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JOURNAL ARTICLE
Tan Doan, Stuart Howell, Stephen Ball, Judith Finn, Peter Cameron, Emma Bosley, Bridget Dicker, Steven Faddy, Ziad Nehme, Natalie Heriot, Andy Swain, Melanie Thorrowgood, Andrew Thomas, Samuel Perillo, Mike McDermott, Tony Smith, Karen Smith, Jason Belcher, Janet Bray
AIM: This study aims to explore regional variation and identify regions within Australia with high incidence of out-of-hospital cardiac arrest (OHCA) and low rates of bystander cardiopulmonary resuscitation (CPR). METHOD: Adult OHCAs of presumed medical aetiology occurring across Australia between 2017 and 2019 were mapped onto local government areas (LGA) using the location of arrest coordinates. Bayesian spatial models were applied to provide "smoothed" estimates of OHCA incidence and bystander CPR rates (for bystander-witnessed OHCAs) for each LGA...
2024: PloS One
#2
REVIEW
Abdur Rauf, Payal B Joshi, Ahmed Olatunde, Nabia Hafeez, Zubair Ahmad, Hassan A Hemeg, Abdullah S M Aljohani, Waleed Al Abdulmonem, Muthu Thiruvengadam, Dhivya Viswanathan, Govindasamy Rajakumar, Rekha Thiruvengadam
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases or disorders. Drug repurposing essentially refers to uncovering approved or failed compounds for use in various diseases. Cancer is a deadly disease and leading cause of mortality. The search for approved non-oncologic drugs for cancer treatment involved in silico modeling, databases, and literature searches. In this review, we provide a concise account of the existing non-oncologic drug molecules and their therapeutic potential in chemotherapy...
April 23, 2024: Medical Oncology
#3
JOURNAL ARTICLE
Rugare Mugumbate, Vinod Gopaldasani, Paul Kidson, Jioji Ravulo
This paper investigates the impact on Culturally and Linguistically Diverse (CALD) communities in Australia of government and community responses to the coronavirus pandemic of 2019 in the domains of education, employment, housing, social connectedness, and public health communication. Most of the examples are drawn from the state of New South Wales. In Australia, CALD refers to people from countries not classified as main English speaking. Most CALD communities reported in this article are from refugee backgrounds, are recently arrived migrants or do not use English in most of their communication...
April 23, 2024: Social Work in Public Health
#4
JOURNAL ARTICLE
Hidetoshi Matsukawa, Kazutaka Uchida, Mohammad-Mahdi Sowlat, Sameh Samir Elawady, Conor Cunningham, Ali Alawieh, Sami Al Kasab, Pascal Jabbour, Justin Mascitelli, Michael R Levitt, Hugo Cuellar, Waleed Brinjikji, Edgar Samaniego, Jan-Karl Burkhardt, Peter Kan, W Christopher Fox, Mark Moss, Mohamad Ezzeldin, Ramesh Grandhi, David J Altschul, Alejandro M Spiotta, Shinichi Yoshimura
BACKGROUND AND OBJECTIVES: The impact of race on outcomes in the treatment of intracranial aneurysm (IA) remains unclear. We aimed to investigate the relationship between race classified into White, Black, Hispanic, and other and treatment outcomes in patients with ruptured and unruptured IAs. METHODS: The study population consisted of 2836 patients with IA with endovascular treatment or microsurgical treatment (MST) from 16 centers in the United States and Asia, all participating in the observational "STAR" registry...
April 23, 2024: Neurosurgery
#5
REVIEW
Ankit Sahoo, Khusbu Dwivedi, Waleed H Almalki, Ashok Kumar Mandal, Abdurrahman Alhamyani, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Nabil K Alruwaili, Pradip Kumar Yadav, Md Abul Barkat, Tanuja Singh, Mahfoozur Rahman
Topical infection affects nearly one-third of the world's population; it may result from poor sanitation, hygienic conditions and crowded living and working conditions that accelerate the spread of topical infectious diseases. The problems associated with the anti-infective agents are drug resistance and long-term therapy. Secondary metabolites are obtained from plants, microorganisms and animals, but they are metabolized inside the human body. The integration of nanotechnology into secondary metabolites is gaining attention due to their interaction at the subatomic and skin-tissue levels...
April 23, 2024: Nanomedicine
#6
JOURNAL ARTICLE
Ghidaa A Alghamdi, Faisal A Alghamdi, Renad M Almatrafi, Arwa Y Sadis, Rozan A Shabkuny, Saad A Alzahrani, Mohammed Q Alessa, Waleed A Hafiz
Background Hajj, the annual Islamic pilgrimage, brings together over two million pilgrims in the city of Makkah to participate in a series of rituals. Given the physically demanding nature of the Hajj, pilgrims are susceptible to musculoskeletal (MSK) injuries and exhaustion. MSK pain and injuries are frequent occurrences among pilgrims, necessitating an assessment of the scope of this issue. Therefore, the primary objective of this study was to determine the prevalence of MSK injuries among pilgrims during the 2023 Hajj season...
March 2024: Curēus
#7
JOURNAL ARTICLE
Benita S Arakal, Richard S Rowlands, Michael McCarthy, David E Whitworth, Sarah E Maddocks, Philip E James, Paul G Livingstone
AIM: Corallococcus species are diverse in the natural environment with ten new Corallococcus species having been characterised in just the last five years. As well as being an abundant myxobacterial genus they produce several secondary metabolites, including Corallopyronin, Corramycin, Coralmycin and Corallorazine. We isolated a novel strain Corallococcus spp RDP092CA from soil in South Wales, United Kingdom using Candida albicans as prey bait and characterised its predatory activities against pathogenic bacteria and yeast...
April 22, 2024: Journal of Applied Microbiology
#8
JOURNAL ARTICLE
Aljazi Al-Maraghi, Waleed Aamer, Mubarak Ziab, Elbay Aliyev, Najwa Elbashir, Sura Hussein, Sasirekha Palaniswamy, Dhullipala Anand, Donald R Love, Adrian Charles, Ammira A S Akil, Khalid A Fakhro
BACKGROUND: Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification...
April 22, 2024: BMC Nephrology
#9
JOURNAL ARTICLE
Mahmoud Shaban, Fahad Nasser Alsunaydih, Hanan Kouta, Samar El-Sanabary, Abdulrahman Alrumayh, Abdulrahman I Alateyah, Majed O Alawad, Waleed H El-Garaihy, Yasmine El-Taybany
The present research applies different statistical analysis and machine learning (ML) approaches to predict and optimize the processing parameters on the wear behavior of ZK30 alloy processed through equal channel angular pressing (ECAP) technique. Firstly, The ECAPed ZK30 billets have been examined at as-annealed (AA), 1-pass, and 4-passes of route Bc (4Bc). Then, the wear output responses in terms of volume loss (VL) and coefficient of friction (COF) have been experimentally investigated by varying load pressure (P) and speed (V) using design of experiments (DOE)...
April 22, 2024: Scientific Reports
#10
JOURNAL ARTICLE
Alison Cooper, Michelle Edwards, Freya Davies, Delyth Price, Pippa Anderson, Andrew Carson-Stevens, Matthew Cooke, Jeremy Dale, Liam Donaldson, Bridie Angela Evans, Barbara Harrington, Julie Hepburn, Peter Hibbert, Thomas C Hughes, Alison Porter, Aloysius Niroshan Siriwardena, Alan Watkins, Helen Snooks, Adrian Edwards
BACKGROUND: Addressing increasing patient demand and improving ED patient flow is a key ambition for NHS England. Delivering general practitioner (GP) services in or alongside EDs (GP-ED) was advocated in 2017 for this reason, supported by £100 million (US$130 million) of capital funding. Current evidence shows no overall improvement in addressing demand and reducing waiting times, but considerable variation in how different service models operate, subject to local context...
April 22, 2024: Emergency Medicine Journal: EMJ
#11
JOURNAL ARTICLE
Owen J Lawrence, Vasudev Shanbhag
Aims In March 2020 the World Health Organisation (WHO) declared the COVID-19 virus a global pandemic. The United Kingdom's National Health Service (NHS) was placed under unprecedented pressure and hospitals were forced to adapt their working practices to continue offering world-leading healthcare. This project aims to highlight the lessons learnt within hand surgical departments throughout Wales. Using this knowledge, we can consider how these lessons can be implemented in both emergency and elective hand practice...
March 2024: Curēus
#12
REVIEW
Hyder Mirghani, Bandar Ahmed Alamrani, Mohammad Omar Aljabri, Fadi Olyan Alamrani, Meshal Saleh Alatawi, Meshari Mohammed Albalawi, Mohammed Abdullah S Alasmari, Ali Fahad B Alsharif, Waleed Muslih B Albalawi, Omar Sabbah Alzamhari
The global adoption of remote thyroidectomy is increasing, with the transoral endoscopic thyroidectomy vestibular approach (TOETVA) and transareolar approach (TAA) emerging as predominant methods. However, existing meta-analyses comparing these approaches to operative surgeries and short-term postoperative complications have significant limitations. To address this gap, our meta-analysis provides a comprehensive comparison between the TOETVA and TAA, focusing on operation time, intraoperative blood loss, postoperative drainage, and hospital stay duration...
March 2024: Curēus
#13
JOURNAL ARTICLE
Jack Barrington, Zaheer Yousef, Christian Peter Subbe
The number of people using wearable technology such as smartwatches and fitness trackers is increasing. Many of these devices can alert the user to a potential arrhythmia such as atrial fibrillation. We aimed to assess potential changes to cardiology practice resulting from their use. An online questionnaire consisting of 12 questions was created and distributed to all consultant cardiologists in Wales. 25 of 102 participants replied, with 92% of these using consumer wearable technology to diagnose atrial fibrillation either 'often' or 'sometimes'...
March 2024: Future Healthcare Journal
#14
JOURNAL ARTICLE
Oluwatobi O Onafowokan, Waleed Ahmad, Kimberly McFarland, Tyler K Williamson, Peter Tretiakov, Jamshaid M Mir, Ankita Das, Joshua Bell, Sara Naessig, Shaleen Vira, Virginie Lafage, Carl Paulino, Bassel Diebo, Andrew Schoenfeld, Hamid Hassanzadeh, Pawel P Jankowski, Aaron Hockley, Peter Gust Passias
BACKGROUND: With the increasing amount of elective spine fusion patients presenting with cardiac disease and congestive heart failure, it is becoming difficult to assess when it is safe to proceed with surgery. Assessing the severity of heart failure (HF) through ejection fraction may provide insight into patients' short- and long-term risks. PURPOSE: The purpose of this study was to assess the severity of HF on perioperative outcomes of spine fusion surgery patients...
2024: Journal of Craniovertebral Junction and Spine
#15
REVIEW
Md Faruque Ahmad, Fakhruddin Ali Ahmad, Nazim Hasan, Abdulrahman A Alsayegh, Othman Hakami, Farkad Bantun, Shadma Tasneem, Waleed M Alamie, Ahmad O Babalghith, Abdullah F Aldairi, Nahla Kambal, Ehab Y Elbendary
Diabetes is a chronic metabolic disorder. Diabetes complications can affect many organs and systems in the body. Ganoderma lucidum (G. lucidum) contains various compounds that have been studied for their potential antidiabetic effects, including polysaccharides, triterpenoids (ganoderic acids, ganoderol B), proteoglycans, and G. lucidum extracts. G. lucidum polysaccharides (GLPs) and triterpenoids have been shown to act through distinct mechanisms, such as improving glucose metabolism, modulating the mitogen-activated protein kinase (MAPK) system, inhibiting the nuclear factor-kappa B (NF-κB) pathway, and protecting the pancreatic beta cells...
April 18, 2024: International Journal of Biological Macromolecules
#16
JOURNAL ARTICLE
Mihail Kantor, Paulo Vieira, Zafar Handoo
Meloidogyne naasi Franklin, 1965, the barley root-knot nematode, was originally found in field crops such as cereals, grasses, and sugar beet (Beta vulgaris L.) in England and Wales, (Franklin,1965). This nematode is one of the most significant root-knot nematodes impacting grains in European countries (Santos et al. 2020). Among root-knot nematode species, M. naasi, exhibits a distinct preference for grasses, with documented impacts on turfgrasses leading to reduced growth and vigor (Skantar et al., 2023; Cook and Yeates, 1993)...
April 19, 2024: Plant Disease
#17
JOURNAL ARTICLE
Rajesh P Haridas
On 7 September 1847, in Melbourne in the Port Phillip District of the Colony of New South Wales, David John Thomas (1813-1871) presented a paper, 'On the inhalation of the vapour of Æther, with cases', at an ordinary monthly meeting of the Port Phillip Medical Association. This is the earliest known presentation of a paper on etherisation in Australia. The partial publication of the manuscript in October 1847 in the Australian Medical Journal may have led to it being returned to Thomas in Melbourne. The handwritten manuscript is now preserved in the Medical History Museum, University of Melbourne, Melbourne, Victoria...
April 19, 2024: Anaesthesia and Intensive Care
#18
Samah A Elshweikh, Amr Abdellatif Ibrahim, Waleed Saleh Almutairi, Fahad AlHarbi, Abdullah A Alrasheedi, Ahmed Negm Eldine Said Mubark, Eman Ibrahim Basha, Reham M Elkolaly
Mycotic (infected) aortic aneurysm is a severe clinical condition with high morbidity and mortality. Salmonella spp. is a Gram-negative, rod-shaped bacteria that is typically limited to the gastrointestinal tract and resolves spontaneously but can progress to invasive infections such as bacteremia. Serious complications may arise, particularly in debilitated, elderly, and neonatal patients. We describe the case of a 74-year-old female with a history of diabetes and hypertension who presented with shortness of breath, fever, chills, abdominal pain, vomiting, and diarrhea...
March 2024: Curēus
#19
JOURNAL ARTICLE
P Braude, F Parry, K Warren, E Mitchell, K McCarthy, R G Khadaroo, B Carter
PURPOSE: Screening for frailty in people admitted with emergency surgical pathology can initiate timely referrals to enhanced perioperative services such as intensive care and geriatric medicine. However, there has been little research exploring surgical healthcare professionals' opinions to frailty assessment, or accuracy in identification. This study aimed to assess the knowledge, behaviour, and attitudes of healthcare professionals to frailty assessment in emergency surgical admissions...
April 18, 2024: European Geriatric Medicine
#20
JOURNAL ARTICLE
Chryso Th Pallari, Souzana Achilleos, Annalisa Quattrocchi, John Gabel, Elena Critselis, Maria Athanasiadou, Mohammad Reza Rahmanian Haghighi, Stefania Papatheodorou, Tianyu Liu, Andreas Artemiou, Jose M Rodriguez-Llanes, Catherine M Bennett, Claudia Zimmermann, Eva Schernhammer, Natalia Bustos Sierra, Reindert Ekelson, Jackeline Lobato, Laylla Macedo, Laust Hvas Mortensen, Julia Critchley, Lucy Goldsmith, Gleb Denissov, Nolwenn Le Meur, Levan Kandelaki, Kostas Athanasakis, Binyamin Binyaminy, Tamar Maor, Fabrizio Stracci, Giuseppe Ambrosio, Kairat Davletov, Nataliya Glushkova, Cyndy Martial, Marie Chan Sun, Terje P Hagen, Mario Chong, Manuel Barron, Błażej Łyszczarz, Ivan Erzen, Pedro Arcos Gonzalez, Bo Burström, Nataliia Pidmurniak, Olesia Verstiuk, Qian Huang, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou
INTRODUCTION: To examine the impact of the COVID-19 pandemic on mortality, we estimated excess all-cause mortality in 24 countries for 2020 and 2021, overall and stratified by sex and age. METHODS: Total, age-specific and sex-specific weekly all-cause mortality was collected for 2015-2021 and excess mortality for 2020 and 2021 was calculated by comparing weekly 2020 and 2021 age-standardised mortality rates against expected mortality, estimated based on historical data (2015-2019), accounting for seasonality, and long-term and short-term trends...
April 18, 2024: BMJ Global Health
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