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Qing Han, Xue Zhao, Chenyu Wang, Bingpeng Chen, Xiaonan Wang, Ziyan Zhang, Kesong Zhang, Yuhao Zheng, Jincheng Wang
INTRODUCTION: Periprosthetic femoral fractures (PFF) around tumor prosthesis of knee are stubborn problems for surgeons, huge bone defect and inappropriate biomechanics of the revision implant design can be disaster for reconstruction. With the development of three-dimensional (3D) printing technology, surgeons participate more in precise preoperative design and simulation for treatment of such fractures. In this study we explored an accurate and feasible way to restore normal anatomy and function of the knee joint with 3D printing technology...
October 2018: Medicine (Baltimore)
Kyoko Ikumi, Shigeto Kobayashi, Naoto Tamura, Kurisu Tada, Hisashi Inoue, Satoshi Osaga, Emi Nishida, Akimichi Morita
OBJECTIVES: The aim of the present study was to determine if the HLA phenotype is related to severe sacroiliitis in Japanese patients with psoriatic arthritis. METHODS: This study was a single-center, retrospective, cross-sectional, observational study. We reviewed the clinical information and radiologic examinations of patients with psoriatic arthritis (PsA) who visited our hospital from January 2011 to December 2016. Radiographic changes in the sacroiliac joints were assessed by four independent investigators according to the recommendations of the Assessment of Spondyloarthritis International Society...
October 18, 2018: Modern Rheumatology
Ouiame El Jouari, Salim Gallouj, Sara Elloudi, Ghita Senhaji, Mouna Rimani, Fatima Zahra Mernissi
BACKGROUND: Glomus tumor is a benign and vascular hamartoma that originates from the neuromyoarterial cells of the normal glomus apparatus in the reticular dermis. The etiology of glomus tumors is unknown. It usually presents as a small, slightly raised, bluish or pinkish-red, painful nodule of the fingertips and the pulp. we report an atypical case of a patient of painless glomus tumor. CASE PRESENTATION: Our patient, a 60-year-old Moroccan man, had a 2.5 cm purplish painless soft tumor, covered with melliciric and hemorrhagic crusts, involving the first phalanx of his right index finger...
October 18, 2018: Journal of Medical Case Reports
Arnold S Mmbando, Halfan Ngowo, Alex Limwagu, Masoud Kilalangongono, Khamis Kifungo, Fredros O Okumu
BACKGROUND: Long-lasting insecticide-treated nets and indoor residual spraying protect against indoor-biting and indoor-resting mosquitoes but are largely ineffective for early-biting and outdoor-biting malaria vectors. Complementary tools are, therefore, needed to accelerate control efforts. This paper describes simple hessian ribbons treated with spatial repellents and wrapped around eaves of houses to prevent outdoor-biting and indoor-biting mosquitoes over long periods of time. METHODS: The eave ribbons are 15 cm-wide triple-layered hessian fabrics, in lengths starting 1 m...
October 17, 2018: Malaria Journal
Rui-Jian Peng, Yong-Hong Zhang, Xiao-Hui Li, Hua-Nan Shi, Yan-Jun Lu, Qi Yang
OBJECTIVE: To discuss clinical outcomes of accordion operation for the Ilizarov technique in treating tibial bone defects. METHODS: From January 2014 to June 2016, 22 patients with tibial bone defects were treated by Ilizarov bone-transport technique, including 19 males and 3 females with an average age of 44.04 years old ranging from 23 to 60 years old;the length of the bone defects before the bone transport was 5 to 11 cm with an average 7.68 cm; Cause of injury invlved traffic accidents in 14 cases, fall injury in 3, smashing injury in 4, high drop injury in 1; 6 cases were on the left and 16 cases were on the right...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hong-Kuan Lin, Zhi-Ping Zhou, Cao-Sheng Lai, Zhi Liu
OBJECTIVE: To study the application and effect of retrograde titanium elastic nails fixation for the treatment of displaced clavicle fracture in children under closed reduction. METHODS: From January 2014 to November 2016, 26 children with displaced fractures of the clavicle were treated by closed reduction and retrograde inserted titanium elastic nails including 14 boys and 12 girls with an average age of 9.2 years old ranging from 7 to 14 years. Time from injury to operation was 2 to 7 days with an average of 2...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hong-Ying He, Jian-Zheng Zhang, Xiao-Wei Wang, Zhi Liu
OBJECTIVE: To evaluate the results of Acumed intramedullary nail for the treatment of adult diaphyseal fractures of both-bone forearm fractures. METHODS: From January 2009 to December 2016, 86 adult patients with both forearm fractures were treated by intramedullary nail including 54 males and 32 females with an average age of 36.8 years old ranging from 18 to 72 years old;There were 50 cases were on the right and 36 cases on the left. The operation time, blood loss and X-ray expose time intra-operation, time of fracture union, complications, DASH(Disabilities of the Arm, Shoulder and Hand questionnaire), Grace-Eversman criteria were recorded to evaluate the clinical outcomes of intramedullary nail for the treatment of forearm fractures...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hong-Ming Lin, Yi-Ping Ma, Cheng-Ting Hu, Zhi-Juan Zhou
OBJECTIVE: To explore the clinical effect of modified Metaizeau's technique for radial neck fractures of Judet II or IV in children, summarizing the value of clinical application. METHODS: From May 2014 to March 2017, 32 children of Judet III or IV radial neck fractures were treated with percutaneous Kirschner wire poking reduction and closed reduction with elastic intramedullary nailing fixation, including 21 boys and 11 girls, aged from 5.7 to 10.6 years old with a mean of 7...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Musa F Alzahrani, Mohammed I AlJasser
New England Journal of Medicine, Volume 379, Issue 16, Page 1561-1561, October 2018.
October 18, 2018: New England Journal of Medicine
María Elena Rodríguez-García, Francisco Javier Cotrina-Vinagre, Jaime Cruz-Rojo, Lucía Garzón-Lorenzo, Patricia Carnicero-Rodríguez, Jaime Sánchez-Del Pozo, Francisco Martínez-Azorín
We report the clinical and genetic findings in a 15-year-old Spanish boy presenting prenatal and postnatal growth retardation, reduced subcutaneous adipose tissue, premature skin wrinkling, sparse hair, short distal phalanges with small nails, umbilical hernia, wide anterior fontanel, and normal cognitive and motor development. Exome sequencing uncovered a heterozygous mutation in SLC25A24 (NM_013386: c.650G>A: p.R217H) that encodes for the calcium-binding mitochondrial carrier protein SCaMC-1. This gain-of-function variant has been previously associated with Fontaine syndrome and Gorlin-Chaudhry-Moss syndrome, two entities that show overlapping features, and have been recently subsumed under the name Fontaine progeroid syndrome (FPS; MIM: 612289) in OMIM...
October 17, 2018: American Journal of Medical Genetics. Part A
Valentin F Reichle, Verena Weber, Stefanie Kellner
In all domains of life, the nucleobases of tRNA can be methylated. These methylations are introduced either by enzymes or by reaction of methylating agents with the nucleophilic centers of the nucleobases. Here, we present a systematic approach for identification of methylation sites within RNA in vitro and in vivo. For discrimination between enzymatic tRNA methylation and tRNA methylation damage in bacteria, we used nucleic acid isotope labeling coupled mass spectrometry (NAIL-MS). With NAIL-MS we clearly observe the formation of 7-methylguanosine, 3-methyluridine and 6-methyladenosine during exposure of bacteria to the alkylating agent methyl-methanesulfonate (MMS) in vivo...
October 17, 2018: Chembiochem: a European Journal of Chemical Biology
Rahul Bhattacharyya, Kapil Sugand, Bilal Al-Obaidi, Ian Sinha, Rajarshi Bhattacharya, Chinmay M Gupte
Background and purpose - Cognitive task analysis (CTA) has been used extensively to train pilots and in other surgical specialties. However, the use of CTA within orthopedics is in its infancy. We evaluated the effectiveness of a novel CTA tool to improve understanding of the procedural steps in antegrade femoral intramedullary nailing. Material and methods - Design: A modified Delphi technique was used to generate a CTA from 3 expert orthopedic trauma surgeons for antegrade femoral intramedullary nailing. The written and audiovisual information was combined to describe the technical steps, decision points, and errors for each phase of this procedure Validation: A randomized double-blind controlled trial was undertaken with 22 medical students (novices) randomized into 2 equal groups...
October 17, 2018: Acta Orthopaedica
Fabrizio Fascione, Michele Di Mauro, Matteo Guelfi, Francesc Malagelada, Andrea Pantalone, Vincenzo Salini
BACKGROUND: The aim of this retrospective study was to evaluate the outcome of patients with intra-articular calcaneal fractures treated using a minimally invasive locking nail (Calcanail® ). METHODS: Between January 2016 and April 2017, 15 patients (9 men and 6 women) with a calcaneal fracture were consecutively treated with Calcanail® . The Böhler angle was recorded on standard X-rays pre- and post-operatively. The articular reduction of the posterior facet was evaluated with the Goldzak index in a CT scan 3 months post-operatively...
August 11, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
J Kruidenier, L W van der Plaat, I N Sierevelt, D Hoornenborg, D Haverkamp
BACKGROUND: With longer follow-up, survival rate of total ankle replacements (TAR) diminishes. It is therefore important to have a reliable fall-back option in case of failed TAR. Revision arthroplasty is often impossible because of loss of bonestock or infection. Conversion to ankle fusion is then indicated. We investigated the clinical, radiographic and patient reported results for fusion after failed TAR in a consecutive group of patients. We concentrated on the influence of inflammatory joint disease (IJD) on union rate...
August 24, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Robin Mirdell, Aukje Nienke Lemstra-Idsardi, Simon Farnebo, Erik Tesselaar
OBJECTIVES: Laser speckle contrast imaging (LSCI) has seen limited use in the study of perfusion dynamics such as vasomotion. The aim of this study was to investigate the effects of a prolonged seated position on perfusion dynamics in the nail bed using LSCI. METHODS: Perfusion was recorded in digits II to IV bilaterally for 20 min during two separate sessions in ten healthy volunteers. The acclimatization period was 5 min for the 1st session and 20 min for the 2nd...
October 12, 2018: Microvascular Research
Ramiz N Hamid, Christine S Ahn, William W Huang
Neratinib is a tyrosine kinase inhibitor that was FDA-approved for extended adjuvant treatment in adults with HER-2 positive breast cancer in 2017. Due to the novelty of the drug, there are no current reports in the literature of adverse cutaneous effects associated with neratinib therapy. We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face...
October 15, 2018: Journal of Dermatological Treatment
Ghasem Janbabai, Abbas Alipour, Sina Ehteshami, Seyedeh-Samaneh Borhani, Touraj Farazmandfar
Trace metals are beneficial nutrient materials that act as essential cofactors in physiological processes. Recent evidence suggests that increase or decrease in certain trace metals may be related with risk and development of chronic diseases such as cancer. This study analyzed some trace elements level in hair and nail of patients with stomach cancer, and compared with their level in healthy controls. Trace elements (Cu, Fe, K, Li, Mg, Mn, Na, P, Se, Sr and Zn) are estimated in hair and nail of the 73 cancer patients and 83 controls by atomic absorption spectrophotometric method...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
Aiham Daniel Ghazali, Elsa Deilhes, Julie Thomas, Catherine Laland, Sarah Thévenot, Jean Pierre Richer, Denis Oriot
BACKGROUND: Hand hygiene is the primary measure for reducing nosocomial infections based on 7 steps recommended by the WHO. The aim of this study was to assess the duration and the quality of hand hygiene before and after simulation-based training (SBT). METHODS: The study took place in a University Hospital Pediatric Department among its residents and nurses. In assessment A, 10 hand-rubbing procedures per participant during a work day were scored by observers using a validated, anatomically based assessment scale...
November 2018: Infection Control and Hospital Epidemiology
Gaetano Caruso, Mattia Andreotti, Francesco Tonon, Carlotta Pari, Leo Massari
We report the case of a 54-year-old man who developed femoral head collapse after removal of a Kuntscher nail used to fix a shaft femoral fracture that occurred 35 years earlier. The removal of fixation devices implanted several years earlier can be a difficult procedure and can expose patients to several complications. Literature is still controversial regarding the correct timing and indications. It is mandatory to evaluate potential complications and inform the patients before undertaking this procedure when really necessary...
2018: Journal of Long-term Effects of Medical Implants
Eser Kaya, Tamer Aksoy, Ahmet Levent Güner, Hakan Temiz, Erkan Vardareli
Primary malignant melanoma occurs most often in the skin and much less frequently in the choroid layer of the eyes, in the leptomeninges, oral cavity, nasal mucosa, pharynx, esophagus, bronchus, under the nail and vaginal or anorectal mucosa. Primary melanoma of the gastrointestinal tract has been confirmed for lesions occurring in the esophagus, stomach, small bowel, and anorectum through several published reports, as these are the areas where melanocytes normally exist. The occurrence of primary malignant melanoma in the colon is relatively rare, because melanocytes are embryologically absent in the large bowel...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
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