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liver development

Zhi Liu, Yang Zhong, Yu Jian Chen, Hui Chen
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging to group C of Sry-related HMG box family whose abnormal expression is frequently seen in many kinds of human cancers. Here, we reported that the expression of SOX11 was decreased in human HCC tumors than that in matched normal tissues. Overexpression of SOX11 promoted growth inhibition and apoptosis in HCC cell line HuH-7...
December 5, 2018: Biotechnology and Applied Biochemistry
Kuei-Yen Tsai, Hsin-An Chen, Wan-Yu Wang, Ming-Te Huang
BACKGROUND: Pulmonary complications remain relatively high in morbidities that arise after liver surgery and are associated with increased length of hospital stay and higher cost. Identification of possible risk factors in this retrospective analysis may help reduce operative morbidity and achieve better outcomes. METHODS: In all, 363 consecutive patients underwent elective hepatectomies between July 2008 and November 2013 and these were identified and analyzed retrospectively...
December 5, 2018: Digestive Surgery
Shinji Furuya, Joseph A Cichocki, Kranti Konganti, Kostiantyn Dreval, Takeki Uehara, Yuuki Katou, Hisataka Fukushima, Hiroshi Kono, Igor P Pogribny, Josepmaria Argemi, Ramon Bataller, Ivan Rusyn
Human alcoholic hepatitis (AH) carries a high mortality rate. AH is an acute-on-chronic form of liver injury characterized by hepatic steatosis, ballooned hepatocytes, neutrophil infiltration, and pericellular fibrosis. We aimed to study the pathogenesis of AH in an animal model which combines chronic hepatic fibrosis with intragastric alcohol administration. Adult male C57BL6/J mice were treated with CCl4 (0.2 ml/kg, 2×weekly by intraperitoneal injections for 6 weeks) to induce chronic liver fibrosis. Then, ethyl alcohol (up to 25 g/kg/day for 3 weeks) was administered continuously to mice via a gastric feeding tube, with or without one-half dose of CCl4...
December 4, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Y T B Bambaradeniya, W A I P Karunaratne, J K Tomberlin, I Goonerathne, R B Kotakadeniya
Chrysomya bezziana Villeneuve is the major human myiasis producer in tropical countries, including Sri Lanka. Although of great medical and veterinary importance, only a single study has been published on the development of C. bezziana. This limitation is due in part to the difficulty of maintaining this species in a colony outside of using a living host. In this study, a novel technique that overcomes this limitation is presented along with development data for C. bezziana fed on three different meat types: swine muscle, swine liver, and bovine muscle at two temperature regimes: 35 and 37°C...
December 4, 2018: Journal of Medical Entomology
Carolina M Pusec, Adam De Jesus, Md Wasim Khan, Alexander R Terry, Anton E Ludvik, Kai Xu, Nicholas Giancola, Haaris Pervaiz, Emily Daviau Smith, Xianzhong Ding, Stephen Harrison, Navdeep S Chandel, Thomas C Becker, Nissim Hay, Hossein Ardehali, Jose Cordoba-Chacon, Brian T Layden
Glucokinase (GCK) is the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. Recently, we proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1 to have low glucose-phosphorylating ability and demonstrate its association with the mitochondria in hepatocytes. As we have shown previously that genetic deletion of HKDC1 leads to altered hepatic triglyceride levels, we also explored the influence of overexpression of HKDC1 in hepatocytes on cellular metabolism observing reduced glycolytic capacity and maximal mitochondrial respiration with concurrent reductions in glucose oxidation and mitochondrial membrane potential...
December 3, 2018: Endocrinology
Delano Gurgel Silveira, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Hermano Alexandre Lima Rocha, Gleydson Cesar de Oliveira Borges
PURPOSE: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE). METHODS: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. The sample consisted of 12 livers of adult pigs weighing between 30 and 45 kg. A circular-shaped HR, 5 cm diameter and deformable materials was developed with a polypropylene cloth, metallic guide wire, epidural needle plastic guide and nylon string...
November 2018: Acta Cirúrgica Brasileira
Naglezi M Lovatto, Bruno B Loureiro, Dirleise Pianesso, Taida J Adorian, Fernanda R Goulart, Caroline S Speroni, Ana Betine B Bender, Jucieli Müller, Leila P DA Silva
The objective of this study was to evaluate growth and metabolic parameters of silver catfish fed with protein concentrates of sunflower meal (SMPC) and crambe meal (CrMPC). The study evaluated two levels of substitution, where 25 or 50% of animal protein was replaced with plant-based protein. A total of 300 silver catfish (14 ± 0.26 g) were used in five treatments and three replications, in fifteen 280-liter experimental units. The results were submitted to analysis of variance and the means of the control diet was compared to the remaining treatments by Dunnett's test at 5% significance level...
October 2018: Anais da Academia Brasileira de Ciências
Carlos Rp Dechandt, Tatiane M Vicentini, Guilherme Pauperio Lanfredi, Rui M P da Silva, Enilza Maria Espreafico, José A C de Oliveira, Vitor Marcel Faça, Norberto Garcia-Cairasco, Luciane C Alberici
The Wistar Audiogenic Rat (WAR) is an animal model of tonic-clonic epileptic seizures, developed after genetic selection by sister x brother inbreeding of Wistar rats susceptible to sound stimuli. Although metabolic changes have been described in this strain, nothing, however, is known about its mitochondrial metabolism. Here, we addressed mitochondrial aspects of OXPHOS, oxidative stress, biogenesis and dynamics in liver, skeletal muscle and heart of male WAR, correlating then to physiological aspects of body metabolism...
December 5, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Weston J Smith, Guankui Wang, Hanmant Gaikwad, Vivian P Vu, Ernest Groman, David W A Bourne, Dmitri Simberg
Long blood half-life is one of the advantages of antibodies over small molecule drugs. At the same time, prolonged half-life is a problem for imaging applications or in the case of antibody-induced toxicities. There is a substantial need for antidotes that can quickly clear antibodies from systemic circulation and peripheral tissues. Engineered nanoparticles exhibit intrinsic affinity for clearance organs (mainly liver and spleen). trans-Cyclooctene (TCO) and methyltetrazine (MTZ) are versatile copper-free click chemistry components that are extensively being used for in vivo bioorthogonal couplings...
December 5, 2018: ACS Nano
Beau Kelly, James E Squires, Brian Feingold, David K Hooper, George V Mazariegos
PURPOSE OF REVIEW: Pediatric transplantation faces unique challenges in implementing dynamic quality improvement measures because of proportionally smaller volumes compared to adults, logistics of being integrated successfully within larger or complex hospital systems, lack of adult-affiliated transplant centers, varying focus in prioritization of relevant outcome metrics, and potential lack of sufficient resources. RECENT FINDINGS: To address these challenges, multiinstitutional collaborations have developed which have proven increasingly effective in driving awareness and quality improvement measures to supplement regulatory efforts in the pediatric population...
December 3, 2018: Current Opinion in Organ Transplantation
Travis D Hull, Gilles Benichou, Joren C Madsen
PURPOSE OF REVIEW: There is great variability in how different organ allografts respond to the same tolerance induction protocol. Well known examples of this phenomenon include the protolerogenic nature of kidney and liver allografts as opposed to the tolerance-resistance of heart and lung allografts. This suggests there are organ-specific factors which differentially drive the immune response following transplantation. RECENT FINDINGS: The specific cells or cell products that make one organ allograft more likely to be accepted off immunosuppression than another are largely unknown...
December 3, 2018: Current Opinion in Organ Transplantation
D Marakushyn, I Karmazina, I Isaeva, N Hloba
The study was conducted as a part of research work "Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors". The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings...
October 2018: Georgian Medical News
Noriaki Kawanishi, Tsubasa Mizokami, Koichi Yada, Katsuhiko Suzuki
Although nonalcoholic steatohepatitis (NASH) is an important component of the metabolic syndrome, scavenger receptor CD36 also modulates NASH development. This study aimed to clarify whether exercise training suppresses CD36 expression in a mouse model of NASH. Male C57BL/6 mice were divided into four groups: normal diet (ND) sedentary, ND exercise, high-fat diet and high-fructose water (HFF) sedentary, and HFF exercise groups. The exercise groups were trained on a motorized treadmill at running speeds of 15-20 m/min for 60 min/day, 5 times/week for 16 weeks...
December 2018: Physiological Reports
Jörn M Schattenberg, Und Rohit Loomba
The epidemic of non-alcoholic fatty liver disease (NAFLD) has created a large demand for diagnostic tools to identify patients at risk of disease progression including the development of end-stage liver disease. The prevalence of NAFLD is rising worldwide and it is estimated that approximately 1 billion individuals may be afflicted with NAFLD globally (1). Currently, the gold standard to diagnose advanced fibrosis and therefore the reference for all non-invasive technology is liver histology and it's assessment by an experienced liver-histopathologist...
December 4, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
C K Indumathi, Aruna Sethuraman, Saurav Jain, Savita Krishnamurthy
OBJECTIVES: To compare the incidence of anti tuberculosis drug-induced hepatotoxicity (ATDH) with those on old vs. revised WHO doses in human immunodeficiency virus (HIV) negative children. The secondary objective was to determine the overall incidence of hepatitis in children on Anti tubercular treatment (ATT) and isoniazid prophylactic therapy (IPT). METHODS: Children attending pediatric outpatient / admitted in wards, on ATT/ IPT between January 2007 and December 2017 (11 y) were included...
December 4, 2018: Indian Journal of Pediatrics
Elena Palma, Ewald Jan Doornebal, Shilpa Chokshi
Human precision-cut liver slices represent a robust and versatile ex vivo model which retains the complex and multi-cellular histoarchitecture of the hepatic environment. As such, they represent an ideal model to investigate the mechanisms of liver injury and for the identification of novel therapeutic targets. Schematic overview to highlight the utility of precision-cut liver slices as a relevant and versatile ex-vivo model of liver disease. Top panel; Precision cut liver slices (PCLS) exposed to ethanol develop mega-mitochondria, a classical hallmark of Alcoholic Liver Disease (ALD)...
December 4, 2018: Hepatology International
Gabriella Guarnieri, Rosana Bizzotto, Ottorino Gottardo, Emanuela Velo, Mauro Cassaro, Stefania Vio, Maria Grazia Putzu, Federica Rossi, Paolo Zuliani, Filippo Liviero, Paola Mason, Piero Maestrelli
INTRODUCTION: Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops). AIM: We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates. METHODS: A confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy...
December 4, 2018: Occupational and Environmental Medicine
Melissa Wasserstein, Carlo Dionisi-Vici, Roberto Giugliani, Wuh-Liang Hwu, Olivier Lidove, Zoltan Lukacs, Eugen Mengel, Pramod K Mistry, Edward H Schuchman, Margaret McGovern
BACKGROUND: Acid sphingomyelinase deficiency (ASMD), a rare lysosomal storage disease, results from mutations in SMPD1, the gene encoding acid sphingomyelinase (ASM). As a result, sphingomyelin accumulates in multiple organs including spleen, liver, lung, bone marrow, lymph nodes, and in the most severe form, in the CNS and peripheral nerves. Clinical manifestations range from rapidly progressive and fatal infantile neurovisceral disease, to less rapidly progressing chronic neurovisceral and visceral forms that are associated with significant morbidity and shorter life span due to respiratory or liver disease...
November 29, 2018: Molecular Genetics and Metabolism
Maria Hukkinen, Anna Kerola, Jouko Lohi, Timo Jahnukainen, Päivi Heikkilä, Mikko P Pakarinen
BACKGROUND: Progression of fibrosis and ensuing complications determine the postoperative course of patients operated on for biliary atresia. We evaluated predictors of the progression of fibrosis in the native liver after operative treatment. METHODS: Among patients whose bilirubin decreased to <34 µmol/L after portoenterostomy (n = 41), predictors of follow-up cirrhosis and the progression of fibrosis were analyzed with logistic regression and survival of their native liver was evaluated with the Kaplan-Meier method...
December 1, 2018: Surgery
Mi-Jin An, Dae-Hyun Kim, Chul-Hong Kim, Mijin Kim, Sangmyung Rhee, Sang-Beom Seo, Jung-Woong Kim
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most lethal cancer worldwide. Although gene mutations associated with HCC development have been intensively studied, how epigenetic factors specifically modulate the functional properties of HCC by regulating target gene expression is unclear. Here we demonstrated the overexpression of KDM3B in liver tissue of HCC patients using public RNA-seq data. Ablation of KDM3B by CRISPR/Cas9 retarded the cell cycle and proliferation of hepatocarcinoma HepG2 cells...
December 1, 2018: Biochemical and Biophysical Research Communications
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