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https://www.readbyqxmd.com/read/28809433/pharmacokinetic-and-ocular-microdialysis-study-of-oral-ginkgo-biloba-extract-in-rabbits-by-uplc-ms-ms-determination
#1
Shuya Wang, Ding Li, Jiaxin Pi, Wen Li, Bing Zhang, Dongli Qi, Nan Li, Pan Guo, Zhidong Liu
OBJECTIVES: The purpose of this work was to determine and investigate the absorption of ginkgo terpenoids (GT) in plasma and aqueous humour after oral administration of ginkgo biloba extract (GBE) by UPLC-MS/MS method. METHODS: The UPLC-MS/MS determination of GT employed the multiple reaction monitoring mode using an electrospray negative ionization. The rabbits were orally administered the suspension of GBE at a dose of 500 mg/kg. Serial plasma and dialysate samples were collected at the corresponding time and then analysed by UPLC-MS/MS...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28807163/effect-of-chinese-herbal-medicine-on-alzheimer-s-disease
#2
Melanie-Jayne R Howes, Rui Fang, Peter J Houghton
Alzheimer's disease (AD) is reaching epidemic proportions yet treatment strategies are limited and are restricted to providing symptomatic relief for the cognitive and behavioral and psychological symptoms of dementia (BPSD). Chinese herbal medicine (CHM) has been a valuable source of medicines for centuries and research has burgeoned in recent years to understand the scientific basis for their use. Some plants have been used in CHM for AD symptoms (e.g., Polygala tenuifolia), while others are CHMs for different conditions, but they show mechanistic effects relevant to AD (e...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28804233/effects-of-physical-activity-and-ginkgo-biloba-on-cognitive-function-and-oxidative-stress-modulation-in-ischemic-rats
#3
Ladan Vaghef, Hassan Bafandeh Gharamaleki
Either exercise or Ginkgo biloba is reported to improve cognitive functioning. The aim of this study is to compare the protective effects of forced exercise and Ginkgo biloba on oxidative stress as well as memory impairments induced by transient cerebral ischemia. Adult male Wistar rats were treated with treadmill running or Ginkgo biloba extract for 2 weeks before cerebral ischemia. Memory was assessed using a Morris water maze (MWM) task. At the end of the behavioral testing, oxidative stress biomarkers were evaluated in the hippocampus tissue...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28800704/qualitative-and-quantitative-analysis-of-carbohydrate-modification-on-glycoproteins-from-seeds-of-ginkgo-biloba
#4
Ting Wang, Xiao-Chun Hu, Zhi-Peng Cai, Josef Voglmeir, Li Liu
Recent progress in the relationship between carbohydrate cross-reactive determinants (CCDs) and allergic response highlights the importance of carbohydrate moieties in innate immune system. A previous research pointed out that the protein allergen in Ginkgo biloba seeds are glycosylated and the oligosaccharides conjugated to these proteins might also contribute to the allergy. The aim of this study was to analyze carbohydrate moieties, especially the N-linked glycans, of glycoproteins from Ginkgo seeds originated from different places for detailed structures, to enable further research on the roles that N-glycans play in Ginkgo-caused allergy...
August 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28797065/a-systematic-review-of-the-pharmacokinetic-and-pharmacodynamic-interactions-of-herbal-medicine-with-warfarin
#5
Songie Choi, Dal-Seok Oh, Ui Min Jerng
OBJECTIVES: The aim of this study was to systematically review data regarding pharmacokinetic (PK)-pharmacodynamic (PD) parameters from randomized controlled trials relating to interactions between herbal medicines and warfarin. METHODS: Three electronic databases were searched to identify relevant trials. Two reviewers independently performed the study selection and data extraction. The risk of bias and reporting quality were also assessed independently by two reviewers using the Cochrane risk of bias tool and the consolidated standards of reporting trials (CONSORT)...
2017: PloS One
https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#6
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28780415/ginkgo-biloba-extracts-loaded-starch-nano-spheres-preparation-characterization-and-in-vitro-release-kinetics
#7
Tao Wang, Caie Wu, Gongjian Fan, Tingting Li, Hao Gong, Fuliang Cao
Ginkgo as a promising edible material and herbal medicine has received much attention due to its abundant starch contents and functional ingredient ginkgo biloba extracts (GBEs). Many foreign scholars suggest that GBEs can effectively ameliorate the symptoms of mild memory impairment and Alzheimer's dementia. However, an insurmountable problem with application of the GBEs is its low bioavailability, which restricts its application in vivo. Considering the biocompatibility between GBEs and starch, we have prepared ginkgo and corn starch-based nano-carriers, and thereby loaded GBEs onto starch nano-spheres (SNPs) by nanoprecipitation...
August 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28772005/the-effects-of-antioxidants-on-ocular-blood-flow-in-patients-with-glaucoma
#8
Alon Harris, Josh Gross, Nicholas Moore, Thai Do, Amelia Huang, Willy Gama, Brent Siesky
PURPOSE: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). METHODS: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28762712/common-herbal-dietary-supplement-drug-interactions
#9
REVIEW
Gary N Asher, Amanda H Corbett, Roy L Hawke
Nearly 25% of U.S. adults report concurrently taking a prescription medication with a dietary supplement. Some supplements, such as St. John's wort and goldenseal, are known to cause clinically important drug interactions and should be avoided by most patients receiving any pharmacologic therapy. However, many other supplements are predicted to cause interactions based only on in vitro studies that have not been confirmed or have been refuted in human clinical trials. Some supplements may cause interactions with a few medications but are likely to be safe with other medications (e...
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28738521/ginkgo-biloba-exocarp-extracts-induces-autophagy-in-lewis-lung-cancer-cells-involving-ampk-mtor-p70s6k-signaling-pathway
#10
Chenjie Cao, Dongdong Han, Ya Su, Yu Ge, Huasheng Chen, Aihua Xu
OBJECTIVES: Ginkgo biloba L. is called a living fossil plant, and could be used for the treatment of cancer thousands of years ago in China. The extracts prepared from the Ginkgo biloba exocarp (Ginkgo biloba exocarp extracts, GBEE) has a significant anti-cancer effect. Autophagy plays an important role in the occurrence and development of cancer as programmed cell death (PCD) type II. Thus it would be interesting to study the effects and mechanisms of GBEE inducing autophagy in Lewis lung cancer (LLC) cells...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28733600/%C3%AE-ginkgotides-hyperdisulfide-constrained-peptides-from-ginkgo-biloba
#11
Ka H Wong, Wei Liang Tan, Tianshu Xiao, James P Tam
Hyperdisulfide-constrained peptides are distinguished by their high stability and diverse functions. Thus far, these peptides have been reported from animals only but their occurrence in plants are rare. Here, we report the discovery, synthesis and characterization of a hyperdisulfide-constrained peptides family of approximately 2 kDa, β-ginkgotides (β-gB1 and β-gB2) from Ginkgo biloba. Proteomic analysis showed β-ginkgotides contain 18‒20 amino acids, of which 16 residues form a conserved six-cysteine core with a highly clustered cysteine spacing of C‒CC‒C‒CC, an arrangement that has not been reported in cysteine-rich peptides...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731887/risk-of-anaphylaxis-in-complementary-and-alternative-medicine
#12
Natasha C Gunawardana
PURPOSE OF REVIEW: Complementary and alternative medicine (CAM) use is widespread across the world. Patients with asthma and allergy regularly use CAM therapies. Allergic and anaphylactic reactions to CAM have been reported. RECENT FINDINGS: Recent attempts to regulate and monitor adverse reaction to these therapies have given us further insight into potential causes of severe allergic reactions. Several culprits identified including Andrographis paniculata, Echinacea species, bee products, Ginkgo biloba and Ginseng are discussed here...
July 20, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28731173/anacardic-acid-induces-cell-apoptosis-of-prostatic-cancer-through-autophagy-by-er-stress-dapk3-akt-signaling-pathway
#13
Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Yao
Anacardic acid, which is commonly seen in plants of Anacardiaceae, is an important composition of cashew, ginkgo leaf and fruit, and it has been suggested in previous research to show antitumor activity. The main aim of the present study was to evaluate the anticancer effects of anacardic acid on cell apoptosis of prostatic cancer and molecular mechanisms of this phenomenon. In this study we found that anacardic acid inhibited cell proliferation, induced apoptosis and caspase-3/9 activities and Bax protein expression of prostatic cancer...
July 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28723603/ginkgo-biloba-in-the-treatment-of-tinnitus-an-updated-literature-review
#14
REVIEW
Mohammad Reza Mahmoudian-Sani, Morteza Hashemzadeh-Chaleshtori, Majid Asadi-Samani, Qian Yang
INTRODUCTION: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical- psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723601/a-review-of-medicinal-plants-for-the-treatment-of-earache-and-tinnitus-in-iran
#15
REVIEW
Mohammad Reza Mahmoudian-Sani, Morteza Hashemzadeh-Chaleshtori, Majid Asadi-Samani, Tahra Luther
BACKGROUND AND PURPOSE: Despite numerous trials, there has not yet been any definite strategy to reduce replicable long-term tinnitus and earache. Complementary and alternative medical approaches have been used to decrease the symptoms of tinnitus and earache. This study was conducted to report medicinal plants that are used to treat ear disorders, especially earache and tinnitus in different regions of Iran. EVIDENCE ACQUISITIONS: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed, LISTA (EBSCO), Embase, and Web of Science were searched using relevant search terms to retrieve eligible publications...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28719153/in-source-collision-induced-dissociation-is-cid-applications-issues-and-structure-elucidation-with-single-stage-mass-analyzers
#16
Jon F Parcher, Mei Wang, Amar G Chittiboyina, Ikhlas A Khan
A discussion of the definition, advantages and issues with the formation of ions in the transition region between an ESI source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so-called in-source collision induced dissociation (IS-CID) process are illustrated. Applications of IS-CID with single-stage mass analyzers, such as structure elucidation and quantitation, are demonstrated. The discussion is illustrated by examples of the in-source fragmentation of ginkgolides, which are marker compounds found only in Ginkgo biloba...
July 18, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28713946/ginkgo-biloba-extract-prevents-acute-myocardial-infarction-and-suppresses-the-inflammation%C3%A2-and-apoptosis%C3%A2-regulating-p38-mitogen%C3%A2-activated-protein-kinases-nuclear-factor%C3%A2-%C3%AE%C2%BAb-and-b%C3%A2-cell-lymphoma-2-signaling-pathways
#17
Yanping Li, Ya Zhang, Min Wen, Ju Zhang, Xia Zhao, Yuan Zhao, Jiagang Deng
Ginkgo biloba is a plant known from the Mesozoic and has been regarded as one of the first to be used in traditional Chinese medicine (TCM). The plant extract has attracted a great deal of attention in recent years. The Ginkgo biloba leaf contains flavones and diterpenes. In addition, Ginkgo biloba performs certain pharmacologic actions, including antioxidant and anti‑aging activities. The aim of the present study was to examine whether Ginkgo biloba extract prevents acute myocardial infarction (AMI)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712049/ginkgolide-b-suppresses-methamphetamine-induced-microglial-activation-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-in-bv2-cells
#18
Fen Wan, Songsong Zang, Guoqing Yu, Hang Xiao, Jun Wang, Jinrong Tang
Accumulating evidence suggests that microglial cells have altered morphology and proliferation in different brain regions of methamphetamine (Meth) abusers and Meth-abusing animal models. However, the possible mechanisms underlying Meth-induced microglial activation remain poorly understood. Meanwhile, Toll-like receptor4 (TLR4) is closely associated with inflammation. Therefore the aim of the present study was to assess whether Meth treatment affects TLR4 expression; in addition, we evaluated the effects of ginkgolide B (GB), a diterpene lactone extracted from Ginkgo biloba, on Meth-mediated inflammation...
July 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28707602/ginkgo-biloba-extract-in-vascular-protection-molecular-mechanisms-and-clinical-applications
#19
Jinfan Tian, Yue Liu, Keji Chen
Background Leaves of Ginkgo biloba, a "living fossil," have been used as traditional herbal medicine for hundreds of years in China. Currently, its application in vascular protection is gaining much attention. Methods In this manuscript, preclinical studies were reviewed to discuss various mechanisms underlying the vascular protection by Ginkgo biloba extract (GBE). Additionally, we reviewed clinical studies to present the application of GBE in the ischaemic disease. Results GBE, a commonly used as a dietary supplement, has been shown to act as an antioxidant and free-radical scavenger, a membrane stabilizer, an inhibitor of the platelet-activating factor, a vasodilator, and a regulator of metabolism...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28707415/effect-of-ginkgo-extract-supplementation-on-in%C3%A2-vitro-rumen-fermentation-and-bacterial-profiles-under-different-dietary-conditions
#20
Seongjin Oh, Satoshi Koike, Yasuo Kobayashi
Ginkgo extract was applied to a batch culture study and evaluated for its potential as a feed additive for ruminant animals under different forage-to-concentrate (F:C) ratios (1:9, 3:7, 5:5, 7:3 and 9:1). Rumen fluid was mixed with respective diet and incubated at 39°C for 24 h with and without ginkgo extract (1.6% fruit equivalent in culture). Methane production was significantly decreased by ginkgo extract, with the greatest reductions found in the 5:5 (41.9%) followed by the 7:3 ratios (36.7%). Total short chain fatty acid and ammonia levels were not affected by ginkgo extract supplementation in any of the five different diets...
July 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
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