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Xiao-Fang Huang, Song-Zhao Zhang, Ya-Yu You, Na Zhang, Hong Lu, Alan Daugherty, Xiao-Jie Xie
Abdominal aortic aneurysms (AAAs) are a chronic vascular disease characterized by pathological luminal dilation. Aortic rupture is the fatal consequence of AAAs. Ginkgo biloba extracts (GBEs), a natural herb extract widely used as food supplements, drugs, and cosmetics, has been reported to suppress development of calcium chloride-induced AAAs in mice. Calcium chloride-induced AAAs do not rupture, while angiotensin II (AngII)-induced AAAs in mice have high rate of aortic rupture, implicating potentially different mechanisms from calcium chloride-induced AAAs...
May 18, 2018: Acta Pharmacologica Sinica
M M Ni, L Liu, R Zhao, M Nie, X H Yang
Objective: To evaluate the effect of systemic and intratympanic dexamethasone combination therapy on sudden deafness. Method: A total of 98 patients randomly divided into three groups: an intravenous corticosteroid (systemic corticosteroid monotherapy group); an intratympanic corticosteroid (IT monotherapy group); and a combination therapy group (IT plus systemic combination group). All patients were treated additionally with ginkgo-damole and mecobalamine and proton pomp inhibitor. An audiometry was performed before and after the therapies in all patients...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Ao Wang, Qiwei Yang, Qiuju Li, Xiaonan Wang, Shuhong Hao, Jincheng Wang, Ming Ren
BACKGROUND The oxidative stress environment of pathological tissue has an adverse effect on the survival of bone marrow mesenchymal stem cells (BMSCs) transplantation. Ginkgo biloba L. extract (EGB) has a potent antioxidant effect. In this research, we assessed the protective effects of EGB and EGB-Containing Serum (EGB CS) on BMSCs against injury induced by hydrogen peroxide (H2O2). MATERIAL AND METHODS BMSCs were pretreated with EGB or EGB CS and treated with H2O2. The cell counting kit-8 (CCK-8) method was utilized to detect cell viability...
May 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Chan Wu, Yong Xiang Wei, Jayant Marian Pinto, Jun Tian, Xian Dao Yuan, Xiao Jun Zhan
Objective: To determine whether ginkgo biloba extract(GBE)combined with dexamethasone(DEX)plays a role in the treatment of allergic rhinitis-related olfactory dysfunction using an animal model. Method: Six week old BALB/C mice were sensitized and challenged with ovalbumin.30 sensitized mice were divided into three groups:Group 1 was given high-dose GBE and DEX(n=10);Group 2 was given low dose GBE and DEX(n=10);Group 3 was given DEX alone(n=10).We assessed the histology of the olfactory mucosa and serum IL-4,IFN-γ,and caspase 1...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Lihu Zhang, Tingting Wu, Wei Xiao, Zhenzhong Wang, Gang Ding, Linguo Zhao
In the present study, the performance and separation characteristics of six macroporous resins for the enrichment and purification of total ginkgo flavonoid O -glycosides (TGFs) (quercetin (I), kaempferol (II), isorhamnetin (III)) from Ginkgo Biloba extracts (EGB) are evaluated. The adsorption and desorption properties of TGFs are studied on macroporous resins, including D101, D201, AB-8, HPD400, D301, and D311. Along with the results, AB-8 resin exhibits the best adsorption and desorption capacity for these three ginkgo flavonoid O -glycosides among the six resins...
May 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Natasha R Catlin, Bradley J Collins, Scott S Auerbach, Stephen S Ferguson, James M Harnly, Chris Gennings, Suramya Waidyanatha, Glenn E Rice, Stephanie L Smith-Roe, Kristine L Witt, Cynthia V Rider
No abstract text is available yet for this article.
May 9, 2018: Food and Chemical Toxicology
Di Tan, Jia-Rui Wu, Ying-Ying Cui, Yi Zhao, Dan Zhang, Shi Liu, Bing Zhang
OBJECTIVE: To provide information about the effectiveness and safety of Ginkgo Leaf Extract and Dipyridamole Injection (GD) as one adjuvant therapy for treating angina pectoris (AP) and to evaluate the relevant randomized controlled trials (RCTs) with meta-analysis. METHODS: RCTs concerning AP treated by GD were searched in China Biology Medicine Disc (SinoMed), PubMed, the China National Knowledge Infrastructure Database (CNKI), the Chinese Scientififi c Journals Database (VIP), Wanfang Database, Embase, and the Cochrane Library, from inception to February, 2017...
May 11, 2018: Chinese Journal of Integrative Medicine
Xueliang Niu, Xiaoyan Li, Wei Chen, Xiaobao Li, Wenju Weng, Chunxiao Yin, Ruixia Dong, Wei Sun, Guangjiu Li
Quercetin belongs to flavonoid drug that has favorable properties such as antiviral, anticancer, anti-allergic and anti-tumor. Therefore a sensitive method is highly required for quercetin determination. In this paper, a three-dimensional reduced graphene oxide aerogel (3D-rGA) with excellent porous framework was synthesized via one-step hydrothermal technique. The characteristics and performances of 3D-rGA were checked by SEM, TEM, BET, XRD, Raman, FT-IR, XPS and electrochemical methods, which exhibited good properties including unique porous structure, large surface area and excellent conductivity...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Hong Liu, Li-Ping Tan, Xin Huang, Yi-Qiu Liao, Wei-Jian Zhang, Pei-Bo Li, Yong-Gang Wang, Wei Peng, Zhong Wu, Wei-Wei Su, Hong-Liang Yao
Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3- O -α-l-glucoside, 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yanying Hu, Qingyuan Hua, Guojuan Sun, Kunpeng Shi, Huitu Zhang, Kai Zhao, Shiru Jia, Yujie Dai, Qingli Wu
The toxic ginkgolic acids are the main safety concern for the application of Ginkgo biloba. In this study, the degradation ability of salicylic acid decarboxylase (SDC) for ginkgolic acids was examined using ginkgolic acid C15:1 as a substrate. The results indicated that the content of ginkgolic acid C15:1 in Ginkgo biloba seeds was significantly decreased after 5 h treatment with SDC at 40 °Cand pH 5.5. In order to explore the structure of SDC and the interaction between SDC and substrates, homology modeling, molecular docking and molecular dynamics were performed...
May 2, 2018: Computational Biology and Chemistry
Hongxiang Li, Xiaoyuan Sun, Fan Yu, Lijia Xu, Jianhua Miu, Peigen Xiao
Based on compelling experimental and clinical evidence, Ginkgo biloba L. exerts a beneficial effect in ameliorating mild to moderate dementia in patients with Alzheimer’s disease (AD) and other neurological disorders, although the pharmacological mechanisms remain unknown. In the present study, compounds, their putative target proteins identified using an inverse docking approach, and clinically tested AD-related target proteins were systematically integrated together with applicable bioinformatics methods in silico ...
May 10, 2018: Nutrients
James B Pease, Joseph W Brown, Joseph F Walker, Cody E Hinchliff, Stephen A Smith
PREMISE OF THE STUDY: Phylogenetic support has been difficult to evaluate within the green plant tree of life partly due to a lack of specificity between conflicted versus poorly informed branches. As data sets continue to expand in both breadth and depth, new support measures are needed that are more efficient and informative. METHODS: We describe the Quartet Sampling (QS) method, a quartet-based evaluation system that synthesizes several phylogenetic and genomic analytical approaches...
March 2018: American Journal of Botany
Dan J Siskind, Michael Lee, Arul Ravindran, Qichen Zhang, Evelyn Ma, Balaji Motamarri, Steve Kisely
BACKGROUND: Although clozapine is the most effective medication for treatment refractory schizophrenia, only 40% of people will meet response criteria. We therefore undertook a systematic review and meta-analysis of global literature on clozapine augmentation strategies. METHODS: We systematically reviewed PubMed, PsycInfo, Embase, Cochrane Database, Chinese Biomedical Literature Service System and China Knowledge Resource Integrated Database for randomised control trials of augmentation strategies for clozapine resistant schizophrenia...
May 1, 2018: Australian and New Zealand Journal of Psychiatry
Rongkun Zhu, Jun Xie
Streptozotocin copied diabetic rats model were studied through aerobic exercise combined with ginkgo polysaccharide. Aimed to offering the updating experimental basis to prevent diabetic through aerobic exercise combined with ginkgo polysaccharide, the effect of aerobic exercise combined with ginkgo polysaccharide were discussed on the weight, blood glucose, glucosylated serum protein and the secretion ability of islet β cells, oral glucose tolerance test, islet cell pathological morophological changes and positive expression of Bax and Bcl-2...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Xia-Lin Chen, Ting Geng, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao
Ginkgo diterpene lactone raw material, as a raw material for ginkgo diterpene lactone meglumine injection, is extracted and purified from ginkgo leaf. ¹H-NMR content determination method and fingerprint analysis method were respectively established for ginkgo diterpene lactone raw material. Content determination was conducted in 3 batches of samples by using ¹H-qNMR, and then the results were basically consistent with the results in HPLC method. Twenty-four proton peaks were identified as common fingerprint peaks, and the fingerprint peaks were identified by using the control product and NMR information...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ting Geng, Wen-Wen Shen, Jia-Jia Wang, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao
Ginkgo terpene lactones, as an important active ingredient from Ginkgo leaves, has high medicinal values and has been widely used in clinics. This article would review the researches both at home and abroad, including chemical composition, structure-activity relationship, analytical methods, pharmacological effects, pharmacokinetic characteristics, and so on, providing a reference for further development and utilization of ginkgo terpene lactones.
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Qingchuan Hu, Peng Shen, Shunjie Bai, Meixue Dong, Zihong Liang, Zhi Chen, Wei Wang, Haiyang Wang, Siwen Gui, Pengfei Li, Peng Xie
Purpose: Ginkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects of DG and venlafaxine (for comparison) on behavioral and metabolite changes in the PFC using mice models and gas chromatography-mass spectrometry-based metabolomics. Materials and methods: Mice were randomly divided into control (saline), DG (12...
2018: Neuropsychiatric Disease and Treatment
Man-Zhong Li, Yi Zhang, Hai-Yan Zou, Jun-Yao Ouyang, Yu Zhan, Le Yang, Brian Chi-Yan Cheng, Lei Wang, Qiu-Xia Zhang, Jian-Feng Lei, Yuan-Yuan Zhao, Hui Zhao
EGb 761 is a standardized natural extract from Ginkgo biloba leaf that has shown neuroprotective effects after ischemic stroke. This study aimed to use magnetic resonance imaging (MRI) to noninvasively evaluate whether EGb 761 promotes neurovascular restoration and axonal remodeling in a rat model of focal cerebral ischemia. Male Sprague-Dawley rats were subjected to permanent right middle cerebral artery occlusion (MCAO) and treated with EGb 761 (60 mg/kg) or saline intragastrically once daily for 15 days starting 6 h after MCAO...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nora Hohmann, Eva M Wolf, Philippe Rigault, Wenbin Zhou, Markus Kiefer, Yunpeng Zhao, Cheng-Xin Fu, Marcus A Koch
BACKGROUND: At the end of the Pliocene and the beginning of Pleistocene glaciation and deglaciation cycles Ginkgo biloba went extinct all over the world, and only few populations remained in China in relict areas serving as sanctuary for Tertiary relict trees. Yet the status of these regions as refuge areas with naturally existing populations has been proven not earlier than one decade ago. Herein we elaborated the hypothesis that during the Pleistocene cooling periods G. biloba expanded its distribution range in China repeatedly...
April 27, 2018: BMC Genomics
Guisheng Zhou, Jiayan Ma, Yuping Tang, Xinmin Wang, Jing Zhang, Jin-Ao Duan
In the present study, the process of ultrasonic assisted enzymatic extraction (UAEE), followed by macroporous resin purification, was successfully developed to achieve maximal recovery of flavonoids and ginkgolides from Ginkgo biloba fallen leaves (GBFL). Three effective extracted factors, including UAE power, EtOH%, and the amount of cellulase were screened by Plackett⁻Burman design (PBD). The important variables were further optimized by rotatable central composite design (RCCD). After the combination of PBD and RCCD, the resulting optimal UAEE conditions were as follows: UAE power of 218 W; EtOH% of 68%; the amount of cellulase of 8...
April 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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