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Maples, A.

Amanda M Maple, Rachel K Rowe, Jonathan Lifshitz, Fabian Fernandez, Amelia L Gallitano
Up to 80% of people meeting DSM-IV definitions for schizophrenia will exhibit difficulties with sleep, along with a breakdown in circadian entrainment and rhythmicity. The changes to the sleep and circadian systems in this population are thought to be interdependent, as evidenced by the frequent use of the combined term "sleep and circadian rhythm disruption" or "SCRD" to describe their occurrence. To understand links between sleep and circadian problems in the schizophrenia population, we analyzed the duration and rhythmicity of sleep behavior in mice lacking function of the immediate early gene early growth response 3 ( Egr3)...
October 15, 2018: Journal of Biological Rhythms
K N Kalubi, P Michael, A Omri
The Greater Sudbury Region has been known as one of the most ecologically disturbed areas in Canada for the past century. Plant adaptation to environmental stressors often results in modifications in gene expression at the transcriptional level. The main objective of the present study was to compare the expression of genes associated with nickel resistance in Acer rubrum and Populus tremuloides growing in areas contaminated and uncontaminated with metals. Primers targeting Nramps4, Nas 3, At2G, MRP4 and alpha-tubulin genes were used to amplify cDNA of both species...
November 2018: Genes & Genomics
Robert S Anderson, Michael S Caterino
The genus Eurhoptus LeConte, 1876 is revised for America north of Mexico. Eight species are recognized including E.pyriformis LeConte, 1876, E.sordidus (LeConte, 1876), E.curtus (Hamilton, 1893), resurrected name, and five new species as follows: E.rileyi new species (type locality, Texas, Hidalgo County, Bentsen Rio Grande State Park), E.imbricatus new species (type locality, Texas, Bandera County, Lost Maples State Natural Area), E.cariniventris new species (type locality, Texas, Bandera County, Lost Maples State Natural Area), E...
2018: ZooKeys
Dongpo Song, Wenjie Li, Chaoping Wei, Weiqing Wang, Jinfeng Lyu
OBJECTIVE: To explore the genetic etiology of a patient with classic maple syrup urine disease (MSUD). METHODS: Next-generation sequencing (NGS) was used to screen the exons of BCKDHA, BCKDHB, DBT and DLD genes. Suspected mutations were verified by Sanger sequencing. Bioinformatic analysis was carried out to predict the influence of mutations on the protein structure and function. RESULTS: NGS and Sanger sequencing have detected a c.550delT mutation in exon 5 of the BCKDHB gene in the mother and a c...
October 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Shiyue Mei, Nan Bai, Shuang Hu, Ning Liu, Zhenhua Zhao, Xiangdong Kong
OBJECTIVE: To carry out mutation analysis for a pedigree affected with maple syrup urine disease (MSUD). METHODS: Clinical data of the proband was collected. Potential mutations of the BCKDHA and BCKDHB genes were analyzed by PCR and Sanger sequencing. Prenatal diagnosis was provided to a high-risk fetus at 12th gestational week through chorionic villus sampling. RESULTS: Two heterozygous mutations c.284G>C (p.Gly95Ala) and c.853C>T (p...
October 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Lieu T Tran, George V Mazariegos, Daniela Damian, Peter J Davis
BACKGROUND: Liver transplantation in children is often associated with coagulopathy and significant blood loss. Available data are limited. In this observational retrospective study, we assessed transfusion practices in pediatric patients undergoing liver transplantation at a single institution over the course of 9 years. METHODS: Data were retrospectively collected from patient medical records at the Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center...
October 3, 2018: Anesthesia and Analgesia
Gaëtan Rensonnet, Benoît Scherrer, Gabriel Girard, Aleksandar Jankovski, Simon K Warfield, Benoît Macq, Jean-Philippe Thiran, Maxime Taquet
Many closed-form analytical models have been proposed to relate the diffusion-weighted magnetic resonance imaging (DW-MRI) signal to microstructural features of white matter tissues. These models generally make assumptions about the tissue and the diffusion processes which often depart from the biophysical reality, limiting their reliability and interpretability in practice. Monte Carlo simulations of the random walk of water molecules are widely recognized to provide near groundtruth for DW-MRI signals. However, they have mostly been limited to the validation of simpler models rather than used for the estimation of microstructural properties...
September 30, 2018: NeuroImage
Guillaume Quang N'guyen, Nathalie Martin, Mani Jain, Luc Lagacé, Christian R Landry, Marie Filteau
Maple sap is a complex nutrient matrix collected during spring to produce maple syrup. The characteristics of sap change over the production period and its composition directly impacts syrup quality. This variability could in part be attributed to changes in tree metabolism following dormancy release, but little is known about these changes in deciduous trees. Therefore, understanding the variation in sap composition associated with dormancy release could help pinpoint the causes of some defects in maple syrup...
October 2, 2018: Scientific Reports
Renae Kirkham, Diana MacKay, Federica Barzi, Cherie Whitbread, Marie Kirkwood, Sian Graham, Paula Van Dokkum, H David McIntyre, Jonathan E Shaw, Alex Brown, Kerin O'Dea, Christine Connors, Jeremy Oats, Paul Zimmet, Jacqueline Boyle, Louise Maple-Brown
BACKGROUND: The postpartum period is a critical time to improve health outcomes for Aboriginal women, particularly for those who have chronic conditions. AIMS: To assess enhanced support methods (for women following diabetes in pregnancy (DIP)) to improve completion rates of recommended postpartum health checks. MATERIALS AND METHODS: Fifty-three Aboriginal women in the Northern Territory (NT) were contacted in the postpartum period to encourage medical check-ups...
October 2, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Johannes J Gaare, Gonzalo S Nido, Paweł Sztromwasser, Per M Knappskog, Olav Dahl, Morten Lund-Johansen, Jodi Maple-Grødem, Guido Alves, Ole-Bjørn Tysnes, Stefan Johansson, Kristoffer Haugarvoll, Charalampos Tzoulis
BACKGROUND: Mitochondrial dysfunction plays a key role in PD, but the underlying molecular mechanisms remain unresolved. We hypothesized that the disruption of mitochondrial function in PD is primed by rare, protein-altering variation in nuclear genes controlling mitochondrial structure and function. OBJECTIVE: The objective of this study was to assess whether genetic variation in genes associated with mitochondrial function influences the risk of idiopathic PD...
September 5, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Julio Arce-Funck, Clément Crenier, Michael Danger, Elise Billoir, Philippe Usseglio-Polatera, Vincent Felten
Headwater organisms are most often simultaneously faced with multiple stressors such as low resource quality and pollutants. Higher food quality has been hypothesized to enhance the tolerance of organisms to pollutants, but the interactive effects of food quality and pollutants on species and ecosystems remain poorly studied. To better understand these interactive effects, we experimentally manipulated the phosphorus (P) content of two leaf litters with contrasted carbon quality (alder and maple). During four weeks, individuals of the detritivorous crustacean Gammarus fossarum were exposed to low levels of cadmium ([Cd] = 0, 0...
December 15, 2018: Science of the Total Environment
Yingying Zhu, Songling Fu, Hua Liu, Zhaocheng Wang, Han Y H Chen
The introduction of species contributes to both ecological restoration and regional economics, while serving as a potential strategy to conserve species under rapid climate change. Despite an anticipated significant increase in temperature at high latitudes by the end of the 21st century, very few experimental migration trials have been conducted regarding large climate range changes. We employed a provenance trial by introducing a temperate sugar maple (Acer saccharum Marsh) of three provenances with a mean annual temperature of 3...
September 19, 2018: Tree Physiology
Sadia Mehmood, Myles Margolis, Chang Ye, Louise Maple-Brown, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
Objective: Women with a history of gestational diabetes mellitus (GDM) have an elevated risk of ultimately developing pre-diabetes and diabetes later in life. They also have an increased prevalence of fatty liver, but recent studies have reported conflicting findings on whether hepatic fat affects their risk of pre-diabetes/diabetes. Thus, we sought to evaluate the associations of liver fat with glucose homeostasis and determinants thereof in women with and without recent gestational dysglycemia...
2018: BMJ Open Diabetes Research & Care
Ernie Zuraida Ali, Lock-Hock Ngu
Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder. This disorder is usually caused by mutations in any one of the genes; BCKDHA , BCKDHB and DBT , which represent E1α, E1β and E2 subunits of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, respectively. This study presents the molecular characterization of 31 MSUD patients. Twenty one mutations including 14 new mutations were identified. The BCKDHB gene was the most commonly affected (45.2%) compared to BCKDHA gene (16...
December 2018: Molecular Genetics and Metabolism Reports
Na Li, Qiuyang Xia, Meihong Niu, Qingwei Ping, Huining Xiao
Biochars produced from two different wood species over a microwave assisted pyrolysis process were used as novel and green-based supports for immobilizing enzyme, laccase in particular. The results obtained from FT-IR, SEM and BET measurements indicated that Maple biochar with honeycomb structure has higher surface area and pore volume than Spruce biochar; and there exist O-H, C-H, C=O and C=C groups in biochars for potential chemical modification. The best laccase immobilization conditions identified from an orthogonal experiment were pH = 3, laccase concentration 16 g/L and contact time 8 h...
September 17, 2018: Scientific Reports
K S Rod, D R Walker, C A Bradley
Pythium seedling blight, which can be caused by a number of Pythium spp., is a disease that affects soybean (Glycine max) in the United States and Canada. Pythium ultimum var. ultimum, one of the most common pathogenic species, is favored by cool, wet conditions in early spring and causes seed decay, root rot, and seedling damping-off. In all, 102 major ancestors of modern North American cultivars and "first progeny" cultivars developed directly from ancestral lines were evaluated for resistance to P...
September 17, 2018: Plant Disease
Didem Ağaç, Leonardo D Estrada, Robert Maples, Lora V Hooper, J David Farrar
The mammalian nervous system communicates important information about the environment to the immune system, but the underlying mechanisms are largely unknown. Secondary lymphoid organs are highly innervated by sympathetic neurons that secrete norepinephrine (NE) as the primary neurotransmitter. Immune cells express adrenergic receptors, enabling the sympathetic nervous system to directly control immune function. NE is a potent immunosuppressive factor and markedly inhibits TNF-α secretion from innate cells in response to lipopolysaccharide (LPS)...
September 5, 2018: Brain, Behavior, and Immunity
Srinivasarao Thota
OBJECTIVES: In this paper, we discuss a Maple package, deaSolve, of the symbolic algorithm for solving an initial value problem for the system of linear differential-algebraic equations with constant coefficients. RESULTS: Using the proposed Maple package, one can compute the desired Green's function of a given IVP. Sample computations are presented to illustrate the Maple package.
September 6, 2018: BMC Research Notes
Catherine Cosgrave, Myfanwy Maple, Rafat Hussain
INTRODUCTION: Rural health workforce shortages are a global phenomenon. Countries like Australia, with industrialised economies, large land masses and broadly dispersed populations, face unique rural health challenges in providing adequate services and addressing workforce shortages. This article focuses on retention of early-career nursing and allied health professionals working in rural and remote Australia. Some of Australia's most severe and protracted rural workforce shortages, particularly among early-career health professionals, are in public sector community mental health (CMH), a multidisciplinary workforce staffed primarily by nurses and allied health professionals...
September 2018: Rural and Remote Health
Denisa Ficai, Valentina Grumezescu, Oana Mariana Fufă, Roxana Cristina Popescu, Alina Maria Holban, Anton Ficai, Alexandru Mihai Grumezescu, Laurentiu Mogoanta, George Dan Mogosanu, Ecaterina Andronescu
The aim of our study was to obtain and evaluate the properties of polymeric coatings based on poly(lactic-co-glycolic) acid (PLGA) embedded with magnetite nanoparticles functionalized with commercial antimicrobial drugs. In this respect, we firstly synthesized the iron oxide particles functionalized (@) with the antibiotic Cefepime (Fe₃O₄@CEF). In terms of composition and microstructure, the as-obtained powdery sample was investigated by means of grazing incidence X-ray diffraction (GIXRD), thermogravimetric analysis (TGA), scanning and transmission electron microscopy (SEM and TEM, respectively)...
August 21, 2018: Nanomaterials
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