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Late iugr

Sumaiya Adam, Melantha Coetzee, Engela Magdalena Honey
Pena-Shokeir syndrome (PSS) type 1, also known as fetal akinesia deformation sequence, is a rare genetic syndrome that almost always results in intrauterine or early neonatal death. It is characterized by markedly decreased fetal movements, intrauterine growth restriction, joint contractures, short umbilical cord, and features of pulmonary hypoplasia. Antenatal diagnosis can be difficult. Ultrasound features are varied and may overlap with those of Trisomy 18. The poor prognosis of PSS is due to pulmonary hypoplasia, which is an important feature that distinguishes PSS from arthrogryposis multiplex congenital without pulmonary hypoplasia, which has a better prognosis...
2018: Application of Clinical Genetics
Megan R Sutherland, Ka Wing Ng, Jörg D Drenckhahn, Mary E Wlodek, Mary Jane Black
Capillarisation plays a key role in the growth of the developing heart. We therefore hypothesised that impaired heart development following intrauterine growth restriction (IUGR) may arise from inadequate myocardial capillary growth. The aims of the study were to examine the effect of IUGR on the growth and diffusion radius of intramyocardial capillaries in rats at postnatal day 1. Uteroplacental insufficiency was induced in rats in late gestation (E18, term=E22) by bilateral uterine artery and vein ligation (Restricted offspring n=12; 6 males and 6 females); offspring from sham-operated dams were used as Controls (n=10; 5 males and 5 females)...
November 24, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Despina D Briana, Aimilia-Eirini Papathanasiou, Stavroula Gavrili, Sophia Georgantzi, Antonios Marmarinos, Christos Christou, Konstantinos Voulgaris, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
BACKGROUND/OBJECTIVE: To study the concentrations of preadipocyte factor-1 (Pref-1) -an inhibitor of adipocyte differentiation, implicated in adipose tissue metabolism, late metabolic disorders and fetal growth- in maternal and umbilical cord serum, as well as maternal milk and correlate above concentrations with intrauterine growth and other perinatal parameters. MATERIAL AND METHODS: Pref-1 concentrations were determined by ELISA in antepartum maternal and umbilical cord serum, as well as day 3 to 4 postpartum breast milk, deriving from 80 women, who delivered 40 appropriate (AGA), 20 large for gestational age (LGA) and 20 intrauterine growth restricted (IUGR) neonates, classified by the use of customized birth-weight standards adjusted for significant determinants of fetal growth...
November 17, 2018: Cytokine
Martina Hutabarat, Noroyono Wibowo, Barbara Obermayer-Pietsch, Berthold Huppertz
BACKGROUND: Preeclampsia and intra-uterine growth restriction (IUGR) are major health problems during pregnancy affecting both mother and child. Defective placental development and failure of trophoblast differentiation during pregnancy are important aspects in the pathogenesis of both syndromes. Recent studies have shown that autophagy is involved in the trophoblast survival capacity. As vitamin D has a central role in many cellular processes, we studied the relation of vitamin D and autophagy in those processes of preeclampsia and IUGR...
2018: PloS One
Leonard Năstase, Dragos Cretoiu, Silvia Maria Stoicescu
Intrauterine growth restriction (IUGR) represents a rate of fetal growth that is less than average for the population and the growth potential of a specific infant. IUGR produces infants who are small for gestational age (SGA) but also appropriate for gestational age (AGA). It refers to growth less than expected for gestational age and is most often under 10th percentiles for age. It develops during the late second and third trimesters of gestation. The etiology of IUGR is multifactorial. One of the most important factors which leads to IUGR is a decrease of nutrients and oxygen delivered to the fetus by the placenta...
2018: Advances in Experimental Medicine and Biology
Yehudit Michelson, Yaniv Lustig, Shira Avivi, Eli Schwartz, Amos Danielli
Background: Zika virus has created global alarm as it has been associated with catastrophic fetal abnormalities, including microcephaly, spontaneous abortion, and intrauterine growth restriction. Current serological assays that detect antiviral antibodies suffer from low sensitivity and high cross-reactivity among different flaviviruses. Methods: Here, utilizing a novel Magnetic Modulation Biosensing (MMB) system and the Zika non-structural 1 (NS1) protein, we show highly sensitive and specific Zika serological assays...
October 18, 2018: Journal of Infectious Diseases
Jeremy A Sandgren, Guorui Deng, Danny W Linggonegoro, Sabrina M Scroggins, Katherine J Perschbacher, Anand R Nair, Taryn E Nishimura, Shao Yang Zhang, Larry N Agbor, Jing Wu, Henry L Keen, Meghan C Naber, Nicole A Pearson, Kathy A Zimmerman, Robert M Weiss, Noelle C Bowdler, Yuriy M Usachev, Donna A Santillan, Matthew J Potthoff, Gary L Pierce, Katherine N Gibson-Corley, Curt D Sigmund, Mark K Santillan, Justin L Grobe
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is sufficient to induce the major phenotypes of PE in mice. Thus, we hypothesized a role for AVP in the pathogenesis of PE. AVP infusion into pregnant C57BL/6J mice resulted in hypertension, renal glomerular endotheliosis, intrauterine growth restriction, decreased placental growth factor (PGF), altered placental morphology, placental oxidative stress, and placental gene expression consistent with human PE...
October 4, 2018: JCI Insight
Asokan Devarajan, Namakkal S Rajasekaran, Claire Valburg, Ekambaram Ganapathy, Snehal Bindra, William A Freije
Intrauterine growth restriction leads to adult obesity, cardiovascular disease, and non-alcoholic fatty liver disease/steatohepatitis. Animal models have shown that combined intrauterine and early postnatal calorie restriction (IPCR) ameliorates these sequelae in adult life. The mechanism by which IPCR protects against adult onset disease is not understood. Autophagy, a lysosomal degradative process, recycles cellular constituents and eliminates damaged organelles, proteins, and oxidants. In this study, we hypothesized that IPCR could regulate autophagy in the liver of male rat offspring...
September 21, 2018: Free Radical Biology & Medicine
Chandrakala Nagarajappa, Sheela Shikaripur Rangappa, Ravishankar Suryanarayana, Sharath Balakrishna
OBJECTIVES: To evaluate the presence of urinary congophilia amongIndian patients with preeclampsia. STUDY DESIGN: A prospective case control study in which congophilia of urine samples from preeclamptic pregnant women (n = 62) and normotensive pregnant women (n = 65) was compared by using Congo Red Dot Blot assay. MAIN OUTCOME MEASURES: Presence of urinary congophilia. RESULTS: Mean percentage of Congo Red Retention was 37...
July 2018: Pregnancy Hypertension
Madhulika B Gupta, Majida Abu Shehab, Karen Nygard, Kyle Biggar, Sahil S Singal, Nanette Santoro, Theresa L Powell, Thomas Jansson
Context: The mechanisms underpinning intrauterine growth restriction (IUGR) due to placental insufficiency remain poorly understood, no specific treatment is available, and clinically useful biomarkers for early detection are lacking. Objective: We hypothesised that human IUGR is associated with inhibition of mechanistic target of rapamycin (mTOR) and activation of the amino acid response (AAR) signaling, increased protein kinase CK2 activity, and increased IGFBP-1 expression and phosphorylation in decidua, and that maternal plasma IGFBP-1 hyperphosphorylation in first trimester predicts later development of IUGR...
August 16, 2018: Journal of Clinical Endocrinology and Metabolism
Amy C Kelly, Christopher A Bidwell, Xiaochuan Chen, Antoni R Macko, Miranda J Anderson, Sean W Limesand
Intrauterine growth restriction (IUGR) increases the risk of developing diabetes in later life, which indicates developmental programming of islets. IUGR fetuses with placental insufficiency develop hypoxemia, elevating epinephrine and norepinephrine (NE) concentrations throughout late gestation. To isolate the programming effects of chronically elevated catecholamines, NE was continuously infused into normally grown sheep fetuses for 7 days. High plasma NE concentrations suppress insulin, but after the NE infusion was terminated, persistent hypersecretion of insulin occurred...
October 1, 2018: Endocrinology
Sonnet S Jonker, Samantha Louey, Charles E Roselli
Polycystic ovary syndrome (PCOS) is a complex and common disorder in women, and those affected experience an increased burden of cardiovascular disease. It is an intergenerational syndrome, as affected women with high androgen levels during pregnancy "program" fetal development, leading to a similar phenotype in their female offspring. The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. METHODS Pregnant ewes received biweekly injections of vehicle (Control) or 100 mg testosterone propionate between 30-59 days of gestation (dGA; Early T) or 60-90 dGA (Late T)...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Valentina Canti, Stefania Del Rosso, Marta Tonello, Roberta Lucianò, Ariela Hoxha, Lavinia A Coletto, Isadora Vaglio Tessitore, Susanna Rosa, Angelo A Manfredi, Maria Teresa Castiglioni, Amelia Ruffatti, Patrizia Rovere-Querini
OBJECTIVE: Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS). METHODS: We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2 -glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, and the patients were prospectively followed for 24 months...
August 2018: Journal of Rheumatology
B H Boehmer, L D Brown, S R Wesolowski, W W Hay, P J Rozance
Impaired β-cell development and insulin secretion are characteristic of intrauterine growth-restricted (IUGR) fetuses. In normally grown late gestation fetal sheep pancreatic β-cell numbers and insulin secretion are increased by 7-10 days of pulsatile hyperglycemia (PHG). Our objective was to determine if IUGR fetal sheep β-cell numbers and insulin secretion could also be increased by PHG or if IUGR fetal β-cells do not have the capacity to respond to PHG. Following chronic placental insufficiency producing IUGR in twin gestation pregnancies (n=7), fetuses were administered a PHG infusion, consisting of 60 min, high rate, pulsed infusions of dextrose three times a day with an additional continuous, low-rate infusion of dextrose to prevent a decrease in glucose concentrations between the pulses or a control saline infusion...
October 2018: Journal of Developmental Origins of Health and Disease
Katja Murtoniemi, Pia M Villa, Jaakko Matomäki, Elina Keikkala, Piia Vuorela, Esa Hämäläinen, Eero Kajantie, Anu-Katriina Pesonen, Katri Räikkönen, Pekka Taipale, Ulf-Håkan Stenman, Hannele Laivuori
BACKGROUND: The proportion of hyperglycosylated human chorionic gonadotropin (hCG-h) to total human chorionic gonadotropin (%hCG-h) during the first trimester is a promising biomarker for prediction of early-onset pre-eclampsia. We wanted to evaluate the performance of clinical risk factors, mean arterial pressure (MAP), %hCG-h, hCGβ, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF) and mean pulsatility index of the uterine artery (Uta-PI) in the first trimester in predicting pre-eclampsia (PE) and its subtypes early-onset, late-onset, severe and non-severe PE in a high-risk cohort...
July 3, 2018: BMC Pregnancy and Childbirth
Oliver Graupner, Silvia M Lobmaier, Javier U Ortiz, Anne Karge, Bettina Kuschel
PURPOSE: The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio has been shown to be a useful parameter for the diagnosis and prediction of preeclampsia (PE). An increased sFlt-1/PlGF ratio can be closely linked to the need to deliver. The aim of the study was to examine the mean time until delivery (MTUD) in pregnant women with a strongly increased sFlt-1/PlGF ratio. METHODS: From 2010 to 2018, the sFlt-1/PlGF ratio was determined in 995 singleton pregnancies with diagnosis or suspicion of PE/HELLP syndrome and/or intrauterine growth restriction (IUGR)...
September 2018: Archives of Gynecology and Obstetrics
Yuhua Zhu, Tiantian Li, Shimeng Huang, Wei Wang, Zhaolai Dai, Cuiping Feng, Guoyao Wu, Junjun Wang
Maternal dietary supplementation with L-glutamine (Gln) has been considered as an option to improve fetal growth and to prevent the occurrence of intrauterine growth restriction (IUGR). This study investigated whether maternal Gln supplementation could improve fetal growth as well as the intestinal development during late pregnancy. Sixty pregnant Landrace × Large White multiparous sows were assigned to two groups, either the group fed the control diet or the group with the diet supplemented with 1% Gln from d 85 of gestation until farrowing...
September 2018: Amino Acids
Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, Claudio Romero Farias Marinho
BACKGROUND: Malaria in pregnancy (MiP) is one of the major causes of mortality and morbidity in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems on pregnancy and malaria could prove to be a useful method of improved decision making for better maternal-child health. METHODS: A population-based observational study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil)...
2018: PloS One
Jia Yin Soo, Michael D Wiese, Mary J Berry, I Caroline McMillen, Janna L Morrison
The effects of intrauterine growth restriction (IUGR) extend well into postnatal life. IUGR is associated with an increased risk of adverse health outcomes, which often leads to greater medication usage. Many medications require hepatic metabolism for activation or clearance, but hepatic function may be altered in IUGR fetuses. Using a sheep model of IUGR, we determined the impact of IUGR on hepatic drug metabolism and drug transporter expression, both important mediators of fetal drug exposure, in late gestation and in neonatal life...
August 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Charline Bertholdt, Olivier Morel, Matthieu Dap, Marion Choserot, Hélène Minebois
INTRODUCTION: The primary objective of this study was to evaluate the success of labor induction for indicated moderate and late preterm birth. As secondary objectives, the mode of delivery was assessed. MATERIAL AND METHODS: This is an observational study conducted in a tertiary care unit between 2013 and 2015. All patients who underwent labor induction for indicated preterm birth between 32+0 and 36+6 weeks of gestation (as premature rupture of membranes, preeclampsia, intrauterine growth restriction, fetomaternal alloimmunization, or intrahepatic cholestasis) were included...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
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