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"Early Cancer" AND (Gastric OR Gastro*)

In-Seob Lee, Hyo Jeong Kang, Young-Soo Park, Min-Hee Ryu, Jeong-Hwan Yook, Yoon-Koo Kang, Byung-Sik Kim
BACKGROUND: In addition to the TNM stage, an additional prognostic factor is needed to assess the prognosis of gastric cancer. Moreover, there is no consensus on high-risk group of recurrence and adjuvant strategy in stage 1B gastric cancers. We aimed to investigate the prognostic significance of extranodal extension (ENE) in stage 1B gastric carcinomas and assess whether ENE can indicate the need for adjuvant treatment. METHODS: The clinicopathological characteristics of 1588 patients who underwent curative gastrectomy with more than D1 plus lymphadenectomy for stage 1B gastric cancer from 2003 to 2010 were reviewed...
June 2018: Surgical Oncology
Gail L Matters, John F Harms
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016 , 13 , 74⁻75). There is an unmet need for reagents that can reliably identify early cancerous or precancerous lesions through various imaging modalities or could be employed to deliver anticancer treatments specifically to tumor cells. However, to date, many PDAC tumor-targeting strategies lack selectivity and are unable to discriminate between tumor and nontumor cells, causing off-target effects or unclear diagnoses...
June 2, 2018: Biomedicines
Tsung-Hsing Chen, Cheng-Tang Chiu, Chieh Lee, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Ren-Chin Wu, Ta-Sen Yeh, Kwang-Huei Lin
BACKGROUND: Gastric cancer has a poor outcome and identifying useful biomarkers from peripheral blood or tissue could allow its early detection, or potentially precancerous changes, thus improving the curative rates. MicroRNAs (miRNAs) have been shown to offer great potential in cancer diagnosis and prediction. AIM: Here, we investigated the role of plasma miRNAs in the natural course of gastric cancer, from intestinal metaplasia to early cancer. The findings were used to understand whether patients at a high risk of malignancy could be given appropriate interventions in the early disease process, such as using endoscopic submucosal dissection to treat gastric dysplasia or early gastric cancer...
May 7, 2018: Digestive Diseases and Sciences
Yan Li, Joseph Jing, Junxiao Yu, Buyun Zhang, Tiancheng Huo, Qiang Yang, Zhongping Chen
Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo. This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs...
May 1, 2018: Optics Letters
Ayse Z Sahan, Tapas K Hazra, Soumita Das
Pathogenic and commensal microbes induce various levels of inflammation and metabolic disease in the host. Inflammation caused by infection leads to increased production of reactive oxygen species (ROS) and subsequent oxidative DNA damage. These in turn cause further inflammation and exacerbation of DNA damage, and pose a risk for cancer development. Helicobacter pylori -mediated inflammation has been implicated in gastric cancer in many previously established studies, and Fusobacterium nucleatum presence has been observed with greater intensity in colorectal cancer patients...
2018: Frontiers in Microbiology
M Ebert
The follow-up care of patients with gastrointestinal cancer is poorly defined. Prospective trials showing that regular follow-up care is advantageous are largely lacking. Follow-up is primarily based on symptom evaluation, as well as on an assessment of nutritional status and the need for psycho-oncological care. Whereas the evidence for regular endoscopic follow-up is well defined in early cancers, the role of follow-up care in advanced cancers is less well defined. This deficit is mainly due to the lack of therapeutic consequences in the case of recurrence...
May 2018: Der Internist
Qiang Shi, Di Sun, Shi-Lun Cai, Mei-Dong Xu, Zhi-Peng Qi, Bing Li, Li-Qing Yao, Yun-Shi Zhong, Ping-Hong Zhou
OBJECTIVE: With the improvement of endoscopic diagnosis, the discovery rate of the synchronous multiple primary early cancers in esophagus and stomach is gradually increased, while the traditional surgery bringing serious damages. Endoscopic submucosal dissection (ESD) has become the first treatment option of early cancer in the digestive tract partly. This study intends to explore the feasibility, safety, and effectiveness of ESD in the treatment of the synchronous multiple early gastric cancer or precancerous lesions in the esophagus and stomach...
April 5, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hae Dong Woo, Nora Fernandez-Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young-Il Kim, Jeongseon Kim, Zdenko Herceg
The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with cancer risk independent of H. pylori. A discovery set of normal gastric mucosa from GC cases (n = 42) and controls (n = 42), nested in a large case-control study and stratified by H. pylori status, were subjected to genome-wide methylation profiling...
August 1, 2018: International Journal of Cancer. Journal International du Cancer
X Liu, C T Guan, L Y Xue, S He, Y M Zhang, D L Zhao, Y Li, F G Liu, J Li, Y F Liu, A S Ling, W Q Wei, G Q Wang
BACKGROUND: Premedication in upper gastrointestinal endoscopy for higher lesions detection rate has not been well studied so far. This study aimed to confirm whether premedication could improve the detection rate of early cancer or precancerous lesions and mucosal visibility. METHOD: From July 2015 to December 2015, 7200 participants from 6 centers were screened by endoscopy with one of the 4 following premedications randomly: (1) water (group D); (2) pronase (group A); (3) simethicone (group B); (4) pronase and simethicone (group C)...
August 2018: Surgical Endoscopy
Sung-Tong Chin, Andrea Romano, Sophie L F Doran, George B Hanna
Disease breathomics is gaining importance nowadays due to its usefulness as non-invasive early cancer detection. Mass spectrometry (MS) technique is often used for analysis of volatile organic compounds (VOCs) associated with cancer in the exhaled breath but a long-standing challenge is the uncertainty in mass peak annotation for potential volatile biomarkers. This work describes a cross-platform MS strategy employing selected-ion flow tube mass spectrometry (SIFT-MS), high resolution gas chromatography-mass spectrometry (GC-MS) retrofitted with electron ionisation (EI) and GC-MS retrofitted with positive chemical ionisation (PCI) as orthogonal analytical approaches in order to provide facile identification of the oxygenated VOCs from breath of cancer patients...
March 23, 2018: Scientific Reports
Maryam Daneshpour, Behzad Karimi, Kobra Omidfar
miRNAs are among the novel biomarkers that can be evaluated for sensitive and early cancer diagnosis. In the present study, an electrochemical nanobiosensor has been fabricated to detect two gastric cancer (GC) related miRNAs simultaneously. By employing Au nanoparticles- and CdSe@CdS quantum dots-contained magnetic nanocomposites as electrochemical labels along with the polythiophene/reduced graphene oxide-modified carbon electrodes, this dual signal nanobiosensor showed a considerable performance in quantifying miR-106a (a GC oncogenic miRNA) and let-7a (a GC tumor suppressor miRNA)...
June 30, 2018: Biosensors & Bioelectronics
Tsung-Hsing Chen, Chieh Lee, Cheng-Tang Chiu, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Yung-Kuan Tsou, Ren-Chin Wu, Tse-Ching Chen, Nien-Chen Chang, Ta-Sen Yeh, Kwang-Huei Lin
MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls...
February 13, 2018: Oncotarget
Michael J Bourke, Horst Neuhaus, Jacques J Bergman
Endoscopic submucosal dissection was developed in Japan, early in this century, to provide a minimally invasive yet curative treatment for the large numbers of patients with early gastric cancer identified by the national screening program. Previously, the majority of these patients were treated surgically at substantial cost and with significant risk of short- and long-term morbidity. En-bloc excision of these early cancers, most with a limited risk of nodal metastasis, allowed complete staging of the tumor, stratification of the subsequent therapeutic approach, and potential cure...
May 2018: Gastroenterology
Takehiro Noji, Yo Kurashima, Yoshitsugu Nakanishi, Toshimichi Asano, Yuma Ebihara, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
Benign biliary strictures have a broad spectrum of etiologies. There have been no reported cases, however, of a biliary stricture secondary to a migrated suture after laparoscopic distal gastrectomy (LDG). Here, we report one such case. The patient was a 60-year-old man who underwent LDG with Roux-en-Y reconstruction for early gastric cancer. Pathology revealed early cancer (T1N0M0) with a curative resection. Two years after LDG, the patient was found to have elevated hepatobiliary enzymes. After further workup, the new diagnosis was invasive cholangiocarcinoma (T2N0M0), and the patient underwent pancreaticoduodenectomy...
February 20, 2018: Asian Journal of Endoscopic Surgery
B Märkl, B Martin
BACKGROUND: Early stage cancers of the gastrointestinal tract are malignant tumors that are eligible for local therapy regimens and show an excellent prognosis. OBJECTIVE: This article explains the histopathological aspects of the various diseases that are covered by this topic. METHODS: Organ-preserving therapies are discussed according to their locations and under consideration of the current guidelines and the relevant literature. RESULTS: The exact histopathological evaluation of early cancers of the gastrointestinal tract is of crucial importance...
May 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Hiroyuki Kato, Hiroyuki Ono, Yasuo Hamamoto, Hitoshi Ishikawa
Recently, endoscopic diagnosis and treatment methods for early cancer in the digestive tract have made rapid progress. As for surgery, laparoscopic and thoracoscopic techniques have achieved rapidly advancing development in the last 2 decades. Early detection of the malignant lesion and the evolution of endoscopic and surgical device enabled in performing the minimally invasive surgery. Collaboration of medical treatment and minimally invasive surgery for advanced cancer is ongoing in the case of some conditions and in a few institutes...
2018: Digestion
Aisha Sooltangos, Matthew Davenport, Stephen McGrath, Jonathan Vickers, Siba Senapati, Kurshid Akhtar, Regi George, Yeng Ang
AIM: To investigate the efficacy of endoscopic submucosal dissection (ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a United Kingdom Caucasian population. METHODS: Data of patients treated with or considered for ESD at a tertiary referral center in the United Kingdom were retrieved for a period of 2 years (May 2015 to June 2017) from the electronic patient records of the hospital. Only Caucasian patients were included. Primary outcomes were curative resection (CR) and were defined as ESD resections with clear horizontal and vertical margin and an absence of lympho-vascular invasion, poor differentiation and submucosal involvement on histological evaluation of the resected specimen...
December 16, 2017: World Journal of Gastrointestinal Endoscopy
Ricardo G Pastorello, Mariana Petaccia de Macedo, Wilson Luiz da Costa Junior, Maria Dirlei F S Begnami
The Roux-en-Y gastric bypass is one of the most common procedures currently performed for surgical treatment of patients with severe obesity. Gastric cancer after bariatric surgery is not common, with most of them arising in the excluded stomach. Gastric mixed adenoneuroendocrine carcinomas are a rare type of stomach malignancy, composed of both adenocarcinoma and neuroendocrine tumor-cell components, with the latter comprising at least 30% of the whole neoplasm. In this article, we report a unique case of a mixed adenoneuroendocrine carcinoma with a mixed adenocarcinoma (tubular and poorly cohesive) component arising in the gastric pouch of a patient who underwent previous Roux-en-Y gastric bypass for glycemic control...
October 2017: Journal of Investigative Medicine High Impact Case Reports
Ying-Jie Xia, Xiao-Ting Jiang, Shi-Bin Jiang, Xu-Jun He, Jun-Gang Luo, Zheng-Chuang Liu, Liang Wang, Hou-Quan Tao, Jian-Zhong Chen
Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association between PHD3 expression and the clinicopathological features of gastric cancer using reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. The effects of PHD3 in gastric cancer cell lines were assessed using western blot analysis and transwell migration assays. The present results revealed that PHD3 expression was increased in adjacent non‑cancerous tissue compared with in gastric cancer tissue, and PHD3 overexpression was correlated with the presence of well‑differentiated cancer cells, early cancer stage classification and the absence of lymph node metastasis...
November 2017: Molecular Medicine Reports
Michael X Ma, Michael J Bourke
Endoscopic submucosal dissection (ESD) was first conceptually described almost 30 years ago in Japan and is now widely practiced throughout East Asia. ESD expands the boundaries of endoscopic resection (ER) by allowing en bloc resection of large early neoplastic lesions within the gastrointestinal tract (GIT). This offers advantages over other ER techniques by facilitating definitive histological staging and curative treatment of early cancer in selected cases. Indeed, the experience of ESD in Eastern countries is significant, and excellent outcomes from high-volume centers are reported...
May 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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