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Noortje Houben, Eveline P C J Janssen, Marike R C Hendriks, Digna van der Kellen, Bas P J van Alphen, Berno van Meijel
The objective was to use various somatic parameters as basis for investigating the physical health of older adults with severe mental illnesses (SMI). A cross-sectional study design is performed by using baseline data from the Physical Health in SMI-elderly (PHiSMI-E) study. Data were collected using the Nursing Monitoring of Somatic Status and Lifestyle - Mental Health instrument in adults aged over 60 with SMI in a large Dutch mental health institute. Ninety-nine elderly SMI patients were included. Somatic comorbidity (84...
October 7, 2018: International Journal of Mental Health Nursing
Bart De Boer, Alfred P See, H Bart Brouwers, Gabriël Rinkel, Ciro Princiotta, Marike L D Broekman
Coil migration following cerebral aneurysm treatment has been described and may result in stroke, recurrent aneurysm, or local mass effect. Cerebral coil embolization is also applied in arteriovenous malformations and arteriovenous fistulas, but these pathologies are relatively rare and coil migration is not as well described. Furthermore, these cases are more commonly treated with combinations of multiple modalities to achieve cure. Embolization, surgery, and radiation each have risks and benefits and combinations may have synergistic risks and benefits not seen in monotherapy...
October 3, 2018: Acta Neurochirurgica
Bruce J Kirenga, Levicatus Mugenyi, Corina de Jong, J Lucian Davis, Winceslaus Katagira, Thys van der Molen, Moses R Kamya, Marike Boezen
BACKGROUND: HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of HIV on asthma prevalence in high HIV burden settings. The objective of this analysis was to compare the prevalence of asthma among persons living with HIV (PLHIV) and those without HIV participating in the Uganda National Asthma Survey (UNAS). METHODS: UNAS was a population-based survey of persons aged ≥12 years. Asthma was diagnosed based on either self-reported current wheeze concurrently or within the prior 12 months; physician diagnosis; or use of asthma medication...
September 21, 2018: Respiratory Research
Tinashe Chikowore, Marike Cockeran, Karin R Conradie, Tertia van Zyl
AIMS: To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. METHODS: We conducted a five year, longitudinal study, nested within the Prospective Urban and Rural Epidemiology study, among 737 apparently healthy, male and female black South Africans of the North West province. Genotyping of the C679X and A443T PCSK9 variants was achieved using Taqman assays from Applied Biosystems...
September 15, 2018: Diabetes Research and Clinical Practice
Petri J C M Embregts, Annemarieke Negenman, Jolanda M Habraken, Marike E de Boer, Brenda J M Frederiks, Cees M P M Hertogh
BACKGROUND: Due to incompatibilities in communication, it is key that family members and support staff can take the perspective of people with moderate to profound intellectual disabilities (ID) whilst putting aside their own perspectives. METHOD: Ten vignettes describing types of restraint interventions (RIs) were presented to 20 unique pairs of support staff and family members related to individuals with moderate to profound ID. RESULTS: In taking their own perspective, more than half of the support staff and family members perceived all RIs as involuntary and severe...
September 7, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
Wilhelm P Greffrath, Jesslee M du Plessis, Michelle Viljoen, Marike Cockeran
Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r). Objectives: To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital. Methods: Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation...
2018: Southern African Journal of HIV Medicine
Tomasz Cudejko, Martin van der Esch, Josien C van den Noort, Judith J M Rijnhart, Marike van der Leeden, Leo D Roorda, Willem Lems, Gordon Waddington, Jaap Harlaar, Joost Dekker
OBJECTIVE: To evaluate whether improvement of proprioception, pain or dynamic knee instability mediate the effect of wearing a soft knee brace on activity limitations in persons with knee osteoarthritis (OA). METHODS: Exploratory analysis from 44 participants with knee OA and self-reported knee instability in a laboratory trial evaluating the effect of wearing a commercially available soft knee brace. Activity limitations were assessed with the 10-meter walk test and the Get up and Go test...
August 12, 2018: Arthritis Care & Research
Maaike de Vries, Diana A van der Plaat, Judith M Vonk, H Marike Boezen
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with cigarette smoke as the main risk factor for its development. Since not every smoker develops COPD, other factors likely underlie differences in susceptibility to develop COPD. Here, we tested if DNA methylation may be such a factor by assessing the association between DNA methylation levels and COPD in never and current smokers from the general population. Methods: For the current study, 1561 subjects were non-randomly selected from the LifeLines cohort study...
2018: BMJ Open Respiratory Research
Sahil Aggarwal, David Ju, Angela M Allen, Laura A Rose, Karam P Gill, S Aricia Shen, Jamie E Temko, Irene Chang, Jessica Faraj, Danielle E Brabender, Sasha Herbst de Cortina, Olivia Marik-Reis, Mitul C Mehta
Background: Visual impairment in developing countries has both social and economic impact on individuals and communities. Understanding the subjective visual functioning of populations will allow for local policymakers to identify the need for optometric or ophthalmic services in their communities. Methods: The authors surveyed 644 adult patients in Mwanza, Tanzania at three clinics (Buzuruga, Mwananchi and Kisesa) using a modified Visual Functioning Questionnaire 25...
July 17, 2018: International Health
Marloes Tenten-Diepenmaat, Marike van der Leeden, Thea P M Vliet Vlieland, Joost Dekker
Background: Foot problems in people with rheumatoid arthritis (RA) are highly prevalent and have a substantial impact on quality of life. Healthcare professionals from various professions can be involved in the management of these foot problems. There is currently no consensus on optimal management. Therefore, the aim of the present study was to develop multidisciplinary recommendations for the management of foot problems in people with RA in the Netherlands. Methods: The recommendations were based on research evidence and consensus among experts, following published strategies for the development of practice recommendations...
2018: Journal of Foot and Ankle Research
Arnoldeen C De Vos, Leone Malan, Yackoob K Seedat, Marike Cockeran, Nicolaas T Malan
BACKGROUND: Low-renin levels in Blacks have been associated with volume-loading hypertension (HT). Depression symptoms, frequently co-occurring with vascular dysregulation, might reflect a disturbed renin-angiotensin-aldosterone-system (RAAS). We aimed to assess prospective changes (∆) in depression symptoms, RAAS (renin, aldosterone), diastolic blood pressure (DBP), and estimated glomerular filtration rate (eGFR) in a bi-ethnic sex cohort. METHODS: We included 195 Black and White teachers (43...
October 1, 2018: Physiology & Behavior
Marike M Leijs, Janna G Koppe, Kees Olie, Pim de Voogt, Wim M C van Aalderen, Gavin W Ten Tusscher
Dioxins (polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDF)), polychlorinated biphenyls (PCBs), and brominated flame retardants (BDEs) are well known toxic environmental contaminants. Their possible role in the incidence of respiratory disease is not yet well understood. Previous studies showed a negative effect on lung function in relation to prenatal and lactational dioxin exposure in pre-pubertal children. Effects of BDE exposure on the lung function have not previously been evaluated...
June 27, 2018: International Journal of Environmental Research and Public Health
Tomasz Cudejko, Martin van der Esch, Jim Schrijvers, Rosie Richards, Josien C van den Noort, Tim Wrigley, Marike van der Leeden, Leo D Roorda, Willem Lems, Jaap Harlaar, Joost Dekker
Objectives: Wearing a soft knee brace has been shown to reduce self-reported knee instability in persons with knee OA. There is a need to assess whether a soft knee brace has a beneficial effect on objectively assessed dynamic knee instability as well. The aims of the study were to evaluate the effect of a soft knee brace on objectively assessed dynamic knee instability and to assess the difference in effect between a non-tight and a tight soft knee brace in persons with knee OA. Methods: Thirty-eight persons with knee OA and self-reported knee instability participated in a laboratory study...
October 1, 2018: Rheumatology
Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K Bolla, Xiao-Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al-Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard T Barfield, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Myrto Barrdahl, Caroline Baynes, Matthias W Beckmann, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Louise Brinton, Per Broberg, Sara Y Brucker, Barbara Burwinkel, Trinidad Caldés, Federico Canzian, Brian D Carter, J Esteban Castelao, Jenny Chang-Claude, Xiaoqing Chen, Ting-Yuan David Cheng, Hans Christiansen, Christine L Clarke, Margriet Collée, Sten Cornelissen, Fergus J Couch, David Cox, Angela Cox, Simon S Cross, Julie M Cunningham, Kamila Czene, Mary B Daly, Peter Devilee, Kimberly F Doheny, Thilo Dörk, Isabel Dos-Santos-Silva, Martine Dumont, Miriam Dwek, Diana M Eccles, Ursula Eilber, A Heather Eliassen, Christoph Engel, Mikael Eriksson, Laura Fachal, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, Mia M Gaudet, Maya Ghoussaini, Graham G Giles, Mark S Goldberg, David E Goldgar, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Emily Hallberg, Ute Hamann, Patricia Harrington, Alexander Hein, Belynda Hicks, Peter Hillemanns, Antoinette Hollestelle, Robert N Hoover, John L Hopper, Guanmengqian Huang, Keith Humphreys, David J Hunter, Anna Jakubowska, Wolfgang Janni, Esther M John, Nichola Johnson, Kristine Jones, Michael E Jones, Audrey Jung, Rudolf Kaaks, Michael J Kerin, Elza Khusnutdinova, Veli-Matti Kosma, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jan Lubinski, Craig Luccarini, Michael P Lux, Robert J MacInnis, Tom Maishman, Ivana Maleva Kostovska, Arto Mannermaa, JoAnn E Manson, Sara Margolin, Dimitrios Mavroudis, Hanne Meijers-Heijboer, Alfons Meindl, Usha Menon, Jeffery Meyer, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Børge G Nordestgaard, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Ross Prentice, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Anja Rudolph, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Rodney J Scott, Christopher G Scott, Sheila Seal, Mitul Shah, Martha J Shrubsole, Ann Smeets, Melissa C Southey, John J Spinelli, Jennifer Stone, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, William Tapper, Jack A Taylor, Mary Beth Terry, Daniel C Tessier, Abigail Thomas, Kathrin Thöne, Rob A E M Tollenaar, Diana Torres, Thérèse Truong, Michael Untch, Celine Vachon, David Van Den Berg, Daniel Vincent, Quinten Waisfisz, Clarice R Weinberg, Camilla Wendt, Alice S Whittemore, Hans Wildiers, Walter C Willett, Robert Winqvist, Alicja Wolk, Lucy Xia, Xiaohong R Yang, Argyrios Ziogas, Elad Ziv, Alison M Dunning, Paul D P Pharoah, Jacques Simard, Roger L Milne, Stacey L Edwards, Peter Kraft, Douglas F Easton, Georgia Chenevix-Trench, Wei Zheng
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas...
July 2018: Nature Genetics
Maarten A van Egmond, Marike van der Schaaf, Eliza R C Hagens, Hanneke W M van Laarhoven, Mark I van Berge Henegouwen, Elizabeth B Haverkort, Raoul H H Engelbert, Suzanne S Gisbertz
BACKGROUND AND PURPOSE: Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperative recovery due to decreased muscle mass. Therefore, in this cross-sectional study, we aimed to investigate the association between muscle mass and muscle strength in predominantly older patients with esophageal cancer awaiting esophagectomy prior to neoadjuvant chemoradiation...
June 1, 2018: Journal of Geriatric Physical Therapy
Sandra H van Oostrom, Peter M Engelfriet, W M Monique Verschuren, Maarten Schipper, Inge M Wouters, Marike Boezen, Henriëtte A Smit, Huib A M Kerstjens, H Susan J Picavet
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards...
2018: PloS One
Bruce J Kirenga, Corina de Jong, Levicatus Mugenyi, Winceslaus Katagira, Abdallah Muhofa, Moses R Kamya, H Marike Boezen, Thys van der Molen
Data on asthma treatment outcomes in Africa are limited. 449 patients with asthma (age 5-93 years) in Uganda were followed up for 2 years to determine rates of exacerbations and mortality and associated factors. During follow-up the median number of exacerbations per patient was 1 (IQR 0-5) and 17 patients died (3.7%, 27.3 deaths per 1000 person years). Considering only the first year of follow-up, 59.6% of the patients experienced at least one exacerbation, 32.4% experienced three or more exacerbations. A multivariable model showed that the likelihood of experiencing at least one exacerbation in the first year of follow-up was lower with better baseline asthma control (higher asthma control test (ACT) score), with OR 0...
May 11, 2018: Thorax
Joeky T Senders, Tom J Snijders, Max van Essen, Gaby M van Bentum, Tatjana Seute, Filip Y de Vos, Timothy R Smith, Pierre A Robe, Marike L D Broekman
OBJECTIVE: High-grade gliomas are associated with venous thromboembolism (VTE). This retrospective study with a parallel cohort design investigated influence of continuing prophylactic anticoagulation after discharge on rate of VTE and intracranial hemorrhage (ICH) in patients operated on for high-grade glioma. METHODS: Consecutive adult patients who underwent subtotal or gross total resection for high-grade glioma at a single institution were included. Multivariable logistic regression analysis was used to investigate the association between duration of thromboprophylaxis (dalteparin administered 21 days vs...
July 2018: World Neurosurgery
Leoné Malan, Andrea de Kock, Mark Hamer, Marike Cockeran, Nicolaas Theodor Malan
OBJECTIVES: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1 -adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1 -adrenergic responsiveness and hypertension risk when habitually using defensive coping. METHODS: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included...
October 2018: Blood Pressure
Karen Charlton, Lisa Jayne Ware, Jeannine Baumgartner, Marike Cockeran, Aletta E Schutte, Nirmala Naidoo, Paul Kowal
OBJECTIVE: The WHO's global targets for non-communicable disease reduction recommend consumption of<5 g salt/day. In 2016, South Africa was the first country to legislate maximum salt levels in processed foods. South Africa's salt iodisation fortification programme has successfully addressed iodine deficiency but information is dated. Simultaneous monitoring of sodium reduction and iodine status is required to ensure compatibility of the two public health interventions. DESIGN/SETTING/PARTICIPANTS: A nested cohort design within WHO's 2015 Study on global AGEing and adult health (n=2887) including individuals from households across South Africa...
March 30, 2018: BMJ Open
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