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Essential Tremor

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https://www.readbyqxmd.com/read/28717511/thalamotomy-for-essential-tremor-fda-approval-brings-brain-treatment-with-fus-to-the-clinic
#1
EDITORIAL
Paul S Fishman
No abstract text is available yet for this article.
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28701548/intermittent-cortical-involvement-in-the-preservation-of-tremor-in-essential-tremor
#2
Sarvi Sharifi, Frauke Luft, Rens Verhagen, Tjitske Heida, Johannes D Speelman, Lo J Bour, Anne-Fleur van Rootselaar
Cortical involvement in essential tremor, an involuntary action tremor supposedly of subcortical origin, is uncertain. Conflicting results of corticomuscular coherence studies in essential tremor might suggest intermittent corticomuscular coupling. Based on the literature, we hypothesize that corticomuscular coupling is influenced by bilateral motor synchronization and 'cognitive states' such as awareness of tremor. Here, we investigated 1) the existence of intermittent CMC in essential tremor, and 2) factors that influence CMC strength...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28690920/do-bradykinesia-and-tremor-interfere-in-voluntary-movement-of-essential-tremor-patients-preliminary-findings
#3
Etienne Goubault, Hung P Nguyen, Fouaz S Ayachi, Sarah Bogard, Christian Duval
BACKGROUND: The aim of this study was to determine whether tremor and bradykinesia impacted a dexterous activity performed by patients with essential tremor (ET). METHODS: Core bradykinesia was assessed in 27 controls and 15 patients with ET using a rapid alternating movement (RAM) task. Then, participants performed a "counting money" counting tasks while equipped with inertial measurement units to detect and quantify tremor during movement. The time required to perform subsections of the tasks and the rate of failure (errors) were compared between groups using Mann-Whitney U tests and a chi-square test, respectively...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28680651/gray-matter-density-loss-in-essential-tremor-a-lobule-by-lobule-analysis-of-the-cerebellum
#4
Jonathan P Dyke, Eric Cameron, Nora Hernandez, Ulrike Dydak, Elan D Louis
BACKGROUND: The pathophysiological basis for essential tremor (ET) remains unclear, although evidence increasingly links it to a disordered and perhaps degenerative cerebellum. Prior imaging studies have treated the cerebellum en bloc. Our hypothesis was that regional differences in cerebellar gray matter (GM) density may better distinguish ET cases from controls. Forty-seven ET cases and 36 control subjects were imaged using magnetic resonance imaging (MRI). The cerebellum was segmented into 34 lobes using a Spatially Unbiased Infra-Tentorial Template (SUIT) atlas within the Statistical Parametric Mapping (SPM) analysis package...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28676263/slight-hypercalcemia-is-not-associated-with-positive-responses-in-the-comet-assay-in-male-rat-liver
#5
Anette Thiel, Annie Hamel, Katrien Schaefer, Renato Cardoso, Paul Beilstein
Maintenance of physiological levels of intracellular and extracellular calcium is essential for life. Increased intracellular calcium levels are involved in cell death (apoptosis and necrosis) and are associated with positive responses in the Comet assay in vitro. In addition, high calcium and vitamin D intakes were reported to induce apoptosis in adipose tissue in obese mice and to increase DNA-migration in the Comet assay. To investigate increased serum concentration of calcium as a potential confounding factor in the regulatory Comet assay in vivo, we induced mild hypercalcemia in male Wistar rats by 3-day continuous intravenous infusion of calcium gluconate and performed the Comet assay in the liver in line with regulatory guidelines...
August 2017: Mutation Research
https://www.readbyqxmd.com/read/28673510/eye-movements-in-essential-tremor-patients-with-parkinsonian-and-cerebellar-signs
#6
Magdalena Wójcik-Pędziwiatr, Elżbieta Mirek, Monika Rudzińska-Bar, Andrzej Szczudlik
Apart from intention tremor essential tremor (ET) patients may display other cerebellar signs, like dysmetria or tandem gait disturbances as well as parkinsonian signs like resting tremor, cogwheel sign, subtle bradykinesia. Previous reports claimed the occurrence of the eye movement abnormalities characteristic for dysfunction of cerebellar dorsal vermis in ET patients with concomitant cerebellar signs. There are no previous reports evaluating the eye movement abnormalities in ET patients with concomitant parkinsonian signs...
May 17, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28665251/stereotactic-radiosurgery-for-medically-refractory-multiple-sclerosis-related-tremor
#7
Sudesh S Raju, Ajay Niranjan, Edward A Monaco, John C Flickinger, L Dade Lunsford
OBJECTIVE Multiple sclerosis (MS) is a neurodegenerative disease that can lead to severe intention tremor in some patients. In several case reports, conventional radiotherapy has been reported to possibly exacerbate MS. Radiosurgery dramatically limits normal tissue irradiation to potentially avoid such a problem. Gamma Knife thalamotomy (GKT) has been established as a minimally invasive technique that is effective in treating essential tremor and Parkinson's disease-related tremor. The goal in this study was to analyze the outcomes of GKT in patients suffering from medically refractory MS-related tremor...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28652667/is-tremor-related-to-celiac-disease
#8
Lucia Ameghino, Malco Damian Rossi, Daniel Cerquetti, Marcelo Merello
Neurological features in celiac disease (CD) are not rare (5%-36%), but tremor is scarcely described. Subjects with CD and healthy controls completed an online survey using WHIGET tremor rating scale. One thousand five hundred and twelve subjects completed the survey, finally 674 CD patients and 290 healthy subjects were included. A higher prevalence of tremor in CD patients was observed in comparison to controls (28% vs 14%, P < 0.001). Frequency of family history of tremor in CD patients with and without tremor was 25% and 20% (P = 0...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28647434/hyperechogenicity-of-substantia-nigra-for-differential-diagnosis-of-parkinson-s-disease-a-meta-analysis
#9
REVIEW
Azin Shafieesabet, Seyed-Mohammad Fereshtehnejad, Azadeh Shafieesabet, Ahmad Delbari, Hamid Reza Baradaran, Ronald B Postuma, Johan Lökk
Studies have suggested that the majority of patients with Parkinson's disease have abnormal ultrasound hyperechogenicity of the substantia nigra, and that this may be useful in diagnosis. We performed a systematic review and meta-analysis to evaluate diagnostic value of substantia nigra ultrasound to differentiate Parkinson's disease from atypical parkinsonism and from essential tremor. We systematically searched PubMed and EMBASE for relevant studies published until November 2016. Eligible articles were screened, data were extracted and study quality was scored by two independent reviewers...
June 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28638597/rest-tremor-revisited-parkinson-s-disease-and-other-disorders
#10
REVIEW
Wei Chen, Franziska Hopfner, Jos Steffen Becktepe, Günther Deuschl
Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson's disease (PD), essential tremor and dystonia, have been carried out...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28632695/serum-ceruloplasmin-and-striatal-dopamine-transporter-density-in-parkinson-disease-comparison-with-123i-fp-cit-spect
#11
Yoo Sung Song, Jong-Min Kim, Kyeong Joon Kim, Ji Young Yun, Sang Eun Kim
PURPOSE: In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin-along with its related serum markers- and striatal presynaptic dopaminergic denervation measured with I-FP-CIT SPECT. METHODS: We analyzed a total of 141 de novo patients divided into 2 groups: the PD group (107 patients with PD) and the disease control group (34 patients with vascular pseudoparkinsonism, essential tremor, or drug-induced parkinsonism)...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28627375/modulation-of-sphingosine-1-phosphate-receptor-ameliorates-harmaline-induced-essential-tremor-in-rat
#12
Narjes Dahmardeh, Majid Asadi-Shekaari, Shokouh Arjmand, Tajpari Kalantaripour, Mohsen Basiri, Mohammad Shabani
Essential tremor (ET) is one of the most common movement disorders with unknown etiology. Despite lack of effective clinical treatments, some potential therapeutic factors and modulation of some neurotransmitters have been utilized to ameliorate motor symptoms in the animal models of tremor. In the current study, male Wistar rats (n=10 in each group) weighing 40-60g were divided into vehicle control groups (saline or DMSO), saline/DMSO+harmaline (30mg/kg, i.p.)+fingolimod (FTY720) (1mg/kg, i.p, 1h before harmaline injection) groups...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28615985/treatment-of-movement-disorders-with-focused-ultrasound
#13
REVIEW
Paul S Fishman, Victor Frenkel
Although the use of ultrasound as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists or neurologists are familiar with this technology. Stereotactic brain lesioning had been widely used as a treatment for medically refractory patients with essential tremor (ET), Parkinson disease (PD), and dystonia but has been largely replaced by deep brain stimulation (DBS) surgery, with advantages both in safety and efficacy. However, DBS is associated with complications including intracerebral hemorrhage, infection, and hardware malfunction...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28615899/clinical-and-imaging-study-of-isolated-and-mixed-rest-and-action-tremor-essential-tremor-versus-parkinson-s-disease
#14
Sandro Zambito Marsala, Michele Pistacchi, Manuela Gioulis, Franco Ferracci, Livio Capus
BACKGROUND: Some patients present an unusual association of both action tremor (AT) and rest tremor (RT) making the differential diagnosis between essential tremor (ET) and Parkinson's disease (PD) difficult. AIM: To investigate this particular clinical picture trying to focus on possible peculiar clinical inferences. PATIENTS AND METHODS: Twenty-three patients with atypical tremor syndrome were selected for the study. They underwent neurological examination, neuroimaging study, and brain DaTSCAN single-photon emission computed tomography...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28597557/adaptive-deep-brain-stimulation-for-movement-disorders-the-long-road-to-clinical-therapy
#15
REVIEW
Anders Christian Meidahl, Gerd Tinkhauser, Damian Marc Herz, Hayriye Cagnan, Jean Debarros, Peter Brown
Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28593500/bilateral-thalamic-deep-brain-stimulation-for-essential-tremor-in-elderly-patients
#16
Johann Klein, Lars Büntjen, Gerrit Jacobi, Imke Galazky, Patricia Panther, Tino Zaehle, Jörn Kaufmann, Hans-Jochen Heinze, Jürgen Voges, Andreas Kupsch
The purpose of this study was to assess the influence of age on thalamic deep brain stimulation (DBS) in essential tremor (ET). Tremor, cognition, mood and adverse events in patients with thalamic DBS for ET were evaluated in 26 consecutive patients with established standardized methods for tremor and cognition. Twelve patients <70 and 14 patients ≥70 years were included and followed for 2 years. Clinical outcomes did not differ significantly. DBS seems to be safe and effective for ET independent of age...
June 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28592900/white-matter-microstructural-changes-are-related-to-cognitive-dysfunction-in-essential-tremor
#17
Julián Benito-León, Virginia Mato-Abad, Elan D Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, Juan Pablo Romero
Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586370/long-term-tremor-therapy-for-parkinson-and-essential-tremor-with-sensor-guided-botulinum-toxin-type-a-injections
#18
Olivia Samotus, Jack Lee, Mandar Jog
OBJECTIVE: Current pharmacological agents used to treat Parkinson disease (PD) tremor and essential tremor (ET) provide suboptimal benefit and are commonly associated with significant adverse effects. Botulinum toxin type A (BoNT-A) has been shown to be effective for wrist tremor though functionally bothersome muscle weakness frequently occurs. This is the longest study to date demonstrating that BoNT-A therapy coupled with kinematic guidance can provide efficacious outcomes for upper limb tremor with minimized unwanted weakness...
2017: PloS One
https://www.readbyqxmd.com/read/28576604/task-dependent-variability-of-essential-tremor
#19
Nicole Schuhmayer, Corinna Weber, Markus Kieler, Bernhard Voller, Walter Pirker, Eduard Auff, Dietrich Haubenberger
INTRODUCTION: In Essential Tremor (ET), tremor characteristics and the impairment caused by tremor may vary from task to task. A variability of tremor frequency between postural and kinetic tasks has been proposed in ET, suggesting either multiple central oscillating networks, or peripheral or proprioceptive feedback-mechanisms. This electrophysiological study aimed to assess tremor frequencies and amplitudes in tasks involving postural and kinetic tremor, and compare findings within and across tasks, to delineate physiological differences underlying individually affected manual tasks in ET...
May 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28564666/a-comprehensive-approach-to-deep-brain-stimulation-for-movement-disorders
#20
Umer Akbar, Wael F Asaad
Deep brain stimulation (DBS) is a well-established form of neuromodulation, used primarily for movement disorders such as Parkinson's disease (PD) and Essential Tremor (ET). The selection of patients who will benefit most from DBS depends on a team of clinicians from various disciplines, including neurology, neurosurgery, psychiatry, neuropsychology and rehabilitation specialists. The actual surgical procedure can take many forms. We apply a combination of multidisciplinary, team-based evaluations and intra-operative neurophysiology, test stimulation and imaging to optimize DBS therapy for individual patients...
June 1, 2017: Rhode Island Medical Journal
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