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https://www.readbyqxmd.com/read/30098645/mental-workload-is-reflected-in-driver-behaviour-physiology-eye-movements-and-prefrontal-cortex-activation
#1
Hannah J Foy, Peter Chapman
Mental workload is an important factor during driving, as both high and low levels may result in driver error. This research examined the mental workload of drivers caused by changes in road environment and how such changes impact upon behaviour, physiological responses, eye movements and brain activity. The experiment used functional near infrared spectroscopy to record prefrontal cortex activation associated with changes in mental workload during simulated driving. Increases in subjective ratings of mental workload caused by changes in road type were accompanied by increases in skin conductance, acceleration signatures and horizontal spread of search...
November 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/30098440/pro-angiogenic-near-infrared-responsive-hydrogels-for-deliberate-transgene-expression
#2
Francisco Martín-Saavedra, Clara Escudero-Duch, Martín Prieto, Silvia Sánchez-Casanova, Daniel López, Manuel Arruebo, Richard Voellmy, Jesús Santamaría, Nuria Vilaboa
CuS nanoparticles (CuSNP) are degradable, readily prepared, inexpensive to produce and efficiently cleared from the body. In this work, we explored the feasibility of CuSNP to function as degradable near infrared (NIR) nanotransducers within fibrin-based cellular scaffolds. To prepare NIR-responsive CuSNP hydrogels, fibrinogen was dissolved in cell culture medium and supplemented with aqueous dispersions of CuSNP. Fibrinogen polymerization was catalyzed by the addition of thrombin. In some experiments, HUVEC, C3H/10T1/2 or C3H/10T1/2-fLuc cells, that harbor a heat-activated and rapamycin-dependent gene switch for regulating the expression of firefly luciferase transgene expression, were incorporated to the sol phase of the hydrogel...
August 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30098115/optical-windows-for-head-tissues-in-near-and-short-wave-infrared-regions-approaching-transcranial-light-applications
#3
Sergii Golovynskyi, Iuliia Golovynska, Ludmila I Stepanova, Oleksandr I Datsenko, Liwei Liu, Junle Qu, Tymish Y Ohulchanskyy
Optical properties of the rat head tissues (brain cortex, cranial bone and scalp skin) are assessed, aiming at transcranial light applications such as optical imaging and phototherapy. The spectral measurements are carried out over the wide spectral range of 350-2800 nm, involving visible, near-infrared (NIR) and short-wave infrared (SWIR) regions. Four tissue transparency windows are considered: ~700-1000 nm (NIR-I), ~1000-1350 nm (NIR-II), ~1550-1870 nm (NIR-III or SWIR) and ~2100-2300 nm (SWIR-II). The values of attenuation coefficient and total attenuation length are determined for all windows and tissue types...
August 11, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/30081227/mesoporous-silica-nanoparticles-for-enhanced-lidocaine-skin-delivery
#4
Shohreh Nafisi, Naghmeh Samadi, Mahboubeh Houshiar, Howard I Maibach
Lidocaine's (Lido) low water solubility and negligible tissue uptake limit its bioavailability when applied to the skin. Nanoparticulate systems would helpaddressthese issues; therefore, lidocaine inclusion complexes with mesoporous silica nanoparticles (MSNs) were prepared and the effect of MCM41 surface functionalization with positively charged amino-propyl groups on the molecule properties studied. It is expected that positively charged nanoparticles can improve lidocaine permeation into the skin. The complexes were prepared in different lidocaine/MSNs ratios (3/1, 2/1, 1/1) and characterized by X-ray powder diffraction (XRD), dynamic light scattering (DLS) and differential scanning calorimetry (DSC)...
August 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30071607/fernblock-prevents-dermal-cell-damage-induced-by-visible-and-infrared-a-radiation
#5
Alicia Zamarrón, Silvia Lorrio, Salvador González, Ángeles Juarranz
Sun overexposure leads to higher risk of photoaging and skin cancer. The contribution of infrared (IR) and visible light (VIS) radiation is currently being taken into account in their pathogenesis. Erythema, hyperpigmentation, genotoxicity or the increase of matrix metalloproteinases (MMPs) expression are some of the effects induced by these types of radiation. Extracts of various botanicals endowed with antioxidant activity are emerging as new photoprotective compounds. A natural extract from Polypodium leucotomos (Fernblock® , FB) has antioxidant and photoprotective properties and exhibits a strong anti-aging effect...
August 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30053489/novel-skin-penetrating-berberine-oleate-complex-capitalizing-on-hydrophobic-ion-pairing-approach
#6
Abrar S Torky, May S Freag, Maha M A Nasra, Ossama Y Abdallah
Berberine hydrochloride (Brb) is a well-known herbal drug that holds a great promise in the recent years thanks to its various pharmacological actions. Currently, Brb is extensively researched as a natural surrogate with evidenced potentiality against numerous types of skin diseases including skin cancer. However, Brb's high aqueous solubility and limited permeability hinder its clinical topical application. In the current work, to enhance Brb's dermal availability, hydrophobic ion pairing approach was implemented combining the privileges of altering the solubility characteristics of Brb and the nanometric size that is usually gained during the ion pairing precipitation process...
July 24, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30053463/bioequivalence-of-topical-generic-products-part-1-where-are-we-now
#7
REVIEW
Margarida Miranda, João José Sousa, Francisco Veiga, Catarina Cardoso, Carla Vitorino
Regulatory accepted methods for bioequivalence assessment of topical generic products generally involve long and expensive clinical endpoint studies. The only alternative relies on pharmacodynamic trials, solely applicable to corticosteroids. Considerable efforts have been channeled towards the development and validation of other analytical surrogates. The majority of these alternative methods rely on in vitro methodologies that allow a more sensitive and reproducible bioequivalence assessment, avoiding at the same time the financial burden that deeply characterizes clinical trials...
July 24, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30046979/the-effect-of-menstrual-cycle-phase-on-foot-skin-temperature-during-mild-local-cooling-in-young-women
#8
Yuki Uchida, Koyuki Atsumi, Akira Takamata, Keiko Morimoto
Japanese women can experience a sensation of cold feet in daily life. It is possible that this sensation of coldness in feet may be associated with female hormones, but to date the effect of menstrual cycle phase on the skin temperature (Tsk ) of the foot during local cooling is unknown. We therefore examined Tsk and partial cutaneous blood flow in the foot during the follicular (F) and luteal (L) phases of the menstrual cycle in women experiencing local cooling. Tsk was measured in the toes and the dorsum of the left foot using infrared thermography, while cutaneous blood flow was evaluated in the big toe of the left foot using laser Doppler flowmetry (LDF), both at 28 °C...
July 25, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/30034957/erythema-ab-igne-from-heating-pad-use-a-report-of-three-clinical-cases-and-a-differential-diagnosis
#9
Alexander B Aria, Leon Chen, Sirunya Silapunt
Erythema ab igne is an asymptomatic cutaneous disorder characterized by erythematous reticulated hyperpigmentation resulting from chronic exposure to infrared radiation in the form of heat. We report three cases of erythema ab igne from chronic heating pad use over a duration of six months to three years. The lesions were asymptomatic in all three patients and were incidental skin findings in two patients, unrelated to their chief complaints. This illustrates the importance of recognizing the morphology and distribution of erythema ab igne...
May 16, 2018: Curēus
https://www.readbyqxmd.com/read/30032183/investigation-of-the-relationship-between-udder-quarter-somatic-cell-count-and-udder-skin-surface-temperature-of-dairy-cows-measured-by-infrared-thermography
#10
D T Byrne, D P Berry, H Esmonde, N McHugh
The objective of the current study was to quantify the relationship between udder skin surface temperature (USST) and somatic cell count (SCC) in lactating dairy cows. Data were recorded on the same 14 Holstein-Friesian cows, at evening (15:00 to 16:00) milking every day over a two-month period. Surface temperature measurements of all udders were extracted from thermal images. Post imaging, milk was extracted from each quarter and analyzed for SCC. Environmental and cow related factors (i.e., ambient temperature, humidity, rainfall, wind speed, distance walked to the parlor, number of days since the udder was shaved, parity, and stage of lactation) were recorded on each day of the experiment...
July 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30030915/detecting-and-quantifying-activity-inflammation-in-localized-scleroderma-with-thermal-imaging
#11
I Ranosz-Janicka, A Lis-Święty, A Skrzypek-Salamon, L Brzezińska-Wcisło
BACKGROUND: The disease phase in localized scleroderma (LoS) is commonly assessed by clinical investigation using the LoS cutaneous assessment tool (LoSCAT). There is a need for more objective methods for assessing the degree of activity/inflammation in LoS. The aim of our work was to evaluate the correlation between severity of the LoS lesions scored using LoSCAT and the degree of hyperthermia observed with infrared thermography (IRT). MATERIALS AND METHODS: The LoS lesions were examined using the LoSCAT and IRT independently by two examiners...
July 21, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/30030176/controlled-temperature-photothermal-and-oxidative-bacteria-killing-and-acceleration-of-wound-healing-by-polydopamine-assisted-au-hydroxyapatite-nanorods
#12
Xiaomo Xu, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Shengli Zhu, Zhaoyang Li, Xubo Yuan, Yufeng Zheng, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Since skin wounds are subject to bacterial infection and tissue regeneration may be impeded, there is demand for biomaterials that possess rapid bactericidal and tissue repair capability. Herein we report in situ promotion of wound healing by a photothermal therapy (PTT) assisted nanocatalytic antibacterial system utilizing a polydopamine (PDA) coating on hydroxyapatite (HAp) incorporated with gold nanoparticles (Au-HAp). The PDA@Au-HAp NPs produce hydroxyl radicals (OH) via catalysis of a small concentration of H2 O2 to render bacteria more vulnerable to the temperature change...
July 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30023570/controlling-the-degree-of-esterification-of-citrus-pectin-for-demanding-applications-by-selection-of-the-source
#13
Rosaria Ciriminna, Alexandra Fidalgo, Riccardo Delisi, Alfredo Tamburino, Diego Carnaroglio, Giancarlo Cravotto, Laura M Ilharco, Mario Pagliaro
Analyzed by a quantitative method based on diffuse reflectance infrared Fourier transform spectroscopy, pectins extracted from different regions (outer skin, peel, and waste) of citrus fruits (red orange, lemon, and grapefruit) via microwave-assisted hydrodiffusion show significant variations. All polymers obtained are low-methoxyl pectins, with high contents in galacturonic acid regions. The degree of esterification (DE) of pectin extracted from different regions increases in the order waste < peel < outer skin for red orange, inverting for lemon...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/30021397/accelerated-skin-wound-healing-by-soy-protein-isolate-modified-hydroxypropyl-chitosan-composite-films
#14
Yanan Zhao, Zijian Wang, Qiang Zhang, Feixiang Chen, Zhiyi Yue, Tiantian Zhang, Hongbing Deng, Céline Huselstein, Debbie P Anderson, Peter R Chang, Yinping Li, Yun Chen
In this study, a series of hydroxypropyl chitosan (HPCS)/soy protein isolate (SPI) composite films (HCSFs) with different SPI contents were developed via crosslinking, solution casting, and evaporation process. Effects of the SPI content on the structure and physical properties of the HCSFs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction patterns, scanning electron microscopy, swelling kinetics analysis, and mechanical testing. The HCSFs exhibited a lower swelling ratio with an increase in the SPI content...
July 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30018278/paeonol-loaded-ethosomes-as-transdermal-delivery-carriers-design-preparation-and-evaluation
#15
Hongdan Ma, Dongyan Guo, Yu Fan, Jing Wang, Jiangxue Cheng, Xiaofei Zhang
Paeonol exhibits a wide range of pharmacological activities, such as anti-inflammatory, antidiabetic as well as pain-relieving activities. However, its intrinsic properties, such as low water solubility, poor stability and low oral bioavailability, restrict its clinical application. The current study aimed to optimize paeonol-loaded ethosomal formulation and characterize it in terms of encapsulation efficiency (EE), vesicle size (VS), zeta potential (ZP) and polydispersity index (PDI), in addition to differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) studies...
July 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30017046/the-influence-of-body-composition-on-exercise-associated-skin-temperature-changes-after-resistance-training
#16
Martin Weigert, Nico Nitzsche, Felix Kunert, Christiane Lösch, Henry Schulz
Resistance exercise leads to an increase in skin temperature (Tskin ) in the area of the exercised muscle. Infrared thermography seems to be applicable to identify these primary used functional muscles with measuring Tskin changes. The aim of the current study was to investigate the influence of body composition on Tskin patterns after resistance exercise. 38 male subjects (19-32 years, BMI 20.4-55.2 kg/m2 ) participated. Body fat percentage and biceps skinfold thickness were calculated. The subjects were divided into two groups: lean group (LG) with body fat percentage < 25%, obese group (OG) with body fat percentage ≥ 25%...
July 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/30004878/haptable-an-interactive-tabletop-providing-online-haptic-feedback-for-touch-gestures
#17
Senem Ezgi Emgin, Amirreza Aghakhani, Metin Sezgin, Cagatay Basdogan
We present HapTable; a multi-modal interactive tabletop that allows users to interact with digital images and objects through natural touch gestures, and receive visual and haptic feedback accordingly. In our system, hand pose is registered by an infrared camera and hand gestures are classified using a Support Vector Machine (SVM) classifier. To display a rich set of haptic effects for both static and dynamic gestures, we integrated electromechanical and electrostatic actuation techniques effectively on tabletop surface of HapTable, which is a surface capacitive touch screen...
July 11, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29998107/oral-photoprotection-effective-agents-and-potential-candidates
#18
REVIEW
Concepción Parrado, Neena Philips, Yolanda Gilaberte, Angeles Juarranz, Salvador González
Electromagnetic radiation in the ultraviolet, visible, and infrared ranges produces biologic effects in humans. Where some of these effects are beneficial, others are harmful to the skin, particularly those stemming from ultraviolet radiation (UVR). Pharmacological photoprotection can be topical or systemic. Systemic photoprotection is often administered orally, complementing topical protection. New and classic oral agents (e.g., essential micronutrients as vitamins, minerals, polyphenols, carotenoids) are endowed with photoprotective and anti-photocarcinogenic properties...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29991491/abcc6-deficiency-promotes-development-of-randall-plaque
#19
Emmanuel Letavernier, Gilles Kauffenstein, Léa Huguet, Nastassia Navasiolava, Elise Bouderlique, Ellie Tang, Léa Delaitre, Dominique Bazin, Marta de Frutos, Clément Gay, Joëlle Perez, Marie-Christine Verpont, Jean-Philippe Haymann, Viola Pomozi, Janna Zoll, Olivier Le Saux, Michel Daudon, Georges Leftheriotis, Ludovic Martin
BACKGROUND: Pseudoxanthoma elasticum (PXE) is a genetic disease caused by mutations in the ABCC6 gene that result in low pyrophosphate levels and subsequent progressive soft tissue calcifications. PXE mainly affects the skin, retina, and arteries. However, many patients with PXE experience kidney stones. We determined the prevalence of this pathology in patients with PXE and examined the possible underlying mechanisms in murine models. METHODS: We conducted a retrospective study in a large cohort of patients with PXE and analyzed urine samples and kidneys from Abcc6 -/- mice at various ages...
July 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29991122/new-approach-for-evaluating-the-effectiveness-of-whole-body-magnetic-field-therapy-in-the-rehabilitation-of-patients-with-lumbar-discectomy
#20
Alexander G Kulikov, Darya D Voronina, Aleksey E Morozov, Tatyana N Zajceva, Ksenia I Ustinova
OBJECTIVE: Magnetic field therapy involves the application of low-intensity magnetic fields (1-3.5 mT) to a patient's whole body. The purpose of this study was to assess the effectiveness of whole-body magnetic field (WBMF) therapy in the early rehabilitation of patients after lumbar discectomy. METHODS: A convenience sample of 73 patients who underwent lumbar discectomy within 1 month previously participated in the study. All patients were randomly assigned to one of two groups and received either a course of conventional rehabilitation (control group) or conventional rehabilitation together with 10 sessions of WBMF therapy (WBMF group)...
June 22, 2018: Journal of Back and Musculoskeletal Rehabilitation
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