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Dolors Mateo-Ortega, Joaquín T Limonero, Jorge Maté-Méndez, Elba Beas, Jesús González-Barboteo, Elisabeth Barbero, Sara Ela, Xavier Gómez-Batiste
OBJECTIVE: The goal of this study is to describe the development of a new tool, the Psychosocial and Spiritual Needs Evaluation scale Instrumento de Evaluación de Necesidades Psicosociales y Espirituales del Enfermo al Final de Vida (ENP-E), designed to assess the psychosocial needs of end-of-life (EOL) patients. And, secondarily, to describe the face validity and psychometric properties of this instrument in the Spanish-speaking context. METHOD: The scale was developed through a seven-stage process: (1) literature review; (2) expert panel establishment; (3) discussion and agreement on the most relevant dimensions of psychosocial care; (4) description of key indicators and consensus-based questions to evaluate such dimensions; (5) assessment of the scale by external palliative care (PC) professionals; (6) evaluation by patients; and (7) analysis of scale's psychometrics properties...
October 16, 2018: Palliative & Supportive Care
Hiromasa Tanino, Tatsuya Sato, Yasuhiro Nishida, Ryo Mitsutake, Hiroshi Ito
BACKGROUND: Dislocation continues to be a common complication following total hip arthroplasty (THA). A larger intraoperative range of motion (ROM) is believed to minimize dislocation risk, and intraoperative stability tests have been used to assess the ROM. However, it is not clear whether or not intraoperative stability tests can predict hip stability after THA. It is also unclear which angles are required in intraoperative stability tests. We investigated the usefulness of intraoperative stability tests, and other risk factors to predict hip stability after THA...
October 15, 2018: BMC Musculoskeletal Disorders
Weera Chaiyamongkol, Apipop Kritsaneephaiboon, Piyawat Bintachitt, Sitthiphong Suwannaphisit, Boonsin Tangtrakulwanich
Study Design: Biomechanical study. Purpose: To investigate the relative stiffness of a new posterior pelvic fixation for unstable vertical fractures of the sacrum. Overview of Literature: The reported operative fixation techniques for vertical sacral fractures include iliosacral screw, sacral bar fixations, transiliac plating, and local plate osteosynthesis. Clinical as well as biomechanical studies have demonstrated that these conventional techniques are insufficient to stabilize the vertically unstable sacral fractures...
October 16, 2018: Asian Spine Journal
Ismail Shaik, Shekhar Yeshwant Bhojraj, Gautam Prasad, Premik Bhupendra Nagad, Priyank Mangaldas Patel, Aaditya Dattatreya Kashikar, Nishant Kumar
Study Design: This retrospective study was conducted including 18 patients who underwent posterior-only stabilization and fusion procedure for pseudoarthrosis in the ankylosed spine from October 2007 to May 2015. Purpose: This study aimed to describe the treatment outcomes in 18 patients with Andersson lesion (AL) who were managed using the posterior-only approach. Literature Review: AL is an unstable, localized, vertebral, or discovertebral lesion of the spine...
October 16, 2018: Asian Spine Journal
Myung-Sang Moon, Sang-Jae Kim, Min-Su Kim, Dong-Suk Kim
Study Design: A case study. Purpose: To assess the chronological changes of the disease-related kyphosis after chemotherapy alone, secondly to clarify the role of growth cartilage in the healed lesion on kyphosis change, and to define the accurate prediction time in assessing residual kyphosis. Overview of Literature: None of the previous papers up to now dealt with the residual kyphosis, stability and remodeling processes of the affected segments...
October 16, 2018: Asian Spine Journal
Longfang Ye, Fang Zeng, Yong Zhang, Xiong Xu, Xiaofan Yang, Qing Huo Liu
We propose and numerically demonstrate two novel terahertz absorbers made up of periodic single- and double-layer decussate graphene ribbon arrays. The simulated results show that the proposed absorbers have narrowband near-unity terahertz absorption with ultra-wide frequency reconfiguration and angular stability. By tuning the Fermi level of graphene ribbons, the over 90% absorbance peak frequency of the absorber with single-layer graphene structure can be flexibly adjusted from 6.85 to 9.85 THz for both the transverse magnetic (TM) and transverse electric (TE) polarizations...
October 14, 2018: Nanomaterials
Wei-Heng Sun, Syh-Shiuh Yeh
This study uses the machine vision method to develop an on-machine turning tool insert condition monitoring system for tool condition monitoring in the cutting processes of computer numerical control (CNC) machines. The system can identify four external turning tool insert conditions, namely fracture, built-up edge (BUE), chipping, and flank wear. This study also designs a visual inspection system for the tip of an insert using the surrounding light source and fill-light, which can be mounted on the turning machine tool, to overcome the environmental effect on the captured insert image for subsequent image processing...
October 14, 2018: Materials
Zdeněk Perutka, Marek Šebela
Trypsin is the protease of choice for protein sample digestion in proteomics. The most typical active forms are the single-chain β-trypsin and the two-chain α-trypsin, which is produced by a limited autolysis of β-trypsin. An additional intra-chain split leads to pseudotrypsin (ψ-trypsin) with three chains interconnected by disulfide bonds, which can be isolated from the autolyzate by ion-exchange chromatography. Based on experimental data with artificial substrates, peptides, and protein standards, ψ-trypsin shows altered kinetic properties, thermodynamic stability and cleavage site preference (and partly also cleavage specificity) compared to the above-mentioned proteoforms...
October 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yizhe Wang, Zhiwei Xu
A single piezoelectric patch can be used as both a sensor and an actuator by means of the self-sensing piezoelectric actuator, and the function of self-sensing shows several advantages in many application fields. However, some problems exist in practical application. First, a capacitance bridge circuit is set up to realize the function of self-sensing, but the precise matching of the capacitance of the bridge circuit is hard to obtain due to the standardization of electric components and variations of environmental conditions...
October 13, 2018: Sensors
J Omar Muñoz-Bello, Leslie Olmedo-Nieva, Leonardo Josué Castro-Muñoz, Joaquín Manzo-Merino, Adriana Contreras-Paredes, Claudia González-Espinosa, Alejandro López-Saavedra, Marcela Lizano
The Wnt/β-catenin signaling pathway regulates cell proliferation and differentiation and its aberrant activation in cervical cancer has been described. Persistent infection with high risk human papillomavirus (HR-HPV) is the most important factor for the development of this neoplasia, since E6 and E7 viral oncoproteins alter cellular processes, promoting cervical cancer development. A role of HPV-16 E6 in Wnt/β-catenin signaling has been proposed, although the participation of HPV-18 E6 has not been previously studied...
October 13, 2018: International Journal of Molecular Sciences
Kyle J Burghardt, Kristen M Ward, Elani J Sanders, Bradley H Howlett, Berhane Seyoum, Zhengping Yi
Atypical antipsychotics (AAPs) are a class of medications associated with significant metabolic side effects, including insulin resistance. The aim of this study was to analyze the skeletal muscle lipidome of patients on AAPs, compared to mood stabilizers, to further understand the molecular changes underlying AAP treatment and side effects. Bipolar patients on AAPs or mood stabilizers underwent a fasting muscle biopsy and assessment of insulin sensitivity. A lipidomic analysis of total fatty acids (TFAs), phosphatidylcholines (PCs) and ceramides (CERs) was performed on the muscle biopsies, then lipid species were compared between treatment groups, and correlation analyses were performed with insulin sensitivity...
October 13, 2018: Metabolites
Ludmila Otilia Cinteza, Cristina Scomoroscenco, Sorina Nicoleta Voicu, Cristina Lavinia Nistor, Sabina Georgiana Nitu, Bogdan Trica, Maria-Luiza Jecu, Cristian Petcu
Silver nanoparticles (AgNPs) are considered a promising alternative to the use of antibiotics in fighting multidrug-resistant pathogens. However, their use in medical application is hindered by the public concern regarding the toxicity of metallic nanoparticles. In this study, rationally designed AgNP were produced, in order to balance the antibacterial activity and toxicity. A facile, environmentally friendly synthesis was used for the electrochemical fabrication of AgNPs. Chitosan was employed as the capping agent, both for the stabilization and to improve the biocompatibility...
October 13, 2018: Nanomaterials
Chao-Zhan Lin, Run-Jing Zhang, Yu-Feng Yao, Xiao-Dan Huang, Rong-Bo Zheng, Bo-Jian Wu, Chen-Chen Zhu
Quality control of Chinese herbal tea remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling and famous brand of beverage in China, Wanglaoji Herbal Tea (WLJHT), via a full component quantitative analysis. In this paper, a total of thirty-two representative constituents were identified or tentatively characterized using ultra-high performance liquid chromatography coupled with quadrupole tandem time-of-flight mass spectrometry (UPLC-Q-TOF-MS)...
October 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Joan Castells-Ballester, Ewa Zatorska, Matthias Meurer, Patrick Neubert, Anke Metschies, Michael Knop, Sabine Strahl
For proteins entering the secretory pathway, a major factor contributing to maturation and homeostasis is glycosylation. One relevant type of protein glycosylation is O -mannosylation, which is essential and evolutionarily-conserved in fungi, animals, and humans. Our recent proteome-wide study in the eukaryotic model organism Saccharomyces cerevisiae revealed that more than 26% of all proteins entering the secretory pathway receive O -mannosyl glycans. In a first attempt to understand the impact of O -mannosylation on these proteins, we took advantage of a tandem fluorescent timer (tFT) reporter to monitor different aspects of protein dynamics...
October 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sasikala Sundar, Ganesh Venkatachalam, Seong Jung Kwon
A facile one-step, eco-friendly, and cost-effective approach for the formation of copper oxide (CuO) nanowires by a green method using saponin-rich Sapindus mukorossi fruit extract (SMFE). The physio-chemical characteristics of the synthesized CuO nanowires have been characterized by X-ray Diffractometry (XRD), X-ray Photoelectron Spectroscopy (XPS), FT-IR (Fourier Transform Infrared Spectroscopy, FE-SEM (Scanning Electron Microscopy), and High-Resolution Transmission Electron Microscopy (HR-TEM). Further, the electrocatalytic activity of the CuO nanowires synthesized with SMFE has been investigated, and they have been used as dopamine (DA) sensors...
October 12, 2018: Nanomaterials
Jiucai Jin, Jie Zhang, Deqing Liu
Unmanned Surface Vehicle (USV) is a novel multifunctional platform for ocean observation, and its heading and velocity control are essential and important for autonomous operation. A coupled heading and velocity controller is designed using backstepping technology for an USV called 'USBV' (Unmanned Surface Bathymetry Vehicle). The USBV is an underactuated catamaran, where the heading and velocity are controlled together by two thrusters at the stern. The three degrees-of-freedom equations are used for USBV's modeling, which is identified using experiment data...
October 12, 2018: Sensors
Michael Z Hu, Chaiwat Engtrakul, Brian L Bischoff, Mi Lu, Mussie Alemseghed
Surface wettability-tailored porous ceramic/metallic membranes (in the tubular and planar disc form) were prepared and studied for both vapor-phase separation and liquid pervaporative separations of water-ethanol mixtures. Superhydrophobic nanoceramic membranes demonstrated more selective permeation of ethanol (relative to water) by cross-flow pervaporation of liquid ethanol⁻water mixture (10 wt % ethanol feed at 80 °C). In addition, both superhydrophilic and superhydrophobic membranes were tested for the vapor-phase separations of water⁻ethanol mixtures...
October 12, 2018: Membranes
Ruyin Cao, Alejandro Giorgetti, Andreas Bauer, Bernd Neumaier, Giulia Rossetti, Paolo Carloni
Human G-protein coupled receptors (GPCRs) are important targets for pharmaceutical intervention against neurological diseases. Here, we use molecular simulation to investigate the key step in ligand recognition governed by the extracellular domains in the neuronal adenosine receptor type 2A (hA2A R), a target for neuroprotective compounds. The ligand is the high-affinity antagonist (4-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol), embedded in a neuronal membrane mimic environment...
October 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Chun-Hung Su, Shing-Hong Liu, Tan-Hsu Tan, Chien-Hsien Lo
The pulse contour method is often used with the Windkessel model to measure stroke volume. We used a digital pressure and flow sensors to detect the parameters of the Windkessel model from the pulse waveform. The objective of this study was to assess the stability and accuracy of this method by making use of the passive leg raising test. We studied 24 healthy subjects (40 ± 9.3 years), and used the Medis® CS 1000, an impedance cardiography, as the comparing reference. The pulse contour method measured the waveform of the brachial artery by using a cuff...
October 12, 2018: Sensors
Thomas Hiller, Johanna Berg, Laura Elomaa, Viola Röhrs, Imran Ullah, Katrin Schaar, Ann-Christin Dietrich, Munir A Al-Zeer, Andreas Kurtz, Andreas C Hocke, Stefan Hippenstiel, Henry Fechner, Marie Weinhart, Jens Kurreck
Bioprinting is a novel technology that may help to overcome limitations associated with two-dimensional (2D) cell cultures and animal experiments, as it allows the production of three-dimensional (3D) tissue models composed of human cells. The present study describes the optimization of a bioink composed of alginate, gelatin and human extracellular matrix (hECM) to print human HepaRG liver cells with a pneumatic extrusion printer. The resulting tissue model was tested for its suitability for the study of transduction by an adeno-associated virus (AAV) vector and infection with human adenovirus 5 (hAdV5)...
October 12, 2018: International Journal of Molecular Sciences
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