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https://www.readbyqxmd.com/read/28434406/efavirenz-based-simplification-after-successful-early-lopinavir-boosted-ritonavir-based-therapy-in-hiv-infected-children-in-burkina-faso-and-c%C3%A3-te-d-ivoire-the-monod-anrs-12206-non-inferiority-randomised-trial
#1
Désiré Lucien Dahourou, Madeleine Amorissani-Folquet, Karen Malateste, Clarisse Amani-Bosse, Malik Coulibaly, Carole Seguin-Devaux, Thomas Toni, Rasmata Ouédraogo, Stéphane Blanche, Caroline Yonaba, François Eboua, Philippe Lepage, Divine Avit, Sylvie Ouédraogo, Philippe Van de Perre, Sylvie N'Gbeche, Angèle Kalmogho, Roger Salamon, Nicolas Meda, Marguerite Timité-Konan, Valériane Leroy
BACKGROUND: The 2016 World Health Organization guidelines recommend all children <3 years start antiretroviral therapy (ART) on protease inhibitor-based regimens. But lopinavir/ritonavir (LPV/r) syrup has many challenges in low-income countries, including limited availability, requires refrigeration, interactions with anti-tuberculous drugs, twice-daily dosing, poor palatability in young children, and higher cost than non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs. Successfully initiating LPV/r-based ART in HIV-infected children aged <2 years raises operational challenges that could be simplified by switching to a protease inhibitor-sparing therapy based on efavirenz (EFV), although, to date, EFV is not recommended in children <3 years...
April 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28410055/olfactory-recognition-based-on-eeg-gamma-band-activity
#2
Onder Aydemir
There are various kinds of brain monitoring techniques, including local field potential, near-infrared spectroscopy, magnetic resonance imaging (MRI), positron emission tomography, functional MRI, electroencephalography (EEG), and magnetoencephalography. Among those techniques, EEG is the most widely used one due to its portability, low setup cost, and noninvasiveness. Apart from other advantages, EEG signals also help to evaluate the ability of the smelling organ. In such studies, EEG signals, which are recorded during smelling, are analyzed to determine the subject lacks any smelling ability or to measure the response of the brain...
April 14, 2017: Neural Computation
https://www.readbyqxmd.com/read/28347845/global-assessment-of-oxidized-free-fatty-acids-in-brain-reveals-an-enzymatic-predominance-to-oxidative-signaling-after-trauma
#3
Tamil S Anthonymuthu, Elizabeth M Kenny, Andrew A Amoscato, Jesse Lewis, Patrick M Kochanek, Valerian E Kagan, Hülya Bayır
Traumatic brain injury (TBI) is a major health problem associated with significant morbidity and mortality. The pathophysiology of TBI is complex involving signaling through multiple cascades, including lipid peroxidation. Oxidized free fatty acids, a prominent product of lipid peroxidation, are potent cellular mediators involved in induction and resolution of inflammation and modulation of vasomotor tone. While previous studies have assessed lipid peroxidation after TBI, to our knowledge no studies have used a systematic approach to quantify the global oxidative changes in free fatty acids...
March 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28306235/gas-cluster-ion-beam-time-of-flight-secondary-ion-mass-spectrometry-high-resolution-imaging-of-cardiolipin-speciation-in-the-brain-identification-of-molecular-losses-after-traumatic-injury
#4
Hua Tian, Louis J Sparvero, Andrew A Amoscato, Anna Bloom, Hülya Bayır, Valerian E Kagan, Nicholas Winograd
Gas cluster ion beam-secondary ion mass spectrometry (GCIB-SIMS) has shown the full potential of mapping intact lipids in biological systems with better than 10 μm lateral resolution. This study investigated further the capability of GCIB-SIMS in imaging high-mass signals from intact cardiolipin (CL) and gangliosides in normal brain and the effect of a controlled cortical impact model (CCI) of traumatic brain injury (TBI) on their distribution. A combination of enzymatic and chemical treatments was employed to suppress the signals from the most abundant phospholipids (phosphatidylcholine (PC) and phosphatidylethanolamine (PE)) and enhance the signals from the low-abundance CLs and gangliosides to allow their GCIB-SIMS detection at 8 and 16 μm spatial resolution...
March 29, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28302120/responsiveness-of-cats-felidae-to-silver-vine-actinidia-polygama-tatarian-honeysuckle-lonicera-tatarica-valerian-valeriana-officinalis-and-catnip-nepeta-cataria
#5
Sebastiaan Bol, Jana Caspers, Lauren Buckingham, Gail Denise Anderson-Shelton, Carrie Ridgway, C A Tony Buffington, Stefan Schulz, Evelien M Bunnik
BACKGROUND: Olfactory stimulation is an often overlooked method of environmental enrichment for cats in captivity. The best known example of olfactory enrichment is the use of catnip, a plant that can cause an apparently euphoric reaction in domestic cats and most of the Pantherinae. It has long been known that some domestic cats and most tigers do not respond to catnip. Although many anecdotes exist of other plants with similar effects, data are lacking about the number of cats that respond to these plants, and if cats that do not respond to catnip respond to any of them...
March 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28292236/microwave-assisted-olefin-metathesis-as-pivotal-step-in-the-synthesis-of-bioactive-compounds
#6
Koffi Sénam Etsè, Alice Ngendera, Ntumba Nelly Tshibalonza, Albert Demonceau, Lionel Delaude, Ileana Dragutan, Valerian Dragutan
Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide elegant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new vistas in organic synthesis and in homogeneous catalysis...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28288512/defect-induced-near-infrared-photoluminescence-of-single-walled-carbon-nanotubes-treated-with-polyunsaturated-fatty-acids
#7
Cheuk Fai Chiu, Wissam A Saidi, Valerian E Kagan, Alexander Star
Single-walled carbon nanotubes (SWCNTs) have been incorporated in many emerging applications in the biomedical field including chemical sensing, biological imaging, drug delivery, and photothermal therapy. To overcome inherent hydrophobicity and improve their biocompatibility, pristine SWCNTs are often coated with surfactants, polymers, DNA, proteins, or lipids. In this paper, we report the effect of polyunsaturated fatty acids (PUFAs) on SWCNT photoluminescence. A decrease in the SWCNT bandgap emission (E11) and a new red-shifted emission (E11(-)) were observed in the presence of PUFAs...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28284412/de-nouvelles-dispositions-pour-d%C3%A3-mocratiser-les-directives-anticip%C3%A3-es
#8
Valériane Dujardin
No abstract text is available yet for this article.
March 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28278010/the-effect-of-valerian-on-the-severity-and-frequency-of-hot-flashes-a-triple-blind-randomized-clinical-trial
#9
Ensiyeh Jenabi, Fatemeh Shobeiri, Seyyed Mohammad Mahdi Hazavehei, Ghodratollah Roshanaei
Valerian is one of the most widely used herbal supplements and a phytoestrogenic herb. The aim of this study was to determine the effect of Valerian on the severity and frequency of hot flashes. This triple-blind, randomized, controlled clinical trial was conducted during a three-month period in Hamadan, Iran, in 60 postmenopausal women aged 45-55 years. Participants were randomly assigned to one of two groups- either placebo or Valerian. An oral Valerian 530 mg capsule was given twice per day for two months...
February 16, 2017: Women & Health
https://www.readbyqxmd.com/read/28230382/animalistic-dehumanization-of-older-people-by-younger-ones-variations-of-humanness-perceptions-as-a-function-of-a-target-s-age
#10
Valérian Boudjemadi, Stéphanie Demoulin, Jennifer Bastart
The present work investigated associations of older people with humanness. Focusing on complementary approaches (attribute-based, metaphor-based, and target-based), 4 studies tested the hypothesis that older people are the targets of animalistic dehumanization. Using an emotional attribution task, Study 1 (N = 112) explored infrahumanization and shows that young participants attributed more uniquely human emotions to young people than to older ones. No such effect occurred with regards to nonuniquely human emotions...
February 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28212735/elimination-of-the-unnecessary-intra-and-extracellular-signaling-by-anionic-phospholipids
#11
REVIEW
Valerian E Kagan, Hülya Bayır, Yulia Y Tyurina, Sergey B Bolevich, John J Maguire, Bengt Fadeel, Krishnakumar Balasubramanian
High fidelity of biological systems is frequently achieved by duplication of the essential intracellular machineries or, removal of the entire cell, which becomes unnecessary or even harmful in altered physiological environments. Carefully controlled removal of these cells, without damaging normal cells, requires precise signaling, and is critical to maintaining homeostasis. This review describes how two anionic phospholipids - phosphatidylserine (PS) and cardiolipin (CL) - residing in distinct compartments of the cell, signal removal of "the unnecessary" using several uniform principles...
January 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28208737/special-issue-on-ruthenium-complexes
#12
EDITORIAL
Ileana Dragutan, Valerian Dragutan, Albert Demonceau
The organic chemistry of ruthenium has been one of the most vigorously growing research areas over the past decades. Considerable effort has been extended towards the design and application of a broad series of ruthenium complexes, which culminated with the development by Ryoji Noyori (2001 Nobel Prize for Chemistry) of chiral ruthenium catalysts for stereoselective hydrogenation reactions [1], and the discovery by Robert H. Grubbs (2005 Nobel Prize for Chemistry) of well-defined ruthenium- benzylidene catalysts for olefin metathesis [2] [...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28177787/-i-i-sporicidal-efficacy-of-thermal-sprayed-copper-alloy-coating
#13
Romina Shafaghi, Javad Mostaghimi, Valerian Pershin, Maurice Ringuette
Approximately 200,000 Canadians acquire healthcare-associated bacterial infections each year and several-fold more acquire food-borne bacterial illnesses.  Bacterial spores are particularly problematic as they survive several months on surfaces.  Due to its sporicidal activity, copper sheet metal is sometimes used in hospital settings but widespread use is limited by cost and incompatibility with complex furniture/instrument design and topographies.  A potential alternative is the use of thermal spray technology to coat surfaces with copper alloys...
January 19, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28148447/les-droits-des-patients-en-fin-de-vie
#14
Valériane Dujardin
No abstract text is available yet for this article.
August 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/28096376/myosin-driven-transport-network-in-plants
#15
Elizabeth G Kurth, Valera V Peremyslov, Hannah L Turner, Kira S Makarova, Jaime Iranzo, Sergei L Mekhedov, Eugene V Koonin, Valerian V Dolja
We investigate the myosin XI-driven transport network in Arabidopsis using protein-protein interaction, subcellular localization, gene knockout, and bioinformatics analyses. The two major groups of nodes in this network are myosins XI and their membrane-anchored receptors (MyoB) that, together, drive endomembrane trafficking and cytoplasmic streaming in the plant cells. The network shows high node connectivity and is dominated by generalists, with a smaller fraction of more specialized myosins and receptors...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28074841/the-mito-damp-cardiolipin-blocks-il-10-production-causing-persistent-inflammation-during-bacterial-pneumonia
#16
Krishnendu Chakraborty, Mahesh Raundhal, Bill B Chen, Christina Morse, Yulia Y Tyurina, Anupriya Khare, Timothy B Oriss, Rachael Huff, Janet S Lee, Claudette M St Croix, Simon Watkins, Rama K Mallampalli, Valerian E Kagan, Anuradha Ray, Prabir Ray
Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (DAMP) cardiolipin can be detected in the lungs. Here we show that mice infected with Klebsiella pneumoniae develop lung injury with accumulation of cardiolipin. Cardiolipin inhibits resolution of inflammation by suppressing production of anti-inflammatory IL-10 by lung CD11b(+)Ly6G(int)Ly6C(lo)F4/80(+) cells...
January 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28039782/reduced-sensitivity-to-social-priors-during-action-prediction-in-adults-with-autism-spectrum-disorders
#17
Valerian Chambon, Chlöé Farrer, Elisabeth Pacherie, Pierre O Jacquet, Marion Leboyer, Tiziana Zalla
An extensive amount of evidence has documented a diminished ability to predict and understand other people's action in individuals with autism spectrum disorders (ASD). Recently, two theoretical accounts, the "Hypo-priors" and the "Aberrant precision" hypotheses, have suggested that attenuated Bayesian priors or an imbalance of the precision ascribed to sensory evidence relative to prior expectations may be responsible for the atypical perceptual experience and difficulties with action understanding in ASD...
March 2017: Cognition
https://www.readbyqxmd.com/read/27982579/lipidomics-characterization-of-biosynthetic-and-remodeling-pathways-of-cardiolipins-in-genetically-and-nutritionally-manipulated-yeast-cells
#18
Yulia Y Tyurina, Wenjia Lou, Feng Qu, Vladimir A Tyurin, Dariush Mohammadyani, Jenney Liu, Maik Hüttemann, Michael A Frasso, Peter Wipf, Hülya Bayir, Miriam L Greenberg, Valerian E Kagan
Cardioipins (CLs) are unique tetra-acylated phospholipids of mitochondria and define the bioenergetics and regulatory functions of these organelles. An unresolved paradox is the high uniformity of CL molecular species (tetra-linoleoyl-CL) in the heart, liver, and skeletal muscles-in contrast to their high diversification in the brain. Here, we combined liquid chromatography-mass-spectrometry-based phospholipidomics with genetic and nutritional manipulations to explore CLs' biosynthetic vs postsynthetic remodeling processes in S...
December 16, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27976277/quality-control-of-valerian-products-by-hplc-fingerprint-analysis
#19
E M Gonulalan, E Nemutlu, L O Demirezer
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27935971/costs-of-care-of-hiv-infected-children-initiating-lopinavir-ritonavir-based-antiretroviral-therapy-before-the-age-of-two-in-cote-d-ivoire
#20
Sophie Desmonde, Divine Avit, Junie Petit, Madeleine Amorissani Folquet, Francois Tanoh Eboua, Clarisse Amani Bosse, Evelyne Dainguy, Véronique Mea, Marguerite Timite-Konan, Sylvie Ngbeché, Andrea Ciaranello, Valeriane Leroy
OBJECTIVES: To access the costs of care for Ivoirian children before and after initiating LPV/r-based antiretroviral therapy (ART) before the age of two. METHODS: We assessed the direct costs of care for all HIV-infected children over the first 12 months on LPV/r-based ART initiated <2 years of age in Abidjan. We recorded all drug prescriptions, ART and cotrimoxazole prophylaxis delivery, medical analyses/examinations and hospital admissions. We compared these costs to those accrued in the month prior to ART initiation...
2016: PloS One
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