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https://www.readbyqxmd.com/read/30077537/giant-ureteric-calculus-in-a-patient-with-bladder-exstrophy
#1
Surya Prakash Vaddi, Seshu Mohan R, Satish Reddy
We report a case of giant ureteric calculus in an adult male with bladder exstrophy who presented with urinary incontinence and recurrent urinary tract infection. Investigations revealed a 16cm ureteric calculus, vesical and left staghorn renal calculi. Ureteric stone was removed by open Ureterolithotomy.
August 2, 2018: Urology
https://www.readbyqxmd.com/read/30076908/clinical-utility-of-total-length-gleason-pattern-4-on-biopsy-in-men-with-grade-group-2-prostate-cancer
#2
Lucas W Dean, Melissa Assel, Daniel D Sjoberg, Andrew J Vickers, Hikmat A Al-Ahmadie, Ying-Bei Chen, Anuradha Gopalan, S Joseph Sirintrapun, Satish K Tickoo, James A Eastham, Peter T Scardino, Victor E Reuter, Behfar Ehdaie, Samson W Fine
PURPOSE: The ideal methodology for quantifying secondary Gleason pattern 4 (GP4) in men with Grade group (GrdGrp) 2/Gleason score (GS) 3+4=7 on biopsy remains unknown. We compared various methods of GP4 quantification and evaluated their association with adverse pathology at radical prostatectomy (RP). MATERIALS AND METHODS: 457 men with GrdGrp 2 prostate cancer on biopsy who subsequently underwent RP at our institution. Only patients with ≥ 12 cores reviewed were included...
August 1, 2018: Journal of Urology
https://www.readbyqxmd.com/read/30060842/diffuse-infiltrative-colonic-lipomatosis-in-a-vietnamese-pot-bellied-pig
#3
A Kokosinska, D R Rissi
Diffuse infiltrative gastrointestinal lipomatosis (DIGIL) is characterized by widespread proliferation of adipose tissue within the submucosal and subserosal layers of the gastrointestinal tract. Here we describe a case of diffuse infiltrative colonic lipomatosis in a 3-year-old male Vietnamese pot-bellied pig. Gross anatomical changes included obesity with sparse small intestinal contents and no colonic contents. The colonic lumen was narrowed and the colonic wall was diffusely thickened (∼5 mm), white, homogeneous and soft...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060251/protective-role-of-surfactant-protein-d-against-lung-injury-and-oxidative-stress-induced-by-nitrogen-mustard
#4
Vasanthi R Sunil, Kinal N Vayas, Jessica A Cervelli, Elena Ebramova, Andrew J Gow, Michael Goedken, Jeffrey D Laskin, Debra L Laskin
Nitrogen mustard (NM) is a vesicant known to cause acute pulmonary injury which progresses to fibrosis. Macrophages contribute to both of these pathologies. Surfactant protein (SP)-D is a pulmonary collectin that suppresses lung macrophage activity. Herein, we analyzed the effects of loss of SP-D on NM-induced macrophage activation and lung toxicity. Wild type (WT) and SP-D-/- mice were treated intratracheally with PBS or NM (0.08 mg/kg). Bronchoalveolar lavage fluid (BAL) and tissue were collected 14 d later...
July 30, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/30058064/management-of-congenital-urethral-strictures-in-infants-case-series
#5
Dalia Gobbi, Francesco Fascetti Leon, Michele Gnech, Paola Midrio, Piergiorgio Gamba, Marco Castagnetti
PURPOSE: Infra-vesical obstruction is uncommon in infants and generally due to urethral valves. Congenital urethral strictures (CUS), instead, defined as a concentric narrowing of the urethral lumen, are exceedingly rare in infants. MATERIALS AND METHODS: We reviewed our experience with 7 patients treated at our institution for CUS <age of 1-year. The study is a retrospective review of 7 patients treated for CUS diagnosed <age 1-year during a 10-year period...
July 28, 2018: Urology Journal
https://www.readbyqxmd.com/read/30058002/expression-of-laminin-332-in-vesicant-skin-injury-and-wound-repair
#6
Yoke-Chen Chang, Marion K Gordon, Donald R Gerecke
Sulfur Mustard (SM) is a potent vesicant or blistering agent. It is a highly reactive bi-functional alkylating agent that cross links proteins, DNA, and other cellular components. Laminin 332 is a heterotrimer glycoprotein and a crucial skin component that attaches the epidermal basal keratinocytes to the dermis. SM wounds histologically appear similar to Epidermolysis Bullosa (EB), human genetic blistering diseases that involve genetic changes in laminin 332. The specific mechanism of action of SM exposure is unknown, but there are several key similarities between vesicant induced cutaneous injury and the Junctional form of EB (JEB) cutaneous injury: 1) Initial alkylation causes blistering similar to JEB; 2) Initial injury is followed by protease activation and prolonged inflammation similar to the chronic inflammation observed in EB; 3) The blister plane is at the level of the lamina lucida in the Basement Membrane Zone (BMZ) for both JEB and SM-induced injury...
2018: Clinical dermatology: research and therapy
https://www.readbyqxmd.com/read/30056748/bidirectional-barbed-only-versus-poliglecaprone-suture-with-rhabdosphincter-reconstruction-for-urethro-vesical-anastomosis-during-robotic-radical-prostatectomy-does-it-make-any-difference
#7
Ozer Ural Cakici, Abdullah Erdem Canda
OBJECTIVES: We investigated the use of bidirectional barbed suture only versus poliglecaprone suture with posterior rhabdosphincter reconstruction for urethro-vesical anastomosis(UVA) during robotic radical prostatectomy(RARP) on cystographic leakage, duration of catheterization and early urinary continence. METHODS: Bidirectional double-armed barbed suture only was used for UVA(n=50) in Group-1. Two 3/0 poliglecaprone 25 sutures were tied to each other to form a double-armed suture used for UVA with posterior rhabdosphincter reconstruction in Group-2(n=50)...
July 28, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/30019909/prognostic-utility-of-neutrophil-to-lymphocyte-and-platelets-to-lymphocyte-ratio-in-predicting-biochemical-recurrence-post-robotic-prostatectomy
#8
Marc Zanaty, Khaled Ajib, Mansour Alnazari, Elie El Rassy, Fouad Aoun, Kevin C Zorn, Assaad El-Hakim
AIM: Utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer. MATERIALS & METHODS: Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status...
August 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29976639/proteomic-analysis-of-pelvic-autonomic-nerve-in-nerve-sparing-radical-hysterectomy-for-cervical-carcinoma
#9
Yoon Hee Lee, Min Kyung Kim, Hee Young Moon, Gun Oh Chong, Hyun Jung Lee, Yoon Soon Lee, Ji Young Park, Chan Hyeong Lee, Moon Chang Baek, Dae Gy Hong
BACKGROUND/AIM: This study was designed to identify candidate proteins which can be used for visualization of pelvic autonomic nerve during nerve-sparing surgery. MATERIALS AND METHODS: Both soft tissue and vesical branch of the inferior hypogastric nerve from five women were collected during surgery. These 10 tissue specimens were analysed using liquid chromatography-mass spectrometry (LC-MS) and Human Protein Atlas (HPA) for protein expression. The existence of nerve fibres was confirmed using haematoxylin and eosin (H&E) and anti-S-100 staining...
July 2018: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29962877/association-between-magnetic-resonance-imaging-findings-of-the-pelvic-floor-and-de-novo-stress-urinary-incontinence-after-vaginal-delivery
#10
Na Li, Can Cui, Yue Cheng, Yanhong Wu, Jianzhong Yin, Wen Shen
Objective: The study aimed to evaluate the contributions of levator ani muscle (LAM) injury, vesical neck movement, urethral length and mobility, and urethral sphincter dysfunction observed on magnetic resonance imaging (MRI) towards stress urinary incontinence (SUI) after vaginal delivery. Materials and Methods: Fifty primiparous women after 6 months of delivery (15 with SUI and 35 without) and 35 nulliparous as continent controls underwent MRI at rest and Valsalva maneuver...
July 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29960749/vesical-imaging-reporting-and-data-system-vi-rads-added-value-for-management-of-bladder-cancer-patients
#11
EDITORIAL
Harriet C Thoeny, Marie-France Bellin, Eva-Maria Comperat, George N Thalmann
No abstract text is available yet for this article.
June 27, 2018: European Urology
https://www.readbyqxmd.com/read/29958261/peripheral-infiltration-and-extravasation-injury-methodology-a-retrospective-study
#12
Brian Odom, Leah Lowe, Charlotte Yates
Peripheral infiltration is defined as the inadvertent delivery of nonvesicant fluid or medication into surrounding tissue that has the potential to harm the patient. Vesicant fluid that has leaked into the tissue space is called extravasation. At present, there is no agreement in the literature on the best practice for managing these injuries in pediatric patients. The purpose of this study was to identify occurrences of peripheral infiltration injuries and examine treatment modalities used to treat pediatric patients who suffered such an injury...
July 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29931789/ics-educational-module-pressure-flow-study-in-children
#13
REVIEW
Jian G Wen, Jens C Djurhuus, Peter F W M Rosier, Stuart B Bauer
AIMS: To introduce the standard procedure and results interpretation of pressure/flow study (PFS) in children. METHODS: The literature on PFS in children in PubMed for the last 20 years was reviewed. The updated knowledge on PFS in children in children regarding indication, preparation, technique, and interpretation were summarized. RESULTS: This educational module explains when and how to do a PFS and how to analyze the results. All requirements and instructions for the PFS in children described in this document follow ICS reports on Good Urodynamic Practice and urodynamic equipment performance as well as guidelines from the ICCS...
June 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29921667/global-proteomic-changes-induced-by-the-epstein-barr-virus-oncoproteins-latent-membrane-protein-1-and-2a
#14
Robert M DeKroon, Harsha P Gunawardena, Rachel Edwards, Nancy Raab-Traub
The Epstein-Barr virus (EBV) oncoproteins latent membrane protein 1 (LMP1) and LMP2A constitutively activate multiple signaling pathways, and both have been shown to interact with cellular ubiquitin ligases and affect cellular ubiquitination. To detect the LMP1- and LMP2A-mediated effects on the global cellular proteome, epithelial cell lines expressing LMP1 or LMP2A were analyzed using label-free quantitative proteomics. To identify proteins whose ubiquitination is affected by the viral proteins, the cells were cultured in the presence and absence of deubiquitinase (DUB) and proteasome inhibitors...
June 19, 2018: MBio
https://www.readbyqxmd.com/read/29909622/efficient-extraction-of-sulfur-and-nitrogen-mustards-from-nonpolar-matrix-and-an-investigation-on-their-sorption-behavior-on-silica
#15
Kanchan Sinha Roy, D Raghavender Goud, Buddhadeb Chandra, Devendra Kumar Dubey
Extraction of vesicant class of chemical warfare agents (CWAs) such as sulfur mustard and nitrogen mustards from the environmental matrices is of prime importance, from a forensic and verification viewpoint of the Chemical Weapons Convention (CWC). For extraction of Convention Related Compounds from nonpolar organic medium, commercially available silica cartridges are used extensively, but silica cartridges exhibit limited efficiency toward vesicant classes of compounds. It is expected that sulfur mustard being nonpolar does not retain sufficiently on silica surface, and nitrogen mustards (being basic) are strongly adsorbed on acidic silica surface, resulting in their poor recoveries...
July 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29903631/-evidence-of-sensory-bladder-inhibitor-reflex
#16
F Charoenwong, A Charlanes, C Chesnel, D Menoux, D Motavasseli, E Tan, F Le Breton, G Amarenco
INTRODUCTION: Need to void level depends on two parameters, bladder volume and attentional process. If it is well known that the maximum voluntary contraction of the perineal muscles may transiently inhibit the micturition reflex itself, no work demonstrates the effect of this contraction on the intensity of the need itself. METHODS: An experimental, prospective, open, monocentric study was conducted between March and April 2017. In total, 15 subjects with no neurological history or neuro-perineal disorders consulting for functional constipation were included...
June 11, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29863084/evaluation-of-risk-of-injury-by-extravasation-of-hyperosmolar-and-vasopressor-agents-in-a-rat-model
#17
Yuuka Shibata, Yumeka Sagara, Tomoharu Yokooji, Takanori Taogoshi, Maiko Tanaka, Michihiro Hide, Hiroaki Matsuo
Inadvertent leakage of noncytotoxic agents causes severe tissue injury. In this study, we macroscopically and histopathologically evaluated the extent of skin injury caused by extravasation of hyperosmolar or vasopressor agents in rats. Rats were intradermally administered saline (100 µL), the hyperosmolar agents mannitol (5-20 mg/100 µL) and glucose (5-50 mg/100 µL), or the vasopressors dopamine (2 mg/100 µL), adrenaline (0.1 mg/100 µL), and noradrenaline (0.1 mg/100 µL). Lesion size (erythema, induration, ulceration, and necrosis) was monitored after agent injection...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29849333/sulfur-mustard-exposure-from-dredged-artillery-shell-in-a-commercial-clammer
#18
Jenna Otter, Alveena Dawood, Joseph D'Orazio
A 40-year-old commercial fisherman presented with a blistering second degree burn to the right arm after handling a dredged and undetonated World War I-era sulfur mustard artillery shell. He sustained isolated second degree cutaneous injury requiring wound care and skin grafting. Sulfur mustard, or dichlorethylsulphide, is a vesicant chemical warfare agent that causes significant cutaneous chemical burn and is managed with burn wound care. Long-term effects include cosmetic disfigurement and increased risk of developing cancer...
November 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29803135/dna-damage-and-telomere-length-shortening-in-the-peripheral-blood-leukocytes-of-20-years-sm-exposed-veterans
#19
Hossein Behboudi, Sakineh Kazemi Noureini, Tooba Ghazanfari, Sussan K Ardestani
Sulfur mustard (SM) is a vesicant chemical warfare agent, and a very potent alkylating agent. SM exerts its cytotoxicity via direct alkylation of biomacromolecules, and overproduction of reactive oxygen species (ROS). Previous studies have shown that SM-induced oxidative stress has adverse effects on antioxidant defense system, and damages lipids and proteins. The aim of this study was to investigate the effect of SM-induced oxidative stress on DNA damage, and cellular senescence in SM-exposed victims. For this purpose, MDA levels as a measure of oxidative stress in the serum, 8-oxo-dG content of the genomic DNA, and OGG1 expression as two biomarkers of oxidative DNA damage, as well as, telomere length, and p16INK4a expression as two biomarkers of cellular senescence were measured in the peripheral blood leukocytes of 215 males who were exposed to SM 20 to 25 years ago, and 53 unexposed healthy males as the control group...
August 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29797334/pelvic-mass-schwannoma-of-the-left-seminal-vesicle
#20
Jun Huang, Zhouping Cheng, Ronggang Li, Nan Yao, Jiazheng Cao, Shuo Deng, Ronghai Wu
Schwannomas rarely occur in seminal vesicles. Here, we report a schwannoma of the left seminal vesicle. A 55-year-old man presented no clinical symptoms, and a mass in the left region of the seminal vesicle was found incidentally in a medical examination. A computed tomography and magnetic resonance imaging of pelvic were obtained and revealed a 5.17 × 2.59 × 3.5 cm mass on the left seminal vesicle. Transrectal ultrasound-guided seminal biopsy revealed a diagnosis of seminal vesical schwannoma. Laparoscopic resection of the tumour was performed...
May 24, 2018: Andrologia
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