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https://www.readbyqxmd.com/read/28797065/a-systematic-review-of-the-pharmacokinetic-and-pharmacodynamic-interactions-of-herbal-medicine-with-warfarin
#1
Songie Choi, Dal-Seok Oh, Ui Min Jerng
OBJECTIVES: The aim of this study was to systematically review data regarding pharmacokinetic (PK)-pharmacodynamic (PD) parameters from randomized controlled trials relating to interactions between herbal medicines and warfarin. METHODS: Three electronic databases were searched to identify relevant trials. Two reviewers independently performed the study selection and data extraction. The risk of bias and reporting quality were also assessed independently by two reviewers using the Cochrane risk of bias tool and the consolidated standards of reporting trials (CONSORT)...
2017: PloS One
https://www.readbyqxmd.com/read/28762712/common-herbal-dietary-supplement-drug-interactions
#2
REVIEW
Gary N Asher, Amanda H Corbett, Roy L Hawke
Nearly 25% of U.S. adults report concurrently taking a prescription medication with a dietary supplement. Some supplements, such as St. John's wort and goldenseal, are known to cause clinically important drug interactions and should be avoided by most patients receiving any pharmacologic therapy. However, many other supplements are predicted to cause interactions based only on in vitro studies that have not been confirmed or have been refuted in human clinical trials. Some supplements may cause interactions with a few medications but are likely to be safe with other medications (e...
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28761777/antimicrobial-activities-of-widely-consumed-herbal-teas-alone-or-in-combination-with-antibiotics-an-in-vitro-study
#3
Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, Gulten Otuk
BACKGROUND: Because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. We examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, methicillin susceptible/resistant Staphylococcus aureus and Candida albicans...
2017: PeerJ
https://www.readbyqxmd.com/read/28731887/risk-of-anaphylaxis-in-complementary-and-alternative-medicine
#4
Natasha C Gunawardana
PURPOSE OF REVIEW: Complementary and alternative medicine (CAM) use is widespread across the world. Patients with asthma and allergy regularly use CAM therapies. Allergic and anaphylactic reactions to CAM have been reported. RECENT FINDINGS: Recent attempts to regulate and monitor adverse reaction to these therapies have given us further insight into potential causes of severe allergic reactions. Several culprits identified including Andrographis paniculata, Echinacea species, bee products, Ginkgo biloba and Ginseng are discussed here...
July 20, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28652934/phytochemical-rich-medicinal-plant-extracts-suppress-bacterial-antigens-induced-inflammation-in-human-tonsil-epithelial-cells
#5
Niluni M Wijesundara, Satvir Sekhon-Loodu, Hp Vasantha Rupasinghe
BACKGROUND: Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives to conventional drugs. This study evaluated anti-inflammatory activity of phytochemical-rich extracts prepared from 12 herbal plants using human tonsil epithelial cells (HTonEpiC) in vitro. METHODS: The HTonEpiC were induced by a mixture of lipoteichoic acid (LTA) and peptidoglycan (PGN) (10 µg/mL; bacterial antigens) for 4 h and then exposed to ethanol extracts (EE) or aqueous extracts (AE) for 20 h...
2017: PeerJ
https://www.readbyqxmd.com/read/28642378/new-genome-sequence-of-an-echinaceapurpurea-endophyte-arthrobacter-sp-strain-epsl27-able-to-inhibit-human-opportunistic-pathogens
#6
Elisangela Miceli, Luana Presta, Valentina Maggini, Marco Fondi, Emanuele Bosi, Carolina Chiellini, Camilla Fagorzi, Patrizia Bogani, Vincenzo Di Pilato, Gian Maria Rossolini, Alessio Mengoni, Fabio Firenzuoli, Elena Perrin, Renato Fani
We announce here the draft genome sequence of Arthrobacter sp. strain EpSL27, isolated from the stem and leaves of the medicinal plant Echinacea purpurea and able to inhibit human-pathogenic bacterial strains. The genome sequencing of this strain may lead to the identification of genes involved in the production of antimicrobial molecules.
June 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28630784/elemental-characterization-of-romanian-crop-medicinal-plants-by-neutron-activation-analysis
#7
Daniela Haidu, Dénes Párkányi, Radu Ioan Moldovan, Cecilia Savii, Iulia Pinzaru, Cristina Dehelean, Ludovic Kurunczi
The metallic elements concentrations of medicinal plants (coriander, dill, Echinacea, lavender, chamomile, mint, and plantain, used for phytopharmaceutical products), cultivated in unpolluted region, were analyzed by neutron activation analysis. The essential nutrients, macro-, micro-, and trace elements (K, Ca, Mg, Na, Fe, Mn, Rb, Sr, and Zn), potentially toxic elements (Al, As, Ba, Co, Sb, Cr, and V), and rare earth elements were monitored and were compared with those presented in the literature. An estimation of their contributions to intake and toxicity for a person was made, which revealed that (a) teas prepared from the examined plants represent useful contribution to the food provided intake of three essential macronutrients (K, Ca, and Mg); (b) the Cu, Mn, Rb, Sr, Zn, and rare earths levels are normal or low; (c) the quantities of As, Ba, Co, Sb, Cr, and V do not represent toxicological concerns; (d) the examination of the estimated Al and Fe quantities recovered in infusions in the conditions of usual daily tea consumption is below the Tolerable Daily Intake values...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28627238/immune-responses-to-killed-reassorted-influenza-virus-supplemented-with-natural-adjuvants
#8
Mona Abdel Fattah Razin, Ahmed Osman, Mohamed Ahmed Ali, Mahmoud Mohamed Bahgat, Amany Sayed Maghraby
In this study, we investigated the immunomodulatory effects of a supplemented killed influenza virus (V) by Echinacea purpurea (E) and Nigella sativa (N) extracts and effect of changing the route of immunization from intramuscular (IM) to intraperitoneal (IP). At the 2(nd)-, 3(rd)- and 4(th)-week post-IM immunizations (WPIMI), the supplemented V with N (VN) induced the most significant IgM response unlike N alone. At the 2(nd) WPIMI, V or VN induced the highest significant IgG levels. At the 2(nd)-week post-IP immunization (WPIPI), E and VN induced the most significant IgG levels...
June 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28610802/herbal-medicine-in-children-with-respiratory-tract-infection-systematic-review-and-meta-analysis
#9
REVIEW
Dennis Anheyer, Holger Cramer, Romy Lauche, Felix Joyonto Saha, Gustav Dobos
BACKGROUND: Herbal medicines are particularly regarded as an alternative or complement to conventional pharmaceuticals in the treatment and prevention of respiratory tract infections (RTI). OBJECTIVE: Therefore the purpose of this review was to identify evidence for herbal therapy in the treatment of RTI concerning effectiveness and safety. DATA SOURCES: Medline/PubMed, Scopus and the Cochrane Library were searched through 12 February 2015...
June 10, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28610718/echinacea-purpurea-derived-alkylamides-exhibit-potent-anti-inflammatory-effects-and-alleviate-clinical-symptoms-of-atopic-eczema
#10
Attila Oláh, Judit Szabó-Papp, Michael Soeberdt, Ulrich Knie, Stephan Dähnhardt-Pfeiffer, Christoph Abels, Tamás Bíró
BACKGROUND: Atopic eczema (AE) is a chronic inflammatory and pruritic skin disease. There is still an unmet need for topical anti-inflammatory and anti-pruritic substances exhibiting an excellent safety profile. The endocannabinoid system is known to regulate various aspects of cutaneous barrier and immune functions, thus targeting it may be a valid approach for alleviating the symptoms of AE. OBJECTIVE: To assess the putative efficacy of Echinacea purpurea-derived alkylamides (Ec...
May 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28606543/structural-investigations-on-arabinogalactan-proteins-from-a-lycophyte-and-different-monilophytes-ferns-in-the-evolutionary-context
#11
Desirée Bartels, Birgit Classen
Today, understanding of cell wall evolution is incomplete due to limited knowledge of cell wall structure of non-flowering plants. Besides polysaccharides, proteoglycans like arabinogalactan-proteins are important constituents of the cell wall of most if not all seed plants. This article provides the first detailed characterization of AGPs from a lycophyte and different ferns, which are the closest living relatives to seed plants. The amount of protein in fern AGPs (6-12%) was in a range comparable to most seed plant AGPs...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28522712/draft-genome-sequence-of-pseudomonas-sp-strain-ep-r1-isolated-from-echinacea-purpurea-roots-and-effective-in-the-growth-inhibition-of-human-opportunistic-pathogens-belonging-to-the-burkholderia-cepacia-complex
#12
Valentina Maggini, Luana Presta, Elisangela Miceli, Marco Fondi, Emanuele Bosi, Carolina Chiellini, Camilla Fagorzi, Patrizia Bogani, Vincenzo Di Pilato, Gian Maria Rossolini, Alessio Mengoni, Fabio Firenzuoli, Elena Perrin, Renato Fani
In this announcement, we detail the draft genome sequence of the Pseudomonas sp. strain Ep R1, isolated from the roots of the medicinal plant Echinacea purpurea The elucidation of this genome sequence may allow the identification of genes associated with the production of antimicrobial compounds.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28359985/an-on-line-hplc-system-for-detection-of-antioxidant-compounds-in-some-plant-extracts-by-comparing-three-different-methods
#13
Nesibe Arslan Burnaz, Murat Küçük, Zeynep Akar
Echinacea (Echinacea purpurea), green tea (Camellia sinensis) and yaylacayi (Thymus praecox OPIZ subsp. grossheimii (Ronniger) Jalas) are herbs used in traditional medicine because of their beneficial health effects. A high performance liquid chromatography (HPLC) post-column method was developed by coupling HPLC with on-line antioxidant assays using diode array (DAD) and ultraviolet (UV) detectors. Thus antioxidant compounds and fifteen phenolic standards were detected in echinacea, green tea and yaylacayi methanol extracts simultaneously...
May 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28344493/volatile-constituents-and-biological-activities-of-the-leaf-and-root-of-echinacea-species-from-south-africa
#14
M Nyalambisa, I A Oyemitan, R Matewu, O O Oyedeji, O S Oluwafemi, S P Songca, B N Nkeh-Chungag, A O Oyedeji
Echinacea is used ethnomedicinally for the treatment of various diseases such as cough, respiratory infections, and bronchitis among other uses in Eastern Cape region of South Africa. This study evaluated the volatile components of the essential oil of the plant, its toxicity, anti-inflammatory and analgesic activities in rodents. Dried leaf and root of the plant were separately processed by hydrodistillation for 4 h and their essential oils (EOs) were collected. Extracted oils were subjected to GC/GC-MS analysis...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28303008/an-analysis-of-echinacea-chloroplast-genomes-implications-for-future-botanical-identification
#15
Ning Zhang, David L Erickson, Padmini Ramachandran, Andrea R Ottesen, Ruth E Timme, Vicki A Funk, Yan Luo, Sara M Handy
Echinacea is a common botanical used in dietary supplements, primarily to treat upper respiratory tract infections and to support immune function. There are currently thought to be nine species in the genus Echinacea. Due to very low molecular divergence among sister species, traditional DNA barcoding has not been successful for differentiation of Echinacea species. Here, we present the use of full chloroplast genomes to distinguish between all 9 reported species. Total DNA was extracted from specimens stored at the National Museum of Natural History, Smithsonian Institution, which had been collected from the wild with species identification documented by experts in the field...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279802/prevention-of-influenza-virus-induced-bacterial-superinfection-by-standardized-echinacea-purpurea-via-regulation-of-surface-receptor-expression-in-human-bronchial-epithelial-cells
#16
Selvarani Vimalanathan, Roland Schoop, Andy Suter, James Hudson
Viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. Such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. Some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may create permissive conditions for co-infections...
March 7, 2017: Virus Research
https://www.readbyqxmd.com/read/28263837/echinacea-pupurea-extracts-promote-murine-dendritic-cell-maturation-by-activation-of-jnk-p38-mapk-and-nf-%C3%AE%C2%BAb-pathways
#17
Yali Li, Yuanyuan Wang, Yanping Wu, Baikui Wang, Xi Chen, Xin Xu, Hongliang Chen, Weifen Li, Xiaogang Xu
Dendritic cells (DCs) comprise a system of highly professional antigen presenting cells (APCs) which connect innate and adaptive immunity by undergoing dramatic shift in their maturation state. Phytomedicine Echinacea purpurea extracts (EE) could modulate murine dendritic cell fate and function. However, the underlying mechanism of EE on DCs development and maturation remains limited. In this study, immature DCs were induced phenotypic maturation with up-regulated expression of key accessory molecules and the phagocytic activity was decreased after being treated with EE (400 μg/ml) for 48 h...
March 2, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28251109/effect-of-hydroalcoholic-extract-of-echinacea-purpurea-in-combination-with-meglumine-antimoniate-on-treatment-of-leishmania-major-induced-cutaneous-leishmaniasis-in-balb-c-mice
#18
Bahador Sarkari, Mobin Mohseni, Mahmoud Reza Moein, Reza Shahriarirad, Qasem Asgari
CONTEXT: Progressive resistance of Leishmania parasite to available drugs including, meglumine antimoniate, has been reported from various regions of the world, especially Iran. AIMS: This study was conducted to evaluate the effect of hydroalcoholic extract of Echinacea purpurea in a combination therapy with glucantime in the treatment of cutaneous leishmaniasis caused by Leishmania major. MATERIALS AND METHODS: Hydroalcoholic extract of E...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28164789/preliminary-data-on-antibacterial-activity-of-echinacea-purpurea-associated-bacterial-communities-against-burkholderia-cepacia-complex-strains-opportunistic-pathogens-of-cystic-fibrosis-patients
#19
Carolina Chiellini, Isabel Maida, Valentina Maggini, Emanuele Bosi, Stefano Mocali, Giovanni Emiliani, Elena Perrin, Fabio Firenzuoli, Alessio Mengoni, Renato Fani
Burkholderia cepacia complex bacteria (Bcc) represent a serious threat for immune-compromised patient affected by Cystic Fibrosis (CF) since they are resistant to many substances and to most antibiotics. For this reason, the research of new natural compounds able to inhibit the growth of Bcc strains has raised new interest during the last years. A source of such natural compounds is represented by medicinal plants and, in particular, by bacterial communities associated with these plants able to produce molecules with antimicrobial activity...
March 2017: Microbiological Research
https://www.readbyqxmd.com/read/28067413/echinacea-purpurea-extract-polarizes-m1-macrophages-in-murine-bone-marrow-derived-macrophages-through-the-activation-of-jnk
#20
Aikun Fu, Yang Wang, Yanping Wu, Hongliang Chen, Shasha Zheng, Yali Li, Xin Xu, Weifen Li
Echinacea purpurea is an indigenous North American purple cone flower used by North Americans for treatment of various infectious diseases and wounds. This study investigated the effect of polysaccharide enriched extract of Echinacea purpurea (EE) on the polarization of macrophages. The results showed that 100 µg/mL of EE could markedly activate the macrophage by increasing the expression of CD80, CD86, and MHCII molecules. Meanwhile, EE upregulated the markers of classically activated macrophages (M1) such as CCR7 and the production of IL-1β, IL-6, IL-12p70, TNF-αand NO...
September 2017: Journal of Cellular Biochemistry
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