keyword
https://read.qxmd.com/read/36694038/ingenol-mebutate-inhibits-the-growth-of-pancreatic-cancer-cells-in-vitro-via-sting-with-an-efficacy-comparable-to-that-of-clinically-used-anticancer-agents
#21
JOURNAL ARTICLE
Fumihiro Kikuyama, Sayo Suzuki, Aya Jibiki, Yuta Yokoyama, Hitoshi Kawazoe, Susumu Kitanaka, Tomonori Nakamura
Pancreatic cancer is associated with a poor prognosis; thus, there is an urgent need to develop new and effective treatments. Ingenol mebutate (IM), which is isolated from the latex of Euphorbia peplus, was recently shown to be effective against pancreatic cancer cell lines; however, its mechanism of action has not been fully elucidated. In this study, we focused on the less drug-sensitive pancreatic cancer cell line Panc-1 and compared IM to commercially available anticancer drugs using cell survival assays...
January 24, 2023: Journal of Natural Medicines
https://read.qxmd.com/read/36604927/-anti-asthma-components-and-mechanism-of-kechuanting-acupoint-application-therapy-based-on-serum-metabolomics-and-network-pharmacology
#22
JOURNAL ARTICLE
Shu-Mei Zhao, Xiao-Yan Gong, Jun Hu, Kuan DI, Jin-Jun Shan, He-Sheng Wang, Cong Zhang, Lan-Ying Liu
This study aims to explore the anti-asthma components and mechanism of Kechuanting acupoint application therapy(KAAT) based on serum metabolomics and network pharmacology. A total of 60 asthma patients who had used low-dose inhaled corticosteroids-formoterol(ICS-formoterol) for a long time were randomized into the western medicine group(low-dose ICS-formoterol) and western medicine+Kechuanting group(KAAT+low-dose ICS-Formoterol), 30 in either group. In addition, 30 healthy people were included as the control(no intervention)...
December 2022: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/36567168/efficacy-of-oral-polypodium-leucotomos-colchicine-cream-and-ingenol-mebutate-in-the-treatment-of-actinic-keratoses-and-cutaneous-field-cancerization-a-randomized-clinical-trial
#23
RANDOMIZED CONTROLLED TRIAL
Anna Carolina Miola, Hélio Amante Miot
No abstract text is available yet for this article.
2023: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/36495205/ingenol-mebutate-is-associated-with-increased-reporting-odds-for-squamous-cell-carcinoma-in-actinic-keratosis-patients-a-pharmacovigilance-study-of-the-fda-adverse-event-reporting-system-faers
#24
JOURNAL ARTICLE
Patrick Michael Jedlowski
BACKGROUND: Recently the production and marketing of ingenol mebutate in the European Union (EU) and Canada was halted due to a possible increased risk of squamous cell carcinoma (SCC) in patients with actinic keratosis (AK). OBJECTIVE: To investigate the relationship between SCC and topical AK medications including ingenol mebutate in the FDA Adverse Event Reporting System (FAERS). METHODS: Case/non-case analyses were performed in FAERS using data from 2012 to 2020 to examine the reporting odds ratio (ROR) signal for SCC for ingenol mebutate and all classes of topical AK medications under multiple conditions: i...
December 10, 2022: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/36454335/treatment-of-actinic-keratosis-a-systematic-review
#25
REVIEW
Brandon Worley, Vishnu Harikumar, Kelly Reynolds, McKenzie A Dirr, Rachel E Christensen, Noor Anvery, Michael D Yi, Emily Poon, Murad Alam
Treatment of actinic keratoses (AKs) can help lower the risk of eventual skin cancer and address field pre-cancerization. This review compares the different therapeutic options for actinic keratosis. Databases used include Medline, EMBASE, Web of Science and the Cochrane Library from inception to December 2019. Randomized control trials that were related to any approved or recognized treatment for actinic keratosis were included. 1186 studies were found, of which 80 with 6748 patients were included in the analysis...
December 1, 2022: Archives of Dermatological Research
https://read.qxmd.com/read/36362165/immunothrombotic-mechanisms-induced-by-ingenol-mebutate-lead-to-rapid-necrosis-and-clearance-of-anogenital-warts
#26
JOURNAL ARTICLE
Stephan A Braun, Alexander T Bauer, Csongor Németh, Annamária Rózsa, Louisa Rusch, Luise Erpenbeck, Sebastian Schloer, Steffi Silling, Dieter Metze, Peter A Gerber, Stefan W Schneider, Rolland Gyulai, Bernhard Homey
Ingenol mebutate (IM) is highly effective in the treatment of human papillomavirus (HPV)-induced anogenital warts (AGW) leading to fast ablation within hours. However, the exact mode of action is still largely unknown. We performed dermoscopy, in vivo confocal microscopy (CLM), histology, immunohistochemistry, and immunofluorescence to gain insights in mechanisms of IM treatment in AGW. In addition, we used in vitro assays (ELISA, HPV-transfection models) to further investigate in vivo findings. IM treatment leads to a strong recruitment of neutrophils with thrombosis of small skin vessels within 8 h, in a sense of immunothrombosis...
November 2, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36267162/attitudes-among-dermatologists-regarding-actinic-keratosis-treatment-options
#27
JOURNAL ARTICLE
Gaia Moretta, Tonia Samela, Francesca Sampogna, Francesco Ricci, Fabio Carlesimo, Annarita Panebianco, Angelo Massimiliano D'Erme, Giovanni Di Lella, Sabatino Pallotta, Elena Dellambra, Damiano Abeni, Luca Fania
Actinic keratosis (AK) is considered a precancerous lesion that can develop into invasive squamous cell carcinoma. Its prevalence is increasing, and it is estimated that it affects between 1% and 44% of the adult population worldwide. Advanced age, fair skin phototypes, and cumulative sun exposure are the main risk factors for AK. Therapies for AK consists of lesion-directed treatment ( i.e. , cryotherapy, curettage, electrocoagulation, and laser therapy) or field therapy [ i.e. , photodynamic therapy (PDT), 5-fluorouracil (5-FU), diclofenac sodium (DIC), imiquimod (IMQ), and ingenol mebutate (Ing Meb)]...
September 14, 2022: Dermatology Reports
https://read.qxmd.com/read/36261393/influence-of-serum-vitamin-d-level-in-the-response-of-actinic-keratosis-to-ingenol-mebutate
#28
JOURNAL ARTICLE
Ricardo Moreno-Alonso de Celada, Tamara Gracia-Cazaña, Laura Najera-Botello, Paulina Cerro-Muñoz, Angeles Juarranz, Salvador Gonzalez, Yolanda Gilaberte
Vitamin D (VD) serum levels, and keratinocytic basal expression of vitamin D receptor (VDR) before treatment of actinic keratoses (AK) have been previously reported as possible biomarkers of the response of AK to treatments. We intended to evaluate the association between these and other serum and immunohistochemical parameters with the response of AK to treatment with topical ingenol mebutate (IM). Twenty-five patients with AK on the head were treated with topical IM 0.015% gel once daily for 3 days. Biopsies were taken at baseline and 6 weeks after treatment...
October 19, 2022: Dermatologic Therapy
https://read.qxmd.com/read/36232651/topical-treatment-of-actinic-keratosis-and-metalloproteinase-expression-a-clinico-pathological-retrospective-study
#29
JOURNAL ARTICLE
Elena Campione, Monia Di Prete, Cosimo Di Raimondo, Gaetana Costanza, Vincenzo Palumbo, Virginia Garofalo, Sara Mazzilli, Chiara Franceschini, Emi Dika, Luca Bianchi, Augusto Orlandi
Actinic keratosis is an intraepithelial proliferation of atypical keratinocytes that could progress into invasive squamous cell carcinoma. Most evidence suggests an important role of the dermal matrix metalloproteinases in the progression of atypical skin epithelial lesions. We evaluated the clinical efficacy of three different therapeutic modalities (a medical device containing 0.8% piroxicam cream and 50+ sunscreen, photodynamic therapy, and ingenol mebutate gel) to treat suspicious actinic keratoses, which were biopsied for histopathological examination and then analyzed for the expression of matrix metalloproteinases by immunohistochemistry...
September 26, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36204585/distinct-role-of-mitochondrial-function-and-protein-kinase-c-in-intimal-and-medial-calcification-in-vitro
#30
JOURNAL ARTICLE
Marina A Heuschkel, Anne Babler, Jonas Heyn, Emiel P C van der Vorst, Marja Steenman, Maren Gesper, Ben A Kappel, David Magne, Yann Gouëffic, Rafael Kramann, Willi Jahnen-Dechent, Nikolaus Marx, Thibaut Quillard, Claudia Goettsch
Introduction: Vascular calcification (VC) is a major risk factor for cardiovascular morbidity and mortality. Depending on the location of mineral deposition within the arterial wall, VC is classified as intimal and medial calcification. Using in vitro mineralization assays, we developed protocols triggering both types of calcification in vascular smooth muscle cells (SMCs) following diverging molecular pathways. Materials and methods and results: Human coronary artery SMCs were cultured in osteogenic medium (OM) or high calcium phosphate medium (CaP) to induce a mineralized extracellular matrix...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36170888/triterpenoids-steroids-and-other-constituents-from-euphorbia-kansui-and-their-anti-inflammatory-and-anti-tumor-properties
#31
JOURNAL ARTICLE
Jian-Chun Li, Shu-Yi Li, Jian-Xian Tang, Dan Liu, Xiao-Yi Feng, Kai-Rui Rao, Xu-Dong Zhao, Hong-Mei Li, Rong-Tao Li
Six undescribed triterpenoids (euphokanols A-F), two undescribed C21 -steroidal glycosides (euphokanosides A and B), together with fifty-four known compounds were isolated from the roots of Euphorbia kansui. Their structures were demonstrated by extensive spectroscopic data (1D, 2D NMR and HR-ESI-MS), and the absolute configuration of euphokanol A was elucidated based on electronic circular dichroism (ECD) calculation. Among them, euphokanol A was a tetracyclic triterpenoid with a 5,10-epoxy moiety and concurrent rearrangement of Me-19(10 → 9) and Me-30 (14 → 8), while euphokanols B and C were rare 19(10 → 9) abeo-tirucallane-type triterpenoids with Δ5(10) double bonds and 7,8-epoxy moieties...
September 25, 2022: Phytochemistry
https://read.qxmd.com/read/35891551/off-target-effect-of-activation-of-nf-%C3%AE%C2%BAb-by-hiv-latency-reversal-agents-on-transposable-elements-expression
#32
JOURNAL ARTICLE
Gislaine Curty, Luis P Iniguez, Marcelo A Soares, Douglas F Nixon, Miguel de Mulder Rougvie
Many drugs have been evaluated to reactivate HIV-1 from cellular reservoirs, but the off-target effects of these latency reversal agents (LRA) remain poorly defined. Transposable elements (TEs) are reactivated during HIV-1 infection, but studies of potential off-target drug effects on TE expression have been limited. We analyzed the differential expression of TEs induced by canonical and non-canonical NF-κB signaling. We evaluated the effect of PKC agonists (Bryostatin and Ingenol B) on the expression of TEs in memory CD4+ T cells...
July 20, 2022: Viruses
https://read.qxmd.com/read/35889247/ethnobotanical-uses-phytochemistry-toxicology-and-pharmacological-properties-of-euphorbia-neriifolia-linn-against-infectious-diseases-a-comprehensive-review
#33
REVIEW
Arifa Sultana, Md Jamal Hossain, Md Ruhul Kuddus, Mohammad A Rashid, Miss Sharmin Zahan, Saikat Mitra, Arpita Roy, Safaet Alam, Md Moklesur Rahman Sarker, Isa Naina Mohamed
Medicinal plants have considerable potential as antimicrobial agents due to the presence of secondary metabolites. This comprehensive overview aims to summarize the classification, morphology, and ethnobotanical uses of Euphorbia neriifolia L. and its derived phytochemicals with the recent updates on the pharmacological properties against emerging infectious diseases, mainly focusing on bacterial, viral, fungal, and parasitic infections. The data were collected from electronic databases, including Google Scholar, PubMed, Semantic Scholar, ScienceDirect, and SpringerLink by utilizing several keywords like ' Euphorbia neriifolia ', 'phytoconstituents', 'traditional uses', 'ethnopharmacological uses', 'infectious diseases', 'molecular mechanisms', 'COVID-19', 'bacterial infection', 'viral infection', etc...
July 8, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35733180/repression-of-hiv-1-reactivation-mediated-by-crispr-dcas9-krab-in-lymphoid-and-myeloid-cell-models
#34
JOURNAL ARTICLE
Lendel Correia da Costa, Larissa Maciel Bomfim, Uilla Victoria Torres Dittz, Camila de Almeida Velozo, Rodrigo Delvecchio da Cunha, Amilcar Tanuri
BACKGROUND: Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, reactivation of the virus from latently infected cell reservoirs is a major challenge toward cure efforts. Two strategies targeting viral latency are currently under investigation: the "shock and kill" and the "block and lock." The "Block and Lock" methodology aims to control HIV-1 latency reactivation, promoting a functional cure. We utilized the CRISPR/dCas9-KRAB platform, which was initially developed to suppress cellular genes transcription, to block drug-induced HIV-1 reactivation in latently infected T cells and myeloid cells...
June 22, 2022: Retrovirology
https://read.qxmd.com/read/35724704/repurposing-of-ingenol-mebutate-for-treating-human-colorectal-cancer-by-targeting-s100-calcium-binding-protein-a4-s100a4
#35
JOURNAL ARTICLE
Yao-Yu Hsieh, Ya-Wen Cheng, Po-Li Wei, Pei-Ming Yang
Colorectal cancer (CRC) is the world's second most common cause of cancer-related death. Novel treatments are still urgently needed. S100 calcium-binding protein A4 (S100A4) was demonstrated to be an anticancer therapeutic target. Herein, we found that higher S100A4 expression was associated with a poorer prognosis in publicly available cohorts and a Taiwanese CRC patient cohort. To identify repurposed S100A4 inhibitors, we mined the Connectivity Map (CMap) database for clinical drugs mimicking the S100A4-knockdown gene signature...
June 18, 2022: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/35721664/ek-16a-liposomes-enhance-hiv-replication-in-ach2-or-j-lat-10-6-cell-engrafted-nsg-mice
#36
JOURNAL ARTICLE
Panpan Lu, Jinlong Yang, Xinyi Yang, Zhiming Liang, Jing Wang, Yanan Wang, Lin Zhao, Hanyu Pan, Xiaoting Shen, Yuqi Zhu, Jingna Xun, Hongzhou Lu, Huanzhang Zhu
Background: Numbers of HIV latency reversal agents (LRAs) have been tested in clinical trials, but with limited effect. EK-16A is an ingenol derivative that isolated from Euphorbia kansui . Our prior studies have suggested that it could reactivate latent HIV and meanwhile inhibit HIV infection in vitro . Here, we further advanced the research in vivo . Methods: In vitro , the activity of EK-16A liposomes was measured in HIV latently infected cells. In serum pharmacology test, BALB/c mice were orally administered with EK-16A liposomes, serum was separated and co-cultured with cells, HIV reactivation was measured...
2022: Nanotheranostics
https://read.qxmd.com/read/35712557/comparative-transcriptomics-and-metabolites-analysis-of-two-closely-related-euphorbia-species-reveal-environmental-adaptation-mechanism-and-active-ingredients-difference
#37
JOURNAL ARTICLE
Han Zheng, Mu-Yao Yu, Yang Han, Badalahu Tai, Sheng-Fa Ni, Rui-Feng Ji, Chun-Juan Pu, Kang Chen, Fu-Quan Li, Hua Xiao, Ye Shen, Xiu-Teng Zhou, Lu-Qi Huang
Roots of Euphorbia fischeriana and Euphorbia ebracteolata are recorded as the source plant of traditional Chinese medicine "Langdu," containing active ingredients with anticancer and anti-AIDS activity. However, the two species have specific patterns in the graphic distribution. Compared with E. ehracteolata, E. fischeriana distributes in higher latitude and lower temperature areas and might have experienced cold stress adaptation. To reveal the molecular mechanism of environmental adaptation, RNA-seq was performed toward the roots, stems, and leaves of E...
2022: Frontiers in Plant Science
https://read.qxmd.com/read/35555684/structural-basis-of-agonist-capture-by-regulatory-c1-domain-of-pkc
#38
JOURNAL ARTICLE
Sachin S Katti, Inna V Krieger, James C Sacchettini, Tatyana I Igumenova
Diacylglycerol (DAG)-sensing C1 domains of Protein kinase C (PKC) isoforms are targets for therapeutic intervention in cancers, neurodegenerative disorders, and HIV latency reversal. High-resolution structural information on the C1 domains complexed to DAG or exogenous PKC agonists remained elusive for nearly 3 decades. This is attributed to the extreme hydrophobicity of the C1 complexes and the need to create an optimal membrane-mimicking environment to facilitate the complex formation and crystallization...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35498090/systematic-characterization-of-metabolic-profiles-of-ingenol-in-rats-by-uplc-q-tof-ms-and-nmr-in-combination-with-microbial-biotransformation
#39
JOURNAL ARTICLE
Si-Jia Xiao, Shan-Shan Li, Bin Xie, Wei Chen, Xi-Ke Xu, Xian-Peng Zu, Yun-Heng Shen
Ingenol, as the precursor of the marketed drug ingenol mebutate, has been proven to have a variety of bioactivities. The purpose of this study was to identify the metabolites of ingenol using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-Q/TOF-MS) combined with UNIFI software. Plasma, urine and fecal samples of rats were obtained and analyzed. A total of 18 metabolites were detected and identified in rat, including five phase II metabolites (M14-M18). Moreover, as microbial biotransformation is helpful to obtain sufficient reference standards of metabolites, the co-culture of ingenol with the fungus Cunninghamella elegans bio-110930 was also studied and yielded 4 phase I metabolites, in which reference standards of three metabolites were further obtained by preparative scale biotransformation...
November 23, 2021: RSC Advances
https://read.qxmd.com/read/35475852/risk-of-invasive-cutaneous-squamous-cell-carcinoma-after-different-treatments-for-actinic-keratosis-a-secondary-analysis-of-a-randomized-clinical-trial
#40
RANDOMIZED CONTROLLED TRIAL
Shima Ahmady, Maud H E Jansen, Patty J Nelemans, Janneke P H M Kessels, Aimee H M M Arits, Michette J M de Rooij, Brigitte A B Essers, Patricia J F Quaedvlieg, Nicole W J Kelleners-Smeets, Klara Mosterd
IMPORTANCE: Treatment of actinic keratosis (AK) aims to prevent cutaneous squamous cell carcinoma (cSCC). However, whether AK can progress into invasive cSCC is a matter of debate, and little is known about the effect of treatment on preventing cSCC. OBJECTIVES: To evaluate the risk of invasive cSCC and factors that may contribute to increased risk in patients with multiple AKs. DESIGN, SETTING, AND PARTICIPANTS: In this secondary analysis of a multicenter randomized clinical trial, 624 patients with a minimum of 5 AKs within an area of 25 to 100 cm2 on the head were recruited from the Department of Dermatology of 4 hospitals in the Netherlands...
June 1, 2022: JAMA Dermatology
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