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Genital warts

C Rossi, C Vanhomwegen, F Laurent
High-risk oncogenic HPVs (HR-HPV) are associated in men with pre-cancerous anal dysplasia, oropharyngeal, anal and penile cancer. Anogenital warts are induced by low-risk HPVs. These manifestations are increasing among men, and especially in some high-risk groups as men who have sex with men (MSM). This review targets HPV-associated disease epidemiology as well as safety, immunogenicity, and efficacy level of HPV vaccine in men. Obstacle and cost-effectiveness analysis of HPV vaccination are discussed. Three HPV vaccines are currently available in Belgium with the 9-valent (" 9HPV " - 6/11/16/18/31/33/45/52/58) offering protection against most of HPVassociated diseases...
2018: Revue Médicale de Bruxelles
Minxi Wei, Daning Wang, Zhihai Li, Shuo Song, Xianglin Kong, Xiaobing Mo, Yurou Yang, Maozhou He, Zhongyi Li, Bo Huang, Zhijie Lin, Huirong Pan, Qingbing Zheng, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia
Human papillomavirus (HPV) is the causative agent in genital warts and nearly all cervical, anogenital, and oropharyngeal cancers. Nine HPV types (6, 11, 16, 18, 31, 33, 45, 52, and 58) are associated with about 90% of cervical cancers and 90% of genital warts. HPV neutralization by vaccine-elicited neutralizing antibodies can block viral infection and prevent HPV-associated diseases. However, there is only one commercially available HPV vaccine, Gardasil 9, produced from Saccharomyces cerevisiae that covers all nine types, raising the need for microbial production of broad-spectrum HPV vaccines...
September 26, 2018: Emerging Microbes & Infections
Marco J Tomassi, Maher A Abbas, Daniel D Klaristenfeld
PURPOSE: To determine the impact of expectant management surveillance for patients at risk for squamous cell carcinoma of the anus (SCCA). METHODS: Adult patients at risk for anal cancer, specifically those with human immunodeficiency virus (HIV) or known human papilloma virus (HPV) infections (anal dysplasia, anogenital warts, cervical dysplasia, or cervical cancer), underwent expectant management surveillance with targeted therapy of only grossly abnormal or symptomatic anoderm lesions...
September 22, 2018: International Journal of Colorectal Disease
Maria Rosaria Gualano, Robin Thomas, Michela Stillo, Maria Valentina Mussa, Francesca Quattrocolo, Alberto Borraccino, Carla Zotti
INTRODUCTION: Human papillomavirus infection (HPV) affects 70-80% of female population throughout the lifetime, exposing them to the risk of developing genital warts and cervical cancer. Despite these correlated risks and the demonstrated efficacy of the vaccine, coverage rates for two-three doses are around 70% in Italy and 67% in Piemonte (below the expected 95%). Aim of the study is to investigate whether this situation is due to a lack of information and awareness among young adults...
September 21, 2018: Human Vaccines & Immunotherapeutics
Mario Puviani, Marco Galluzzo, Marina Talamonti, Sara Mazzilli, Elena Campione, Luca Bianchi, Massimo Milani, Ivano Luppino, Giuseppe Micali
External genital warts (EGW) are the most common viral sexually transmitted infection. Ablative treatments like cryotherapy, curettage, and CO2 laser therapies offer rapid onset of effect, fast clearance, and reduction of virus load. However, these procedures are associated with high recurrence rates (RRs) ranging from 20% to 77% in the short and medium terms and do not provide sustained clearance. After laser therapy removal of EGW, an RR up to 77% has been reported. Topical sinecatechins (TS) 10% is a patient-applied regimen for the treatment of EGW with a low RR (<6...
September 20, 2018: International Journal of STD & AIDS
Chunping Ao, Jiajia Xie, Li Wang, Songshan Li, Junpeng Li, Lifen Jiang, Hui Liu, Kang Zeng
BACKGROUND: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata...
September 2018: Photodiagnosis and Photodynamic Therapy
A Kelati, A Khemis, H Montaudié, J-P Lacour, T Passeron
No abstract text is available yet for this article.
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Jacqueline Hirth
Human papillomavirus (HPV) is a common sexually transmitted infection which is the cause of several cancers, including cervical cancer, and genital warts. Although cervical cancer can be prevented through screening, this cancer persists in the US. More recently, HPV vaccination has the potential to decrease the burden of HPV-related disease among young HPV-unexposed adolescents. Several initiatives aimed to encourage HPV vaccination have been adopted. Unfortunately, uptake of the HPV vaccine remains modest, despite evidence that vaccine-type HPV prevalence is decreasing as a result of HPV vaccination...
August 27, 2018: Human Vaccines & Immunotherapeutics
Philip Zeuschner, Stefan Ueberdiek, Alexey Pryalukhin, Christian Veith, Matthias Saar, Sigrun Smola, Rainer Maria Bohle, Kerstin Junker, Michael Stöckle, Julia Heinzelbecker
Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present the case of a 77-year-old Caucasian male with enormous genital warts of the penis, scrotum, groins and anus. Lesions were excised by electrosurgery. The histological examination revealed Condylomata gigantea as well as an invasive perianal squamous cell carcinoma. Mucosal "low-risk" HPV type 6 was detected. The patient had a history of an immunosuppressing disease. During the 4-year follow-up, multiple relapses occurred...
August 21, 2018: Urologia Internationalis
Nahid Hemmatian Boroujeni, Farhad Handjani
Background: Warts are one of the most common infections in humans. Plantar warts are a subtype of non-genital warts, and several procedures and topical treatments have been used in its treatment. Cryotherapy is one of the most popular modalities, but it is time-consuming and remission rates vary in different studies. CO2 laser was the first laser used for treating warts. To date, no clinical trial has been done to compare CO2 laser with cryotherapy in the treatment of plantar warts. Patients and Methods: This randomized controlled trial was performed in order to compare the efficacy and number of sessions needed to treat plantar warts in 60 patients who had received no previous treatment in the previous 3 months...
July 2018: Dermatology Practical & Conceptual
Julia Ml Brotherton
BACKGROUND: Australia has included quadrivalent human papillomavirus (HPV) vaccination in its national program since 2007. Significant declines have been observed in the incidence of HPV infection, genital warts and high-grade cervical lesions. In 2018, the program changed to a nonavalent HPV vaccine administered over a routine two-dose schedule for the target cohort of adolescents aged 12-13 years. OBJECTIVE: The aim of this article is to provide an overview of the nonavalent HPV vaccine, the rationale for its use and expected outcomes, and to review the updated dose scheduling requirements for HPV vaccines...
July 2018: Australian journal of general practice
Bigyan Mainali, Matthew B Schabath, Staci L Sudenga, Cynthia Ye, Howard W Wiener, Luisa L Villa, Anna R Giuliano, Sadeep Shrestha
OBJECTIVES: While most human papillomavirus (HPV) infection clears on its own, persistent HPV infection can cause genital warts and anal, penile and oropharyngeal cancers in men. We conducted genetic analysis in a sub-cohort of the HPV infection in men (HIM) study to test the hypothesis that differences in host genes influence HPV persistence in men. METHODS: Baseline and longitudinal genital HPV status at the genitals was measured every 6-months using the Linear Array assay amplified HPV L1 gene fragment using the PGMY09/11 L1 consensus primer system...
August 6, 2018: Papillomavirus Research
Helle Kiellberg Larsen, Louise T Thomsen, Merete Haedersdal, Christian Dehlendorff, Søren Schwartz Sørensen, Susanne K Kjaer
Genital warts (GWs) are a risk factor for subsequent human papillomavirus (HPV)-related anogenital cancers. In this register-based, prospective cohort study, we estimated the risk of GWs in renal transplant recipients (RTRs) compared with a nontransplanted cohort. In a nationwide database, we identified first-time RTRs in Denmark during 1996 to 2015. For each RTR, 50 age- and sex-matched nontransplanted individuals were selected from the population registry. Information on GWs, sociodemographic characteristics, HPV vaccination, and other causes of immunosuppression was retrieved from registries...
August 6, 2018: American Journal of Transplantation
Maurice A Recanati, Katherine J Kramer, John J Maggio, Conrad R Chao
Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0...
2018: Clinical and Experimental Obstetrics & Gynecology
Seyed Ghasem Mirbahari, Masoud Sadeghi
Introduction: Human papillomavirus (HPV) infection is strongly associated with risk of cervical cancer and genital warts. Aim: The study aimed to report the prevalence of genus alpha human papillomavirus (HPV) types in women with cervical infection and/or inflammatory in Western Iran. Materials and Methods: In a cross-sectional study, 435 women were clinically diagnosed with cervical infections. The method of HPVs detection was polymerase chain reaction (PCR)...
June 2018: Materia Socio-medica
Zhili Hu, Junpeng Li, Hui Liu, Lishi Liu, Lifen Jiang, Kang Zeng
BACKGROUND: Genital HPV infections are extremely prevalent. HPV can persist and be transmitted to partners even after warts are gone. The HPV genotype and viral load assay can reveal whether infections are persistent or latent, and it can serve as a predictor of infection clearance. Although numerous studies have demonstrated that photodynamic therapy (PDT) is effective against condyloma acuminata, there is no data on its effects on latent, persistent infections. METHODS: A total of 20 patients with latent or subclinical HPV infection were obtained...
July 23, 2018: Photodiagnosis and Photodynamic Therapy
Tom Nadarzynski, Helen Smith, Daniel Richardson, Stephen Bremner, Carrie Llewellyn
BACKGROUND: Men who have sex with men (MSM) are recommended the Human Papillomavirus (HPV) vaccination due to their higher risk of genital warts and anal cancer. PURPOSE: To examine HPV vaccine acceptability amongst MSM in the UK. METHODS: Using advertisements via Facebook, MSM were recruited to an online survey measuring motivations for HPV vaccination. Logistic regression was performed to identify predictors of HPV vaccine acceptability...
August 9, 2018: Vaccine
Kristina R Dahlstrom, Shuangshuang Fu, Wenyaw Chan, Zeena Shelal, Lois M Ramondetta, David R Lairson
INTRODUCTION: Genital warts are caused by infection with human papillomavirus (HPV) and are associated with significant morbidity. Primary prevention of genital warts is possible through HPV vaccination, but vaccination rates remain low in the USA. When deciding to implement HPV vaccination programs, public health officials and policy makers rely on cost-effectiveness studies that accurately reflect costs associated with morbidity and mortality. However, previous information on the cost of treating genital warts was outdated...
November 2018: PharmacoEconomics
Hillary M Topazian, Debanjali Kundu, Kathryn Peebles, Silvina Ramos, Karen Morgan, Chan Joo Kim, Karin L Richter, Noel T Brewer, Mercè Peris, Jennifer S Smith
STUDY OBJECTIVE: To assess adolescent health care providers' recommendations for, and attitudes towards human papillomavirus (HPV) vaccination in 5 countries. DESIGN: In-depth interviews of adolescent health care providers, 2013-2014. SETTING: Five countries where HPV vaccination is at various stages of implementation into national programs: Argentina, Malaysia, South Africa, South Korea, and Spain. PARTICIPANTS: Adolescent health care providers (N = 151) who had administered or overseen provision of adolescent vaccinations (N = Argentina: 30, Malaysia: 30, South Africa: 31, South Korea: 30, Spain: 30)...
July 12, 2018: Journal of Pediatric and Adolescent Gynecology
Elisabeth McClymont, Marette Lee, Janet Raboud, François Coutlée, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Marina B Klein, Marianne Harris, Jeffrey Cohen, Mark H Yudin, Wendy Wobeser, Deborah Money
Background: Human papillomavirus (HPV) vaccination is safe and efficacious in women without HIV. While good immunogenicity has been observed in women living with HIV (WLWH), efficacy data in this population are needed. Methods: We enrolled 420 females aged ≥9 years (range: 9-65) living with HIV. Participants were to receive 3 doses of qHPV vaccine (0/2/6 months). The main endpoint was vaccine failure (i.e., incident persistent qHPV infection, cervical intraepithelial neoplasia of grade 2 or higher (CIN2+), or genital warts)...
July 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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