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Essential Tremor

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https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#1
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28217089/differential-modulation-of-rhythmic-brain-activity-in-healthy-adults-by-a-t-type-calcium-channel-blocker-an-meg-study
#2
Kerry D Walton, Emeline L Maillet, John Garcia, Timothy Cardozo, Isaac Galatzer-Levy, Rodolfo R Llinás
1-octanol is a therapeutic candidate for disorders involving the abnormal activation of the T-type calcium current since it blocks this current specifically. Such disorders include essential tremor and a group of neurological and psychiatric disorders resulting from thalamocortical dysrhythmia (TCD). For example, clinically, the observable phenotype in essential tremor is the tremor itself. The differential diagnostic of TCD is not based only on clinical signs and symptoms. Rather, TCD incorporates an electromagnetic biomarker, the presence of abnormal thalamocortical low frequency brain oscillations...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28195360/what-is-the-pathway-forward-for-the-surgical-management-of-essential-tremor
#3
Elan D Louis, Amar Patel, Jason L Gerrard
No abstract text is available yet for this article.
February 13, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28176975/familial-aggregation-of-the-cerebellar-signs-in-familial-essential-tremor
#4
Elan D Louis, Nora Hernandez, Karen P Chen, Kelly V Naranjo, Jemin Park, Lorraine N Clark, Ruth Ottman
BACKGROUND: Although the hallmark feature of essential tremor (ET) is kinetic tremor, patients may exhibit additional motor features (e.g., intention tremor and mild gait ataxia) that are markers of an underlying abnormality of cerebellar function. ET is also a highly familial disorder, but we do not know whether the presence and expression of cerebellar signs are similar across family members. There are simply no published data. The alternative possibility is that these features are not heritable...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28175401/136%C3%A2-field-steering-rescue-lead-therapy-for-patients-with-essential-tremor-refractory-to-ventralis-intermedius-deep-brain-stimulation
#5
Vishad Sukul, David A Isaacs, Srivatsan Pallavaram, William Rodriguez, Jonathan Butler, Hong Yu, Joseph Samir Neimat, Peter Konrad
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28165334/sensitivity-of-simulated-transcranial-ultrasound-fields-to-acoustic-medium-property-maps
#6
James L B Robertson, Eleanor Martin, Ben Cox, Bradley Treeby
High intensity transcranial focused ultrasound is an FDA approved treatment for essential tremor, while low-intensity applications such as neurostimulation and opening the blood brain barrier are under active research. Simulations of transcranial ultrasound propagation are used both for focusing through the skull, and predicting intracranial fields. Maps of the skull acoustic properties are necessary for accurate simulations, and can be derived from medical images using a variety of methods. The skull maps range from segmented, homogeneous models, to fully heterogeneous models derived from medical image intensity...
February 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28164457/isometric-thermogenesis-at-rest-and-during-movement-a-neglected-variable-in-energy-expenditure-and-obesity-predisposition
#7
REVIEW
A G Dulloo, J L Miles-Chan, J-P Montani, Y Schutz
Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most physical activities of everyday life. Over the past 75 years, there has been sporadic interest into the relevance of isometric work to thermoregulatory thermogenesis and to adaptive thermogenesis pertaining to body-weight regulation...
February 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28163141/probabilistic-conversion-of-neurosurgical-dbs-electrode-coordinates-into-mni-space
#8
Andreas Horn, Andrea A Kühn, Angela Merkl, Ludy Shih, Ron Alterman, Michael Fox
In neurosurgical literature, findings such as deep brain stimulation (DBS) electrode positions are conventionally reported in relation to the anterior and posterior commissures of the individual patient (AC/PC coordinates). However, the neuroimaging literature including neuroanatomical atlases, activation patterns, and brain connectivity maps has converged on a different population-based standard (MNI coordinates). Ideally, one could relate these two literatures by directly transforming MRIs from neurosurgical patients into MNI space...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28160355/the-effect-of-uni-and-bilateral-thalamic-deep-brain-stimulation-on-speech-in-patients-with-essential-tremor-acoustics-and-intelligibility
#9
Johannes Becker, Michael T Barbe, Mariam Hartinger, Till A Dembek, Jil Pochmann, Jochen Wirths, Niels Allert, Doris Mücke, Anne Hermes, Ingo G Meister, Veerle Visser-Vandewalle, Martine Grice, Lars Timmermann
BACKGROUND: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is performed to suppress medically-resistant essential tremor (ET). However, stimulation induced dysarthria (SID) is a common side effect, limiting the extent to which tremor can be suppressed. To date, the exact pathogenesis of SID in VIM-DBS treated ET patients is unknown. OBJECTIVE: We investigate the effect of inactivated, uni- and bilateral VIM-DBS on speech production in patients with ET...
February 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28158909/teneurin-transmembrane-protein-4-is-not-a-cause-for-essential-tremor-in-a-canadian-population
#10
Gabrielle Houle, Jean-François Schmouth, Claire S Leblond, Amirthagowri Ambalavanan, Dan Spiegelman, Sandra B Laurent, Cynthia V Bourassa, Michel Panisset, Sylvain Chouinard, Nicolas Dupré, Carles Vilariño-Güell, Alex Rajput, Patrick A Dion, Guy A Rouleau
INTRODUCTION: Mutations in teneurin transmembrane protein 4 were reported to be a risk factor for essential tremor, but the relevance of this across different population remains to be examined. The aim of this study was to determine the frequency and spectrum of variations in teneurin transmembrane protein 4 in a cohort of Canadian essential tremor cases. METHODS: The coding portion of teneurin transmembrane protein 4 was sequenced in 269 unrelated essential tremor cases and 288 matched control individuals using a targeted and high-throughput sequencing approach...
February 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28149393/eye-movement-abnormalities-in-essential-tremor
#11
Magdalena Wójcik-Pędziwiatr, Klaudia Plinta, Agnieszka Krzak-Kubica, Katarzyna Zajdel, Marcel Falkiewicz, Jacek Dylak, Jan Ober, Andrzej Szczudlik, Monika Rudzińska
Essential tremor (ET) is the most prevalent movement disorder, characterized mainly by an action tremor of the arms. Only a few studies published as yet have assessed oculomotor abnormalities in ET and their results are unequivocal. The aim of this study was to assess the oculomotor abnormalities in ET patients compared with the control group and to find the relationship between oculomotor abnormalities and clinical features of ET patients. We studied 50 ET patients and 42 matched by age and gender healthy controls...
September 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28145626/evaluation-of-quantitative-measurement-techniques-for-head-tremor-with-thalamic-deep-brain-stimulation
#12
Arun Chockalingam, Hans Boggs, Julia Prusik, Adolfo Ramirez-Zamora, Paul Feustel, Abigail Belasen, Youngwon Youn, Chris Fama, Jessica Haller, Julie Pilitsis
BACKGROUND: Ventralis intermedius thalamic deep brain stimulation (VIM DBS) has shown to be safe and effective for medically refractory essential tremor (ET). We evaluate the use of quantitative tremor measurement methods for head tremor in ET using a "smart" hat and a smartphone application. METHODS: We enrolled 13 ET patients who previously underwent VIM DBS. Head and arm tremor was measured ON and OFF stimulation using the clinical gold standard Fahn-Tolosa-Marin Tremor Rating Scale (TRS)...
February 1, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28131225/-131-i-mibg-myocardial-scintigraphy-for-differentiation-of-parkinson-s-disease-from-multiple-system-atrophy-or-essential-tremor-in-chinese-population
#13
Tuanfeng Yang, Li Wang, Yuan Li, Min Cheng, Jinsong Jiao, Qian Wang, Huailian Guo
OBJECTIVE: Clinical distinction of Parkinson's disease (PD) from multiple system atrophy (MSA) or essential tremor (ET) is sometimes difficult. The purpose of this study was to assess changes in cardiac sympathetic nerve function in PD, MSA, and ET by (131)I-MIBG myocardial scintigraphy METHODS: Patients with PD (25), MSA (18), or ET (11) and 10 healthy controls (HC) were enrolled. (131)I-MIBG myocardial scintigraphy was performed for each subject, and heart/mediastinum (H/M) ratios were calculated at two sample times (15min and 4h after the injection of (131)I-MIBG), representing the (131)I-MIBG myocardial uptake ratios...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130602/rapid-battery-depletion-and-loss-of-therapy-due-to-a-short-circuit-in-bipolar-dbs-for-essential-tremor
#14
Niels Allert, Michael Thomas Barbe, Lars Timmermann, Volker Arnd Coenen
Technical dysfunctions have been reported reducing efficacy of deep brain stimulation (DBS). Here, we report on an essential-tremor patient in whom a short circuit in bipolar DBS resulted not only in unilateral loss of therapy but also in high current flow and thereby rapid decline of the impulse-generator battery voltage from 2.83 V a week before the event to 2.54 V, indicating the need for an impulse-generator replacement. Immediate re-programming restored therapeutic efficacy. Moreover, the reduction in current flow allowed the battery voltage to recover without immediate surgical intervention to 2...
January 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28124434/speech-and-language-adverse-effects-after-thalamotomy-and-deep-brain-stimulation-in-patients-with-movement-disorders-a-meta-analysis
#15
REVIEW
Soha Alomar, Nicolas K K King, Joseph Tam, Ausaf A Bari, Clement Hamani, Andres M Lozano
BACKGROUND: The thalamus has been a surgical target for the treatment of various movement disorders. Commonly used therapeutic modalities include ablative and nonablative procedures. A major clinical side effect of thalamic surgery is the appearance of speech problems. OBJECTIVE: This review summarizes the data on the development of speech problems after thalamic surgery. METHODS: A systematic review and meta-analysis was performed using nine databases, including Medline, Web of Science, and Cochrane Library...
January 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28116753/essential-pitfalls-in-essential-tremor
#16
REVIEW
Alberto J Espay, Anthony E Lang, Roberto Erro, Aristide Merola, Alfonso Fasano, Alfredo Berardelli, Kailash P Bhatia
Although essential tremor has been considered the most common movement disorder, it has largely remained a diagnosis of exclusion: many tremor and nontremor features must be absent for the clinical diagnosis to stand. The clinical features of "essential tremor" overlap with or may be part of other tremor disorders and, not surprisingly, this prevalent familial disorder has remained without a gene identified, without a consistent natural history, and without an acceptable pathology or pathophysiologic underpinning...
January 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28095756/low-dose-acute-vanillin-is-beneficial-against-harmaline-induced-tremors-in-rats
#17
Al Asmari Abdulrahman, Kunnathodi Faisal, Ali Al Amri Meshref, Mohammed Arshaduddin
OBJECTIVE: To study the effect of pretreatment with low doses of vanillin, a flavoring agent used as a food additive, on harmaline-induced tremor in rats. METHODS: Sprague Dawley rats (110 ± 5 g) were divided into groups of six animals each. Vanillin (6.25 mg, 12.5 mg, and 25 mg/kg) was administered by gavage to different groups of rats, 30 minutes before the induction of tremor. Harmaline (10 mg/kg, i.p.) was used for the induction of tremor. The latency of onset, duration, tremor intensity, tremor index, and spontaneous locomotor activity were recorded...
March 2017: Neurological Research
https://www.readbyqxmd.com/read/28068428/a-network-model-of-local-field-potential-activity-in-essential-tremor-and-the-impact-of-deep-brain-stimulation
#18
Nada Yousif, Michael Mace, Nicola Pavese, Roman Borisyuk, Dipankar Nandi, Peter Bain
Essential tremor (ET), a movement disorder characterised by an uncontrollable shaking of the affected body part, is often professed to be the most common movement disorder, affecting up to one percent of adults over 40 years of age. The precise cause of ET is unknown, however pathological oscillations of a network of a number of brain regions are implicated in leading to the disorder. Deep brain stimulation (DBS) is a clinical therapy used to alleviate the symptoms of a number of movement disorders. DBS involves the surgical implantation of electrodes into specific nuclei in the brain...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28062908/role-of-altered-cerebello-thalamo-cortical-network-in-the-neurobiology-of-essential-tremor
#19
Abhishek Lenka, Ketaki Swapnil Bhalsing, Rajanikant Panda, Ketan Jhunjhunwala, Rajini M Naduthota, Jitender Saini, Rose Dawn Bharath, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Essential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI. METHODS: Resting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained...
January 6, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28044461/equivalence-of-cell-survival-data-for-radiation-dose-and-thermal-dose-in-ablative-treatments-analysis-applied-to-essential-tremor-thalamotomy-by-focussed-ultrasound-and-gamma-knife
#20
D Schlesinger, M Lee, G Ter Haar, B Sela, M Eames, J Snell, N Kassell, J Sheehan, J M Larner, J-F Aubry
Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order to achieve ablation. The purpose of this paper is to use the proportion of cell survival as a potential common unit by which to measure the biological effect of each procedure. Survival curves for both thermal and radiation doses have been extracted from previously published data for three different cell types...
January 31, 2017: International Journal of Hyperthermia
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