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JOURNAL ARTICLE
Clément Daigmorte, Daniela Usturoi, Clément Fournier, Frederic Wallyn, Christine Lorut, Valentin Héluain, Julien Mazières, Julien Legodec, Bruno Escarguel, Thomas Egenod, Laurent Cellerin, Nicolas Favrolt, Samy Lachkar, Adrian Crutu, Amandine Briault, Christophe Gut-Gobert, Valerian Bourinet, Juliette Camuset, Perrot Loïc, Pascal Schlossmacher, Michele Porzio, Antoine Luchez, Jean-Michel Vergnon, Marie-Christelle Pajiep Chapda, Pascalin Roy, Hervé Dutau, Nicolas Guibert
BACKGROUND AND OBJECTIVE: Little is known about malignant central airway obstruction (MCAO) complicating the metastatic spread of non-bronchogenic solid cancers (NBC) and their bronchoscopic management. This study aimed to describe the epidemiology of this population and determine prognostic factors before therapeutic bronchoscopy (TB). METHODS: In this multicenter study using the EpiGETIF registry, we analysed patients treated with TB for MCAO caused by NBC between January 2019 and December 2022...
April 18, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#2
JOURNAL ARTICLE
Daniela Ramos, Karina V B Yazbek, Amanda C Brito, Barbara Georgetti, Luisa M L Dutra, Fabiola O P Leme, Angélica S Vasconcellos
Canine fear of fireworks is a common problem worldwide, with serious implications for the welfare of both dogs and their owners. Therapies for the problem are available, and herbal and nutraceutical agents are increasingly suggested by professionals; nonetheless, studies on their real efficacy in reducing firework fear are lacking. In a randomised, double-blinded, placebo-controlled study, 44 dogs (25 in the "supplement" group and 19 in the "placebo" group) completed a long-term continuous treatment with either a supplement made of tryptophan, valerian, and passiflora or a placebo, including two real exposures to fireworks (on 2020 Christmas and 2021 New Years' Eve, after 42 and 48 days of treatment, respectively)...
March 28, 2024: Animals: An Open Access Journal From MDPI
#3
REVIEW
Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Insomnia affects millions of people worldwide, prompting considerable interest in herbal remedies for its treatment. This review aims to assess the therapeutic potential of such remedies for insomnia by analyzing current scientific evidence. The analysis identified several herbs, including Rosmarinus officinalis, Crocus sativus, Rosa damascena, Curcuma longa, Valeriana officinalis, Lactuca sativa, Portulaca oleracea, Citrus aurantium, Lippia citriodora, and Melissa officinalis, which show promise in improving overall sleep time, reducing sleep latency, and enhancing sleep quality...
April 10, 2024: Phytotherapy Research: PTR
#4
RANDOMIZED CONTROLLED TRIAL
Sebastián Antonio Gutiérrez-Romero, Erika Sofía Torres-Narváez, Adrián Camilo Zamora-Gómez, Silvana Castillo-Castillo, Angela Liliana Latorre-Velásquez, Carolina Betancourt-Villamizar, Carlos O Mendivil
In this randomised, placebo-controlled trial, adults with impaired sleep (Pittsburgh Sleep Quality Index ≥ 5) were randomly assigned using a minimization algorithm to receive a formulation containing L-theanine plus lemon balm, valerian, and saffron extracts, or placebo, during 6 weeks. Objective sleep quality parameters were measured using an actigraphy device. We enrolled and randomised 64 individuals, 31 from the active group and 27 from the placebo group completed the 6 week follow-up...
April 5, 2024: Scientific Reports
#5
JOURNAL ARTICLE
Shanchun Ge, Lei Wang, Chang Jin, Haifeng Xie, Guoping Zheng, Zhengguo Cui, Chaofeng Zhang
BACKGROUND: Ischemic stroke is a leading cause of death and long-term disability worldwide. Studies have suggested that cerebral ischemia induces massive mitochondrial damage. Valerianic acid A (VaA) is the main active ingredient of valerianic acid with neuroprotective activity. PURPOSE: This study aimed to investigate the neuroprotective effects of VaA with ischemic stroke and explore the underlying mechanisms. METHOD: In this study, we established the oxygen-glucose deprivation and reperfusion (OGD/R) cell model and the middle cerebral artery occlusion and reperfusion (MCAO/R) animal model in vitro and in vivo...
March 20, 2024: Phytomedicine
#6
REVIEW
Haroon A M Saeed, Veronica Valerian Kazimoto, Weilin Xu, Hongjun Yang
The global increase in population, the phenomenon of climate change, the issue of water pollution and contamination, and the inadequate management of water resources all exert heightened strain on freshwater reserves. The potential utilization of the interfacial solar steam generation (ISSG) system, which utilizes photothermal conversion to generate heat on material surfaces for wastewater purification and desalination purposes, has been successfully demonstrated. Textile-material-based ISSG devices, including (woven, nonwoven, and knitted) fabrics and electrospinning membranes, exhibit distinct properties such as a rough surface texture, high porosity, significant surface area, exceptional flexibility, and robust mechanical strength...
March 13, 2024: Polymers
#7
JOURNAL ARTICLE
Jeanne-Marie Perotin, Anaëlle Muggeo, Quentin Lecomte-Thenot, Audrey Brisebarre, Sandra Dury, Claire Launois, Julien Ancel, Valérian Dormoy, Thomas Guillard, Gaëtan Deslee
PURPOSE: The heterogeneity of clinical features in COPD at stable state has been associated with airway microbiota. Blood eosinophil count (BEC) represents a biomarker for a pejorative evolution of COPD, including exacerbations and accelerated FEV1 decline. We aimed to analyse the associations between BEC and airway microbiota in COPD at stable state. PATIENTS AND METHODS: Adult COPD patients at stable state (RINNOPARI cohort) were included and characterised for clinical, functional, biological and morphological features...
2024: International Journal of Chronic Obstructive Pulmonary Disease
#8
Valérian Rivet, Vincent Sibaud, Jérémie Dion, Thibaut Volosov, Mélanie Biteau, Andréa Pastissier, Karen Delavigne, Pierre Cougoul, Odile Rauzy, Thibault Comont
INTRODUCTION: Immune checkpoint inhibitors (ICIs) are used in several advanced malignancies and may cause various immune-related adverse events (irAEs). Among them, hematological irAEs are less described. Acquired amegakaryocytic thrombocytopenia (AAT) is a rare immune hematologic disorder characterized by severe thrombocytopenia and complete absence of megakaryocytes in bone marrow. CASE PRESENTATION: Herein, we present the case of a patient in their 40s with metastatic melanoma who developed an AAT after 12 cycles of nivolumab (anti-PD1)...
2024: Frontiers in Oncology
#9
JOURNAL ARTICLE
Valerian Mwenda, Martin Mwangi, Gladwell Gathecha, Joseph Kibachio, Robert Too, Zeinab Gura, Marleen Temmerman
BACKGROUND: Cervical cancer is the leading cause of cancer mortality among women in Kenya. Two thirds of cervical cancer cases in Kenya are diagnosed in advanced stages. We aimed to identify factors associated with late diagnosis of cervical cancer, to guide policy interventions. METHODS: An unmatched case control study (ratio 1:2) was conducted among women aged ≥ 18 years with cervical cancer at Kenyatta National and Moi Teaching and Referral Hospitals...
April 2024: Gynecologic Oncology Reports
#10
JOURNAL ARTICLE
Rodolphe Laurence, Julien Ancel, Maëva A Devilliers, Sophie Carre, Sandra Dury, Valérian Dormoy, Gaëtan Deslée, Jeanne-Marie Perotin
BACKGROUND: Severe asthma is characterized by frequent exacerbations, altered lung function, and impaired quality of life. Tailored patient education allows for the improvement of both asthma management and quality of life. Our study aimed to assess the needs of severe asthma patient in therapeutic education, according to previous therapeutic patient education background and asthma phenotype. METHODS: Consecutive patients monitored for severe asthma in a tertiary referral center were considered for inclusion and answered a questionnaire detailing their patient education needs and the topics they would like to discuss...
March 15, 2024: BMC Pulmonary Medicine
#11
JOURNAL ARTICLE
Dan Cao, Xiuzhi Jiang, Tiantian Wu, Yanghui Xiang, Jiaying Liu, Zhen Li, Xin Yuan, Kefan Bi, Xu Dong, Tone Tønjum, Kaijin Xu, Ying Zhang
PURPOSE: To identify essential oils (EOs) active against non-growing stationary phase Mycobacterium abscessus and multidrug-resistant M. abscessus strains. METHODS: The activity of EOs against both stationary and log phase M. abscessus was evaluated by colony forming unit (CFU) assay and minimum inhibitory concentration (MIC) testing. RESULTS: We assessed the activity of 80 EOs against stationary phase M. abscessus and found 12 EOs (Cinnamon, Satureja montana, Palmarosa, Lemon eucalyptus, Honey myrtle, Combava, Health shield, Mandarin, Thyme, Rosewood, Valerian Root and Basil) at 0...
March 15, 2024: Heliyon
#12
REVIEW
Xin Chen, Andrey S Tsvetkov, Han-Ming Shen, Ciro Isidoro, Nicholas T Ktistakis, Andreas Linkermann, Werner J H Koopman, Hans-Uwe Simon, Lorenzo Galluzzi, Shouqing Luo, Daqian Xu, Wei Gu, Olivier Peulen, Qian Cai, David C Rubinsztein, Jen-Tsan Chi, Donna D Zhang, Changfeng Li, Shinya Toyokuni, Jinbao Liu, Jong-Lyel Roh, Enyong Dai, Gabor Juhasz, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling-Qiang Zhu, Weiping Zou, Mauro Piacentini, Wen-Xing Ding, Zhenyu Yue, Yangchun Xie, Morten Petersen, David A Gewirtz, Michael A Mandell, Charleen T Chu, Debasish Sinha, Eftekhar Eftekharpour, Boris Zhivotovsky, Sébastien Besteiro, Dmitry I Gabrilovich, Do-Hyung Kim, Valerian E Kagan, Hülya Bayir, Guang-Chao Chen, Scott Ayton, Jan D Lünemann, Masaaki Komatsu, Stefan Krautwald, Ben Loos, Eric H Baehrecke, Jiayi Wang, Jon D Lane, Junichi Sadoshima, Wan Seok Yang, Minghui Gao, Christian Münz, Michael Thumm, Martin Kampmann, Di Yu, Marta M Lipinski, Jace W Jones, Xuejun Jiang, Herbert J Zeh, Rui Kang, Daniel J Klionsky, Guido Kroemer, Daolin Tang
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles...
March 5, 2024: Autophagy
#13
JOURNAL ARTICLE
Chethan K N, Nadine Schmidt Genannt Waldschmidt, John Valerian Corda, Satish Shenoy, Sawan Shetty, Laxmikant G Keni, Shyamasunder Bhat, Nishant Nikam, Senay Mihcin
The femur is one of the most important bones in the human body, as it supports the body's weight and helps with movement. The aging global population presents a significant challenge, leading to an increasing demand for artificial joints, particularly in knee and hip replacements, which are among the most prevalent surgical procedures worldwide. This study focuses on hip fractures, a common consequence of osteoporotic fractures in the elderly population. To accurately predict individual bone properties and assess fracture risk, patient-specific finite element models (FEM) were developed using CT data from healthy male individuals...
March 4, 2024: Biomedical Physics & Engineering Express
#14
JOURNAL ARTICLE
Nicolas Guibert, Pascalin Roy, Lyria Amari, Julien Legodec, Bruno Escarguel, Clément Fournier, Frederic Wallyn, Laurent Cellerin, Christine Lorut, Daniela Usturoi, Thomas Egenod, Nicolas Favrolt, Pascal Schlossmacher, Valerian Bourinet, Perrot Loïc, Samy Lachkar, Juliette Camuset, Amandine Briault, Romain Kessler, Christophe Gut-Gobert, Gilles Mangiapan, Nicolas Carnot, Eric Briens, Adrian Crutu, Armelle Marceau, Bénédicte Toublanc, Gaëtan Deslée, Maxime Dewolf, Julien Dutilh, Julie Tronchetti, Philippe Astoul, Jean-Michel Vergnon, Hervé Dutau
BACKGROUND AND OBJECTIVE: EpiGETIF is a web-based, multicentre clinical database created in 2019 aiming for prospective collection of data regarding therapeutic rigid bronchoscopy (TB) for malignant central airway obstruction (MCAO). METHODS: Patients were enrolled into the registry from January 2019 to November 2022. Data were prospectively entered through a web-interface, using standardized definitions for each item. The objective of this first extraction of data was to describe the population and the techniques used among the included centres to target, facilitate and encourage further studies in TB...
March 3, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#15
JOURNAL ARTICLE
Arash Mokhtari, Mansoor Omidi, Morteza Ebrahimi, Houshang Alizadeh, Ahmad Sobhani, Pejman Azadi, Nafiseh Noormohammadi, Mozhdeh Shafaie
It is estimated that 80% of all synthetic drugs are derived from medicinal plants, and nowadays, many synthetic drugs are derived from medicinal plants. Valeriana officinalis can treat many diseases of the nervous system. A crucial aspect of valerian extract is that it inhibits the proliferation of breast cancer cells. To optimize the yield of bioactive compounds in the V. officinalis root extraction, a response surface methodology-based D-optimal design was used. To fulfill this aim, the effects of various factors such as solvent type and concentration, mixing temperature, ultrasound time, and drying method were examined...
March 3, 2024: Preparative Biochemistry & Biotechnology
#16
REVIEW
Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E Kagan, Hülya Bayir, Wan Seok Yang, Ana J Garcia-Saez, Maria S Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun Xie, Florian R Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I Gabrilovich, Jinbao Liu, Herbert J Zeh, Donna D Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E Adolph, Jen-Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I Bush, Binghui Li, Gerry Melino, Eric H Baehrecke, Michael T Lotze, Daniel J Klionsky, Brent R Stockwell, Guido Kroemer, Daolin Tang
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases...
February 29, 2024: Nature Cell Biology
#17
JOURNAL ARTICLE
Valériane Malika Keita, Yi Qing Lee, Meiyappan Lakshmanan, Dave Siak-Wei Ow, Paul Staniland, Jessica Staniland, Ian Savill, Kang Lan Tee, Tuck Seng Wong, Dong-Yup Lee
BACKGROUND: Yeasts exhibit promising potential for the microbial conversion of crude glycerol, owing to their versatility in delivering a wide range of value-added products, particularly lipids. Sweetwater, a methanol-free by-product of the fat splitting process, has emerged as a promising alternative feedstock for the microbial utilization of crude glycerol. To further optimize sweetwater utilization, we compared the growth and lipid production capabilities of 21 oleaginous yeast strains under different conditions with various glycerol concentrations, sweetwater types and pH...
February 24, 2024: Microbial Cell Factories
#18
JOURNAL ARTICLE
Pascalin Roy, Clément Fournier, Robby Barnestein, Frédéric Wallyn, Valérian Bourinet, Amandine Briault, Juliette Camuset, Laurent Cellerin, Adrian Crutu, Maxime Dewolf, Thomas Egenod, Nicolas Favrolt, Valentin Héluain, Christine Lorut, Gilles Mangiapan, Pascal Schlossmacher, Benedicte Toublanc, Daniela Usturoi, Julien Legodec, Jean-Michel Vergnon, Marie-Christelle Pajiep Chapda, Hervé Dutau, Nicolas Guibert
No abstract text is available yet for this article.
February 23, 2024: Annals of the American Thoracic Society
#19
JOURNAL ARTICLE
Bindu Kumari, Usha Kumari, Dhananjay Kumar Singh, Gulam Mohammad Husain, Dinesh Kumar Patel, Anshul Shakya, Ravi Bhushan Singh, Gyan Prakash Modi, Gireesh Kumar Singh
BACKGROUNDS: Postbiotics produced by gut microbiota have exhibited diverse pharmacological activities. Valeric acid, a postbiotic material produced by gut microbiota and some plant species like valerian, has been explored to have diverse pharmacological activities. METHODS: This narrative review aims to summarise the beneficial role of valeric acid for different health conditions along with its underlying mechanism. In order to get ample scientific evidence, various databases like Science Direct, PubMed, Scopus, Google Scholar and Google were exhaustively explored to collect relevant information...
February 16, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
#20
JOURNAL ARTICLE
Maëva A Devilliers, Audrey Brisebarre, Laure M G Petit, Myriam Polette, Gaëtan Deslée, Ratko Djukanović, Valérian Dormoy, Jeanne-Marie Perotin
No abstract text is available yet for this article.
February 19, 2024: Allergy
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