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https://www.readbyqxmd.com/read/29470346/utilisation-of-declined-liver-grafts-yields-comparable-transplant-outcomes-and-previous-decline-should-not-be-a-deterrent-to-graft-use
#1
Francesca Marcon, Andrea Anja Schlegel, David Bartlett, Marit Kalisvaart, Dawn Bishop, Hynek Mergental, Keith Roberts, Darius Mirza, John Isaac, Paolo Muiesan, Thamara Perera
BACKGROUND: In the United Kingdom, up to 20% of liver graft offers are not utilized for transplantation and the reasons for graft refusal are multi-factorial and not consistent amongst transplant units. METHODS: Liver grafts previously declined by other transplant centers in UK but transplanted in our unit in Birmingham between 2011 and 2015 were analyzed. According to the indicated reason for previous declines, liver grafts were categorized into 3 refusal groups: "quality", "logistics" and "other reasons"...
February 22, 2018: Transplantation
https://www.readbyqxmd.com/read/29452371/a-bidirectional-association-between-cognitive-ability-in-young-adulthood-and-epilepsy-a-population-based-cohort-study
#2
Merete Osler, Erik L Mortensen, Kaare Christensen, Gunhild T Christensen
Aim: To investigate the bidirectional association between cognitive ability in young adulthood and epilepsy. Methods: This cohort study included 1 159 076 men enrolled in the mandatory conscription board examination from the Danish Conscription Database (DCD; 658 465 men examined 1957-84), the Danish Defence Personnel Organization Database (DPOD; 216 509 men examined 1987-2005) and the Danish Conscription Registry (DCR; 284 102 men examined 2006-15). A supplementary analysis included 14 814 female volunteers...
February 14, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29449571/an-in-silico-argument-for-mitochondrial-microrna-as-a-determinant-of-primary-non-function-in-liver-transplantation
#3
Shirin Elizabeth Khorsandi, Siamak Salehi, Miriam Cortes, Hector Vilca-Melendez, Krishna Menon, Parthi Srinivasan, Andreas Prachalias, Wayel Jassem, Nigel Heaton
Mitochondria have their own genomic, transcriptomic and proteomic machinery but are unable to be autonomous, needing both nuclear and mitochondrial genomes. The aim of this work was to use computational biology to explore the involvement of Mitochondrial microRNAs (MitomiRs) and their interactions with the mitochondrial proteome in a clinical model of primary non function (PNF) of the donor after cardiac death (DCD) liver. Archival array data on the differential expression of miRNA in DCD PNF was re-analyzed using a number of publically available computational algorithms...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433886/expanding-the-donor-lung-pool-how-many-donations-after-circulatory-death-organs-are-we-missing
#4
William Zachary Chancellor, Eric J Charles, James Hunter Mehaffey, Robert B Hawkins, Carrie A Foster, Ashish K Sharma, Victor E Laubach, Irving L Kron, Curtis G Tribble
BACKGROUND: The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is to determine the potential donor pool expansion with increased procurement of DCD organs from patients who die at hospitals. MATERIAL AND METHODS: The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433607/developmental-coordination-disorder-psychopathology-and-iq-in-22q11-2-deletion-syndrome
#5
Adam C Cunningham, Sue Delport, Wendy Cumines, Monica Busse, David E J Linden, Jeremy Hall, Michael J Owen, Marianne B M van den Bree
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology. METHOD: Neurocognitive assessments and psychiatric interviews of 70 children with 22q11...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29426379/success-in-adults-with-probable-developmental-coordination-disorder-using-structural-equation-modeling
#6
Miri Tal-Saban, Asher Ornoy, Shula Parush
OBJECTIVE: The aim of this study was to conduct a broad in-depth examination of the relationship between developmental coordination disorder (DCD) and use of executive strategies, daily life activities, emotional state, and internal factors attributed to success. METHOD: We used a large randomized cohort of young adults. Structural equation modeling was performed to test both the direct effects and the mediated effects of the independent variable (probable DCD) on dependent variables (executive functions, academic and nonacademic activities, emotional state, and attribution to success)...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29413728/bereaved-donor-families-experiences-of-organ-and-tissue-donation-and-perceived-influences-on-their-decision-making
#7
Magi Sque, Wendy Walker, Tracy Long-Sutehall, Myfanwy Morgan, Gurch Randhawa, Amanda Rodney
PURPOSE: To elicit bereaved families' experiences of organ and tissue donation. A specific objective was to determine families' perceptions of how their experiences influenced donation decision-making. METHODS: Retrospective, qualitative interviews were undertaken with 43 participants of 31 donor families to generate rich, informative data. Participant recruitment was via 10 National Health Service Trusts, representative of five regional organ donation services in the UK...
January 16, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29413431/evaluating-the-evidence-for-motor-based-interventions-in-developmental-coordination-disorder-a-systematic-review-and-meta-analysis
#8
REVIEW
Bouwien Smits-Engelsman, Sabine Vinçon, Rainer Blank, Virgínia H Quadrado, Helene Polatajko, Peter H Wilson
BACKGROUND: As part of the process of creating an update of the clinical practice guidelines for developmental coordination disorder (DCD) (Blank, Smits-Engelsman, Polatajko, & Wilson, 2012), a systematic review of intervention studies, published since the last guidelines statement was conducted. AIM: The aim of this study was to 1) systematically review the evidence published from January 2012 to February 2017 regarding the effectiveness of motor based interventions in individuals with DCD, 2) quantify treatment effects using a meta-analysis, 3) examine the available information on different aspects of delivery including use of group intervention, duration and frequency of therapy, and 4) identify gaps in the literature and make recommendations for future intervention research...
January 24, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29408162/sensory-and-motor-differences-in-autism-spectrum-conditions-and-developmental-coordination-disorder-in-children-a-cross-syndrome-study
#9
Penny Hannant, Sarah Cassidy, Rosaline Van de Weyer, Sophia Mooncey
Recent research has shown that Developmental coordination disorder (DCD) can present with some similar symptomology as Autism Spectrum Conditions (ASC). This paper therefore explored the similarities and differences in coordination and sensory responsivity between DCD and ASC. 77 children took part: 42 (35 male, 7 female) with ASC (ages 7-21: mean age 12.23 years), 26 (19 male, 7 female) with DCD (ages 7-21; mean age 11.07 years) and 9 (2 male, 7 female) with ASC and DCD (ages 8-15; mean age 12.27). All groups completed a battery of validated parent report measures online that included motor coordination (DCDQ), sensory responsivity (SPC-R) and social communication measures (AQ)...
January 26, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29389767/outcomes-of-donation-after-cardiac-death-liver-grafts-from-donors-%C3%A2-50-years-of-age-a-multi-center-analysis
#10
Kristopher P Croome, Amit K Mathur, David D Lee, Adyr A Moss, Charles B Rosen, Julie K Heimbach, C Burcin Taner
INTRODUCTION: As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be expected. The aim of this study was to analyze a multi-institutional experience in liver transplantation using DCD donor age ≥50 years. METHODS: All DCD LT performed at Mayo Clinic Florida, Mayo Clinic Rochester and Mayo Clinic Arizona from 2002-2016 were included. Recipients of DCD LT were divided into 2 groups: those with donor age ≥50 years(N=155) and those with donor age <50 years(N=316)...
January 31, 2018: Transplantation
https://www.readbyqxmd.com/read/29382564/diabetic-cognitive-dysfunction-is-associated-with-increased-bile-acids-in-liver-and-activation-of-bile-acid-signaling-in-intestine
#11
Xue Wang, Fangyu Wang, Yidan Zhang, Hui Xiong, Yanjun Zhang, Pengwei Zhuang, Youcai Zhang
Impaired regulation of bile acid (BA) homeostasis has been suggested to be associated with adverse metabolic consequences. However, whether BA homeostasis is altered in diabetes-induced cognitive dysfunction (DCD) remains unknown. In the present study, mice were divided into four groups, namely normal control (NC) group, high-fat diet (HFD) group, diabetes without cognitive dysfunction (unDCD) group, and DCD group. Compared to HFD mice, the concentration of total BAs in liver was higher in unDCD and DCD mice, due to increased intestinal BA absorption...
January 27, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29380523/dcd-donor-hemodynamics-as-predictor-of-outcome-after-kidney-transplantation
#12
H Peters-Sengers, J H E Houtzager, M B A Heemskerk, M M Idu, R C Minnee, R W Klaasen, S E Joor, J A M Hagenaars, P M Rebers, J J Homan van der Heide, J I Roodnat, F J Bemelman
Insufficient hemodynamics during agonal phase-i.e. the period between withdrawal of life-sustaining treatment and circulatory arrest-in Maastricht category III circulatory-death donors (DCD) potentially exacerbate ischemia/reperfusion injury. We included 409 Dutch adult recipients of DCD donor kidneys transplanted between 2006 and 2014. Peripheral oxygen saturation (SpO2-with pulse oximetry at the fingertip) and systolic blood pressure (SBP-with arterial catheter) were measured during agonal phase, and were dichotomized into minutes of SpO2>60% or SpO2<60%, and minutes of SBP>80 mmHg or SBP<80 mmHg...
January 30, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29377119/secular-changes-in-the-symptom-level-of-clinically-diagnosed-autism
#13
Olof Arvidsson, Christopher Gillberg, Paul Lichtenstein, Sebastian Lundström
BACKGROUND: The prevalence of autism has been reported to have increased worldwide. A decrease over time in the number of autism symptoms required for a clinical autism diagnosis would partly help explain this increase. This study aimed to determine whether the symptom level of clinically diagnosed autism cases below age 13 had changed over time. METHODS: Parents of Swedish 9-year old twins (n = 28,118) participated in a telephone survey, in which symptoms and dysfunction/suffering related to neurodevelopmental disorders [including autism, but also attention-deficit/hyperactivity disorder (ADHD), Developmental Coordination Disorder (DCD), and Learning Disabilities (LD)] in their children were assessed over a 10-year period...
January 29, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29374912/-selective-preimplantation-pathological-evaluation-in-renal-transplantation-a-single-center-s-experience
#14
F H Peng, J J Chen, L K Peng, X B Xie, G B Lan, S J Yu, Y Wang, X T Tang, H L Dai, C Gao, C H Fang
Objective: To summarize the clinical data of pre-implantation biopsy donors in our hospital and explore the clinical characteristics of those donors in pathological high-risk, and to provide references for the selective histological evaluation of extended criteria donor kidneys. Methods: We retrospectively reviewed the clinical data and pre-implantation renal pathologic score of donors from January 1, 2015 to May 1, 2017.During this period, 247 cases of donation after citizen's death (DCD) occurred.After clinical evaluation and selective machine perfusion( Lifeport) evaluation, 30 cases of pre-implantation pathological evaluation were performed...
January 16, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29374911/-distribution-and-drug-resistance-of-pathogens-in-infected-organ-donors-from-donation-after-the-citizen-death
#15
Z Chen, X X Lai, L Zhang, J L Fang, J J Ma, G H Li, L Xu, W Yin, Y H Guo
Objective: To investigate the distribution and drug resistance of pathogens in infected organ donors from donation after the citizen death (DCD). Methods: Clinical data of 217 DCD donors from January 2013 to June 2017 were retrospectively analyzed.The phlegm, urine, blood and drainage fluid from all of the donors were routinely cultured.The infection rate of the donors, the composition ratio of pathogens and the distribution of specimen sources were observed and the drug resistance was analyzed. Results: Of all the 217 donors, 128 were infected and the infection rate was 59%...
January 16, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29372061/analysis-of-changes-in-trends-in-the-consumption-rates-of-benzodiazepines-and-benzodiazepine-related-drugs
#16
Miguel Angel Fernández García, Antonio Olry de Labry Lima, Ingrid Ferrer Lopez, Clara Bermúdez-Tamayo
Background: To analyse trends in the rates of consumption of benzodiazepine (BZD) anxiolytics, BZD hypnotics and non-BZD hypnotics and the association with contextual factors. Methods: Descriptive time series study. Units of analysis were monthly dose per inhabitant per day (DID) and dose per medical card per day(DCD) of benzodiazepine(BZD anxiolytics(BZD-A), BZD hypnotics(BZD-H) and non-BZD hypnotics(Non-BZD-H) between January 2006-December 2015. We analysed 6 primary healthcare districts(PHD) and used defined daily doses (DDDs) to calculate the monthly DIDs(overall and by ATC group)...
2018: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29369470/hypothermic-oxygenated-machine-perfusion-reduces-bile-duct-reperfusion-injury-after-transplantation-of-donation-after-circulatory-death-livers
#17
Rianne van Rijn, Otto B van Leeuwen, Alix P M Matton, Laura C Burlage, Janneke Wiersema-Buist, Marius C van den Heuvel, Ruben H J de Kleine, Marieke T de Boer, Annette S H Gouw, Robert J Porte
INTRODUCTION: Dual hypothermic oxygenated machine perfusion (DHOPE) of the liver has been advocated as a method to reduce ischemia-reperfusion injury. This study aimed to determine whether DHOPE reduces IR injury of the bile ducts in DCD liver transplantation. MATERIALS AND METHODS: In a recently performed phase 1-trial, ten DCD livers were preserved with DHOPE after static cold storage (SCS) (www.trialregister.nl NTR4493). Bile duct biopsies were obtained at the end of SCS (before DHOPE; baseline) and after graft reperfusion in the recipient...
January 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29360615/patient-and-graft-survival-biliary-complications-after-liver-transplantation
#18
Michael Senter-Zapata, Adeel S Khan, Tanvi Subramanian, Neeta Vachharajani, Leigh Anne Dageforde, Jason R Wellen, Surendra Shenoy, Maria B Majella Doyle, William C Chapman
BACKGROUND: Biliary complications (BC) effect upto to 34% of liver transplant (LT) recipients and are a major source of morbidity and cost. This is a 13-year review of BC after LT at a tertiary care center. STUDY DESIGN: Single center retrospective review of prospective database to assess BC in adult (≥18yrs) LT recipients over a 13 period (2002-2014). BC were divided into three sub-groups: leak alone(L), stricture alone(S), and both leak and strictures(LS). Controls (no BC) were used for comparison...
January 19, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29358139/variable-effects-of-biochar-application-to-soils-on-nitrification-mediated-n2o-emissions
#19
Gayoung Yoo, Yong Oon Lee, Tae Jin Won, Jun Ge Hyun, Weixin Ding
Although a meta-analysis on biochar's effects on N2O emission reported an overall reduction in N2O emission by adding biochar to the soils, there are still variations in the changes in N2O emission, especially from field results. The objectives of this study are 1) to compare the effects of biochar addition on N2O emission between three agricultural upland field experiments, where soil water status was dry favoring nitrification and 2) to identify main factors explaining biochar's variable effects on N2O emission...
January 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29351369/heparin-but-not-tissue-plasminogen-activator-improves-outcomes-in-dcd-liver-transplantation-in-a-porcine-model
#20
Amelia J Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García-Valdecasas, Pilar Taurá, Constantino Fondevila
BACKGROUND: Ischemic type biliary lesions arise most frequently after DCD liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication. In theory, microvascular thrombi deposited during donor warm ischemia might be implicated in ITBL pathogenesis. Herein, we aim to evaluate the effects of the administration of either heparin or the fibrinolytic drug TPA as means to improve DCD liver graft quality and potentially avoid ITBL...
January 19, 2018: Liver Transplantation
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