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https://www.readbyqxmd.com/read/29772094/quantifying-biomolecular-binding-constants-using-video-paper-analytical-devices
#1
Benjamin S Miller, Claudio Parolo, Valerian Turbé, Candice E Keane, Eleanor R Gray, Rachel McKendry
We report a novel ultralow-cost biochemical analysis platform to quantify protein dissociation binding constants and kinetics using paper microfluidics. Our approach marries video imaging with one of humankind's oldest materials - paper, requiring no large, expensive laboratory equipment, complex microfluidics or external power. Temporal measurements of nanoparticle-antibody conjugates binding on paper is found to follow the Langmuir Adsorption Model. This is exploited to measure a series of antibody-antigen dissociation constants on paper, showing excellent agreement with a gold-standard benchtop interferometer...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29764454/screening-a-repurposing-library-the-medicines-for-malaria-venture-stasis-box-against-schistosoma-mansoni
#2
Valérian Pasche, Benoît Laleu, Jennifer Keiser
BACKGROUND: The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, which have already unblocked several essential steps along the drug development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis Box). METHODS: All 400 compounds were initially tested in vitro against the larval stage of Schistosoma mansoni at 10 μM...
May 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29764338/the-prognostic-relevance-of-psychological-factors-with-regard-to-participation-and-success-in-table-tennis
#3
Guillaume Martinent, Valérian Cece, Marije Titia Elferink-Gemser, Irene Renate Faber, Jean-Claude Decret
This study examined the prognostic relevance of self-determined motivation, coping, burnout, perceived stress and recovery experienced by 159 youth table-tennis players involved in intensive training centers with regard to their participation and success six years later. Results of ANCOVAs showed that players who still practiced at time 2 (T2; six years later; n = 130) reported lower time 1 (T1; while they were involved in intensive training centers) amotivation (large effect), disengagement-oriented coping, sport devaluation and reduced accomplishment (moderate effects) than their counterparts who dropped out at T2 (n = 29)...
May 15, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29757094/implicit-sex-guilt-predicts-sexual-behaviors-evidence-for-the-validity-of-the-sex-guilt-implicit-association-test
#4
Delaram A Totonchi, Valerian J Derlega, Louis H Janda
Self-report measures of sexuality may be influenced by people's conscious concerns about confidentiality and social desirability. Alternatively, non-conscious measures (e.g., implicit association tests; IATs) are designed to minimize these validity concerns. We constructed an IAT measure of sex guilt using 154 male and female university students. The sex guilt IAT demonstrated convergent validity as it correlated with various sexual behaviors and incremental validity as it improved the prediction of several sexual behaviors beyond that provided by the Mosher sex guilt scale...
May 14, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29727458/access-to-antiretroviral-therapy-in-hiv-infected-children-aged-0-19-years-in-the-international-epidemiology-databases-to-evaluate-aids-iedea-global-cohort-consortium-2004-2015-a-prospective-cohort-study
#5
Sophie Desmonde, Franck Tanser, Rachel Vreeman, Elom Takassi, Andrew Edmonds, Pagakrong Lumbiganon, Jorge Pinto, Karen Malateste, Catherine McGowan, Azar Kariminia, Marcel Yotebieng, Fatoumata Dicko, Constantin Yiannoutsos, Mwangelwa Mubiana-Mbewe, Kara Wools-Kaloustian, Mary-Ann Davies, Valériane Leroy
INTRODUCTION: Access to antiretroviral therapy (ART) is a global priority. However, the attrition across the continuum of care for HIV-infected children between their HIV diagnosis and ART initiation is not well known. We analyzed the time from enrollment into HIV care to ART initiation in HIV-infected children within the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium. METHODS AND FINDINGS: We included 135,479 HIV-1-infected children, aged 0-19 years and ART-naïve at enrollment, between 1 January 2004 and 31 December 2015, in IeDEA cohorts from Central Africa (3 countries; n = 4,948), East Africa (3 countries; n = 22,827), West Africa (7 countries; n = 7,372), Southern Africa (6 countries; n = 93,799), Asia-Pacific (6 countries; n = 4,045), and Latin America (7 countries; n = 2,488)...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29722827/a-broadly-conserved-nerd-genetically-interacts-with-the-exocyst-to-affect-root-growth-and-cell-expansion
#6
Rex Cole, Valera Peremyslov, Savanah Van Why, Ibrahim Moussaoui, Ann Ketter, Renee Cool, Matthew Andres Moreno, Zuzana Vejlupkova, Valerian Dolja, John E Fowler
The exocyst, a conserved, octameric protein complex helps mediate secretion at the plasma membrane, facilitating specific developmental processes that include control of root meristem size, cell elongation, and tip growth. A genetic screen for second-site enhancers in Arabidopsis identified NEW ENHANCER of ROOT DWARFISM1 (NERD1) as an exocyst interactor. Mutations in nerd1 combined with weak exocyst mutations in SEC8 and EXO70A1 result in a synergistic reduction in root growth. Alone, nerd1 alleles modestly reduce primary root growth, both by shortening the root meristem and by reducing cell elongation, but also result in a slight increase in root hair length, bulging, and rupture...
May 2, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29710491/valerian-cascade-mixture-promotes-sleep-by-increasing-non-rapid-eye-movement-nrem-in-rodent-model
#7
Hyeon-Son Choi, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. The mixture significantly increased the non-rapid eye movement (NREM) sleep time by 53% compared with the control, while REM sleeping time was decreased by 33% with Valerian/Cascade mixture, in Electroencephalography (EEG) analysis, resulting in the increase of total sleep time and the decrease of awakening...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29694986/-kissing-nodules-in-saber-sheath-trachea
#8
Julien Guinde, Samer Georges, Valerian Bourinet, Sophie Laroumagne, Philippe Astoul, Hervé Dutau
No abstract text is available yet for this article.
April 25, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29680923/taxonomy-of-the-family-arenaviridae-and-the-order-bunyavirales-update-2018
#9
Piet Maes, Sergey V Alkhovsky, Yīmíng Bào, Martin Beer, Monica Birkhead, Thomas Briese, Michael J Buchmeier, Charles H Calisher, Rémi N Charrel, Il Ryong Choi, Christopher S Clegg, Juan Carlos de la Torre, Eric Delwart, Joseph L DeRisi, Patrick L Di Bello, Francesco Di Serio, Michele Digiaro, Valerian V Dolja, Christian Drosten, Tobiasz Z Druciarek, Jiang Du, Hideki Ebihara, Toufic Elbeaino, Rose C Gergerich, Amethyst N Gillis, Jean-Paul J Gonzalez, Anne-Lise Haenni, Jussi Hepojoki, Udo Hetzel, Thiện Hồ, Ní Hóng, Rakesh K Jain, Petrus Jansen van Vuren, Qi Jin, Miranda Gilda Jonson, Sandra Junglen, Karen E Keller, Alan Kemp, Anja Kipar, Nikola O Kondov, Eugene V Koonin, Richard Kormelink, Yegor Korzyukov, Mart Krupovic, Amy J Lambert, Alma G Laney, Matthew LeBreton, Igor S Lukashevich, Marco Marklewitz, Wanda Markotter, Giovanni P Martelli, Robert R Martin, Nicole Mielke-Ehret, Hans-Peter Mühlbach, Beatriz Navarro, Terry Fei Fan Ng, Márcio Roberto Teixeira Nunes, Gustavo Palacios, Janusz T Pawęska, Clarence J Peters, Alexander Plyusnin, Sheli R Radoshitzky, Víctor Romanowski, Pertteli Salmenperä, Maria S Salvato, Hélène Sanfaçon, Takahide Sasaya, Connie Schmaljohn, Bradley S Schneider, Yukio Shirako, Stuart Siddell, Tarja A Sironen, Mark D Stenglein, Nadia Storm, Harikishan Sudini, Robert B Tesh, Ioannis E Tzanetakis, Mangala Uppala, Olli Vapalahti, Nikos Vasilakis, Peter J Walker, Guópíng Wáng, Lìpíng Wáng, Yànxiăng Wáng, Tàiyún Wèi, Michael R Wiley, Yuri I Wolf, Nathan D Wolfe, Zhìqiáng Wú, Wénxìng Xú, Li Yang, Zuòkūn Yāng, Shyi-Dong Yeh, Yǒng-Zhèn Zhāng, Yàzhōu Zhèng, Xueping Zhou, Chénxī Zhū, Florian Zirkel, Jens H Kuhn
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future.
April 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29667336/optimal-breastfeeding-durations-for-hiv-exposed-infants-the-impact-of-maternal-art-use-infant-mortality-and-replacement-feeding-risk
#10
Divya Mallampati, Rachel L MacLean, Roger Shapiro, Francois Dabis, Barbara Engelsmann, Kenneth A Freedberg, Valeriane Leroy, Shahin Lockman, Rochelle Walensky, Nigel Rollins, Andrea Ciaranello
INTRODUCTION: In 2010, the WHO recommended women living with HIV breastfeed for 12 months while taking antiretroviral therapy (ART) to balance breastfeeding benefits against HIV transmission risks. To inform the 2016 WHO guidelines, we updated prior research on the impact of breastfeeding duration on HIV-free infant survival (HFS) by incorporating maternal ART duration, infant/child mortality and mother-to-child transmission data. METHODS: Using the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Infant model, we simulated the impact of breastfeeding duration on 24-month HFS among HIV-exposed, uninfected infants...
April 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29666544/efficiency-of-selected-food-ingredients-on-protein-efficiency-ratio-glycemic-index-and-in-vitro-digestive-properties
#11
M B Anusha, Naveen Shivanna, G Phani Kumar, K R Anilakumar
The human body on exposure to high-altitude, undergoes many physiological challenges. The cardiopulmonary reserves are favoured against the digestive system. Hence, the efficiency of digestion is compromised to a great extent, which leads to anorexia, hypophagia, epigastralgia, dyspepsia, nausea, and peptic ulcers. The present study was focused on in vitro digestive influence of selected food ingredients viz. cardamom, carom, cumin, coriander, fennel, fenugreek, ginger, pepper, star anise, turmeric, papaya, orange, pineapple, liquorice, valerian, and tarragon on the activities of digestive enzymes of rat pancreas, duodenum, and small intestine...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29659361/-one-hundred-years-after-the-spanish-flu
#12
Isabel A Lüthy, Viviana Ritacco, Isabel N Kantor
The "Spanish" flu pandemic, which occurred a century ago, is considered the most devastating in human history. An estimated one third of world population fell ill with flu and more than 2.5% of them died. The course of the epidemic had two main waves (1918 and 1919) and showed an unusual W-shaped morbidity/mortality distribution. Death was not a direct outcome of flu itself but rather a consequence of secondary bacterial bronchopneumonia, for which antibiotics had not yet been discovered. Pre-existing pulmonary tuberculosis was also accountable for increased flu death rates during the pandemic...
2018: Medicina
https://www.readbyqxmd.com/read/29621756/experience-with-transcordal-silicone-stents-in-adult-laryngotracheal-stenosis-a-bicentric-retrospective-study
#13
Valerian Bourinet, Thibaut Raguin, Marc Fortin, Elsa Chetrit, Julien Guinde, Sophie Laroumagne, Nicolas Fakhry, Philippe Astoul, Christian Debry, Hervé Dutau
BACKGROUND: Benign stenosis involving laryngeal and upper tracheal structures represents a therapeutic challenge. Open surgery and endoscopic management have to be discussed by a multidisciplinary board in order to evaluate the risk and benefit for each patient. OBJECTIVE: The objective of this retrospective study was to report the experience of two French centers with transcordal silicone stents (TSS) in the endoscopic management of benign laryngotracheal stenosis (BLTS) in adults, with focus on efficacy, safety, and tolerability...
April 5, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29617778/scaling-up-voluntary-medical-male-circumcision-for-human-immunodeficiency-virus-prevention-for-adolescents-and-young-adult-men-a-modeling-analysis-of-implementation-and-impact-in-selected-countries
#14
Emmanuel Njeuhmeli, Marjorie Opuni, Melissa Schnure, Michel Tchuenche, Peter Stegman, Elizabeth Gold, Valerian Kiggundu, Nida Parks, Kim Seifert Ahanda, Maria Carrasco, Katharine Kripke
Background: The new World Health Organization and Joint United Nations Programme on HIV/AIDS strategic framework for voluntary medical male circumcision (VMMC) aims to increase VMMC coverage among males aged 10-29 years in priority settings to 90% by 2021. We use mathematical modeling to assess the likelihood that selected countries will achieve this objective, given their historical VMMC progress and current implementation options. Methods: We use the Decision Makers' Program Planning Toolkit, version 2, to examine 4 ambitious but feasible scenarios for scaling up VMMC coverage from 2017 through 2021, inclusive in Lesotho, Malawi, Mozambique, Namibia, South Africa, Swaziland, Tanzania, Uganda, and Zimbabwe...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29610484/fino-2-initiates-ferroptosis-through-gpx4-inactivation-and-iron-oxidation
#15
Michael M Gaschler, Alexander A Andia, Hengrui Liu, Joleen M Csuka, Brisa Hurlocker, Christopher A Vaiana, Daniel W Heindel, Dylan S Zuckerman, Pieter H Bos, Eduard Reznik, Ling F Ye, Yulia Y Tyurina, Annie J Lin, Mikhail S Shchepinov, Amy Y Chan, Eveliz Peguero-Pereira, Maksim A Fomich, Jacob D Daniels, Andrei V Bekish, Vadim V Shmanai, Valerian E Kagan, Lara K Mahal, K A Woerpel, Brent R Stockwell
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineered cancer cells. We investigated the mechanism and structural features necessary for ferroptosis initiation by FINO2 . We found that FINO2 requires both an endoperoxide moiety and a nearby hydroxyl head group to initiate ferroptosis. In contrast to previously described ferroptosis inducers, FINO2 does not inhibit system xc - or directly target the reducing enzyme GPX4, as do erastin and RSL3, respectively, nor does it deplete GPX4 protein, as does FIN56...
April 2, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29579267/myosin-xi-k-is-involved-in-root-organogenesis-polar-auxin-transport-and-cell-division
#16
Mohamad Abu-Abied, Eduard Belausov, Sapir Hagay, Valera Peremyslov, Valerian Dolja, Einat Sadot
The interplay between myosin- and auxin-mediated processes was investigated by following root development in the triple myosin knockout mutant xi-k xi-1 xi-2 (3KO). It was found that the 3KO plants generated significantly more lateral and adventitious roots than the wild type plants or rescued plant line expressing functional myosin XI-K:YFP (3KOR). Using the auxin-dependent reporter DR5:venus, a significant change in the auxin gradient toward the root tip was found in 3KO plants, which correlated with the loss of polar localization of the auxin transporter PIN1 in the stele and with the increased number of the stele cells with oblique cell walls...
March 22, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29566546/systematic-review-of-the-effect-of-economic-compensation-and-incentives-on-uptake-of-voluntary-medical-male-circumcision-among-men-in-sub-saharan-africa
#17
Maria A Carrasco, Jonathan M Grund, Stephanie M Davis, Renee Ridzon, Meghan Mattingly, Jessica Wilkinson, Benjamin Kasdan, Valerian Kiggundu, Emmanuel Njeuhmeli
Voluntary medical male circumcision (VMMC) prevalence in priority countries in sub-Saharan Africa, particularly among men aged ≥20 years, has not yet reached the goal of 80% coverage recommended by the World Health Organization. Determining novel strategies to increase VMMC uptake among men ≥20 years is critical to reach HIV epidemic control. We conducted a systematic review to analyze the effectiveness of economic compensation and incentives to increase VMMC uptake among older men in order to inform VMMC demand creation programs...
March 22, 2018: AIDS Care
https://www.readbyqxmd.com/read/29545148/de-novo-synthesis-of-the-sedative-valerenic-acid-in-saccharomyces-cerevisiae
#18
Jeff Wong, Leo d'Espaux, Ishaan Dev, Cas van der Horst, Jay Keasling
Valeriana officinalis (Valerian) root extracts have been used by European and Asian cultures for millennia for their anxiolytic and sedative properties. However, the efficacy of these extracts suffers from variable yields and composition, making these extracts a prime candidate for microbial production. Recently, valerenic acid, a C15 sesquiterpenoid, was identified as the active compound that modulates the GABAA channel. Although the first committed step, valerena-4,7(11)-diene synthase, has been identified and described, the complete valerenic acid biosynthetic pathway remains to be elucidated...
March 12, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29525019/les-mesures-de-protection-juridique-des-majeurs
#19
Valériane Dujardin
No abstract text is available yet for this article.
March 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29509590/time-to-first-line-art-failure-and-time-to-second-line-art-switch-in-the-iedea-pediatric-cohort
#20
Kara Wools-Kaloustian, Irene Marete, Samuel Ayaya, Annette H Sohn, Lam Van Nguyen, Shanshan Li, Valériane Leroy, Beverly S Musick, Jamie E Newman, Andrew Edmonds, Mary-Ann Davies, François T Eboua, Marie-Thérèse Obama, Marcel Yotebieng, Shobna Sawry, Lynne M Mofenson, Constantin T Yiannoutsos
BACKGROUND: Globally, 49% of the estimated 1.8 million children living with HIV are accessing antiretroviral therapy (ART). There are limited data concerning long-term durability of first-line ART regimens and time to transition to second-line. METHODS: Children initiating their first ART regimen between 2 and 14 years of age and enrolled in one of 208 sites in 30 Asia-Pacific and African countries participating in the Pediatric International Epidemiology Databases to Evaluate AIDS consortium were included in this analysis...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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