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Antimicrobials in dentistry

L S Gu, X Cai, J M Guo, D H Pashley, L Breschi, H H K Xu, X Y Wang, F R Tay, L N Niu
Instability of resin-dentin bonds is the Achilles' heel of adhesive dentistry. To address this problem, a chelate-and-rinse extrafibrillar dentin demineralization strategy has been developed that keeps intrafibrillar minerals within collagen fibrils intact to prevent activation of endogenous proteases that are responsible for collagen degradation within hybrid layers. The objective of the present study was to evaluate the potential of using chitosan >40 kDa as an antimicrobial extrafibrillar dentin-chelating agent to enhance bond durability...
October 16, 2018: Journal of Dental Research
Seetharam Charannya, Dasarathan Duraivel, Krishnan Padminee, Saravanan Poorni, Cruz Nishanthine, Manali Ramakrishnan Srinivasan
Context: Silver nanoparticle (AgNP) is a potent antimicrobial that is widely used in several fields of medicine. Chlorhexidine (CHX) gluconate is a well-known agent used in dentistry to eliminate oral microbial flora. Aims: The aim of this study is to evaluate the efficacy of AgNPs, 2% CHX gluconate, and the combination of two solutions against endodontic pathogens such as Enterococcus faecalis , Klebsiella pneumoniae , and Candida albicans . These organisms are frequently found in the root canal space and their persistence may lead to endodontic failure...
September 2018: Contemporary Clinical Dentistry
Carly C Dixon, Francesca J Thomson, Siobhan M Barry
Autoimmune neutropenia is a self-limiting condition characterized by the presence of granulocyte-specific autoantibodies. This case report describes a 2-year-old female who presented to the Department of Pediatric Dentistry with a history of oral ulceration, complicated by high temperature, gingival hypertrophy and gingival hemorrhage. These symptoms had precipitated an admission to a district general hospital and diagnosis of viral tonsillitis. The severity of the presentation to the Pediatric Dental Department prompted a review of recent discharge blood investigations, which revealed a neutrophil count of 0...
October 5, 2018: Journal of Clinical Pediatric Dentistry
Kelli Stein, Julie Farmer, Sonica Singhal, Fawziah Marra, Susan Sutherland, Carlos Quiñonez
BACKGROUND: To describe antibiotic prescribing behaviors in dentistry, including clinical and nonclinical indications for their use, the type and regimen of antibiotics prescribed, and factors influencing their prescription, the authors conducted a scoping review. TYPES OF STUDIES REVIEWED: The authors conducted a scoping review of published literature by searching multiple databases. Key search terms included dentist, antibiotic, antimicrobial, antibacterial, prophylaxis, prescription, pattern, habit, knowledge, and practice...
October 2018: Journal of the American Dental Association
Preetika Chandna, Nikhil Srivastava, Alpana Sharma, Vrinda Sharma, Nidhi Gupta, Vivek Kumar Adlakha
Aim: This study aimed to quantitatively assess the levels of Scardovia wiggsiae in caries-free and early childhood caries (ECC)- and severe ECC (SECC)-affected children using real-time polymerase chain reaction (RT-PCR). Methods: Forty-five children aged <71 months were randomly recruited from the Outpatient Clinic at the Department of Pedodontics and Preventive Dentistry at Subharti Dental College and Hospital, Meerut, India. Fifteen children suffering from ECC, 15 with SECC, and 15 children without ECC were enrolled in the study...
July 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
P A Calderón-Ávila, J A Garrocho-Rangel, J A Cepeda-Bravo, M S Ruiz-Rodríguez, M Pierdant-Pérez, A Pozos-Guillén
BACKGROUND: Eisenmenger syndrome (ES) is a heart cyanotic condition characterised by elevated pulmonary vascular resistance and an intra-cardiac right-to-left shunting of blood through a systemic-to-pulmonary circulation connection. Affected children usually exhibit severe hypoxia, clubbing of fingers/toes, haemoptysis, anaemia, and organ damage. CASE REPORT: During autumn 2015, the patient and her parents arrived at the paediatric dentistry clinic. The patient presented with the main complaint of generalised inflamed gingival tissues, severely protruded upper incisors, and evident abnormal mouth breathing...
September 8, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Thanawat Kaewjiaranai, Ratchapin Laovanitch Srisatjaluk, Watus Sakdajeyont, Verasak Pairuchvej, Natthamet Wongsirichat
Topical anesthetics are commonly used in oral & maxillofacial surgery to control pain in the oral cavity mucosa before local anesthetic injection. These anesthetic agents come in many forms, developed for different usages, to minimize adverse reactions, and for optimal anesthetic efficiency. Earlier studies have revealed that these agents may also limit the growth of microorganisms in the area of anesthetic application. Many topical anesthetic agents show different levels of antimicrobial activity against various bacterial strains and Candida...
August 2018: Journal of Dental Anesthesia and Pain Medicine
Hanaa M Elgamily, Hoda S El-Sayed, Ali Abdelnabi
Introduction: Bacteria residing in the oral cavity penetrate freely through the resultant fissures under the fillings, which might lead to the development of secondary caries. Nowadays dentistry, different nanotechnological materials with antibacterial activity are being developed for oral cavity disinfection. Aim: This study aims to investigate the antibacterial activity of a new cavity disinfectant NanoCare Plus Silver Gold® (NanoCare) in comparison to (0.2%) chlorhexidine (CHX) gluconate disinfectant against Streptococcus mutans growth and colony count using Agar well diffusion method and contact test, respectively, and also, to assess the nanoparticles (NPs) size distribution and Zeta potential of a NanoCare disinfectant...
July 2018: Contemporary Clinical Dentistry
Ali Saafan, Mohamed H Zaazou, Marwa K Sallam, Osama Mosallam, Heba A El Danaf
AIM: To assess the antibacterial competence of 650 nm diode laser, Methylene Blue (MB) and Silver Nano-Particles (Ag NPs) on Streptococcus mutans in biofilm-induced caries models. MATERIAL AND METHODS: One hundred eighty specimens were prepared and equally divided into 6 groups. One group was untreated (control), and the others were subjected to either MB, laser, Ag NPs, the combination of MB and Laser or MB, laser and Ag NPs. RESULTS: Comparison of the log10 mean Colony Forming Units per millilitre (CFU/ml) values of each of the treated 5 groups and the control group was found statistically significant (P-value < 0...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Ranjeet A Bapat, Tanay V Chaubal, Chaitanya P Joshi, Prachi R Bapat, Hira Choudhury, Manisha Pandey, Bapi Gorain, Prashant Kesharwani
Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Ning Zhang, Ke Zhang, Michael D Weir, David J Xu, Mark A Reynolds, Yuxing Bai, Hockin H K Xu
Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability...
June 21, 2018: International Journal of Oral Science
Marta Ribeiro, Joana Malheiro, Liliana Grenho, Maria Helena Fernandes, Manuel Simões
Background: Dental caries remains the most prevalent and costly oral infectious disease worldwide, encouraging the search for new and more effective antimicrobials. Therefore, the aim of this work was to study the antimicrobial action of selected phytochemicals (eugenol, citronellol, sabinene hydrate, trans-cinnamaldehyde, terpineol and cinnamic acid) against Streptococcus mutans in planktonic and biofilm states as well as the cytotoxicity of these compounds. Methods: The antibacterial activity of the selected compounds was evaluated by the determination of the minimal bactericidal concentration...
2018: PeerJ
P Shubha, K Byrappa, K Namratha, Jit Chaterjee, M S Mustak
BACKGROUND: Facile, environmental friendly synthesis of metal oxide nanoparticles is of paramount importance when its biological applications are considered. OBJECTIVE: Current study reports phyto-fabrication of Zinc oxide nanoparticles using aqueous extract of Piper betel leaves as stabilizing and capping agent using co-precipitation method. RESULTS: P betel synthesized ZnO nanoparticles (PZnO) was characterized using Powder X-ray diffraction, UV-Visible spectroscopy, scanning electron microscopy and dynamic light scattering...
June 10, 2018: Pharmaceutical Nanotechnology
Maciej Kawala, Joanna Smardz, Lukasz Adamczyk, Natalia Grychowska, Mieszko Wieckiewicz
BACKGROUND: Polymers are widely applied in medicine, including dentistry, i.e. in prosthodontics. AIM: The following paper is aimed at demonstrating the applications of selected modern polymers in prosthetic dentistry based on the reported literature. MATERIAL AND METHODS: The study was conducted using the PubMed, SCOPUS and CINAHL databases in relation to documents published during 1999-2017. The following keywords were used: polymers with: prosthetic dentistry, impression materials, denture base materials, bite registration materials, denture soft liners, occlusal splint materials and 3D printing...
May 10, 2018: Current Medicinal Chemistry
Fabian Cieplik, Viktoria-Sophia Steinwachs, Denise Muehler, Karl-Anton Hiller, Thomas Thurnheer, Georgios N Belibasakis, Wolfgang Buchalla, Tim Maisch
In light of increasing resistance toward conventional antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a valuable alternative, especially for use in dentistry. In this regard, photosensitizers (PS) based on a phenalen-1-one structure seem to be especially favorable due to their high singlet oxygen quantum yield. However, the actual target structures of phenalen-1-one-mediated aPDT are still unclear. The aim of the present study was to investigate the antimicrobial efficacy of aPDT mediated by phenalen-1-one derivatives SAPYR and SAGUA for inactivation of a polymicrobial biofilm consisting of three putative periodontal pathogens in vitro and to get first insights in the mechanism of action of phenalen-1-one-mediated aPDT by assessing damage of cytoplasmic membranes...
2018: Frontiers in Microbiology
Pooyan Makvandi, Rezvan Jamaledin, Mostafa Jabbari, Nasser Nikfarjam, Assunta Borzacchiello
OBJECTIVE: Quaternary ammonium compounds (QACs) represent one of the most effective classes of disinfectant agents in dental materials and resin nanocomposites. This reviews aims to give a wide overview on the research in the field of antibacterial QACs in dental materials and nanocomposites. METHOD: An introduction to dental materials components as well as the microorganisms and methods of evaluation for the antimicrobial assays are presented. Then, the properties and synthesis route of QACs, as monomer and filler, are shown...
June 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Oliver James Dyar, Holly Hills, Lara-Turiya Seitz, Alex Perry, Diane Ashiru-Oredope
The Global Action Plan on Antimicrobial Resistance highlights the importance of training all healthcare professionals. No study has assessed patterns of students' knowledge, attitudes and practices concerning antibiotic use simultaneously across different healthcare course types. We conducted a cross-sectional multi-center survey among UK students. The survey was advertised through local survey coordinators at 25 universities. The online survey was accessible from 10th October to 17th November 2016 (before European Antibiotic Awareness Day)...
January 30, 2018: Antibiotics
Carolina Santezi, Bárbara Donadon Reina, Lívia Nordi Dovigo
BACKGROUND: Recent evidences show the promising applications of Curcumin (CUR) against different diseases, including some of the main oral pathologies. The objective of this review paper was to catalog articles that investigated the photodynamic effect of CUR for oral diseases in the last 15 years. METHODS: The establishment of defined criteria for data collection was proposed and a total of 173 articles were identified, but only 26 were eligible for full text reading...
March 2018: Photodiagnosis and Photodynamic Therapy
A Monajemzadeh, S Ahmadi Asoor, S Aslani, B Sadeghi-Nejad
Background and Purpose: Root canal therapy is the primary method for the treatment of an infected pulp in modern dentistry. The main aim of endodontic treatment is the elimination of bacteria and their products from infected root canals. In this study, we attempted to investigate the antimicrobial activity of three root canal sealers against oral pathogens. Materials and Methods: The antimicrobial effectiveness of three endodontic sealers with different chemical compositions, namely resin (AH 26), zinc oxide eugenol (ZOE), and mineral trioxide aggregate (MTA), against Candida albican s, Streptococcus sanguis, Streptococcus salivarius, Streptococcus mutans , and Lactobacillus casei was assayed by agar well diffusion method (AWDM)...
June 2017: Advances in Medical Mycology (Iran)
Jorgiana Sangalli, Elerson Gaetti Jardim Júnior, Carlos Roberto Emerenciano Bueno, Rogério Castilho Jacinto, Gustavo Sivieri-Araújo, João Eduardo Gomes Filho, Luciano Tavares Ângelo Cintra, Eloi Dezan Junior
OBJECTIVE: Evaluate, in vitro, the antimicrobial activity of Psidium cattleianum leaf extracts combined with calcium hydroxide against Enterococcus faecalis and Candida albicans biofilm. MATERIALS AND METHODS: Dentin specimens obtained from extracted bovine incisors were infected during 14 days with E. faecalis ATCC 29212 and C. albicans ATCC 10231. The specimens were filled with calcium hydroxide pastes prepared with the following vehicles: Psidium cattleianum ethanolic, Psidium cattleianum propylene glycolic, distilled water, and saline as control...
July 2018: Clinical Oral Investigations
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