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Myocardial ischemia and infarction

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https://www.readbyqxmd.com/read/30517389/clinical-epidemiological-aspects-of-patients-submitted-to-percutaneous-coronary-intervention-in-a-university-hospital
#1
Maria Solange Moreira de Lima, Rodrigo Assis Neves Dantas, Neyse Patrícia do Nascimento Mendes, Louise Constância de Melo Alves, Tamara Taynah Medeiros da Silva, Andréa Gomes da Rocha Brito, Daniele Vieira Dantas
OBJECTIVE: To outline the clinical-epidemiological profile of patients submitted to Percutaneous Coronary Intervention in a Reference Hospital in Urgent Cardiology Clinic of the state of Rio Grande do Norte. METHOD: This is a descriptive, exploratory, prospective study with a quantitative approach developed in a Brazilian University Hospital with patients submitted to Percutaneous Coronary Intervention. Data collection occurred between April and October 2017. RESULTS: The sample consisted of 222 patients, of whom 58...
November 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/30517374/the-prognostic-value-and-clinical-use-of-myocardial-perfusion-scintigraphy-in-asymptomatic-patients-after-percutaneous-coronary-intervention
#2
Larissa Franco de Andrade, Ana Carolina Souza, Thais Peclat, Caio Bartholo, Thalita Pavanelo, Ronaldo de Souza Leão Lima
BACKGROUND: The role of myocardial perfusion scintigraphy (MPS) in the follow-up of asymptomatic patients after percutaneous coronary intervention (PCI) is not established. OBJECTIVES: To evaluate the prognostic value and clinical use of MPS in asymptomatic patients after PCI. METHODS: Patients who underwent MPS consecutively between 2008 and 2012 after PCI were selected. The MPS were classified as normal and abnormal, the perfusion scores, summed stress score (SSS), and summed difference score (SDS) were calculated and converted into percentage of total perfusion defect and ischemic defect...
December 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/30517239/the-artery-of-mouchet-blood-supply-of-the-septomarginal-trabecula-in-50-human-hearts
#3
Carlos Chagas, Lucas Pires, Tulio Leite, Marcio Babinski
The septomarginal trabecula is a muscular structure which transmits the right branch of the atrioventricular bundle. It is usually supplied by a branch from the second anterior septal artery. Anastomoses between the right and left coronary arteries may happen on the septomarginal trabecula. They are of great significance in order to prevent ischemia during a myocardial infarction. Surgeries such as Konno's and Ross' procedures implies in knowledge of these vessels anatomy. The coronary arteries of 50 human hearts were injected with latex and subsequentely dissected with the purpose of identifying the arterial branch that supplied the septomarginal trabecula...
October 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30516526/is-there-a-gender-gap-in-secondary-prevention-of-coronary-artery-disease-in-turkey
#4
Duygu Koçyiğit, Lale Tokgözoğlu, Meral Kayıkçıoğlu, Servet Altay, Sinan Aydoğdu, Cem Barçın, Cem Bostan, Hüseyin Altuğ Çakmak, Alp Burak Çatakoğlu, Samim Emet, Oktay Ergene, Ali Kemal Kalkan, Barış Kaya, Cansın Kaya, Cihangir Kaymaz, Nevrez Koylan, Hakan Kültürsay, Aytekin Oğuz, Ebru Özpelit, Serkan Ünlü
OBJECTIVE: It has been reported that women receive fewer preventive recommendations regarding pharmacological treatment, lifestyle modifications, and cardiac rehabilitation compared with men who have a similar risk profile. This study was an investigation of the impact of gender on cardiovascular risk profile and secondary prevention measures for coronary artery disease (CAD) in the Turkish population. METHODS: Statistical analyses were based on the European Action on Secondary and Primary Prevention through Intervention to Reduce Events (EUROASPIRE)-IV cross-sectional survey data obtained from 17 centers in Turkey...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/30516280/melatonin-attenuates-myocardial-ischemia-reperfusion-injury-via-improving-mitochondrial-fusion-mitophagy-and-activating-the-ampk-opa1-signaling-pathways
#5
Ying Zhang, Yue Wang, Junnan Xu, Feng Tian, Shunying Hu, Yundai Chen, Zhenhong Fu
Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial stress in the setting of cardiac ischemia reperfusion (I/R) injury. Our results indicated that OPA1, mitochondrial fusion and mitophagy were significantly repressed by I/R injury, accompanied by infarction area expansion, heart dysfunction, myocardial inflammation, and cardiomyocyte oxidative stress...
December 5, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/30513423/impact-of-summer-season-on-pre-hospital-time-delays-in-women-and-men-undergoing-primary-percutaneous-coronary-intervention
#6
Caroline E Gebhard, Catherine Gebhard, Foued Maafi, Marie-Jeanne Bertrand, Barbara E Stähli, Monika Maredziak, Susan Bengs, Ahmed Haider, Zheng W Zhang, David C Smith, Hung Q Ly
BACKGROUND: Pre-hospital delays have been associated with poor outcomes in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). It is currently unknown how environmental variables affect treatment delays in these patients. METHODS AND RESULTS: The association between environmental variables, time to treatment including transportation times and adverse in-hospital events was assessed in 1828 consecutive patients with STEMI undergoing primary PCI between 2010 and 2014 in the Montreal metropolitan area...
November 26, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30507935/weight-cycling-and-cardiovascular-outcome-in-women-with-suspected-ischemia-a-report-from-the-nhlbi-sponsored-wise-study
#7
C Noel Bairey Merz, Marian B Olson, Sheryl F Kelsey, Vera Bittner, Steven E Reis, Nathaniel Reichek, Eileen Handberg
BACKGROUND: We previously reported in a cross-sectional analysis an adverse relationship between weight cycling and HDL-cholesterol but not angiographic obstructive coronary artery disease (CAD) among women undergoing coronary angiography for suspected ischemia in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE). We now examine the relationship between weight cycling and prospective adverse cardiovascular outcome in this group. METHODS: 795 women enrolled between 1996-2001 in the WISE undergoing coronary angiography for evaluation of suspected ischemia and followed for a median of 6...
2018: PloS One
https://www.readbyqxmd.com/read/30504832/pretreatment-with-total-flavonoid-extract-from-dracocephalum-moldavica-l-attenuates-ischemia-reperfusion-induced-apoptosis
#8
Cheng Zeng, Wen Jiang, Xiaoyi Yang, Chenghui He, Wen Wang, Jianguo Xing
We previously demonstrated the cardio-protection mediated by the total flavonoid extracted from Dracocephalum moldavica L. (TFDM) following myocardial ischemia reperfusion injury (MIRI). The present study assessed the presence and mechanism of TFDM-related cardio-protection on MIRI-induced apoptosis in vivo. Male Sprague-Dawley rats experienced 45-min ischemia with 12 h of reperfusion. Rats pretreated with TFDM (3, 10 or 30 mg/kg/day) were compared with Sham (no MIRI and no TFDM), MIRI (no TFDM), and Positive (trapidil tablets, 13...
November 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30500639/association-between-perioperative-fibrinogen-levels-and-mid-term-outcome-in-patients-undergoing-elective-endovascular-repair-of-abdominal-aortic-aneurysms
#9
Dimitrios Kapetanios, Christos D Karkos, Ioannis Pliatsios, Maria Mitka, Ioakeim T Giagtzidis, Konstantinos Konstantinidis, Konstantinos O Papazoglou
BACKGROUND: We investigated the potential association between perioperative fibrinogen levels and outcome in patients undergoing elective endovascular repair (EVAR) of abdominal aortic aneurysms (AAAs). METHODS: Consecutive patients with an intact AAA undergoing elective EVAR with a specific bifurcated endograft (ENDURANT, MEDTRONIC) were recruited between December 2012 and October 2016. Preoperative and 24-hour postoperative fibrinogen levels were recorded and potential associations with outcome were tested...
November 27, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30499878/pharmacological-inhibition-of-pten-restores-remote-ischemic-postconditioning-cardioprotection-in-hypercholesterolemic-mice-potential-role-of-pten-akt-gsk3%C3%AE-signals
#10
Jun Hong, Hong-Wei Ge, Jing-Quan Liu, Ren-Hua Sun, Fei-Juan Kong
Although remote ischemic postconditioning (RIPC) was shown to confer cardioprotection against myocardial ischemia/reperfusion (I/R) injury in normal animals, whether RIPC-induced cardioprotection are altered in the presence of hypercholesterolemia, a comorbidity with acute myocardial infarction (AMI) patients, has yet to be determined. Normal or 2% cholesterol chow was fed to male C57BL/6J mice for 12 weeks to induce hypercholesterolemia, then normal or hypercholesterolemic murine hearts were exposed to AMI by coronary artery ligation...
November 28, 2018: Shock
https://www.readbyqxmd.com/read/30498333/asiatic-acid-protests-against-myocardial-ischemia-reperfusion-injury-via-modulation-of-glycometabolism-in-rat-cardiomyocyte
#11
Yang Dai, Ziwei Wang, Minxue Quan, Yanni Lv, Yunman Li, Hong-Bo Xin, Yisong Qian
Background: Asiatic acid is a reported glycogen phosphorylase inhibitor derived from the tropical medicinal plant Centella asiatica and exhibits myocardial protection both in vivo and in vitro. The purpose of this study was to evaluate the effects of asiatic acid on myocardial ischemia/reperfusion (MI/R) injury and investigate the underlying mechanisms associated with the modulation of glycometabolism in cardiomyocyte. Materials and methods: The rats were subjected to MI/R with or without asiatic acid pretreatment...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/30496354/endothelial-and-cardiomyocyte-pi3k%C3%AE-divergently-regulate-cardiac-remodeling-in-response-to-ischemic-injury
#12
Xueyi Chen, Pavel Zhabyeyev, Abul K Azad, Wang Wang, Rachel A Minerath, Jessica DesAulniers, Chad E Grueter, Allan G Murray, Zamaneh Kassiri, Bart Vanhaesebroeck, Gavin Y Oudit
Aims: Cardiac remodeling in the ischemic heart determines prognosis in patients with ischemic heart disease (IHD), while enhancement of angiogenesis and cell survival has shown great potential for IHD despite translational challenges. Phosphoinositide 3-kinase (PI3K)/Akt signaling pathway plays a critical role in promoting angiogenesis and cell survival. However, the effect of PI3Kβ in the ischemic heart is poorly understood. This study investigates the role of endothelial and cardiomyocyte PI3Kβ in post-infarct cardiac remodeling...
November 28, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30487989/severe-hypocalcemia-mimicking-acute-inferior-st-segment-elevation-myocardial-infarction
#13
Muhammad Y Adeel, John-Ross D Clarke, Safal Shetty, Ashish Arora, Michael G Buscher
We report the case of a 52-year-old gentleman, admitted to the medical intensive care unit with multiple organ system dysfunction due to acute severe pancreatitis. He was found to have severe hypocalcemia, bradycardia and an electrocardiogram (EKG) showing ST-segment elevation in infero-lateral leads. The patient was treated with intravenous calcium gluconate with prompt improvement of heart rate and reversal of EKG changes. Subsequent evaluation for myocardial ischemia was negative. We believe the EKG changes mimicking acute ST-segment elevation myocardial infarction were due to severe hypocalcemia...
December 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/30485489/the-%C3%AE-subunit-of-soluble-guanylyl-cyclase-gucy1b3-exerts-cardioprotective-effects-against-ischemic-injury-via-the-pkc%C3%AE%C2%B5-akt-pathway
#14
Xiaomin Wang, Wei Du, Meng Li, Yong Zhang, Hongyu Li, Kai Sun, Jianping Liu, Pengxia Dong, Xianda Meng, Wensi Yi, Liu Yang, Ruiping Zhao, Jiang Hu
The soluble form of guanylyl cyclase (sGC) is the main receptor for the signaling agent nitric oxide (NO), which regulates cardiomyocyte contractile function and attenuates cardiomyocyte hypertrophy. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), a regulator of vascular tone, and cardiac NO-sGC-cGMP signaling modulates cardiac stress responses, including ischemia and reperfusion (IR) injury. Here, we investigated the role of GUCY1B3 (the β subunit of sGC) in cardiomyocyte IR injury and myocardial infarction (MI) in vitro and in vivo...
November 28, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30485429/the-novel-relationship-between-sirt3-and-autophagy-in-myocardial-ischemia-reperfusion
#15
REVIEW
Yitian Zheng, Binhao Shi, Mengqing Ma, Xiaoqin Wu, Xianhe Lin
Class III histone deacetylases (HDACs) belong to the proteasome family, comprising seven family members identified in mammalian cells, identified Sirt1-Sirt7. As an important member of HDACs, Sirt3 is hotly debated for its multiple functions. It was reported that Sirt3 got involved in the alleviation of multiple diseases, including myocardial infarction, neuron ischemia, hypertrophy, and diabetic myopathy. Through regulating many cellular mechanisms, such as apoptosis, autophagy, and clearance of reactive oxygen species (ROS), Sirt3 played an important role in the alleviation of myocardial ischemia-reperfusion injury...
November 28, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30482637/the-prognostic-value-of-coronary-flow-velocity-reserve-in-two-coronary-arteries-during-vasodilator-stress-echocardiography
#16
Lauro Cortigiani, Fausto Rigo, Francesco Bovenzi, Rosa Sicari, Eugenio Picano
BACKGROUND: Vasodilator stress echocardiography (SE) allows combined evaluation of regional wall motion and Doppler coronary flow velocity reserve (CFVR) of both the left anterior descending coronary artery (LAD) and the right coronary artery (RCA). The aim of this study was to prospectively assess the prognostic correlates of LAD and RCA CFVR on SE. METHODS: A total of 1,365 patients with known or suspected coronary artery disease underwent dipyridamole SE with combined evaluation of CFVR in both the LAD and the RCA...
October 25, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/30481260/atorvastatin-protects-cardiac-progenitor-cells-from-hypoxia-induced-cell-growth-inhibition-via-meg3-mir-22-hmgb1-pathway
#17
Jinwen Su, Ming Fang, Bei Tian, Jun Luo, Can Jin, Xuejun Wang, Zhongping Ning, Xinming Li
Heart failure (HF) induced by ischemia myocardial infarction (MI) is one of the major causes of morbidity and mortality all around the world. Atorvastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, has been demonstrated to benefit patients with ischemic or non-ischemic-induced HF, but the mechanism is still poorly understood. Increasing evidence indicates that lncRNAs play important role in variety of human disease. However, the role and underlying molecular mechanisms remain largely unclear. In our work, we applied 0...
November 27, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30477987/the-relationship-between-visfatin-and-cardiac-markers-on-induced-myocardial-infarction-in-rats
#18
Mehmet Erten, İclal Geyikli Çimenci, Tuncay Kuloğlu, Mehmet Kalaycı, Füsun Erten
Myocardial infarction (MI) is one of the most important reason of mortality into worldwide. Visfatin is a novel adipokine which was reported increased in metabolic syndrome and obesity. Moreover, it is known that visfatin increases in aterosclerotic endotelial dysfunction. In our study we want to demonstrate how visfatin changes in isoproterenol (ISO) induced MI. Rats were allocated into 4 groups in which each group included 6 rats in this study. 200 mg/kg ISO was administered into rats except control group to induce MI...
November 23, 2018: Cytokine
https://www.readbyqxmd.com/read/30474396/the-protective-effects-of-preconditioning-with-dioscin-on-myocardial-ischemia-reperfusion-induced-ventricular-arrhythmias-by-increasing-connexin-43-expression-in-rats
#19
Jin Cheng, Chuang Sun, Jingyu Zhang, Qing Zou, Qimeng Hao, Yugang Xue
Myocardial ischemia-reperfusion (IR) injury is associated with high disability and mortality worldwide. This study was to explore the roles of dioscin in the myocardial IR rats and discover the related molecular mechanisms. Rats were divided into 5 groups: sham, IR, IR + 15 mg/kg dioscin, IR + 30 mg/kg dioscin, and IR + 60 mg/kg dioscin. Heart rate (HR), mean arterial blood pressure (MAP), and rate pressure product (RPP) were evaluated at 10 minutes before ischemia, immediately after ischemia, and at the beginning, middle, and end of reperfusion...
November 26, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30473889/acute-pancreatitis-mimicking-st-segment-elevation-myocardial-infarction
#20
Akanksha Agrawal, Nuzhat Sayyida, Jorge Luis Penalver, Mary R Ziccardi
Introduction: Electrocardiographic changes imitating myocardial ischemia have been occasionally reported in patients with intra-abdominal pathology including acute pancreatitis. Case Report: A 60-year-old man with no past medical history presented to the emergency department (ED) after a syncopal episode. In ED, his vitals were stable. His ECG showed sinus bradycardia at 53 beats per minute, peaked T waves, 1 mm ST-segment elevation in leads II, III, and aVF, and 2 mm ST elevation in V3 as shown in the figures...
2018: Case Reports in Cardiology
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