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Essential Tremor

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https://www.readbyqxmd.com/read/27932961/patient-specific-electric-field-simulations-and-acceleration-measurements-for-objective-analysis-of-intraoperative-stimulation-tests-in-the-thalamus
#1
Simone Hemm, Daniela Pison, Fabiola Alonso, Ashesh Shah, Jérôme Coste, Jean-Jacques Lemaire, Karin Wårdell
Despite an increasing use of deep brain stimulation (DBS) the fundamental mechanisms of action remain largely unknown. Simulation of electric entities has previously been proposed for chronic DBS combined with subjective symptom evaluations, but not for intraoperative stimulation tests. The present paper introduces a method for an objective exploitation of intraoperative stimulation test data to identify the optimal implant position of the chronic DBS lead by relating the electric field (EF) simulations to the patient-specific anatomy and the clinical effects quantified by accelerometry...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#2
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27909628/deep-brain-stimulation-salvages-a-flourishing-dental-practice-a-dentist-with-essential-tremor-recounts-his-experience
#3
EDITORIAL
Guy Giacopuzzi, Melanie Lising, Casey H Halpern
In recounting his experience with deep brain stimulation (DBS), a practicing dentist challenged with long-standing bilateral essential tremor of the hands shares insights into his diagnosis, treatments, and ultimately successful DBS surgery at Stanford University Medical Center, CA, USA. Now nearly one year after his surgery, his practice continues to flourish and he encourages others in his profession to consider the possibility of DBS as a definitive treatment for tremors of the hand, which may salvage their practice...
October 22, 2016: Curēus
https://www.readbyqxmd.com/read/27905365/-gait-disorders-and-postural-instability-in-patients-with-an-essential-tremor
#4
S V Vasichkin, O S Levin
AIM: To study gait disorders and postural instability in patients with essential tremor (ET). MATERIAL AND METHODS: Forty patients with ET, aged from 29 to 82 years, (mean 64.2±13.0) were examined. Tandem walk, tremor, stability and stabilometry were studied. RESULTS AND CONCLUSION: A half of the patients had gait disorders and postural instability. Though these disorders were mild to moderate, they caused significant subjective discomfort and influenced quality of life...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27896018/development-and-preliminary-results-of-bimanual-smart-micro-surgical-system-using-a-ball-lens-coupled-oct-distance-sensor
#5
Dongwoo Koo, Hyun-Cheol Park, Peter L Gehlbach, Cheol Song
Bimanual surgery enhances surgical effectiveness and is required to successfully accomplish complex microsurgical tasks. The essential advantage is the ability to simultaneously grasp tissue with one hand to provide counter traction or exposure, while dissecting with the other. Towards enhancing the precision and safety of bimanual microsurgery we present a bimanual SMART micro-surgical system for a preliminary ex-vivo study. To the best of our knowledge, this is the first demonstration of a handheld bimanual microsurgical system...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27893132/essential-tremor
#6
Christopher C Muth
No abstract text is available yet for this article.
November 22, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27887893/emotion-modulation-of-the-startle-reflex-in-essential-tremor-blunted-reactivity-to-unpleasant-and-pleasant-pictures
#7
Jacob A Lafo, Ania Mikos, Paul C Mangal, Bonnie M Scott, Erin Trifilio, Michael S Okun, Dawn Bowers
BACKGROUND: Essential tremor is a highly prevalent movement disorder characterized by kinetic tremor and mild cognitive-executive changes. These features are commonly attributed to abnormal cerebellar changes, resulting in disruption of cerebellar-thalamo-cortical networks. Less attention has been paid to alterations in basic emotion processing in essential tremor, despite known cerebellar-limbic interconnectivity. OBJECTIVES: In the current study, we tested the hypothesis that a psychophysiologic index of emotional reactivity, the emotion modulated startle reflex, would be muted in individuals with essential tremor relative to controls...
November 17, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27881096/a-step-toward-essential-tremor-gene-discovery-identification-of-extreme-phenotype-and-screening-of-htra2-and-ano3
#8
Mathilde Renaud, Christophe Marcel, Gabrielle Rudolf, Mickaël Schaeffer, Ouhaïd Lagha-Boukbiza, Jean-Baptiste Chanson, Jamel Chelly, Mathieu Anheim, Christine Tranchant
BACKGROUND: Essential tremor (ET) is characterized by a frequent family history. No monogenic form of ET has been identified. We aimed at exploring ET patients to identify distinct subgroups and facilitate the identification of ET genes. We tested for the presence of HTRA2 p.G399S, and ANO3 p. W490C, p. R484 W and p. S685G mutations. METHODS: Between June 2011 and November 2013, all consecutive patients suspected with ET were prospectively included in a prospective, monocentric study...
November 23, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27876040/botulinum-toxin-treatment-for-essential-palatal-tremors-presenting-with-nasal-clicks-instead-of-pulsatile-tinnitus-a-case-report
#9
Yufeng Ye, Shiyu Liao, Baozhen Luo, Liyan Ni
BACKGROUND: In this study, we report a rare case of an adult patient with essential palatal tremors (EPT) presenting as nasal clicks, instead of otic clicks or objective pulsatile tinnitus in common EPT. CASE PRESENTATION: Nasal endoscopic examination and EMG recordings of the soft palate muscles were performed to confirm the source of the clicks. Initial treatment with lidocaine provided symptomatic relief for four hours. The patient was then treated with four simultaneous injections of 12...
November 22, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27871441/daytime-sleepiness-and-nighttime-sleep-quality-across-the-full-spectrum-of-cognitive-presentations-in-essential-tremor
#10
Brittany Rohl, Kathleen Collins, Sarah Morgan, Stephanie Cosentino, Edward D Huey, Elan D Louis
There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27869322/tmem230-stop-codon-mutation-is-rare-in-parkinson-s-disease-and-essential-tremor-in-eastern-china
#11
Ya-Chao He, Pei Huang, Qiong-Qiong Li, Qian Sun, Dun-Hui Li, Tian Wang, Jun-Yi Shen, Sheng-Di Chen
No abstract text is available yet for this article.
November 21, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27858575/chronic-electrocorticography-for-sensing-movement-intention-and-closed-loop-deep-brain-stimulation-with-wearable-sensors-in-an-essential-tremor-patient
#12
Jeffrey A Herron, Margaret C Thompson, Timothy Brown, Howard J Chizeck, Jeffrey G Ojemann, Andrew L Ko
Deep brain stimulation (DBS) has become a widespread and valuable treatment for patients with movement disorders such as essential tremor (ET). However, current DBS treatment constantly delivers stimulation in an open loop, which can be inefficient. Closing the loop with sensors to provide feedback may increase power efficiency and reduce side effects for patients. New implantable neuromodulation platforms, such as the Medtronic Activa PC+S DBS system, offer important data sources by providing chronic neural sensing capabilities and a means of investigating dynamic stimulation based on symptom measurements...
November 18, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27852372/-evaluating-the-electrophysiological-features-of-tremor-in-parkinson-s-disease-and-essential-tremor-using-accelerometry
#13
C Y Xu, H M Yin, B R Zhang
Objective: To investigate the electrophysiological features of tremor intensity, frequency and frequency dispersion of Parkinsonian (PT group) and essential (ET group) tremors using accelerometry. Methods: The amplitude, frequency and frequency dispersion of rest tremor, postural tremor and the influence of weight on tremor of 35 PT patients and 40 ET patients in Department of Neurology, the Second Affiliated Hospital Zhejiang University School of Medicine from May 2015 to April 2016 were retrospectively analyzed and compared...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27835783/analysis-of-the-tremor-in-juvenile-myoclonic-epilepsy
#14
Zeynep Aydin-Özemir, Zeliha Matur, Betul Baykan, Başar Bilgic, Pınar Tekturk, Nerses Bebek, Candan Gurses, Hasmet Hanagasi, Ali Emre Oge
PURPOSE: We aimed to investigate juvenile myoclonic epilepsy (JME) patients complaining of tremor unrelated to valproate (VPA) treatment and evaluate if there were differences between JME patients with and without tremor and essential tremor (ET) patients to exclude comorbidity. METHODS: Fifteen JME cases with the complaint of tremor, 14 JME patients without tremor, 14 patients with ET and 14 healthy subjects (HS) were included. Regularity, frequency and amplitude of the tremor and superimposed myoclonia were assessed by accelerometric analysis...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27822200/immediate-and-longitudinal-alterations-of-functional-networks-after-thalamotomy-in-essential-tremor
#15
Changwon Jang, Hae-Jeong Park, Won Seok Chang, Chongwon Pae, Jin Woo Chang
Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablation technique, we investigated functional network changes due to a focal lesion. To classify the diverse time courses of those network changes with respect to symptom-related long-lasting treatment effects and symptom-unrelated transient effects, we applied graph-theoretic analyses to longitudinal resting-state functional magnetic resonance imaging data before and 1 day, 7 days, and 3 months after thalamotomy with essential tremor...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27816778/thalamic-deep-brain-stimulation-decelerates-automatic-lexical-activation
#16
Felicitas Ehlen, Isabelle Vonberg, Hannes O Tiedt, Andreas Horn, Ortwin Fromm, Andrea A Kühn, Fabian Klostermann
BACKGROUND: Deep Brain Stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) is a therapeutic option for patients with essential tremor. Despite a generally low risk of side effects, declines in verbal fluency (VF) have previously been reported. OBJECTIVES: We aimed to specify effects of VIM-DBS on major cognitive operations needed for VF task performance, represented by clusters and switches. Clusters are word production spurts, thought to arise from automatic activation of associated information pertaining to a given lexical field...
November 2, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27814991/mutation-analysis-of-chchd2-gene-in-chinese-han-familial-essential-tremor-patients-and-familial-parkinson-s-disease-patients
#17
Chao Gao, Yi-Meng Chen, Qian Sun, Ya-Chao He, Pei Huang, Tian Wang, Dun-Hui Li, Liang Liang, Jun Liu, Qin Xiao, Sheng-Di Chen
CHCHD2 is the latest identified Parkinson's disease (PD)-causing gene, and previous studies have reported the same CHCHD2 variant (182C>T, Thr61Ile) in both PD and essential tremor (ET) patients. Whether CHCHD2 gene mutations are involved in both of these diseases remains unclear. We sequenced CHCHD2 gene in 171 familial ET patients, 133 autosomal dominant Parkinson's disease patients, and 211 normal controls. No pathogenic mutations were found, suggesting that CHCHD2 gene may not play a major role in our familial Chinese Han ET and PD patients...
October 11, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27812758/autonomic-dysfunction-in-patients-with-essential-tremor
#18
Yasin Habipoglu, Murat Alpua, Cemil Bilkay, Yakup Turkel, Ersel Dag
The aim of this study was to evaluate the autonomic function in patients with essential tremor (ET). Thirty-one adult patients with ET and 26 healthy controls were enrolled in the study. The electrophysiological evaluations of the autonomic nervous system function were performed by sympathetic skin response (SSR) and R-R interval variation (RRIV) tests. The mean latency of SSR in ET patients was significantly delayed compared with the controls (P = 0.01). The mean amplitude of sympathetic skin response was significantly lower in ET patients in comparison to the controls (P = 0...
November 3, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27811916/movement-disorders-novel-genetic-risk-variants-for-essential-tremor
#19
Hemi Malkki
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27797806/genome-wide-association-study-in-essential-tremor-identifies-three-new-loci
#20
Stefanie H Müller, Simon L Girard, Franziska Hopfner, Nancy D Merner, Cynthia V Bourassa, Delia Lorenz, Lorraine N Clark, Lukas Tittmann, Alexandra I Soto-Ortolaza, Stephan Klebe, Mark Hallett, Susanne A Schneider, Colin A Hodgkinson, Wolfgang Lieb, Zbigniew K Wszolek, Manuela Pendziwiat, Oswaldo Lorenzo-Betancor, Werner Poewe, Sara Ortega-Cubero, Klaus Seppi, Alex Rajput, Anna Hussl, Ali H Rajput, Daniela Berg, Patrick A Dion, Isabel Wurster, Joshua M Shulman, Karin Srulijes, Dietrich Haubenberger, Pau Pastor, Carles Vilariño-Güell, Ronald B Postuma, Geneviève Bernard, Karl-Heinz Ladwig, Nicolas Dupré, Joseph Jankovic, Konstantin Strauch, Michel Panisset, Juliane Winkelmann, Claudia M Testa, Eva Reischl, Kirsten E Zeuner, Owen A Ross, Thomas Arzberger, Sylvain Chouinard, Günther Deuschl, Elan D Louis, Gregor Kuhlenbäumer, Guy A Rouleau
We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor. The molecular genetic determinants of essential tremor are unknown. We included 2807 patients and 6441 controls of European descent in our two-stage genome-wide association study. The 59 most significantly disease-associated markers of the discovery stage were genotyped in the replication stage...
December 2016: Brain: a Journal of Neurology
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