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Gargi Mahapatra, Ashwathy Varughese, Qinqin Ji, Icksoo Lee, Jenney Liu, Asmita Vaishnav, Christopher Sinkler, Alexandr A Kapralov, Carlos T Moraes, Thomas H Sanderson, Timothy L Stemmler, Lawrence I Grossman, Valerian E Kagan, Joseph S Brunzelle, Arthur R Salomon, Brian F P Edwards, Maik Hüttemann
Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in the electron transport chain (ETC) and as a trigger of apoptosis when released from the mitochondria. However, its regulation is not well understood. We show that the major fraction of Cytc isolated from kidneys is phosphorylated on Thr28, leading to a partial inhibition of respiration in the reaction with cytochrome c oxidase. To further study the effect of Cytc phosphorylation in vitro, we generated Thr28Glu phosphomimetic Cytc, revealing superior behavior regarding protein stability and its ability to degrade reactive oxygen species compared to wild-type unphosphorylated Cytc...
October 7, 2016: Journal of Biological Chemistry
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
October 14, 2016: Clinical Therapeutics
Tyler B Mason, Ralitsa S Maduro, Valerian J Derlega, Desi S Hacker, Barbara A Winstead, Jacqueline E Haywood
Objective: This research focused on how race-based rejection sensitivity (RS-Race) and components of racial identity intensify negative psychological reactions to an incident of vicarious racism. We examined how these individual difference variables directly and/or indirectly predicted African American students' reactions to the trial of George Zimmerman in the killing of the African American teenager, Trayvon Martin. Method: In Study 1, 471 African American students completed measures of RS-Race, thought intrusions about the Zimmerman trial, and outcome variables (negative affect about the Zimmerman trial and forgiveness for Mr...
October 13, 2016: Cultural Diversity & Ethnic Minority Psychology
Sophie Desmonde, Tessa Goetghebuer, Claire Thorne, Valériane Leroy
PURPOSE OF REVIEW: The number of HIV-exposed but uninfected (HEU) infants exposed to both HIV and multiple antiretroviral drugs in utero and during prolonged breastfeeding is increasing in low-income countries where HIV prevalence is the highest. We review recent evidence on the effects of perinatal/postnatal exposure to maternal HIV and combined antiretroviral therapy (cART) on health outcomes of HEU children (mitochondrial and metabolic toxicity, adverse pregnancy outcomes, neurodevelopment, growth, infectious morbidity, and mortality)...
September 2016: Current Opinion in HIV and AIDS
Salvatore Butticè, Tarik Emre Sener, Valerian Ciprian Lucan, Luca Lunelli, Antonio Simone Laganà, Salvatore Giovanni Vitale, Christopher Netsch, Yiloren Tanidir, Rosa Pappalardo, Carlo Magno
OBJECTIVES: To evaluate our experience in patients undergoing hybrid transvaginal NOTES nephrectomy and evaluate the sexual functions in the post-operative period. METHODS: Prospective data of 71 patients with renal tumors who underwent hybrid NOTES radical nephrectomy in three different centers were collected from March 2010 to October 2015. Patient and surgical characteristics are recorded. Sexual function was evaluated with Female Sexual Function Index (FSFI) questionnaire, the day prior to the operation and three months after...
September 27, 2016: Urology
Valerian Ciprian Lucan, Luisa Berardinelli
Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant immunosuppressant medication. In fact, for any immunosuppressant therapy, certain standardized precepts and attitudes that aim to reduce the incidence and the impact of the medication side effects must be applied. Many patients undergo renal transplantation and the physicians have to be aware of the advantages and the risks associated...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
Tolani F Olonisakin, Huihua Li, Zeyu Xiong, Elizabeth J K Kochman, Minting Yu, Yanyan Qu, Mei Hulver, Jay K Kolls, Claudette St Croix, Yohei Doi, Minh-Hong Nguyen, Robert M Q Shanks, Rama K Mallampalli, Valerian E Kagan, Anuradha Ray, Roy L Silverstein, Prabir Ray, Janet S Lee
Klebsiella pneumoniae remains an important cause of intrapulmonary infection and invasive disease worldwide. Klebsiella pneumoniae can evade serum killing and phagocytosis primarily through the expression of a polysaccharide capsule, but its pathogenicity is also influenced by host factors. We examined whether CD36, a scavenger receptor that recognizes pathogen and modified-self ligands, is a host determinant of Klebsiella pneumoniae pathogenicity. Despite differences in serum sensitivity and virulence of three distinct Klebsiella pneumoniae (hypermucoviscous K1, research K2, carbapenemase-producing ST258) strains utilized, the absence of CD36 significantly increased host susceptibility to acute intrapulmonary infection by K...
September 28, 2016: Journal of Infectious Diseases
Oliver T R Toovey, Ian R Edmond, Nikolaos Makris
A 47-year-old woman presented with seizures secondary to euvolaemic hyponatraemia. A collateral history revealed recent increased oral fluid intake and increased use of herbal remedies including valerian root over the New Year period. There was no history of psychiatric disease to support psychogenic polydipsia. She responded to careful sodium replacement in the intensive care unit and was discharged with no neurological sequelae.
2016: BMJ Case Reports
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
Ya-Guang Sun, Yi-Ning Sun, Li-Xin You, Yi-Nan Liu, Fu Ding, Bao-Yi Ren, Gang Xiong, Valerian Dragutan, Ileana Dragutan
New cytotoxic, mononuclear Pt and Pd coordination complexes featuring the planar, multi-donor ligand (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid (H2PPDA) have been synthesized under hydrothermal conditions (in water, at high temperature and pressure) and fully characterized. The complexes were proven to be isostructural by applying the single-crystal X-ray diffraction technique. UV-Vis and fluorescence spectroscopy investigations on their interaction with fish sperm DNA revealed a considerable binding capacity while gel electrophoresis provided evidence in favor of cleavage of pBR322 plasmid DNA...
September 14, 2016: Journal of Inorganic Biochemistry
Valériane Dujardin
No abstract text is available yet for this article.
August 2016: Revue de L'infirmière
Jordan A Francke, Martina Penazzato, Taige Hou, Elaine J Abrams, Rachel L MacLean, Landon Myer, Rochelle P Walensky, Valériane Leroy, Milton C Weinstein, Robert A Parker, Kenneth A Freedberg, Andrea Ciaranello
BACKGROUND:  Early infant HIV diagnosis (EID) and antiretroviral therapy dramatically reduce mortality. EID is recommended at six weeks of age, but many infant infections are missed. DESIGN/METHODS:  We simulated four EID strategies for HIV-exposed infants in South Africa: no EID (diagnosis only after illness), testing once (birth alone; 6 weeks alone) and twice (birth and 6 weeks). We calculated incremental cost-effectiveness ratios (ICERs) using discounted costs and life expectancies for all HIV-exposed (infected and uninfected) infants...
August 17, 2016: Journal of Infectious Diseases
Shino Arikawa, Tanoh Eboua, Kouadio Kouakou, Marie-Sylvie N'Gbeche, Madeleine Amorissani-Folquet, Corinne Moh, Ursula Belinda Amoussou-Bouah, Patrick Ahuatchi Coffie, Renaud Becquet, Valériane Leroy
OBJECTIVE: Adolescents living with HIV are sexually active and engaged in risky sexual behaviors. Knowledge on how and to what extent adolescents in HIV care are affected by pregnancy is needed so as to adopt better preventive services. We estimated 4-year pregnancy incidence and correlates among HIV-infected female adolescents in HIV care in urban Côte d'Ivoire. DESIGN: We conducted retrospective analysis of a pediatric prospective cohort of the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa Collaboration...
2016: Global Health Action
John J Maguire, Yulia Y Tyurina, Dariush Mohammadyani, Aleksandr A Kapralov, Tamil S Anthonymuthu, Feng Qu, Andrew A Amoscato, Louis J Sparvero, Vladimir A Tyurin, Joan Planas-Iglesias, Rong-Rong He, Judith Klein-Seetharaman, Hülya Bayır, Valerian E Kagan
Since its discovery 75years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an "eat-me" signal...
August 4, 2016: Biochimica et Biophysica Acta
Zahra Behboodi Moghadam, Elham Rezaei, Roghaieh Shirood Gholami, Masomeh Kheirkhah, Hamid Haghani
Premenstrual syndrome (PMS) is a common disorder. Due to the knowledge lack of the precise etiology of this syndrome, different treatment methods are recommended, one of them is the use of medicinal herbs. This study aimed to investigate the effect of Valerian ( xié cǎo) root extract on the intensity of PMS symptoms. In this double-blind clinical trial, 100 female students of Islamic Azad University, Tonekabon Branch, Mazandaran Province, Iran, with PMS were randomly divided into groups receiving Valerian (scientific name: Valeriana officinalis) and placebo in 2013...
July 2016: Journal of Traditional and Complementary Medicine
William K Petry, Judith D Soule, Amy M Iler, Ana Chicas-Mosier, David W Inouye, Tom E X Miller, Kailen A Mooney
Males and females are ecologically distinct in many species, but whether responses to climate change are sex-specific is unknown. We document sex-specific responses to climate change in the plant Valeriana edulis (valerian) over four decades and across its 1800-meter elevation range. Increased elevation was associated with increased water availability and female frequency, likely owing to sex-specific water use efficiency and survival. Recent aridification caused male frequency to move upslope at 175 meters per decade, a rate of trait shift outpacing reported species' range shifts by an order of magnitude...
July 1, 2016: Science
Michael Schomaker, Valeriane Leroy, Tom Wolfs, Karl-Günter Technau, Lorna Renner, Ali Judd, Shobna Sawry, Madeleine Amorissani-Folquet, Antoni Noguera-Julian, Frank Tanser, François Eboua, Maria Luisa Navarro, Cleophas Chimbetete, Clarisse Amani-Bosse, Josiane Warszawski, Sam Phiri, Sylvie N'Gbeche, Vivian Cox, Fla Koueta, Janet Giddy, Haby Sygnaté-Sy, Dorthe Raben, Geneviève Chêne, Mary-Ann Davies
BACKGROUND: There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. METHODS: A total of 20 576 antiretroviral treatment (ART)-naïve patients, aged 1-16 years at enrolment, from 19 cohorts in Europe, Southern Africa and West Africa, were included. We compared mortality and growth outcomes for different ART initiation criteria, aligned with previous and recent World Health Organization criteria, for 5 years of follow-up, adjusting for all measured baseline and time-dependent confounders using the g-formula...
June 24, 2016: International Journal of Epidemiology
Detcho A Stoyanovsky, Jianfei Jiang, Michael P Murphy, Michael Epperly, Xiaolan Zhang, Song Li, Joel Greenberger, Valerian Kagan, Hülya Bayır
[This corrects the article DOI: 10.1021/ml5003635.].
June 9, 2016: ACS Medicinal Chemistry Letters
Masumeh Ghazanfarpour, Ramin Sadeghi, Somayeh Abdolahian, Robab Latifnejad Roudsari
BACKGROUND: Hot flashes are the most common symptoms experienced by women around the time of menopause. Many women are interested in herbal medicines because of fear of side effects of hormone therapy. OBJECTIVE: The aim of this systematic review was to assess the effectiveness of Iranian herbal medicines in alleviating hot flashes. MATERIALS AND METHODS: MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015) were searched along with, SID, Iran Medex, Magiran, Medlib and Irandoc...
March 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Paul Vargas Jentzsch, Valerian Ciobotă, Wilson Salinas, Bernd Kampe, Pedro M Aponte, Petra Rösch, Jürgen Popp, Luis A Ramos
Cocoa (Theobroma cacao) is a crop of economic importance. In Ecuador, there are two predominant cocoa varieties: National and CCN-51. The National variety is the most demanded, since its cocoa beans are used to produce the finest chocolates. Raman measurements of fermented, dried and unpeeled cocoa beans were performed using a handheld spectrometer. Samples of the National and CCN-51 varieties were collected from different provinces and studied in this work. For each sample, 25 cocoa beans were considered and each bean was measured at 4 different spots...
November 15, 2016: Food Chemistry
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