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Neonatal Perinatal Asphyxia

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https://www.readbyqxmd.com/read/30541643/-efficacy-and-safety-of-selective-brain-hypothermia-therapy-on-neonatal-hypoxic-ischemic-encephalopathy
#1
Xin Chen, Wansheng Peng, Zhen Zhang, Qian Zhao, Yan Zhou, Li Chen, Jiahua Pan
OBJECTIVE: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100. METHODS: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/30529344/threshold-of-metabolic-acidosis-associated-with-newborn-cerebral-palsy-medical-legal-implications
#2
Michael G Ross
Obstetricians and gynecologists belong to one of the medical specialties with the highest rate of litigation claims. Among birth injury cases, those with cerebral palsy outcomes account for litigation settlements or judgements often in the millions of dollars. In cases of potential perinatal asphyxia, a threshold level of metabolic acidosis (base deficit (BD) >12 mmol/l) is necessary to attribute neonatal encephalopathy to an intrapartum hypoxic event. With increasing duration or severity of a hypoxic stress resulting in metabolic acidosis, newborn umbilical artery BD increases...
December 6, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30515406/prevalence-and-associated-factors-of-perinatal-asphyxia-among-neonates-in-general-hospitals-of-tigray-ethiopia-2018
#3
Gdiom Gebreheat, Tesfay Tsegay, Dessalegn Kiros, Hirut Teame, Natnael Etsay, Guesh Welu, Desta Abraha
Perinatal asphyxia is one of the most important causes of morbidity and mortality in neonates. Perinatal asphyxia occurs in association with maternal, fetal, and maternofetal factors. However, the magnitude and associated factors of perinatal asphyxia are not well studied in Tigray, Ethiopia. Therefore, our study is conducted to determine the prevalence and factors associated with perinatal asphyxia among neonates in general hospitals of Tigray. An observational hospital-based cross-sectional study was conducted in randomly selected general hospitals...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30498346/gold-nanorods-sirna-complex-administration-for-knockdown-of-parp-1-a-potential-treatment-for-perinatal-asphyxia
#4
Valentina Vio, Ana L Riveros, Andrea Tapia-Bustos, Carolyne Lespay-Rebolledo, Ronald Perez-Lobos, Luis Muñoz, Paola Pismante, Paola Morales, Eyleen Araya, Natalia Hassan, Mario Herrera-Marschitz, Marcelo J Kogan
Background: Perinatal asphyxia interferes with neonatal development, resulting in long-term deficits associated with systemic and neurological diseases. Despite the important role of poly (ADP-ribose) polymerase 1 (PARP-1) in the regulation of gene expression and DNA repair, overactivation of PARP-1 in asphyxia-exposed animals worsens the ATP-dependent energetic crisis. Inhibition of PARP-1 offers a therapeutic strategy for diminishing the effects of perinatal asphyxia. Methods: We designed a nanosystem that incorporates a specific siRNA for PARP-1 knockdown...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30487486/comparison-of-serum-electrolytes-abnormality-and-renal-function-status-in-asphyxiated-and-normal-baby-in-a-tertiary-level-hospital
#5
M K Das, M A Ali, T Latif, M N Islam, M A Hossain, M M Moniruzzaman, M Oliullah, S A Haque, A K Gosh
Complication of perinatal asphyxia is a major cause of neonatal mortality & morbidity in developing countries. This comparative cross sectional study was conducted in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from May 2012 to September 2012 to determine electrolytes & renal function status in perinatal asphyxia & their impact on outcome. Thirty term normal birth weight babies with perinatal asphyxia in neonatal ward were included as a case group and thirty term normal birth weight neonates of same gestational age, without perinatal asphyxia in the department of Gynae & Obs were enrolled as a control group...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30475817/temporal-patterns-of-circulating-cell-free-dna-cfdna-in-a-newborn-piglet-model-of-perinatal-asphyxia
#6
Sophia Manueldas, Torkil Benterud, Corina Silvia Rueegg, Håvard Tetlie Garberg, Marianne Ullestad Huun, Leonid Pankratov, Monica Åsegg-Atneosen, Rønnaug Solberg, Javier Escobar, Ola Didrik Saugstad, Lars Oliver Baumbusch
Perinatal asphyxia is a severe medical condition resulting from oxygen deficiency (hypoxia) at the time of birth, causing worldwide approximately 680,000 newborn deaths every year. Better prediction of severity of damages including early biomarkers is highly demanded. Elevated levels of circulating cell-free DNA (cfDNA) in blood have been reported for a range of different diseases and conditions, including cancer and prematurity. The objective of this study was to validate methods for assessing cfDNA in blood and cerebrospinal fluid (CSF) and to explore temporal variations in a piglet model of neonatal hypoxia-reoxygenation...
2018: PloS One
https://www.readbyqxmd.com/read/30430678/adverse-pregnancy-and-perinatal-outcome-in-patients-with-recurrent-pregnancy-loss-multiple-imputation-analyses-with-propensity-score-adjustment-applied-to-a-large-scale-birth-cohort-of-the-japan-environment-and-children-s-study
#7
Mayumi Sugiura-Ogasawara, Takeshi Ebara, Yasuyuki Yamada, Naoto Shoji, Taro Matsuki, Hirohisa Kano, Takahiro Kurihara, Toyonori Omori, Motohiro Tomizawa, Maiko Miyata, Michihiro Kamijima, Shinji Saitoh
PROBLEM: Several studies have reported the increased risk of preterm birth, premature rupture of membranes and low birth weight in patients with recurrent pregnancy loss (RPL). There have been a limited number of large population-based studies examining adverse pregnancy and perinatal outcome after RPL. Multiple-imputed analyses (MIA) adjusting for biases due to missing data is also lacking. METHOD OF STUDY: A nationwide population-based birth cohort study known as the "Japan Environment and Children's Study (JECS)" was conducted by the Ministry of the Environment...
November 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/30425338/planned-home-deliveries-in-finland-1996-2013
#8
Katja Ovaskainen, Riitta Ojala, Kati Tihtonen, Mika Gissler, Tiina Luukkaala, Outi Tammela
OBJECTIVE: To evaluate trends and perinatal outcomes of planned home deliveries in Finland. STUDY DESIGN: All infants born in 1996-2013, excluding those born preterm, by operative delivery, and without information on birth mode or gestational age, were studied. The study group included 170 infants born at home as planned, 720,047 infants born at hospital were controls. RESULT: The rate of planned home deliveries increased from 8.3 to 39.4 per 100,000...
November 13, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30419568/outcome-of-infants-with-therapeutic-hypothermia-after-perinatal-asphyxia-and-early-onset-sepsis
#9
Mariam Hakobyan, Koen P Dijkman, Sabrina Laroche, Gunnar Naulaers, Monique Rijken, Katerina Steiner, Henrica L M van Straaten, Renate M C Swarte, Hendrik J Ter Horst, Alexandra Zecic, Inge A Zonnenberg, Floris Groenendaal
BACKGROUND: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. OBJECTIVES: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. METHODS: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42...
November 12, 2018: Neonatology
https://www.readbyqxmd.com/read/30361107/population-based-rates-timing-and-causes-of-maternal-deaths-stillbirths-and-neonatal-deaths-in-south-asia-and-sub-saharan-africa-a-multi-country-prospective-cohort-study
#10
(no author information available yet)
BACKGROUND: Modelled mortality estimates have been useful for health programmes in low-income and middle-income countries. However, these estimates are often based on sparse and low-quality data. We aimed to generate high quality data about the burden, timing, and causes of maternal deaths, stillbirths, and neonatal deaths in south Asia and sub-Saharan Africa. METHODS: In this prospective cohort study done in 11 community-based research sites in south Asia and sub-Saharan Africa, between July, 2012, and February, 2016, we conducted population-based surveillance of women of reproductive age (15-49 years) to identify pregnancies, which were followed up to birth and 42 days post partum...
December 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30349732/a-retrospective-analysis-of-adverse-obstetric-and-perinatal-outcomes-in-adolescent-pregnancy-the-case-of-luapula-province-zambia
#11
Albertina Ngomah Moraes, Rosemary Ndonyo Likwa, Selestine H Nzala
Background: About three in ten young women aged 15-19 have begun childbearing among the Zambian population, with adolescent pregnancy levels as high as 35% in rural areas. In 2009, Luapula reported 32.1% adolescent pregnancies. The study sought to investigate obstetric and perinatal outcomes among adolescents compared to mothers aged 20-24 years delivering at selected health facilities in Kawambwa and Mansa districts of Luapula. Methods: A retrospective analysis was carried out of all deliveries to mothers aged between 10 and 24 years for the period January 2012 to January 2013...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/30337987/non-catether-induced-renal-and-inferior-vena-cava-trombosis-in-a-neonate-a-case-report
#12
Natasha Aluloska, Snezana Janchevska, Velibor Tasic
BACKGROUND: Neonatal renal vein thrombosis is the most common vascular condition in the newborn kidney, which could lead to serious complication in infants. CASE REPORT: We report a case of the unilateral renal vein and inferior vena cava thrombosis, presented with gross hematuria and thrombocytopenia in a neonate. The neonate was a macrosomic male born to a mother with hyperglycemia in pregnancy. The baby was born with perinatal asphyxia and early neonatal infection and massive hematuria...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/30312312/parental-costs-for-in-patient-neonatal-services-for-perinatal-asphyxia-and-low-birth-weight-in-ghana
#13
Christabel C Enweronu-Laryea, Hilary D Andoh, Audrey Frimpong-Barfi, Francis M Asenso-Boadi
The major causes of newborn deaths in sub-Saharan Africa are well-known and countries are gradually implementing evidence-based interventions and strategies to reduce these deaths. Facility-based care provides the best outcome for sick and or small babies; however, little is known about the cost and burden of hospital-based neonatal services on parents in West Africa, the sub-region with the highest global neonatal death burden. To estimate the actual costs borne by parents of newborns hospitalised with birth-associated brain injury (perinatal asphyxia) and preterm/low birth weight, this study examined economic costs using micro-costing bottom-up approach in two referral hospitals operating under the nationwide social health insurance scheme in an urban setting in Ghana...
2018: PloS One
https://www.readbyqxmd.com/read/30300885/prognostic-accuracy-of-heart-rate-variability-analysis-in-neonatal-encephalopathy-a-systematic-review
#14
REVIEW
Vânia Oliveira, Rui Martins, Natasha Liow, Justinas Teiserskas, Wilhelm von Rosenberg, Tricia Adjei, Vijayakumar Shivamurthappa, Peter J Lally, Danilo Mandic, Sudhin Thayyil
BACKGROUND: Heart rate variability analysis offers real-time quantification of autonomic disturbance after perinatal asphyxia, and may therefore aid in disease stratification and prognostication after neonatal encephalopathy (NE). OBJECTIVE: To systematically review the existing literature on the accuracy of early heart rate variability (HRV) to predict brain injury and adverse neurodevelopmental outcomes after NE. DESIGN/METHODS: We systematically searched the literature published between May 1947 and May 2018...
October 9, 2018: Neonatology
https://www.readbyqxmd.com/read/30236080/perinatal-death-beyond-41-weeks-pregnancy-an-evaluation-of-causes-and-substandard-care-factors-as-identified-in-perinatal-audit-in-the-netherlands
#15
Joep C Kortekaas, Anke C Scheuer, Esteriek de Miranda, Aimée E van Dijk, Judit K J Keulen, Aafke Bruinsma, Ben W J Mol, Frank P H A Vandenbussche, Jeroen van Dillen
BACKGROUND: Late- and postterm pregnancy are associated with adverse perinatal outcomes, like perinatal death. We evaluated causes of death and substandard care factors (SSFs) in term and postterm perinatal death. METHODS: We used data from the Perinatal Audit Registry of the Netherlands (PARS). Women with a term perinatal death registered in PARS were stratified by gestational age into early-/full-term (37.0-40.6) and late-/postterm (≥41.0 weeks) death. Cause of death and SSFs ≥41 weeks were scored and classified by the local perinatal audit teams...
September 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30234170/decreasing-birth-asphyxia-utility-of-statistical-process-control-in-a-low-resource-setting
#16
Mariya Mukhtar-Yola, Lamidi Isah Audu, Oluyinka Olaniyan, Henry T Akinbi, Adekunle Dawodu, Edward F Donovan
The neonatal period is a critical time for survival of the child. A disproportionate amount of neonatal deaths occur in low-resource countries and are attributable to perinatal events, especially birth asphyxia. This project aimed to reduce the incidence of birth asphyxia by 20% by June 2014 through training in neonatal resuscitation and improving the availability of resuscitation equipment in the delivery room in the National Hospital Abuja, Nigeria. A prospective, longitudinal study using statistical process control analytical methods was done enrolling babies delivered at the National Hospital Abuja...
2018: BMJ open quality
https://www.readbyqxmd.com/read/30178296/altered-expression-of-umbilical-cord-blood-levels-of-mir-181b-and-its-downstream-target-much-l1-in-infants-with-moderate-and-severe-neonatal-hypoxic-ischaemic-encephalopathy
#17
A M Looney, M P O'Sullivan, C E Ahearne, M Finder, U Felderhoff-Mueser, G B Boylan, B Hallberg, Deirdre M Murray
Hypoxic-ischaemic encephalopathy (HIE) remains one of the leading causes of neurological disability worldwide. No blood biomarker capable of early detection and classification of injury severity in HIE has been identified. This study aimed to investigate the potential of miRNA-181b (miR-181b) and its downstream target, ubiquitin C-terminal hydrolase-L1 (UCH-L1), to predict the severity of HIE. Full-term infants with perinatal asphyxia were recruited at birth and observed for the development of HIE, along with healthy controls...
September 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30175999/the-perinatal-asphyxiated-lamb-model-a-model-for-newborn-resuscitation
#18
Payam Vali, Sylvia Gugino, Carmon Koenigsknecht, Justin Helman, Praveen Chandrasekharan, Munmun Rawat, Satyan Lakshminrusimha, Jayasree Nair
Birth asphyxia accounts for nearly one million deaths worldwide each year, and is one of the primary causes of early neonatal morbidity and mortality. Many aspects of the current neonatal resuscitation guidelines remain controversial given the difficulties in conducting randomized clinical trials owing to the infrequent and often unpredictable need for extensive resuscitation. Most studies on neonatal resuscitation stem from manikin models that fail to truly reflect physiologic changes or piglet models that have cleared their lung fluid and that have completed the transition from fetal to neonatal circulation...
August 15, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30149778/perinatal-hypoxic-ischemic-brain-injury-in-large-animal-models-relevance-to-human-neonatal-encephalopathy
#19
Raymond C Koehler, Zeng-Jin Yang, Jennifer K Lee, Lee J Martin
Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our understanding of cellular mechanisms of neural injury in developing brain, but have limitations in simulating the range, accuracy, and physiology of clinical hypoxia-ischemia and the relevant systems neuropathology that contribute to the human brain injury pattern. Large animal models of perinatal hypoxia-ischemia, such as partial or complete asphyxia at the time of delivery of fetal monkeys, umbilical cord occlusion and cerebral hypoperfusion at different stages of gestation in fetal sheep, and severe hypoxia and hypoperfusion in newborn piglets, have largely overcome these limitations...
December 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30149475/transplacental-lidocaine-intoxication
#20
V Demeulemeester, H V Hauthem, F Cools, J Lefevere
Neonatal seizures are frequent in neonatal intensive care and the most common cause is perinatal asphyxia. Among other causes, toxin exposure is rare.We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures. There was no hypoxic ischemic encephalopathy and brain imaging was normal. Toxicology screening revealed a toxic concentration of lidocaine in his blood. The intoxication was transplacental, as a cord blood sample confirmed the toxic level...
August 21, 2018: Journal of Neonatal-perinatal Medicine
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