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Kemi E Wright, Bonnie J Furzer, Melissa K Licari, Ashleigh L Thornton, James A Dimmock, Louise H Naylor, Siobhan L Reid, Stephanie R Kwan, Ben Jackson
Children with low movement proficiency have been identified as having poorer physiological and psychosocial outcomes; however, the varied measurement approaches used to assess these outcomes have varied resulting in conflicting evidence regarding the presence and magnitude of differences compared to Typically Developing (TD) children. Additionally, there has been limited research into the role of parental support for physical activity (PA) in this group. We compared children with varying levels of movement proficiency on physiological characteristics and self-perceptions regarding PA...
June 16, 2018: Research in Developmental Disabilities
Heather C Karras, Danita N Morin, Kamaldeep Gill, Sara Izadi-Najafabadi, Jill G Zwicker
BACKGROUND: Although Developmental Coordination Disorder (DCD) is primarily a motor disorder, it can also impact emotional and psychosocial functioning of children with this condition. Evidence suggests that children with DCD experience lower quality of life than their peers, but few studies have explicitly examined the health-related quality of life (HRQOL) of these children. AIMS: To: (1) describe HRQOL of children with DCD compared to typically-developing children; (2) compare HRQOL from the perspectives of children with DCD and their parents; and (3) explore predictors of HRQOL for children with DCD...
June 12, 2018: Research in Developmental Disabilities
Jian Zhang, Jun Lin, Ye Tian, Linlin Ma, Wen Sun, Lei Zhang, Yichen Zhu, Wei Qiu, Lujia Zhang
BACKGROUND: Due to the increasing number of DCD transplantations since 2015, the transmission of rabies through solid organ transplantation has become a notable problem in China and has attracted the attention of the public. CASE PRESENTATION: From 2015 to 2017, four solid organ recipients in our centre were successively diagnosed with rabies that was considered to have been transmitted from two donors who died due to viral encephalitis of unknown cause and acute disseminated encephalomyelitis...
June 14, 2018: BMC Infectious Diseases
Soizic Gauthier, Salvatore M Anzalone, David Cohen, Mohamed Zaoui, Mohamed Chetouani, François Villa, Alain Berthoz, Jean Xavier
Background: In motor imitation, taking a partner's perspective often involves a mental body transformation from an embodied, ego-centered viewpoint to a disembodied, hetero-centered viewpoint. Impairments of both own-body-transformation (OBT) and abnormalities in visual-spatial processing have been reported in patients with neurodevelopmental disorders including autism spectrum disorder (ASD). In the context of a visual-motor interactive task, studying OBT impairments while disentangling the contribution of visual-spatial impairments associated with motor coordination problems has not been investigated...
2018: Frontiers in Psychology
V Opatrný, J Moláček, V Třeška, R Matějka, O Hes
INTRODUCTION: There is still a lack of organs for kidney transplantation. The aim of our experimental animal study was to improve the quality of the kidney grafts from donors after cardiac death (DCD) using immediate start of machine perfusion instead of perfusion based on hydrostatic pressure. METHODS: Ten rabbits were used as an experimental model. In group A, 5 kidneys after ischemic injury were perfused in situ using hydrostatic pressure. In group B, 5 kidneys were perfused in situ using machine pulsatile perfusion...
June 2018: Transplantation Proceedings
D Zhu, K McCague, W Lin, R Rong, M Xu, L Chan, T Zhu
BACKGROUND: Kidney transplantation is limited by the shortage of donor kidneys. Donation after cardiac death (DCD) has been explored to alleviate this problem. To better understand the outcome of DCD kidney transplantation, we reanalyzed the Mycophenolic Renal Transplant (MORE) Registry. METHODS: We compared delayed graft function (DGF), biopsy-proved acute rejection (BPAR), graft loss, and patient death between DCD and donation after brain death (DBD) kidney transplantations...
June 2018: Transplantation Proceedings
Jenna R DiRito, Sarah A Hosgood, Gregory T Tietjen, Michael L Nicholson
Normothermic machine perfusion (NMP) is a technique that utilizes extra-corporeal membrane oxygenation to recondition and repair kidneys at near body temperature prior to transplantation. The application of this new technology has been fuelled by a significant increase in the use of the kidneys donated after circulatory death (DCD), which are more susceptible to ischaemic injury. Preliminary results indicate that normothermic machine perfusion itself may be able to repair marginal organs prior to transplantation...
June 7, 2018: American Journal of Transplantation
Weiyang He, Shaojun Ye, Cheng Zeng, Shuai Xue, Xiaoyan Hu, Xingjian Zhang, Siqi Gao, Yan Xiong, Xueyu He, Soatina Vivalda, Ling Li, Yanfeng Wang, Qifa Ye
Hypothermic oxygenated perfusion (HOPE) is a relatively new dynamic preservation procedure that has not been widely implemented in liver transplantation despite its advantages. Improved graft protection is one such advantage offered by HOPE and has been attributed to multiple mechanisms, one of which may be the modulation of the thioredoxin-interacting protein (TXNIP)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway. The TXNIP/NLRP3 inflammasome pathway plays a critical role in sterile inflammation under oxidative stress as a result of ischemia/reperfusion injury (IRI)...
June 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Santiago Amador-Ruiz, David Gutierrez, Vicente Martínez-Vizcaíno, Roberto Gulías-González, María J Pardo-Guijarro, Mairena Sánchez-López
BACKGROUND: Motor competence (MC) affects numerous aspects of children's daily life. The aims of this study were to: evaluate MC, provide population-based percentile values for MC; and determine the prevalence of developmental coordination disorder (DCD) in Spanish schoolchildren. METHODS: This cross-sectional study included 1562 children aged 4 to 6 years from Castilla-La Mancha, Spain. MC was assessed using the Movement Assessment Battery for Children-Second Edition...
July 2018: Journal of School Health
Jessie Cooper
Controlled organ donation after circulatory death (DCD) has recently been revived in the UK, as part of attempts to increase organ donation rates. The re-introduction of DCD has subsequently become the focus of bioethical controversy, since it necessitates intervening in the care of dying patients to obtain quality donor organs. Transplant policy responses to these concerns have generated new legal and ethical guidelines to address uncertainties around DCD, producing claims that the UK has overcome' the ethical challenge of DCD...
May 25, 2018: Social Science & Medicine
Wendy Aertssen, Emmanuel Bonney, Gillian Ferguson, Bouwien Smits-Engelsman
PURPOSE: Children with Developmental Coordination Disorder (DCD) are known to have poor physical fitness. However, differentiating homogenous subgroups of DCD using fitness performance has not yet been established. Therefore the purpose of this study was to identify subtypes in children with and without DCD using measures of physical fitness. METHOD: Children (aged 6-10 years, n = 217) constituted the sample for this study. They were assessed on 1) aerobic fitness (20m Shuttle Run test), 2) anaerobic fitness (Muscle Power Sprint Test), 3) isometric muscle strength (handheld dynamometry) 4) functional upper and lower body strength (Functional Strength Measurement) and 5) motor coordination [Movement Assessment Battery for Children-2nd edition (MABC-2) test]...
May 28, 2018: Human Movement Science
Lin-Ya Hsu, Tracy Jirikowic, Marcia A Ciol, Madisen Clark, Deborah Kartin, Sarah Westcott McCoy
AIMS: The purposes were to examine construct validity of the Motor Planning Maze Assessment (Maze) and three items from the Functional Gait Assessment (FGA) that were modified for children (pediatric modified FGA, pmFGA), by comparing performance of children with DCD and age matched peers with typical development (TD); the construct validity of total scores of the Dynamic Gait Index (DGI) and the FGA. METHODS: Twenty pairs of children with DCD and TD, age from 5 to 12 years, participated in this study...
May 31, 2018: Physical & Occupational Therapy in Pediatrics
Shuai Xue, Weiyang He, Xianpeng Zeng, Zimei Tang, Shoucheng Feng, Zibiao Zhong, Yan Xiong, Yanfeng Wang, Qifa Ye
Hypothermic machine perfusion (HMP) has been demonstrated to be a more effective method for preserving livers donated after circulatory death (DCD) than cold storage (CS); however, the underlying mechanisms remain unclear. The aim of the present study was to investigate the protective effects of HMP on rat DCD livers and the possible role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway. A total of 18 adult male rats were randomly divided into three groups: Control, HMP and CS (n=6 per group)...
May 23, 2018: Molecular Medicine Reports
Adriano Peris, Chiara Lazzeri, Giovanni Cianchi, Manuela Bonizzoli, Stefano Batacchi, Andrea Franci, Mario Rugna, Lucia De Vito, Pier F Ticali, Vincenzo Li Marzi, Maria L Migliaccio
BACKGROUND: Donation after circulatory death (DCD) is an emerging way to implement organ procurement for transplantation. In Italy, until June 2016, the only formal DCD program was implemented in Pavia, the so-called "Alba program". METHODS: We describe our one-year experience of the DCD program implemented at the Careggi Teaching Hospital (Florence, Italy) since June 2016. We specifically describe organizational changes induced by the DCD program on our pre-existing Donation After Brain Death (DBD ) program and DCD activity...
May 28, 2018: Minerva Anestesiologica
Yoko Kishi, Kenta Kikuchi, Mariko Hasegawa, Kenjiro Ohgushi, Akihiro Igarashi, Masahiro Hatanaka, Junko Fujino, Hitoshi Ikeda
Background and aims: It is generally thought that bleeding from a hemangioma is difficult to stop. With development of the long pulse dye laser (LPDL), it has become possible to treat hemangioma with a large blood vessel diameter. Thus, it is effective in treating infantile hemangioma and pyogenic granuloma. Materials and methods: Five patients who visited our hospital from July 2015 to July 2017 due to hemorrhagic hemangioma were treated using a flash lamp excitation pulse dye laser with parameters of 7 mm spot size, 3 msec pulse width, fluence 12-14J/cm2 , DCD 30 msec, and delay 30 msec...
March 31, 2018: Laser Therapy
Barbara G Jericho
Donation after circulatory death (DCD) is an increasingly utilized practice that can contribute to reducing the difference between the supply of organs and the demand for organs for transplantation. As the number of transplanted organs from DCD donors continues to increase, there is an essential need to address the ethical aspects of DCD in institutional DCD protocols and clinical practice. Ethical issues of respecting the end-of-life wishes of a potential donor, respecting a recipient's wishes, and addressing potential conflicts of interest are important considerations in developing policies and procedures for DCD programs...
May 21, 2018: Anesthesia and Analgesia
S Kostidis, J R Bank, D Soonawala, E Nevedomskaya, C van Kooten, O A Mayboroda, J W de Fijter
Extending kidney donor criteria, including donation after circulatory death (DCD), has resulted in increased rates of delayed graft function (DGF) and primary nonfunction. Here, we used Nuclear Magnetic Resonance (NMR) spectroscopy to analyze the urinary metabolome of DCD transplant recipients at multiple time points (days 10, 42, 180 and 360 after transplantation). The aim was to identify markers that predict prolonged duration of functional DGF (fDGF). Forty-seven metabolites were quantified and their levels were evaluated in relation to fDGF...
May 22, 2018: American Journal of Transplantation
Pello Latasa, Angel Gil de Miguel, Maria Dolores Barranco Ordoñez, Inmaculada Rodero Garduño, Juan Carlos Sanz Moreno, María Ordobás Gavín, María Esteban-Vasallo, Macarena Garrido-Estepa, Luis García-Comas
BACKGROUND: Chickenpox is a contagious airborne disease. Immunization by varicella vaccine is an effective preventive measure. The objective of this study is to evaluate the impact and effectiveness of a single-dose vaccination against chickenpox at 15 months of age. METHODS: Observational study based on data from the Epidemiological Surveillance System of the Autonomous Community of Madrid from 2001 to 2015. The years were grouped into 4 periods according to epidemic cycles and vaccination schedule: 2001-06, 2007-10, 2011-13 and 2014-15...
May 17, 2018: Human Vaccines & Immunotherapeutics
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
Hassiba Smail, Diana Garcia Saez, Ulrich Stock, Hesham Ahmed Hassan, Christopher Bowles, Barlomiej Zych, Prashant N Mohite, Olaf Maunz, Andre R Simon
The most extended technique of Heart procurement from donors after circulatory death (DCD)involves direct procurement and reperfusion in ex situ normothermic platform using Organ Care System (OCS). We describe a modified technique at our institution with rapid donor blood drainage using a cell saver and synchronised perfusion on the OCS.
May 9, 2018: Annals of Thoracic Surgery
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