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https://www.readbyqxmd.com/read/30339942/near-infrared-light-controllable-on-demand-antibiotics-release-using-thermo-sensitive-hydrogel-based-drug-reservoir-for-combating-bacterial-infection
#1
Ge Gao, Yao-Wen Jiang, Hao-Ran Jia, Fu-Gen Wu
A near-infrared (NIR) light-triggerable thermo-sensitive hydrogel-based drug reservoir that can realize on-demand antibiotics release and hyperthermia-assisted bacterial inactivation was prepared to combat bacterial infection and promote wound healing. The drug reservoir was fabricated by mixing ciprofloxacin (Cip, a potent antibiotic)-loaded polydopamine (PDA) nanoparticles (NPs) and glycol chitosan (GC) to form an injectable hydrogel (PDA NP-Cip/GC hydrogel, abbreviated as Gel-Cip). On the one hand, the positive charge of GC and the adsorbability of PDA NPs made bacteria be readily trapped on the surface of Gel-Cip...
October 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/30338888/visualized-identification-of-the-maximal-surgical-delay-effect-in-a-rat-flap-model
#2
Xiucun Li, Miao Chen, Zhenmin Jiang, Yang Liu, Laijin Lu, Xu Gong
PURPOSES: Currently, experimental evidence suggests that the surgical delay can increase flap survival area, but its effect may decrease if the optimal delay period is missed. The aim of this study is to establish a sensitive and objective modality based on the visualized and individualized infrared thermography for identifying the maximal surgical delay effect. METHODS: A rectangular three-angiosome flap was designed on the unilateral dorsum of the rat. Ninety-six rats were randomly divided into 6 groups according to the various delay time...
October 19, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30338163/full-video-pulse-extraction
#3
Wenjin Wang, Albertus C den Brinker, Gerard de Haan
This paper introduces a new method to automate heart-rate detection using remote photoplethysmography (rPPG). The method replaces the commonly used region of interest (RoI) detection and tracking, and does not require initialization. Instead, it combines a number of candidate pulse-signals computed in the parallel, each biased towards differently colored objects in the scene. The method is based on the observation that the temporally averaged colors of video objects (skin and background) are usually quite stable over time in typical application-driven scenarios, such as the monitoring of a subject sleeping in bed, or an infant in an incubator...
August 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30333329/tissue-oximetry-during-cardiac-surgery-and-in-the-cardiac-intensive-care-unit-a-prospective-observational-trial
#4
Benjamin J Heller, Pranav Deshpande, Joshua A Heller, Patrick McCormick, Hung-Mo Lin, Ruiqi Huang, Gregory Fischer, Menachem M Weiner
Background: Cerebral oximetry using near-infrared spectroscopy (NIRS) has well-documented benefits during cardiac surgery. The authors tested the hypothesis that NIRS technology can be used at other sites as a tissue oximeter during cardiac surgery and in the Intensive Care Unit (ICU). Aims: To establish feasibility of monitoring tissue oximetry during and after cardiac surgery, to examine the correlations between tissue oximetry values and cerebral oximetry values, and to examine correlations between oximetry values and mean arterial pressure (MAP) in order to test whether cerebral oximetry can be used as an index organ...
October 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/30332360/early-detection-of-deep-wound-infection-in-bladder-exstrophy-and-hypospadias-using-a-novel-intervention
#5
Shabnam Sabetkish, Nastaran Sabetkish, Abdol-Mohammad Kajbafzadeh
OBJECTIVE: To introduce a practical technique for the early detection and prompt management of a probable bladder dehiscence (BD) and glanular dehiscence (GD) in patients with bladder exstrophy epispadias complex (BEEC) and hypospadias. METHOD: In this prospective study, paediatric patients with BEEC (group 1) and with proximal hypospadias (group 2) underwent body temperature measurement using a non-contact infrared radiant digital temperature measurement device in four body regions, including the surgical wound, forehead, right hand, and right foot at eight hour intervals, postoperatively...
October 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/30327869/relation-between-finger-cold-induced-vasodilation-and-rewarming-speed-after-cold-exposure
#6
C F Kingma, I I Hofman, H A M Daanen
PURPOSE: The risk for local cold injuries has been linked to poor cold-induced vasodilation (CIVD) during cold exposure and to poor rewarming after cold exposure. The purpose of this study is to establish the relation between CIVD and rewarming speed. METHODS: Twelve participants immersed one hand in ice water for 30 min to evoke CIVD and the other hand in ice water for 10 min to investigate the rewarming profile. The ring, middle and index fingertip temperatures were monitored during hand immersion and the resistance index of frostbite (RIF) was calculated...
October 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/30326222/hydrogel-and-membrane-scaffold-formulations-of-frutalin-breadfruit-lectin-within-a-polysaccharide-galactomannan-matrix-have-potential-for-wound-healing
#7
Felipe Domingos de Sousa, Pedrinha Diógenes Vasconselos, Ayrles Fernanda Brandão da Silva, Erika Freitas Mota, Adriana da Rocha Tomé, Francisco Rogênio da Silva Mendes, Anida Maria Moraes Gomes, David J Abraham, Xu Shiwen, James S Owen, Marcos Roberto Lourenzoni, Adriana Rolim Campos, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira
Plant lectins are carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions. Here, we have extracted, purified and part-characterized the bioactivity of Jacalin, Frutalin, DAL and PNA, before evaluating their potential for wound healing in cultured human skin fibroblasts. Only Frutalin stimulated fibroblast migration in vitro, prompting further studies which established its low cytotoxicity and interaction with TLR4 receptors...
October 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30319906/swept-wavelength-lasers-based-on-gasb-gain-chip-technology-for-non-invasive-biomedical-sensing-applications-in-the-1-7-2-5-%C3%AE-m-wavelength-range
#8
Augustinas Vizbaras, Ieva Šimonytė, Arūnas Miasojedovas, Augustinas Trinkūnas, Tadas Bučiūnas, Mindaugas Greibus, Greta Naujokaitė, Nicolas Torcheboeuf, Serge Droz, Dmitri Boiko, Žilvinas Dambrauskas, Antanas Gulbinas, Kristijonas Vizbaras
The infrared spectral region beyond 1.7 μm is of utmost interest for biomedical applications due to strong overtone and combination absorption bands in a variety of important biomolecules such as lactates, urea, glucose, albumin, etc. In this article, we report on recent progress in widely tunable swept-wavelength lasers based on type-I GaSb gain-chip technology, setting a new state-of-the-art in the 1.7 - 2.5 μm range laser sources. We provide an application example for the spectroscopic sensing of several biomolecules in a cuvette as well as an experimental demonstration of a non-invasive in-vivo sensing of human serum albumin through the skin...
October 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30310284/antibacterial-and-biodegradable-tissue-nano-adhesives-for-rapid-wound-closure
#9
Meng-Meng Lu, Jing Bai, Dan Shao, Jing Qiu, Ming Li, Xiao Zheng, Yun Xiao, Zheng Wang, Zhi-Min Chang, Li Chen, Wen-Fei Dong, Chun-Bo Tang
Background: Although various organic tissue adhesives designed to facilitate would healing are gaining popularity in diverse clinical applications, they present significant inherent limitations, such as rejection, infections, toxicity and/or excessive swelling. It is highly desirable to develop efficient, biocompatible and anti-bacterial tissue adhesives for skin wound healing. Purpose: Inspired by the fact that inorganic nanoparticles can directly glue tissues through the "nanobridging effect", herein disulfide bond-bridged nanosilver-decorated mesoporous silica nanoparticles (Ag-MSNs) was constructed as an effective and safe tissue adhesive with antibacterial and degradable properties for wound closure and healing...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30306802/transdermal-delivery-system-of-nanostructured-lipid-carriers-loaded-with-celastrol-and-indomethacin-optimization-characterization-and-efficacy-evaluation-for-rheumatoid-arthritis
#10
Qian Kang, Jia Liu, Ying Zhao, Xin Liu, Xin-Yan Liu, Yong-Jie Wang, Nuo-Lan Mo, Qing Wu
Co-encapsulation of drugs provides a convenient means for treating different symptoms of a disease. Celastrol (Cel) shows potent anti-arthritic activity and Indomethacin (Indo) is effective in relieving inflammatory pain. Nanostructured lipid carriers loaded with Celastrol and Indomethacin (Cel-Indo-NLCs) were prepared by emulsification evaporation-solidification method, optimized by the Box-Behnken design and characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and powder X-ray diffraction analysis (PXRD)...
October 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/30306328/accuracy-of-automated-patient-positioning-in-ct-using-a-3d-camera-for-body-contour-detection
#11
Ronald Booij, Ricardo P J Budde, Marcel L Dijkshoorn, Marcel van Straten
OBJECTIVE: To assess the accuracy of a 3D camera for body contour detection and patient positioning in CT compared to routine manual positioning by radiographers. METHODS AND MATERIALS: Four hundred twenty-three patients that underwent CT of the head, thorax, and/or abdomen on a scanner with manual table height selection and 254 patients on a scanner with table height suggestion by a 3D camera were retrospectively included. Within the camera group, table height suggestion was based on infrared body contour detection and fitting of a scalable patient model to the 3D data...
October 10, 2018: European Radiology
https://www.readbyqxmd.com/read/30300812/permeability-and-microstructure-of-cholesterol-depleted-skin-lipid-membranes-and-human-stratum-corneum
#12
Michaela Sochorová, Pavla Audrlická, Martina Červená, Andrej Kováčik, Monika Kopečná, Lukáš Opálka, Petra Pullmannová, Kateřina Vávrová
Cholesterol (Chol) is one of the major skin barrier lipids. The physiological level of Chol in the stratum corneum (SC) appears to exceed its miscibility with other barrier lipids, as some Chol is phase separated. Chol synthesis is essential for epidermal homeostasis, yet the role of these Chol domains in SC permeability is unknown. We investigated the impact of Chol depletion on the permeability properties and microstructure of model membranes and human SC. X-ray powder diffraction of membranes constructed from isolated human skin ceramides or synthetic ceramides confirmed that only approximately half of the normal Chol amount can be incorporated in either long or short periodicity lamellar phases...
October 1, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30298119/preclinical-evaluation-of-white-led-activated-non-porphyrinic-photosensitizer-or141-in-3d-tumor-spheroids-and-mouse-skin-lesions
#13
Bastien Doix, Estelle Bastien, Alix Rambaud, Adán Pinto, Caroline Louis, Vincent Grégoire, Olivier Riant, Olivier Feron
Photodynamic therapy (PDT) is used to treat malignancies and precancerous lesions. Near-infrared light delivered by lasers was thought for a while to be the most appropriate option to activate photosensitizers, mostly porphyrins, in the depth of the diseased tissues. More recently, however, several advantages including low cost and reduced adverse effects led to consider light emitting diodes (LED) and even daylight as an alternative to use PDT to treat accessible lesions. In this study we examined the capacity of OR141, a recently identified non-porphyrin photosensitizer (PS), to exert significant cytotoxic effects in various models of skin lesions and tumors upon white light activation...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30283998/non-invasive-monitoring-of-blood-glucose-using-optical-methods-for-skin-spectroscopy-opportunities-and-recent-advances
#14
REVIEW
Sven Delbeck, Thorsten Vahlsing, Steffen Leonhardt, Gerald Steiner, H Michael Heise
Diabetes mellitus is a widespread disease with greatly rising patient numbers expected in the future, not only for industrialized countries but also for regions in the developing world. There is a need for efficient therapy, which can be via self-monitoring of blood glucose levels to provide tight glycemic control for reducing the risks of severe health complications. Advancements in diabetes technology can nowadays offer different sensor approaches, even for continuous blood glucose monitoring. Non-invasive blood glucose assays have been promised for many years and various vibrational spectroscopy-based methods of the skin are candidates for achieving this goal...
October 3, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/30283925/the-promising-indicators-of-the-thermal-and-mechanical-properties-of-collagen-from-bass-and-tilapia-synergistic-effects-of-hydroxyproline-and-cysteine
#15
Zixian Bao, Yue Sun, Kamal Rai, Xinying Peng, Shilu Wang, Rui Nian, Mo Xian
Collagen has been widely documented as one of the most promising and competitive biomaterials for tissue engineering and medical applications. However, the properties of collagen differ from one source to another. In the present study, type I collagen (COL-I) was extracted and purified from the skins of Japanese sea bass (Lateolabrax japonicus) and Nile tilapia (Oreochromis niloticus). Ultraviolet (UV) spectroscopy, Fourier transform infrared spectroscopy (FTIR) and SDS-PAGE were performed to characterize both COL-Is...
October 4, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30281381/the-effectiveness-of-intermittent-pneumatic-compression-in-therapy-of-lymphedema-of-lower-limbs-methods-of-evaluation-and-results
#16
Marzanna T Zaleska, Waldemar L Olszewski
BACKGROUND: Evaluation of intermittent pneumatic compression (IPC) in lymphedema is classically based on measurements of circumferences and volume of the edematous limb. However, although important, it provides only a general information without insight into what proceeds under the skin with respect to hydromechanical and structural changes. AIM AND METHODS: We present the multimodal evaluation of the effectiveness of IPC device in limb edema by measuring tissue stiffness, fluid pressure, and flow volume, and lymphoscintigraphic and near-infrared fluorescence (NIRF) indocyanine green (ICG) lymphography imaging of edema fluid movement, before and after one 45-60 minute compression cycle in over 50 patients with lymphedema stage II and III...
October 3, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/30281374/photodynamic-therapy-on-skin-melanoma-and-epidermoid-carcinoma-cells-using-conjugated-5-aminolevulinic-acid-with-microbial-synthesized-silver-nanoparticles
#17
Aishwarya Shivashankarappa, Konasur Rajesh Sanjay
The present research work describes the use of Photodynamic Therapy (PDT) ofdrug 5-aminolevulinic acid (5-ALA) conjugated with microbial synthesizedsilver nanoparticles on skin melanoma (B16F10) and epidermoid carcinoma (A431) cell lines. Silver nanoparticles were synthesized using the bacterial strain Bacillus licheniformis.The morphology of the nanoparticles were studied using Scanning Electron Microscopy (SEM) and elemental analysis of nanoparticles were carried out using Energy Dispersive X-Ray spectroscopy (EDX)...
October 3, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/30274067/fabrication-and-characterization-of-pcl-zein-gum-arabic-electrospun-nanocomposite-scaffold-for-skin-tissue-engineering
#18
Zahra Pedram Rad, Javad Mokhtari, Marjan Abbasi
The main role of tissue engineering is to produce the artificial tissue for replacing the biological functions in tissue regeneration and wounds healing. The purpose of this research was to produce porous nanofiber scaffold by electrospinning to compensate deep skin damages. In order to simulate a scaffold similar to the natural extracellular matrix of the skin, a mixture of corn protein (Zein), polycaprolactone (PCL) and gum arabic (GA) was used with different concentrations and ratios. Zein and GA polymers were used as a protein and polysaccharide component of the scaffold and PCL polymer for elasticity, strength and time setting of scaffold degradability...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30266925/deactivation-of-the-prefrontal-cortex-during-exposure-to-pleasantly-charged-emotional-challenge
#19
Kanji Matsukawa, Ryota Asahara, Miho Yoshikawa, Kana Endo
Our laboratory reported that facial skin blood flow may serve as a sensitive tool to assess an emotional status and that both prefrontal oxygenation (as index of regional cerebral blood flow) and facial skin blood flow decrease during positively-charged emotional stimulation, without changing hand skin blood flow and arterial pressure. However, the focal location of the prefrontal responses in concentration of oxygenated haemoglobin (Oxy-Hb) that correlate with peripheral autonomic reaction remained unknown...
September 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30264838/elemental-and-optical-imaging-evaluation-of-zwitterionic-gold-nanoclusters-in-glioblastoma-mouse-models
#20
Xavier Le Guével, Maxime Henry, Vincent Motto-Ros, Elena Longo, Maria I Montañez, Frédéric Pelascini, Ombeline de La Rochefoucauld, Philippe Zeitoun, Jean-Luc Coll, Véronique Josserand, Lucie Sancey
We report in this study the in vivo biodistribution of ultra-small luminescent gold (Au) particles (∼1.5 nm core size; 17 kDa), so-called nanoclusters (NCs), stabilized by bidentate zwitterionic molecules in subcutaneous (s.c.) and orthotopic glioblastoma mice models. Particular investigations on renal clearance and tumor uptake were performed using highly sensitive advanced imaging techniques such as multi-elemental Laser-Induced Breakdown Spectroscopy (LIBS) imaging and in-line X-ray Synchrotron Phase Contrast Tomography (XSPCT)...
October 21, 2018: Nanoscale
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