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https://www.readbyqxmd.com/read/30517930/dialysate-calcium-levels-do-they-matter
#1
REVIEW
Frank M van der Sande, Karlien J A Ter Meulen, Peter Kotanko, Jeroen P Kooman
BACKGROUND: Calcium (Ca) is an essential element that plays a critical role in many biological processes. In dialysis patients, the regulation of Ca balance is highly complex, given the absence of kidney function, endocrine disturbances and the use of drugs such as phosphate binders, vitamin D analogues, and calcimimetics. Also, the use of different dialysate Ca (DCa) baths has profound effect on Ca balance, which depends both on the difference between the Ca concentration in the bath and the serum of the patients, as on the ultrafiltration volume...
December 5, 2018: Blood Purification
https://www.readbyqxmd.com/read/30517907/muscular-tension-significantly-affects-stability-in-standing-posture
#2
Simone Tassani, Josep M Font-Llagunes, Miguel Ángel González Ballester, Jérôme Noailly
BACKGROUND: Muscular co-contraction is a strategy commonly used by elders with the aim to increase stability. However, co-contraction leads to stiffness which in turns reduces stability. Some literature seems to suggest an opposite approach and to point out relaxation as a way to improve stability. Teaching relaxation is therefore becoming the aim of many studies letting unclear whether tension or relaxation are the most effective muscular strategy to improve stability. Relaxation is a misleading concept in our society...
November 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30517906/haptic-information-provided-by-anchors-and-the-presence-of-cognitive-tasks-contribute-separately-to-reducing-postural-sway-in-young-adults
#3
Rosangela Alice Batistela, Alison Oates, Renato Moraes
BACKGROUND: Haptic information provided by the anchors reduces postural sway while standing upright. It is unclear whether this benefit would remain in the presence of cognitive tasks combined with a more challenging postural task. RESEARCH QUESTION: Our aim was to investigate the effects of the anchors and visual and auditory cognitive tasks on postural control in young adults in a challenging balancing task. METHODS: Twenty young adults stood upright on a balance beam with the central portion of each foot placed over the beam and feet at shoulder width without and with the use of the anchors in three cognitive conditions: control, visual Stroop task, and auditory digit-monitoring task...
November 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30517905/rational-design-of-polymer-lipid-nanoparticles-for-docetaxel-delivery
#4
Juan M R Albano, Lígia Nunes de Morais Ribeiro, Verônica Muniz Couto, Mariana Barbosa Messias, Gustavo Henrique Rodrigues da Silva, Márcia Cristina Breitkreitz, Eneida de Paula, Monica Pickholz
In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the effects of the polymers in the final composition. In this direction, two poloxoamers -Pluronic F127 and F68- were selected. Some poloxamers are well known to be inhibitors of the P-glycoprotein efflux pump. Additionally, their poly-ethylene-oxide blocks can help them to escape the immune system, making the poloxamers appealing to be present in a nanoparticle designed for the treatment of cancer...
November 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30517878/cervical-cancer-cell-lines-are-sensitive-to-sub-erythemal-uv-exposure
#5
Wenyi Gu, Surong Sun, Andrew Kahn, Dalton Dacus, Sebastian O Wendel, Nigel McMillan, Nicholas A Wallace
High risk human papillomavirus (HPV) infections are the causative agent in virtually every cervical cancer as well as a host of other anogenital and oropharyngeal malignancies. These viruses must activate DNA repair pathways to facilitate their replication, while avoiding the cell cycle arrest and apoptosis that can accompany DNA damage. HPV oncoproteins facilitate each of these goals, but also reduce genome stability. Our data dissect the cytotoxic and cytoprotective characteristics of HPV oncogenes in cervical cancer cells...
December 2, 2018: Gene
https://www.readbyqxmd.com/read/30517871/histone-deacetylase-sirt1-targets-plk2-to-regulate-centriole-duplication
#6
Hongbo Ling, Lirong Peng, Jianbo Wang, Raneen Rahhal, Edward Seto
The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning SIRT1 controlled centrosome-associated events. Here we report that the centrosome protein Plk2 is acetylated and undergoes deacetylation by SIRT1. Acetylation protects Plk2 from ubiquitination, and SIRT1-mediated deacetylation promotes ubiquitin-dependent degradation of Plk2...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30517863/hdac3-regulates-the-transition-to-the-homeostatic-myelinating-schwann-cell-state
#7
Laura H Rosenberg, Anne-Laure Cattin, Xavier Fontana, Elizabeth Harford-Wright, Jemima J Burden, Ian J White, Jacob G Smith, Ilaria Napoli, Victor Quereda, Cristina Policarpi, Jamie Freeman, Robin Ketteler, Antonella Riccio, Alison C Lloyd
The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated with neuropathies. The histone deacetylases histone deacetylase 1 (HDAC1) and HDAC2 are required for the myelination transcriptional program. Here, we show a distinct role for HDAC3, in that, while dispensable for the formation of mSCs, it is essential for the stability of the myelin sheath once formed-with loss resulting in progressive severe neuropathy in adulthood...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30517848/interaction-of-hsp90aa1-with-phospholipids-stabilizes-membranes-under-stress-conditions
#8
Pengpeng Li, Jingjing Wang, Ye Zou, Zhilan Sun, Muhan Zhang, Zhiming Geng, Weimin Xu, Daoying Wang
During heat shock conditions, structural changes in cellular membranes may lead to cell death. Hsp90AA1 and other heat shock proteins involved in membranes are responsible for protecting membrane stabilization. However, the membrane binding mechanism of Hsp90AA1 remains largely uncharacterized. In this study, we showed Hsp90AA1 interacts with phospholipid membrane with high affinity. Using the depth-dependent fluorescence-quenching with brominated lipids, we found Hsp90AA1 penetrated 10.7 Å into the hydrocarbon core of the lipid bilayer...
December 2, 2018: Biochimica et biophysica acta. Biomembranes
https://www.readbyqxmd.com/read/30517843/%C3%AF-%C3%AF-stacking-interaction-is-a-key-factor-for-the-stability-of-gh11-xylanases-at-low-ph
#9
Hui-Hua Ge, Yue Qiu, Zhi-Wei Yi, Run-Ying Zeng, Guang-Ya Zhang
Acidic xylanases possess the unique features necessary for the tolerance of acidic environments, which may have great potentials for industrial purposes. However, factors controlling the pH-dependent stability of xylanases are only partially known. Here we proposed a residue interaction networks based method to analyze the differences of residue interactions between 6 pairs of experimentally verified acidic and neutral xylanases. They had very close numbers of aromatic amino acids, however extremely significant more (p < 0...
December 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30517842/dimerization-ability-denaturation-mechanism-and-the-stability-of-a-staphylococcal-phage-repressor-and-its-two-domains
#10
Anindya Biswas, Semanti Ghosh, Debabrata Sinha, Anindya Dutta, Soham Seal, Anshuman Bagchi, Subrata Sau
The lysogenic growth of phage ф11 in Staphylococcus aureus is controlled by a repressor (CI) that harbors an N-terminal domain (NTD), and a C-terminal domain (CTD). Previously, NTD, like CI, showed DNA binding activity and dimerized in the aqueous solution. To precisely understand the folding mechanism, function, and the stability of CI, NTD, and CTD, we have investigated their recombinant forms, rCI, rNTD, and rCTD, using various probes. The data reveal that rCTD, like rCI and rNTD, is a well-structured protein and produces dimers in the aqueous environment...
December 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30517796/combination-of-the-searches-for-pair-produced-vectorlike-partners-of-the-third-generation-quarks-at-sqrt-s-13-tev-with-the-atlas-detector
#11
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, D K Abhayasinghe, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adam, L Adamczyk, J Adelman, M Adersberger, A Adiguzel, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, M Alhroob, B Ali, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, A Ambler, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, C R Anelli, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J A Antrim, F Anulli, M Aoki, J A Aparisi Pozo, L Aperio Bella, G Arabidze, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, A Armstrong, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, M K Ayoub, A M Azoulay, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, A J Bailey, J T Baines, M Bajic, C Bakalis, O K Baker, P J Bakker, D Bakshi Gupta, S Balaji, E M Baldin, P Balek, F Balli, W K Balunas, J Balz, E Banas, A Bandyopadhyay, S Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J Barkeloo, T Barklow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, S Batlamous, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, T Beau, P H Beauchemin, P Bechtle, H C Beck, H P Beck, K Becker, M Becker, C Becot, A Beddall, A J Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, P Bellos, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R Bi, R M B Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, M Birman, T Bisanz, J P Biswal, C Bittrich, D M Bjergaard, J E Black, K M Black, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, D Boye, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, L Brenner, R Brenner, S Bressler, B Brickwedde, D L Briglin, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F C Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, D W Casper, R Castelijn, F L Castillo, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, J D Chapman, B Chargeishvili, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C H Chen, H Chen, J Chen, J Chen, S Chen, S J Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, H Cohen, A E C Coimbra, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, L D Corpe, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, S Czekierda, P Czodrowski, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, F Dallaire, C Dallapiccola, M Dam, G D'amen, J Damp, J R Dandoy, M F Daneri, N P Dang, N D Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, S D'Auria, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R De Asmundis, A De Benedetti, M De Beurs, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, M De Santis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, Y Delabat Diaz, D Delgove, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, L D'Eramo, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, G Di Gregorio, B Di Micco, R Di Nardo, K F Di Petrillo, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias Do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B Do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, A D'onofrio, M D'Onofrio, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, Y Du, F Dubinin, M Dubovsky, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A C Dudder, E M Duffield, L Duflot, M Dührssen, C Dülsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, S Dysch, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, A Emerman, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Faisca Rodrigues Pereira, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, F M Follega, N Fomin, G T Forcolin, A Formica, F A Förster, A C Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, A N Fray, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, E M Freundlich, D C Frizzell, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, J Gao, Y Gao, Y S Gao, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, S George, D Gerbaudo, G Gessner, S Ghasemi, M Ghasemi Bostanabad, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, A Giannini, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Goncalves Gama, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, C Goy, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, F G Gravili, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, N A Grieser, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, C Grud, A Grummer, L Guan, W Guan, J Guenther, A Guerguichon, F Guescini, D Guest, R Gugel, B Gui, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, Z Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, K Han, L Han, S Han, K Hanagaki, M Hance, D M Handl, B Haney, R Hankache, P Hanke, E Hansen, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, S Harkusha, P F Harrison, N M Hartmann, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, L B Havener, M Havranek, C M Hawkes, R J Hawkings, D Hayden, C Hayes, C P Hays, J M Hays, H S Hayward, S J Haywood, M P Heath, V Hedberg, L Heelan, S Heer, K K Heidegger, J Heilman, S Heim, T Heim, B Heinemann, J J Heinrich, L Heinrich, C Heinz, J Hejbal, L Helary, A Held, S Hellesund, S Hellman, C Helsens, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, G H Herbert, H Herde, V Herget, Y Hernández Jiménez, H Herr, M G Herrmann, T 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Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, Y Zhao, Z Zhao, A Zhemchugov, Z Zheng, D Zhong, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Therefore, combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517793/observation-of-centrality-dependent-acoplanarity-for-muon-pairs-produced-via-two-photon-scattering-in-pb-pb-collisions-at-sqrt-s_-nn-5-02-tev-with-the-atlas-detector
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M Scyboz, J Searcy, C D Sebastiani, P Seema, S C Seidel, A Seiden, T Seiss, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, N Semprini-Cesari, S Sen, S Senkin, C Serfon, L Serin, L Serkin, M Sessa, H Severini, F Sforza, A Sfyrla, E Shabalina, J D Shahinian, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, A S Sharma, A Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, Y Shen, N Sherafati, A D Sherman, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, D R Shope, S Shrestha, E Shulga, P Sicho, A M Sickles, P E Sidebo, E Sideras Haddad, O Sidiropoulou, A Sidoti, F Siegert, Dj Sijacki, J Silva, M Silva, M V Silva Oliveira, S B Silverstein, L Simic, S Simion, E Simioni, M Simon, R Simoniello, P Sinervo, N B Sinev, M Sioli, G Siragusa, I Siral, S Yu Sivoklokov, J Sjölin, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, J Smiesko, N Smirnov, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, J W Smith, M N K Smith, M Smizanska, K Smolek, A Smykiewicz, A A Snesarev, I M Snyder, S Snyder, R Sobie, A M Soffa, A Soffer, A Søgaard, D A Soh, G Sokhrannyi, C A Solans Sanchez, M Solar, E Yu Soldatov, U Soldevila, A A Solodkov, A Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, W Song, W Y Song, A Sopczak, F Sopkova, D Sosa, C L Sotiropoulou, S Sottocornola, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, T M Spieker, R Spighi, G Spigo, L A Spiller, D P Spiteri, M Spousta, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, B Stanislaus, M M Stanitzki, B Stapf, S Stapnes, E A Starchenko, G H Stark, J Stark, S H Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, M Stegler, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, M C Stockton, G Stoicea, P Stolte, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, D M S Sultan, S Sultansoy, T Sumida, S Sun, X Sun, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, A Sydorenko, I Sykora, T Sykora, D Ta, K Tackmann, J Taenzer, A Taffard, R Tafirout, E Tahirovic, N Taiblum, H Takai, R Takashima, E H Takasugi, K Takeda, T Takeshita, Y Takubo, M Talby, A A Talyshev, J Tanaka, M Tanaka, R Tanaka, B B Tannenwald, S Tapia Araya, S Tapprogge, A Tarek Abouelfadl Mohamed, S Tarem, G Tarna, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, A J Taylor, G N Taylor, P T E Taylor, W Taylor, A S Tee, P Teixeira-Dias, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, D W Thomas, J P Thomas, A S Thompson, P D Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, K G Tomiwa, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, J C-L Tseng, P V Tsiareshka, A Tsirigotis, N Tsirintanis, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, E Tzovara, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, W Van Den Wollenberg, H Van der Graaf, P Van Gemmeren, J Van Nieuwkoop, I Van Vulpen, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, K E Varvell, G A Vasquez, J G Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, C M Vergel Infante, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, M Vicente Barreto Pinto, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E Von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, T Šfiligoj, R Vuillermet, I Vukotic, T Ženiš, L Živković, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, V M Walbrecht, J Walder, R Walker, S D Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, P Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, W T Wang, W Wang, W X Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S A Weber, S M Weber, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, L J Wilkins, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Woźniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H J Yang, H T Yang, S Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C J S Young, C Young, J Yu, J Yu, X Yue, S P Y Yuen, B Zabinski, G Zacharis, E Zaffaroni, R Zaidan, A M Zaitsev, T Zakareishvili, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, D R Zaripovas, S V Zeißner, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, P Zhao, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02  TeV with an integrated luminosity of 0.49  nb^{-1}. The azimuthal angle and transverse momentum correlations between the muons are measured as a function of collision centrality. The muon pairs are produced from γγ through the interaction of the large electromagnetic fields of the nuclei. The contribution from background sources of muon pairs is removed using a template fit method...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517789/vapor-assisted-ex-situ-doping-of-carbon-nanotube-towards-efficient-and-stable-perovskite-solar-cells
#13
Jin-Wook Lee, Il Jeon, Haosheng Lin, Seungju Seo, Tae-Hee Han, Anton Anisimov, Esko I Kauppinen, Yutaka Matsuo, Shigeo Maruyama, Yang Yang
Single-walled carbon nanotubes (CNTs) has been considered as a promising material for a top electrode of perovskite solar cells owing to its hydrophobic nature, earth-abundance, and mechanical robustness. However, its poor conductivity, a shallow work function, and non-reflective nature have limited further enhancement in power conversion efficiency (PCE) of top CNT electrode-based perovskite solar cells. Here, we introduced a simple and scalable method to address these issues by utilizing an ex-situ vapor-assisted doping method...
December 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/30517788/computational-investigation-of-rna-a-bulges-related-to-microtubule-associated-protein-tau-causing-frontotemporal-dementia-and-parkinsonism
#14
David J Wales, Matthew D Disney, Ilyas Yildirim
Mutations in the human tau gene result in alternative splicing of the tau protein, which cause frontotemporal dementia and Parkinsonism. One disease mechanism is linked to the stability of a hairpin within microtubule-associated protein tau (MAPT) mRNA, which contains an A-bulge. Here we employ computational methods to investigate the structural and thermodynamic properties of several A-bulge RNAs with different closing base-pairs. We find that the current amber RNA force field has a preference to overstabilize base-triple over stacked states, even though some of the A-bulges are known to prefer stacked states according to NMR studies...
December 5, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30517787/lithium-plating-and-stripping-on-carbon-nanotube-sponge
#15
Gaojing Yang, Yejing Li, Yuxin Tong, Jiliang Qiu, Shuai Liu, Simeng Zhang, Zhaoruxin Guan, Bin Xu, Zhaoxiang Wang, Liquan Chen
Lithium metal is an ideal anode material due to its high specific capacity and low electrochemical potential. However, issues such as dendritic growth and low coulombic efficiency prevent its application in secondary lithium batteries. The use of three-dimensional (3D) porous current collector is an effective strategy to solve these problems. Herein, commercial carbon nanotube (CNT) sponge is used as a 3D current collector for dendrite-free lithium metal deposition to improve the coulombic efficiency and the cycle stability of the lithium metal batteries...
December 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/30517776/allograft-reconstruction-of-the-humerus-complications-and-revision-surgery
#16
Paul T Ogink, Frederik R Teunissen, Julie R Massier, Kevin A Raskin, Joseph H Schwab, Santiago A Lozano-Calderon
BACKGROUND AND OBJECTIVES: Allograft reconstruction of the humerus after resection is preferred by many because of bone stock restoration and biologic attachment of ligaments and muscles to the allograft, theoretically obtaining superior stability and functionality. Our aim was to assess the prevalence of complications and the incidence and etiology for revision surgery in humeral allograft reconstructions. METHODS: We included patients 18 years and older who underwent wide resection and allograft reconstruction of the humerus for primary and metastatic lesions at our institution between 1990 and 2013...
December 5, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30517736/extensive-crispr-rna-modification-reveals-chemical-compatibility-and-structure-activity-relationships-for-cas9-biochemical-activity
#17
Daniel O'Reilly, Zachary J Kartje, Eman A Ageely, Elise Malek-Adamian, Maryam Habibian, Annabelle Schofield, Christopher L Barkau, Kushal J Rohilla, Lauren B DeRossett, Austin T Weigle, Masad J Damha, Keith T Gagnon
CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofactors to guide catalysis. Therefore, chemical modification of the guide RNA can be used to characterize structure-activity relationships within CRISPR ribonucleoprotein (RNP) enzymes and identify compatible chemistries for controlling activity...
December 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30517713/rna-binding-protein-rps3-contributes-to-hepatocarcinogenesis-by-post-transcriptionally-up-regulating-sirt1
#18
Lijun Zhao, Jianzhong Cao, Kexin Hu, Penghui Wang, Guodong Li, Xiaodong He, Tanjun Tong, Limin Han
Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions and mechanisms remain to be determined. By performing bioinformatics analysis using well-established hepatocellular carcinoma (HCC) datasets, we identified a set of HCC progression-associated RBPs (HPARBPs) and found that the global expression of HPARBPs was significantly correlated with patient prognosis. Among the 42 HPARBPs, human ribosomal protein S3 (RPS3) was one of the most abundant genes whose role remains uncharacterized in HCC...
December 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30517685/rna-dna-fibers-and-polygons-with-controlled-immunorecognition-activate-rnai-fret-and-transcriptional-regulation-of-nf-%C3%AE%C2%BAb-in-human-cells
#19
Weina Ke, Enping Hong, Renata F Saito, Maria Cristina Rangel, Jian Wang, Mathias Viard, Melina Richardson, Emil F Khisamutdinov, Martin Panigaj, Nikolay V Dokholyan, Roger Chammas, Marina A Dobrovolskaia, Kirill A Afonin
Nucleic acid-based assemblies that interact with each other and further communicate with the cellular machinery in a controlled manner represent a new class of reconfigurable materials that can overcome limitations of traditional biochemical approaches and improve the potential therapeutic utility of nucleic acids. This notion enables the development of novel biocompatible 'smart' devices and biosensors with precisely controlled physicochemical and biological properties. We extend this novel concept by designing RNA-DNA fibers and polygons that are able to cooperate in different human cell lines and that have defined immunostimulatory properties confirmed by ex vivo experiments...
December 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30517682/a-light-responsive-rna-aptamer-for-an-azobenzene-derivative
#20
Thea S Lotz, Thomas Halbritter, Christoph Kaiser, Martin M Rudolph, Leon Kraus, Florian Groher, Sabrina Steinwand, Josef Wachtveitl, Alexander Heckel, Beatrix Suess
Regulation of complex biological networks has proven to be a key bottleneck in synthetic biology. Interactions between the structurally flexible RNA and various other molecules in the form of riboswitches have shown a high-regulation specificity and efficiency and synthetic riboswitches have filled the toolbox of devices in many synthetic biology applications. Here we report the development of a novel, small molecule binding RNA aptamer, whose binding is dependent on light-induced change of conformation of its small molecule ligand...
December 5, 2018: Nucleic Acids Research
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