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Genital warts

Nahid Hemmatian Boroujeni, Farhad Handjani
Background: Warts are one of the most common infections in humans. Plantar warts are a subtype of non-genital warts, and several procedures and topical treatments have been used in its treatment. Cryotherapy is one of the most popular modalities, but it is time-consuming and remission rates vary in different studies. CO2 laser was the first laser used for treating warts. To date, no clinical trial has been done to compare CO2 laser with cryotherapy in the treatment of plantar warts. Patients and Methods: This randomized controlled trial was performed in order to compare the efficacy and number of sessions needed to treat plantar warts in 60 patients who had received no previous treatment in the previous 3 months...
July 2018: Dermatology Practical & Conceptual
Julia Ml Brotherton
BACKGROUND: Australia has included quadrivalent human papillomavirus (HPV) vaccination in its national program since 2007. Significant declines have been observed in the incidence of HPV infection, genital warts and high-grade cervical lesions. In 2018, the program changed to a nonavalent HPV vaccine administered over a routine two-dose schedule for the target cohort of adolescents aged 12-13 years. OBJECTIVE: The aim of this article is to provide an overview of the nonavalent HPV vaccine, the rationale for its use and expected outcomes, and to review the updated dose scheduling requirements for HPV vaccines...
July 2018: Australian journal of general practice
Bigyan Mainali, Matthew B Schabath, Staci L Sudenga, Cynthia Ye, Howard W Wiener, Luisa L Villa, Anna R Giuliano, Sadeep Shrestha
OBJECTIVES: While most human papillomavirus (HPV) infection clears on its own, persistent HPV infection can cause genital warts and anal, penile and oropharyngeal cancers in men. We conducted genetic analysis in a sub-cohort of the HPV infection in men (HIM) study to test the hypothesis that differences in host genes influence HPV persistence in men. METHODS: Baseline and longitudinal genital HPV status at the genitals was measured every 6-months using the Linear Array assay amplified HPV L1 gene fragment using the PGMY09/11 L1 consensus primer system...
August 6, 2018: Papillomavirus Research
Helle Kiellberg Larsen, Louise T Thomsen, Merete Haedersdal, Christian Dehlendorff, Søren Schwartz Sørensen, Susanne K Kjaer
Genital warts (GWs) are a risk factor for subsequent human papillomavirus (HPV)-related anogenital cancers. In this register-based, prospective cohort study, we estimated the risk of GWs in renal transplant recipients (RTRs) compared with a non-transplanted cohort. In a nationwide database, we identified first-time RTRs in Denmark during 1996-2015. For each RTR, 50 age- and sex-matched non-transplanted individuals were selected from the population registry. Information on GWs, socio-demographic characteristics, HPV vaccination, and other causes of immunosuppression was retrieved from registries...
August 6, 2018: American Journal of Transplantation
Maurice A Recanati, Katherine J Kramer, John J Maggio, Conrad R Chao
Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0...
2018: Clinical and Experimental Obstetrics & Gynecology
Seyed Ghasem Mirbahari, Masoud Sadeghi
Introduction: Human papillomavirus (HPV) infection is strongly associated with risk of cervical cancer and genital warts. Aim: The study aimed to report the prevalence of genus alpha human papillomavirus (HPV) types in women with cervical infection and/or inflammatory in Western Iran. Materials and Methods: In a cross-sectional study, 435 women were clinically diagnosed with cervical infections. The method of HPVs detection was polymerase chain reaction (PCR)...
June 2018: Materia Socio-medica
Zhili Hu, Junpeng Li, Hui Liu, Lishi Liu, Lifen Jiang, Kang Zeng
BACKGROUND: Genital HPV infections are extremely prevalent. HPV can persist and be transmitted to partners even after warts are gone. The HPV genotype and viral load assay can reveal whether infections are persistent or latent, and it can serve as a predictor of infection clearance. Although numerous studies have demonstrated that photodynamic therapy (PDT) is effective against condyloma acuminata, there is no data on its effects on latent, persistent infections. METHODS: A total of 20 patients with latent or subclinical HPV infection were obtained...
July 23, 2018: Photodiagnosis and Photodynamic Therapy
Tom Nadarzynski, Helen Smith, Daniel Richardson, Stephen Bremner, Carrie Llewellyn
BACKGROUND: Men who have sex with men (MSM) are recommended the Human Papillomavirus (HPV) vaccination due to their higher risk of genital warts and anal cancer. PURPOSE: To examine HPV vaccine acceptability amongst MSM in the UK. METHODS: Using advertisements via Facebook, MSM were recruited to an online survey measuring motivations for HPV vaccination. Logistic regression was performed to identify predictors of HPV vaccine acceptability...
August 9, 2018: Vaccine
Kristina R Dahlstrom, Shuangshuang Fu, Wenyaw Chan, Zeena Shelal, Lois M Ramondetta, David R Lairson
INTRODUCTION: Genital warts are caused by infection with human papillomavirus (HPV) and are associated with significant morbidity. Primary prevention of genital warts is possible through HPV vaccination, but vaccination rates remain low in the USA. When deciding to implement HPV vaccination programs, public health officials and policy makers rely on cost-effectiveness studies that accurately reflect costs associated with morbidity and mortality. However, previous information on the cost of treating genital warts was outdated...
July 18, 2018: PharmacoEconomics
H M Topazian, D Kundu, K Peebles, S Ramos, K Morgan, C J Kim, K L Richter, N T Brewer, M Peris, J S Smith
STUDY OBJECTIVE: To assess adolescent health care providers' recommendations for, and attitudes towards HPV vaccination in five countries. DESIGN: In-depth interviews of adolescent health care providers, 2013-2014. SETTING: Five countries where HPV vaccination is at various stages of implementation into national programs: Argentina, Malaysia, South Africa, South Korea, and Spain. PARTICIPANTS: Adolescent health care providers (N=151) who had administered or overseen provision of adolescent vaccinations...
July 11, 2018: Journal of Pediatric and Adolescent Gynecology
Elisabeth McClymont, Marette Lee, Janet Raboud, François Coutlée, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Marina B Klein, Marianne Harris, Jeffrey Cohen, Mark H Yudin, Wendy Wobeser, Deborah Money
Background: Human papillomavirus (HPV) vaccination is safe and efficacious in women without HIV. While good immunogenicity has been observed in women living with HIV (WLWH), efficacy data in this population are needed. Methods: We enrolled 420 females aged ≥9 years (range: 9-65) living with HIV. Participants were to receive 3 doses of qHPV vaccine (0/2/6 months). The main endpoint was vaccine failure (i.e., incident persistent qHPV infection, cervical intraepithelial neoplasia of grade 2 or higher (CIN2+), or genital warts)...
July 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Begum Akuzum, Sinae Kim, Tam Thanh Nguyen, Jeawoo Hong, Siyoung Lee, Eunhye Kim, Joohee Kim, Yeook Choi, Hyunjhung Jhun, Youngmin Lee, Hyunwoo Kim, Dong Hyun Sohn, Soohyun Kim
Virus-like particles (VLPs) derived from human papillomavirus (HPV) L1 capsid proteins were used for HPV quadrivalent recombinant vaccine. The HPV quadrivalent vaccine is administrated in a 3-dose regimen of initial injection followed by subsequent doses at 2 and 6 months to prevent cervical cancer, vulvar, and vaginal cancers. The type 6, 11, 16, or 18 of HPV infection is associated with precancerous lesions and genital warts in adolescents and young women. The HPV vaccine is composed of viral L1 capsid proteins are produced in eukaryotic expression systems and purified in the form of VLPs...
June 2018: Immune Network
Lin-Lin Hu, Xin Zhou, Hao-Lin Zhang, Lan-Lan Wu, Lian-Sheng Tang, Ling-Li Chen, Jin-Liang Duan
Podophyllotoxin is used as medical cream which is widely applied to genital warts and molluscum contagiosum. Although previous study showed that podophyllotoxin had minimal toxicity, it was forbidden to use during pregnancy since it might be toxic to the embryos. In present study we used mouse as the model and tried to examine whether podophyllotoxin exposure was toxic to oocyte maturation, which further affected embryo development. Our results showed that podophyllotoxin exposure inhibited mouse oocyte maturation, showing with the failure of polar body extrusion, and the inhibitory effects of podophyllotoxin on oocytes was dose-depended...
July 5, 2018: Scientific Reports
Shih-Fen Chen, Jen-Huai Chiang, Chung-Y Hsu, Yu-Chih Shen
OBJECTIVES: In Taiwan, there has been a growing emphasis on physical health screening, health education and improving access to treatment in patients with schizophrenia (SCZ). However, sexual health needs, including screening and prevention of sexually transmitted infections (STI), are neglected in this population. The study aimed to investigate the association between SCZ and the subsequent incident STI and to examine potential risk factors. METHODS: Using the National Health Insurance Research Database of Taiwan, 58,948 SCZ patients and 235,784 controls matched by gender and age were enrolled between 2000 and 2010 and followed until the end of 2011...
June 25, 2018: Schizophrenia Research
L J Wang, Z Li, M Li, L Weng, W H Li, J DU, J Z Zhang
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Eman Salah
Background: Extragenital warts (E-GWs) are common benign skin lesions caused by human papilloma virus. Surprisingly, there is no clear data about the impact of multiple E-GWs on quality of life in immune-competent adult patients in comparison to GWs, which have been frequently reported to exhibit a strong negative impact on life quality. Patients and methods: This cross-sectional study investigated the impact of multiple E-GWs on quality of life in immune-competent adults as they are more commonly encountered in daily practice than their genital counterpart in the Egyptian population...
2018: Clinical, Cosmetic and Investigational Dermatology
Teris Cheung, Joseph T F Lau, Johnson Z Wang, P K H Mo, Y S Ho
OBJECTIVES: The highly infectious human papillomavirus (HPV) causes both genital warts and cervical cancer in women. In 2009, the prevalence of genital warts in Hong Kong was 203.7 per 100,000 person-years. Cervical cancer, more seriously, was the eight most common cancer among women and girls in Hong Kong, accounting for 2.3% of all new cancer cases in females in 2014. Cervical cancer is a significant global public health problem and HPV is a major risk factor leading to the development of cervical cancer...
2018: PloS One
Eliana Marcia Wendland, Juliana Caierão, Carla Domingues, Ana Goretti Kalume Maranhão, Flávia Moreno Alves de Souza, Luciano Serpa Hammes, Maicon Falavigna, Juliana Balbinot Hilgert, Fernando Neves Hugo, Marina Bessel, Luisa Lina Villa, Adele Schwartz Benzaken
INTRODUCTION: Human papillomavirus (HPV) is associated with the development of genital warts and different types of cancer, including virtually all cervical cancers and a considerable number of penile, anal and oropharyngeal cancers. Data regarding the prevalence of HPV infection in Brazil are limited and fragmented. We aim to determine HPV prevalence in sexually active women and men aged 16-25 years and to investigate regional differences in virus prevalence and types. METHODS AND ANALYSIS: This is a nationwide, multicentric, cross-sectional, prospective study that will include participants aged 16-25 years from all Brazilian capital cities...
June 7, 2018: BMJ Open
Jennifer J Buechel, Cynthia D Connelly
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection, with at least half of sexually active people contracting the virus-a leading etiology for genital warts and anal, cervical, laryngeal, penile, vaginal, and vulvar cancers. Research suggests HPV is higher among U.S. military personnel than in U.S. civilian populations and can result in significant morbidity or complications and limit U.S. military's duties or deployable status. OBJECTIVES: The aim of the study was to identify determinants of HPV vaccination among U...
July 2018: Nursing Research
Helle Kiellberg Larsen, Kristian Kofoed
Ano-genital warts are in general considered as benign lesions, as they are mostly caused by the non-oncogenic HPV types 6 and 11. In this review, there is a focus on the problematic issues, that these lesions and their treatments can cause. Both topical and ablative treatments are associated with side effects, and the varying effect of the treatments combined with an uncertain timeline to clearance are known to cause psychological distress. Vaccination against HPV-6 and -11 has been shown to reduce the incidence of this troublesome infection substantially in both women and men in countries with high vaccine coverage...
May 14, 2018: Ugeskrift for Laeger
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