sen, R K Jetley
200 eyes of 110 male serving military personnel showing retinal vasculitis in various stages were managed with institution of steroids, ATT, photocoagulation, cryoablation and vitreo retinal surgery as indicated in a span of 78 months. 156 eyes showing evidence of vasoproliferation responded favourably to laser photocoagulation. Over all 80% of the patients showed good functional recovery with combined modalities of management thereby obviating recurrent morbidity and invalidation in trained combatant manpower in wage earning age group...
July 1999: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28547316/preliminary-study-of-the-safety-and-efficacy-of-medium-chain-triglycerides-for-use-as-an-intraocular-tamponading-agent-in-minipigs
#6
Vincent J Soler, Camille Laurent, Frédéric Sakr, Alain Regnier, Cyrielle Tricoire, Olivier Cases, Renata Kozyraki, Jean-Yves Douet, Véronique Pagot-Mathis
PURPOSE: To date, only silicone oils and gases have the appropriate characteristics for use in vitreo-retinal surgery as vitreous substitutes with intraocular tamponading properties. This preliminary study evaluated the safety and efficacy of medium-chain triglycerides (MCTs) for use as a tamponading agent in minipigs. METHODS: In 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined. In Group A (ten eyes), the surgical procedure before MCT injection included induced rhegmatogenous retinal detachment (RRD), retina flattening, and retinopexy...
August 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28258307/nutrition-for-diabetic-retinopathy-plummeting-the-inevitable-threat-of-diabetic-vision-loss
#7
REVIEW
Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu
Diabetic retinopathy (DR) is among the leading causes of preventable blindness. Hyperglycemia, hypertension, hyperlipidemia and anemia majorly predispose its pathogenesis. The current treatment modalities of DR include laser photocoagulation therapy, intravitreal corticosteroids, intravitreal anti-vascular endothelial growth factor (VEGF) agents and vitreo-retinal surgery which are costly, highly invasive, unproven for prolonged use and opted in advanced stages of DR. By then retina already encounters a vast damage...
September 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/27930437/case-of-metastatic-urothelial-carcinoma-of-the-retina-and-vitreous
#8
Katherine E Whalen, Ralph C Eagle, Tamara R Vrabec
PURPOSE: To report a rare case of vitreo-retinal metastasis from urothelial carcinoma of the bladder. METHODS: Case report. RESULTS: A 55-year-old man with a history of bladder cancer developed atypical vitritis and a white fundus mass. Intravenous fluorescein angiography demonstrated connection between the retinal and tumor vasculature consistent with a retinal malignancy. Cytologic analysis of the vitreous sample revealed large, atypical cells with pleomorphic nuclei, mucin vacuoles, and rare mitotic figures...
July 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27088344/biometry-optical-coherence-tomography-and-further-clinical-observations-in-knobloch-syndrome
#9
Amani AlBakri, Nicola G Ghazi, Arif O Khan
PURPOSE: Knobloch syndrome is a pathognomonic vitreo-retinopathy that includes zonular weakness, high myopia, and a distinct fundus appearance with tessellation out of proportion to the degree of myopia. Whether myopia in Knobloch syndrome is axial or lenticular is unclear. Also not known are the optical coherence tomography (OCT) correlates to the distinct fundus appearance. In this study we assess cycloplegic refraction, biometry, and macular spectral domain (SD) OCT in children with Knobloch syndrome...
March 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/26999941/-bilateral-abnormalities-in-central-serous-chorioretinopathy-seen-in-optical-coherence-tomography-ultra-widefield-fluorescein-angiography-and-microperimetry-case-report
#10
Magdalena Tylus, Anna Święch-Zubilewicz, Joanna Dolar-Szczasny, Jerzy Mackiewicz
Central serous chorioretinopathy is a common retinopathy, which is manifested by the idiopathic detachment of the neurosensory retina in the posterior pole, secondary to fluid leakage from choroidal vessels at the level of retinal pigment epithelium. The disease is typically unilateral and affects young men. We present a case of a 48-year old man, admitted to the Department of Vitreo-Retinal Surgery, Medical University in Lublin, reporting vision impairment in his right eye. The bilateral ocular exam followed by optical coherence tomography, ultra-widefield fluorescein angiography and microperimetry revealed bilateral central serous chorioretinopathy...
2015: Klinika Oczna
https://www.readbyqxmd.com/read/26776338/nucleus-drop-during-small-incision-cataract-surgery-a-report-of-four-cases
#11
Adekunle Rotimi-Samuel, Adeola Olukorede Onakoya, Olufisayo Temitayo Aribaba, Kareem Olatubosun Musa, A Sunday Alabi, Folashade Bolanle Akinsola
Small incision cataract surgery (SICS) offers the benefits of a phacoemulsification (phaco) surgery without the attendant high cost, but it is not without certain risk such as nucleus drop into the vitreous as seen in phaco. A retrospective study of SICS and associated factors leading to nucleus drop during surgery, challenges of management and the visual outcomes. Of 793 eye surgeries performed during the study 586 were SICSs. Nucleus drop during SICS occurred in 0.68% of patients. Can-opener technique of capsulotomy, use of dispersive viscoelastic, diabetes mellitus, lack of anterior vitrectomy machine and poor access to immediate posterior vitrectomy were important problems in the management of the cases of nucleus drop in this study...
October 2015: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/26530343/combined-depth-imaging-of-choroid-in-uveitis
#12
Padmamalini Mahendradas, Sumukh Madhu, Ankush Kawali, Indu Govindaraj, Poornachandra B Gowda, Anand Vinekar, Naren Shetty, Rohit Shetty, Bhujang K Shetty
BACKGROUND: Understanding the changes that occur in the choroid is of paramount importance in various uveitis entities. B-scan ultrasonography and indocyanine green angiography can be used to study choroid. Currently, spectral-domain optical coherence tomography is used as the standard noninvasive technique to study the choroid by enhanced depth imaging. Our aim was to study the structural visibility of the choroid using spectral-domain optical coherence tomography in the same area of interest in patients with uveitis with posterior segment manifestations using conventional, enhanced depth imaging (EDI), and combined depth imaging (CDI) techniques...
December 2014: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/26511080/ocriplasmin-use-in-a-selected-case-with-preserved-visual-acuity
#13
Settimio Rossi, Ada Orrico, Paolo Melillo, Francesco Testa, Francesca Simonelli, Michele Della Corte
BACKGROUND: Previous studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity. We describe the first case of a patient with 20/20 visual acuity and vitreo-macular traction treated with Ocriplasmin, and, for the first time in literature, we evaluated the functional changes of the macula in response to pharmacological treatment through multifocal-electroretinogram. CASE PRESENTATION: We report the case of a female Caucasian patient aged 67 years with vitreo-macular traction in the right eye, treated with Ocriplasmin, at the Eye Clinic of the Second University of Naples...
October 29, 2015: BMC Ophthalmology
https://www.readbyqxmd.com/read/26366887/recent-progress-in-using-biomaterials-as-vitreous-substitutes
#14
REVIEW
Xinyi Su, Mein Jin Tan, Zibiao Li, Meihua Wong, Lakshminarayanan Rajamani, Gopal Lingam, Xian Jun Loh
Vitreous substitutes are crucial adjuncts during vitreo-retinal surgery for retinal diseases such as complicated retinal detachment, macular holes, complications of diabetic retinopathy, and ocular trauma involving posterior segment. In retinal detachment surgery, an internal tamponade agent is required to provide internal pressure for reattachment of the detached neurosensory retina. Current available options serve only as a temporary surgical adduct or short-term solution and are associated with inherent problems...
October 12, 2015: Biomacromolecules
https://www.readbyqxmd.com/read/26350534/controversies-in-anticoagulant-therapy-in-vitreo-retinal-surgery
#15
REVIEW
Andrzej Grzybowski, Konrad Kupidura-Majewski, Paulina Kupidura
The number of elderly patients using anticoagulant and antiplatelet treatment in prevention of thromboembolism has significantly increased in recent years. It was believed for many years that those patients may be at higher risk for hemorhages during ocular surgery. Different strategies were proposed to prevent these complications, including discontinuation of anticoagulants, dose reduction, or substitution with low molecular weight heparin. The objective of this work was to evaluate the results of studies presenting the results of vitreoretinal surgeries in patients continuing antiplatelet and/or anticoagulant treatment...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26329974/wide-angle-viewing-system-versus-conventional-indirect-ophthalmoscopy-for-scleral-buckling
#16
Yohei Tomita, Toshihide Kurihara, Atsuro Uchida, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
Wide-angle viewing systems (WAVSs) were originally established for pars plana vitrectomy. However, their application to scleral buckling surgery was recently reported. In this study, we compared the outcomes of scleral buckling using a noncontact WAVS with that of scleral buckling using conventional indirect ophthalmoscopy for rhegmatogenous retinal detachment. The clinical records of 39 eyes (39 patients) with rhegmatogenous retinal detachment primarily treated between November 2012 and June 2014 at the Vitreo-Retina Surgical Division Clinic at the Department of Ophthalmology, Keio University Hospital were retrospectively reviewed...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26299697/familial-exudative-vitreoretinopathy-spectral-domain-optical-coherence-tomography-of%C3%A2-the%C3%A2-vitreoretinal-interface-retina-and-choroid
#17
Yoshihiro Yonekawa, Benjamin J Thomas, Kimberly A Drenser, Michael T Trese, Antonio Capone
PURPOSE: The in vivo microstructural features of familial exudative vitreoretinopathy (FEVR) have not been well described. We present new anatomic features of FEVR with functional and genetic correlations. DESIGN: Consecutive, retrospective, observational case series. PARTICIPANTS: Patients with FEVR treated from 2009 to 2014. METHODS: We identified 346 patients with FEVR. Those imaged with spectral-domain optical coherence tomography (SD OCT) with or without enhanced depth imaging (EDI) were included, and images were correlated with best-corrected visual acuity (BCVA), widefield angiography, fundus autofluorescence (AF), and wnt signaling pathway mutations...
November 2015: Ophthalmology
https://www.readbyqxmd.com/read/26142226/-the-role-of-the-vitreous-body-in-diseases-of-neighboring-structures
#18
REVIEW
K Gekeler, S Priglinger, F Gekeler, C Priglinger
BACKGROUND: The vitreoretinal interface is not merely the space between the vitreous body and the retina but it is also a site for highly complex pathologies with the vitreous body exerting an influence on all the neighbouring structures. METHODS: A literature search was performed in Pubmed and current book articles RESULTS: This review article highlights the role of the vitreous body in vitreomacular adhesion and traction, in the development of macular holes and epiretinal membranes as well as its role in age-related macular degeneration...
July 2015: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/26065393/whole-vitreous-humor-dissection-for-vitreodynamic-analysis
#19
Karthik Murali, Amir H Kashani, Mark S Humayun
The authors propose an effective technique to isolate whole, intact vitreous core and cortex from post mortem enucleated porcine eyes. While previous studies have shown the results of such dissections, the detailed steps have not been described, precluding researchers outside the field from replicating their methods. Other studies harvest vitreous either through aspiration, which does not maintain the vitreous structure anatomy, or through partial dissection, which only isolates the vitreous core. The proposed method isolates the whole vitreous body, with the vitreous core and cortex intact, while maintaining vitreous anatomy and structural integrity...
2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26047507/macular-microcysts-in-mitochondrial-optic-neuropathies-prevalence-and-retinal-layer-thickness-measurements
#20
Michele Carbonelli, Chiara La Morgia, Giacomo Savini, Maria Lucia Cascavilla, Enrico Borrelli, Filipe Chicani, Carolina do V F Ramos, Solange R Salomao, Vincenzo Parisi, Jerry Sebag, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
PURPOSE: To investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON). METHODS: All patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls...
2015: PloS One
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