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"Early Cancer" AND (Gastric OR Gastro*)

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https://www.readbyqxmd.com/read/30268294/endoscopic-resection-in-the-esophagus
#1
REVIEW
Andrew F Feczko, Brian E Louie
The article is a review of the principles behind endoscopic resection of esophageal dysplasia and early cancers. The techniques of endoscopic mucosal resection and endoscopic submucosal dissection are reviewed, and the supporting literature compared. Endoscopic resection is compared with esophagectomy for the management of these lesions and current areas of controversy with regard to T1b lesions and gastroesophageal reflux following resection are addressed.
November 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/30264277/a-multicenter-retrospective-study-of-endoscopic-submucosal-tunnel-dissection-for-large-lesser-gastric-curvature-superficial-neoplasms
#2
Xing Zhang, Dongtao Shi, Zhuwen Yu, Rui Li, Weichang Chen, Feihu Bai, Xudong Wu, Cuie Cheng, Ruihua Shi, Pengfei Liu
BACKGROUND AND AIM: Endoscopic submucosal tunnel dissection (ESTD) has been used for dissection of esophageal and gastric lesions. However, outcomes of ESTD for large lesions in the lesser gastric curvature had not been acknowledged because previous reports had the limitations of being single-center studies. We aimed to clarify the outcomes of ESTD for large lesser gastric curvature superficial neoplasms and provide our experience to accelerate its application. METHODS: Between July 2014 and July 2016, 87 patients with early cancer in the lesser gastric curvature treated at six Chinese institutions were enrolled...
September 27, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30256171/comparison-of-laparoscopic-versus-open-gastrectomy-for-treatment-of-gastric-cancer-analysis-of-a-textbook-outcome
#3
Pablo Priego, Marta Cuadrado, Araceli Ballestero, Julio Galindo, Eduardo Lobo
INTRODUCTION: Open gastrectomy (OG) has long been the preferred surgical approach worldwide for treatment of gastric cancer (GC). Nowadays, several randomized prospective trials have confirmed improvements in postoperative outcomes for laparoscopic gastrectomy (LG) compared with open procedures, with similar oncologic outcomes. However, many of these studies come from Eastern countries. MATERIALS AND METHODS: A prospective nonrandomized study was conducted with all patients operated of GC at Ramón y Cajal University Hospital from January 2015 to December 2017...
September 25, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/30251300/do-pharmacists-contribute-to-patients-management-of-symptoms-suggestive-of-cancer-a-qualitative-study
#4
Frances Notman, Terry Porteous, Peter Murchie, Christine M Bond
OBJECTIVES: Limited awareness of cancer symptoms results in patient delay in seeking help and contributes to delay in diagnosis. Few UK studies have investigated the potential for community pharmacists to facilitate earlier detection of cancer. This study aimed to investigate what actions patients take to manage their early cancer symptoms, to identify the extent of current community pharmacy involvement and to consider the potential role for community pharmacists to facilitate appropriate management and appraisal of potential early cancer symptoms...
September 25, 2018: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30250534/role-of-gastroscopic-biopsy-of-gastric-ulcer-margins-and-healed-sites-in-the-diagnosis-of-early-gastric-cancer-a-clinical-controlled-study-of-513-cases
#5
Jing-Jing Wan, Su-Juan Fei, Sheng-Xiang Lv, Shu-Tang Han, Xing-Gang Ma, Dong-Sheng Xu, Hong-Mei Chen, Ju Zhang
The present case study aimed to evaluate the effect of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer. A total of 513 patients who were diagnosed with gastric ulcers using gastroscopy between January 1999 and December 2013 were included in the present study and were divided into either the experimental or the control group. In the control group, samples were only taken from the ulcer margin, whereas in the experimental group samples were taken from the ulcer margin and from the ulcer base...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30228922/early-gastric-cancer-with-purely-enteroblastic-differentiation-and-no-conventional-adenocarcinoma-component
#6
Rin Yamada, Shin-Ichiro Horiguchi, Tomoko Onishi, Toru Motoi, Tsunekazu Hishima
Gastric carcinoma with enteroblastic differentiation (GCED) is a rare variant of gastric carcinoma, and a part of GCED produces alpha-fetoprotein. GCED is characterized by cells with clear cytoplasm and a tubulopapillary and solid growth pattern resembling those in the primitive gut. GCED is typically overlaid by a conventional adenocarcinoma (CA) component, implying that CA in the mucosa differentiates into GCED during tumor invasion and proliferation. We present the case of a 73-year-old woman with a 10-mm superficial elevated lesion and a slight central depression at the anterior wall of the lower gastric body...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29937185/prognostic-impact-of-extranodal-extension-in-stage-1b-gastric-carcinomas
#7
In-Seob Lee, Hyo Jeong Kang, Young-Soo Park, Min-Hee Ryu, Jeong-Hwan Yook, Yoon-Koo Kang, Byung-Sik Kim
BACKGROUND: In addition to the TNM stage, an additional prognostic factor is needed to assess the prognosis of gastric cancer. Moreover, there is no consensus on high-risk group of recurrence and adjuvant strategy in stage 1B gastric cancers. We aimed to investigate the prognostic significance of extranodal extension (ENE) in stage 1B gastric carcinomas and assess whether ENE can indicate the need for adjuvant treatment. METHODS: The clinicopathological characteristics of 1588 patients who underwent curative gastrectomy with more than D1 plus lymphadenectomy for stage 1B gastric cancer from 2003 to 2010 were reviewed...
June 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29865257/utilizing-peptide-ligand-gpcrs-to-image-and-treat-pancreatic-cancer
#8
REVIEW
Gail L Matters, John F Harms
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016 , 13 , 74⁻75). There is an unmet need for reagents that can reliably identify early cancerous or precancerous lesions through various imaging modalities or could be employed to deliver anticancer treatments specifically to tumor cells. However, to date, many PDAC tumor-targeting strategies lack selectivity and are unable to discriminate between tumor and nontumor cells, causing off-target effects or unclear diagnoses...
June 2, 2018: Biomedicines
https://www.readbyqxmd.com/read/29736829/circulating-microrna-22-3p-predicts-the-malignant-progression-of-precancerous-gastric-lesions-from-intestinal-metaplasia-to-early-adenocarcinoma
#9
Tsung-Hsing Chen, Cheng-Tang Chiu, Chieh Lee, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Ren-Chin Wu, Ta-Sen Yeh, Kwang-Huei Lin
BACKGROUND: Gastric cancer has a poor outcome and identifying useful biomarkers from peripheral blood or tissue could allow its early detection, or potentially precancerous changes, thus improving the curative rates. MicroRNAs (miRNAs) have been shown to offer great potential in cancer diagnosis and prediction. AIM: Here, we investigated the role of plasma miRNAs in the natural course of gastric cancer, from intestinal metaplasia to early cancer. The findings were used to understand whether patients at a high risk of malignancy could be given appropriate interventions in the early disease process, such as using endoscopic submucosal dissection to treat gastric dysplasia or early gastric cancer...
May 7, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29714749/multimodality-endoscopic-optical-coherence-tomography-and-fluorescence-imaging-technology-for-visualization-of-layered-architecture-and-subsurface-microvasculature
#10
Yan Li, Joseph Jing, Junxiao Yu, Buyun Zhang, Tiancheng Huo, Qiang Yang, Zhongping Chen
Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo. This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs...
May 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29696001/the-pivotal-role-of-dna-repair-in-infection-mediated-inflammation-and-cancer
#11
REVIEW
Ayse Z Sahan, Tapas K Hazra, Soumita Das
Pathogenic and commensal microbes induce various levels of inflammation and metabolic disease in the host. Inflammation caused by infection leads to increased production of reactive oxygen species (ROS) and subsequent oxidative DNA damage. These in turn cause further inflammation and exacerbation of DNA damage, and pose a risk for cancer development. Helicobacter pylori -mediated inflammation has been implicated in gastric cancer in many previously established studies, and Fusobacterium nucleatum presence has been observed with greater intensity in colorectal cancer patients...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651511/-follow-up-care-for-gastrointestinal-tumors
#12
M Ebert
The follow-up care of patients with gastrointestinal cancer is poorly defined. Prospective trials showing that regular follow-up care is advantageous are largely lacking. Follow-up is primarily based on symptom evaluation, as well as on an assessment of nutritional status and the need for psycho-oncological care. Whereas the evidence for regular endoscopic follow-up is well defined in early cancers, the role of follow-up care in advanced cancers is less well defined. This deficit is mainly due to the lack of therapeutic consequences in the case of recurrence...
May 2018: Der Internist
https://www.readbyqxmd.com/read/29620969/clinical-analysis-of-endoscopic-submucosal-dissection-for-the-synchronous-multiple-primary-early-cancers-in-esophagus-and-stomach-12-cases-report
#13
Qiang Shi, Di Sun, Shi-Lun Cai, Mei-Dong Xu, Zhi-Peng Qi, Bing Li, Li-Qing Yao, Yun-Shi Zhong, Ping-Hong Zhou
OBJECTIVE: With the improvement of endoscopic diagnosis, the discovery rate of the synchronous multiple primary early cancers in esophagus and stomach is gradually increased, while the traditional surgery bringing serious damages. Endoscopic submucosal dissection (ESD) has become the first treatment option of early cancer in the digestive tract partly. This study intends to explore the feasibility, safety, and effectiveness of ESD in the treatment of the synchronous multiple early gastric cancer or precancerous lesions in the esophagus and stomach...
September 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29574700/genome-wide-profiling-of-normal-gastric-mucosa-identifies-helicobacter-pylori-and-cancer-associated-dna-methylome-changes
#14
Hae Dong Woo, Nora Fernandez-Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young-Il Kim, Jeongseon Kim, Zdenko Herceg
The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with cancer risk independent of H. pylori. A discovery set of normal gastric mucosa from GC cases (n = 42) and controls (n = 42), nested in a large case-control study and stratified by H. pylori status, were subjected to genome-wide methylation profiling...
August 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29572630/effect-of-premedication-on-lesion-detection-rate-and-visualization-of-the-mucosa-during-upper-gastrointestinal-endoscopy-a-multicenter-large-sample-randomized-controlled-double-blind-study
#15
X Liu, C T Guan, L Y Xue, S He, Y M Zhang, D L Zhao, Y Li, F G Liu, J Li, Y F Liu, A S Ling, W Q Wei, G Q Wang
BACKGROUND: Premedication in upper gastrointestinal endoscopy for higher lesions detection rate has not been well studied so far. This study aimed to confirm whether premedication could improve the detection rate of early cancer or precancerous lesions and mucosal visibility. METHOD: From July 2015 to December 2015, 7200 participants from 6 centers were screened by endoscopy with one of the 4 following premedications randomly: (1) water (group D); (2) pronase (group A); (3) simethicone (group B); (4) pronase and simethicone (group C)...
August 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29572531/cross-platform-mass-spectrometry-annotation-in-breathomics-of-oesophageal-gastric-cancer
#16
Sung-Tong Chin, Andrea Romano, Sophie L F Doran, George B Hanna
Disease breathomics is gaining importance nowadays due to its usefulness as non-invasive early cancer detection. Mass spectrometry (MS) technique is often used for analysis of volatile organic compounds (VOCs) associated with cancer in the exhaled breath but a long-standing challenge is the uncertainty in mass peak annotation for potential volatile biomarkers. This work describes a cross-platform MS strategy employing selected-ion flow tube mass spectrometry (SIFT-MS), high resolution gas chromatography-mass spectrometry (GC-MS) retrofitted with electron ionisation (EI) and GC-MS retrofitted with positive chemical ionisation (PCI) as orthogonal analytical approaches in order to provide facile identification of the oxygenated VOCs from breath of cancer patients...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29567564/simultaneous-detection-of-gastric-cancer-involved-mir-106a-and-let-7a-through-a-dual-signal-marked-electrochemical-nanobiosensor
#17
Maryam Daneshpour, Behzad Karimi, Kobra Omidfar
miRNAs are among the novel biomarkers that can be evaluated for sensitive and early cancer diagnosis. In the present study, an electrochemical nanobiosensor has been fabricated to detect two gastric cancer (GC) related miRNAs simultaneously. By employing Au nanoparticles- and CdSe@CdS quantum dots-contained magnetic nanocomposites as electrochemical labels along with the polythiophene/reduced graphene oxide-modified carbon electrodes, this dual signal nanobiosensor showed a considerable performance in quantifying miR-106a (a GC oncogenic miRNA) and let-7a (a GC tumor suppressor miRNA)...
June 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29535809/circulating-microrna-196a-is-an-early-gastric-cancer-biomarker
#18
Tsung-Hsing Chen, Chieh Lee, Cheng-Tang Chiu, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Yung-Kuan Tsou, Ren-Chin Wu, Tse-Ching Chen, Nien-Chen Chang, Ta-Sen Yeh, Kwang-Huei Lin
MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29486200/endoscopic-submucosal-dissection-indications-and-application-in-western-endoscopy-practice
#19
REVIEW
Michael J Bourke, Horst Neuhaus, Jacques J Bergman
Endoscopic submucosal dissection was developed in Japan, early in this century, to provide a minimally invasive yet curative treatment for the large numbers of patients with early gastric cancer identified by the national screening program. Previously, the majority of these patients were treated surgically at substantial cost and with significant risk of short- and long-term morbidity. En-bloc excision of these early cancers, most with a limited risk of nodal metastasis, allowed complete staging of the tumor, stratification of the subsequent therapeutic approach, and potential cure...
May 2018: Gastroenterology
https://www.readbyqxmd.com/read/29464866/biliary-stricture-due-to-a-migrated-suture-after-laparoscopic-distal-gastrectomy
#20
Takehiro Noji, Yo Kurashima, Yoshitsugu Nakanishi, Toshimichi Asano, Yuma Ebihara, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
Benign biliary strictures have a broad spectrum of etiologies. There have been no reported cases, however, of a biliary stricture secondary to a migrated suture after laparoscopic distal gastrectomy (LDG). Here, we report one such case. The patient was a 60-year-old man who underwent LDG with Roux-en-Y reconstruction for early gastric cancer. Pathology revealed early cancer (T1N0M0) with a curative resection. Two years after LDG, the patient was found to have elevated hepatobiliary enzymes. After further workup, the new diagnosis was invasive cholangiocarcinoma (T2N0M0), and the patient underwent pancreaticoduodenectomy...
February 20, 2018: Asian Journal of Endoscopic Surgery
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