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Nathalie van den Tempel, Kishan A T Naipal, Anja Raams, Dik C van Gent, Martine Franckena, Joost L Boormans, Roland Kanaar
INTRODUCTION: Bladder cancer (urothelial carcinoma) is a common malignancy characterized by high recurrence rates and intense clinical follow-up, indicating the necessity for more effective therapies. Current treatment regimens include intra-vesical administration of mitomycin C (MMC) for non-muscle invasive disease and systemic cisplatin for muscle-invasive or metastatic disease. Hyperthermia, heating a tumor to 40-44°C, enhances the efficacy of these chemotherapeutics by various modes of action, one of which is inhibition of DNA repair via homologous recombination...
2018: PloS One
Jacinta H Martin, R John Aitken, Elizabeth G Bromfield, Brett Nixon
BACKGROUND: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. If structural alterations result and are left unrepaired, they have the potential to cause mutations and propagate disease...
December 12, 2018: Human Reproduction Update
Tarun Javali, Arvind Nayak K, S M L Prakash Babu
Objective: To describe the effectiveness and safety of our novel technique of simultaneous percutaneous cystolithotripsy with transurethral resection of prostate (TURP) for patients with benign prostatic hyperplasia (BPH) complicated with large vesical calculi. Patients and methods: This was a retrospective analysis of 25 patients who underwent simultaneous percutaneous cystolithotripsy with TURP between January 2012 and January 2016. Technique: A 28-F Amplatz sheath was inserted percutaneously into the bladder after sequential dilatation under cystoscopic guidance...
December 2018: Arab Journal of Urology
Elena Villafranca, Paola Navarrete, Amaya Sola, Juan Carlos Muruzabal, Sara Aguirre, Santiago Ostiz, Carmen Sanchez, Rosa Guarch, Nuria Lainez, Marta Barrado
Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma. Material and methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Two implants: 2008-2011: 5 fractions of 6 Gy, 2011: 2016, 4 fractions of 7 Gy. MRI/TAC were done in each implant...
November 2018: Reports of Practical Oncology and Radiotherapy
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Seyhun Sucu, Özcan Balat
PURPOSE: This study described a new technique to minimize the bleeding resulted from aberrant engorged vessels and unintended bladder injury in cases with abnormally invaded placenta adjacent to posterior bladder wall at cesarean hysterectomy. METHODS: After filling the bladder with 300 ml saline aberrant engorged vessels were identified and skeletonized between lower uterine segment and bladder with blunt dissection by index finger down to the distal end point of cervix...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
Markus Siegert, Felix Gandor, Andreas Kranawetvogl, Hans Börner, Horst Thiermann, Harald John
Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of SM is hypothesized to be due to the alkylation of DNA bases and nucleophilic amino acid side chains in proteins (adducts) by forming the hydroxyethylthioethyl (HETE) moiety. Despite of its prohibition by the chemical weapons convention, SM still represents a serious threat to military personnel and civilians. Therefore, development and improvement of forensic analytical methods for the verification of SM exposure is of high interest...
November 23, 2018: Drug Testing and Analysis
Jaya Mini Gill, Janice Frost, Rachelle Park, Marlon G Saria
Venous flare reaction, a localized allergic response associated with the administration of an irritant, is one of the most common chemotherapy infusion-related reactions. Etoposide, a drug commonly used in patients with lung cancer, has been reported to be an irritant with vesicant properties depending on the volume administered. This article presents the case of a patient who has a venous flare reaction immediately following the administration of etoposide for the treatment of diffuse large B-cell lymphoma...
December 1, 2018: Clinical Journal of Oncology Nursing
Ian S McAdams, Steve J A Majerus, Brett Hanzlicek, Christian Zorman, Dennis Bourbeau, Margot S Damaser
New research tools are essential to help understand the neural control of the lower urinary tract (LUT). A more nuanced understanding of the neuroanatomy of bladder function could enable new treatment options or neuroprosthesis to eliminate incontinence. Here we describe the design, prototyping and validation of a sensing mechanism for a catheter-free fluid volume estimating system for chronic neurophysiological studies of the lower urinary tract and ambulatory urodynamics. The system consists of two stimulation electrodes, one sensing anode, and a microcontroller for control and recording...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
R B Nerli, Shridhar C Ghagane, Abhijit Musale, Sushant Deole, Murigendra B Hiremath, Neeraj S Dixit, Parveen Pathan
No abstract text is available yet for this article.
January 2019: Urology Case Reports
Antonio Benito Porcaro, Salvatore Siracusano, Leonardo Bizzotto, Marco Sebben, Giovanni Cacciamani, Nicolò De Luyk, Paolo Corsi, Alessandro Tafuri, Tania Processali, Daniele Mattevi, Maria Angela Cerruto, Matteo Brunelli, Giovanni Novella, Vincenzo De Marco, Walter Artibani
OBJECTIVE: To investigate by means of a randomized clinical trial the safety of no drain in the pelvic cavity after Robot-assisted radical prostatectomy (RARP) with or without extended pelvic lymph node dissection (ePLND). MATERIALS AND METHODS: From May to December 2016, 112 consecutive patients who underwent RARP with or without ePLND were prospectively randomized in a control (CG) and study (SG) group. In the CG, a drain was placed in the pelvic cavity at the end of surgery and removed after 24 hours...
November 6, 2018: Journal of Endourology
Shannon Acker, Alberto Peña, Duncan Wilcox, Veronica Alaniz, Andrea Bischoff
PURPOSE: Traditionally, the care of children and adults has been arbitrarily separated into pediatric and adult medicine and surgery. Despite progress in pediatric surgical techniques, patients born with congenital anomalies still suffer from significant functional sequelae, which persist into adulthood. We aim to describe some of the most common problems experienced by adult patients with congenital colorectal malformations. METHODS: Following IRB approval, we performed a retrospective database review of all adult patients who were treated by our group from 1983 until 2017...
November 3, 2018: Pediatric Surgery International
Fatnassi Ridha, Merzougui Latifa, Rebhi Ines, Hajji Maamar, Braiek Salem
Iatrogenic ureteral lesions may occur after any pelvic surgery. They are severe and can affect renal function and even vital prognosis. This study aimed to determine the clinical aspects and the therapeutic approaches of this injury. We conducted a retrospective study of six patients with iatrogenic ureteral lesions following gynecologic or obstetric surgery whose data were collected in the Department of Urology in Kairouan on a period of 4 years (2012-2016). The average age of our patients was 46 years. They were all multiparous...
2018: Pan African Medical Journal
Simon J Crabb, James Douglas
Introduction: Bladder cancer carries a high healthcare burden and a poor prognosis once distant metastatic spread has occurred. Sources of data: We utilised a PubMed/MEDLINE literature search using the terms bladder cancer, chemotherapy, immunotherapy, intra-vesical therapy, surgery and radiotherapy, and current clinical management guidelines (Association of Cancer Physicians, British Association of Urological Surgeons, National Institute for Health and Care Excellence, European Association of Urology)...
October 29, 2018: British Medical Bulletin
Jing Dong, Hongjin Lv, Xiangrong Sun, Yin Wang, Yuanman Ni, Bo Zou, Nan Zhang, Anxiang Yin, Yingnan Chi, Changwen Hu
A decontaminating composite, Mg3Al-LDH-Nb6, has been successfully prepared by immobilizing Lindqvist [H3Nb6O19]5- (Nb6) into Mg3Al-based layered double hydroxide (Mg3Al-LDH). To our knowledge, this represents the first successful approach to immobilize polyoxoniobate. As a versatile catalyst, Mg3Al-LDH-Nb6 can effectively catalyze the degradation of both vesicant and nerve agent simulants via multiple pathways under mild conditions. Specifically, the sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES), converts to the corresponding nontoxic 2-chloroethyl ethyl sulfoxide (CEESO) by selective oxidation; while the tabun (G-type nerve agent) simulant, diethyl cyanophosphonate (DECP), and the VX (V-type nerve agent) simulant, O,S-diethyl methylphosphonothioate (OSDEMP), are detoxified through hydrolysis and perhydrolysis, respectively...
October 24, 2018: Chemistry: a European Journal
Dewen Yan, Zhan Shi, Liping Wang, Xiumin Zhao
CASE: Although many complications have been reported with intrauterine contraceptive devices (IUDs), vesicovaginal fistula with secondary vaginal stones is rare. We report the case of a 46-year-old woman who presented with a vaginal discharge lasting 2 months. Two years previously, she had undergone cystoscopic lithotripsy and surgery to remove an IUD, after pelvic radiography had revealed a fractured Chinese stainless steel ring IUD with secondary vesical stones that had been the cause of her urinary tract symptoms...
October 16, 2018: European Journal of Contraception & Reproductive Health Care
Karmel Webb, Pradhib Venkatesan
Introduction: Guillain Barré Syndrome (GBS) has rarely been associated with tuberculosis and has been previously reported after Bacille Calmette Guérin (BCG) vaccination, but we report an association of GBS with intra-vesical BCG instillations followed by the clinical picture of disseminated BCGosis. Case presentation: A 68-year-old man with bladder carcinoma had a transurethral tumour resection followed by repeated BCG instillations. Catheterization for his eighth dose was traumatic, causing frank haematuria...
August 2018: JMM Case Reports
Graziano Vignolini, Riccardo Campi, Francesco Sessa, Isabella Greco, Aida Larti, Saverio Giancane, Arcangelo Sebastianelli, Mauro Gacci, Adriano Peris, Vincenzo Li Marzi, Alberto Breda, Giampaolo Siena, Sergio Serni
OBJECTIVE: To report the development of the first robot-assisted kidney transplantation (RAKT) program from deceased donors examining technical feasibility and early perioperative and functional outcomes at a referral academic Centre. PATIENTS AND METHODS: A robotic kidney transplantation program was developed in 2016 at our Institution following a structured modular training. Specific inclusion/exclusion criteria for both living and deceased donors were set. Data from patients undergoing RAKT from January 2017 to April 2018 were prospectively collected in an a priori developed web-based dataset...
October 12, 2018: BJU International
Felicidad Espinoza, Lluis Cecchini, Juan Morote, Ricard Marcos, Susana Pastor
It has been suggested that the frequency of micronuclei (MN) in defoliated urothelial cells could be used as a biomarker for both the potential risk of bladder cancer (BC) and its progression. To prove this we have carried out a large study evaluating the MN frequency in a group of 383 hospital patients submitted to cystoscopy. From them, 77 were negative in their first cystoscopy, and were considered as a reference group; 79 were positive and were classified as patients with tumor; and 227 with previous bladder cancer submitted to follow-up monitoring were negative and classified as BC patients without tumor...
October 4, 2018: Environmental and Molecular Mutagenesis
Kristina Bowles Miller, Amandine Lejeune, Rebecca Regan, Anna Szivek, Kevin Kow
Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors' knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature. In this case series, seven dogs are described to have experienced injuries following a suspected carboplatin extravasation resembling vesicant injuries a median of 7 days after carboplatin administration (range 4-15 days)...
November 2018: Journal of the American Animal Hospital Association
David D Eveleth, Jennifer J Eveleth, Amuthakannan Subramaniam, Rita Hahn, Peihong Zhou, Marion K Gordon, Ralph A Bradshaw
Purpose: Organ cultures of rabbit corneas have been used to ascertain the effectiveness of a human fibroblast growth factor (FGF)-1 derivative (TTHX1114), lacking cysteine residues, to protect against and/or repair epithelial lesions following exposure to nitrogen mustard (NM). Methods: Rabbit corneas were exposed to NM and cultured for up to 14 days, with or without drug (TTHX1114). At specified times, tissue was examined by histopathology and graded by a novel composite scale...
September 4, 2018: Investigative Ophthalmology & Visual Science
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